Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 75832551 . G A CCDS7340.1:NM_003373.3:c.563cGa>cAa_NP_003364.1:p.188R>Q Homo sapiens vinculin (VCL), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
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label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6upw 1 P18206 100.0 0.0 EM
 2020-09-30 ARG A:188 NA:NA DO NA DO DO DO NA NA NA
ARG C:188 NA:NA DO NA DO DO DO NA NA NA
7ktt 1 P18206 100.0 0.0 EM
 2021-01-27 ARG A:188 A:188 50.0 0.222 H -65.8 -36.4 50.0 0.222 0.0
7ktu 1 P18206 100.0 0.0 EM
 2021-01-27 ARG A:188 A:188 45.0 0.2 H -65.9 -45.3 45.0 0.2 0.0
7ktv 1 P18206 100.0 0.0 EM
 2021-01-27 ARG A:188 A:188 44.0 0.196 H -74.3 -36.7 44.0 0.196 0.0
7ktw 1 P18206 100.0 0.0 EM
 2021-01-27 ARG A:188 A:188 43.0 0.191 H -63.4 -41.4 43.0 0.191 0.0
1tr2 1 P18206 90.83 0.0 X-RAY
 2005-11-15 ARG A:188 A:188 64.0 0.284 H -66.7 -30.8 64.0 0.284 0.0 HOH
 2.724
 NH2
 O
ARG B:188 B:188 63.0 0.28 H -56.8 -29.8 NA NA NA
6fuy 1 P18206 90.48 0.0 X-RAY
 2018-03-14 ARG A:188 A:188 62.0 0.276 H -57.4 -44.1 62.0 0.276 0.0 HOH
 7.612
 N
 O
6nr7 1 P12003 86.42 0.0 X-RAY
 2020-01-29 ARG A:208 A:188 68.0 0.302 H -49.0 -28.2 68.0 0.302 0.0 SO4
HOH
 8.341
8.235
 N
NH1
 O3
O
1st6 1 P12003 86.42 0.0 X-RAY
 2004-08-03 ARG A:191 A:188 72.0 0.32 H -73.6 -31.1 72.0 0.32 0.0
2gdc 1 P12003 98.12 0.0 X-RAY
 2006-08-08 ARG A:188 A:188 52.0 0.231 H -62.1 -38.5 52.0 0.231 0.0
3rf3 1 P18206 100.0 0.0 X-RAY
 2011-04-27 ARG A:188 A:188 55.0 0.244 H -60.5 -46.6 55.0 0.244 0.0 CAC
HOH
 9.732
1.764
 O
HH22
 C2
O
ARG B:188 B:188 57.0 0.253 H -60.7 -47.1 NA NA NA
4dj9 1 P18206 100.0 0.0 X-RAY
 2012-02-29 ARG A:188 A:188 68.0 0.302 H -62.2 -47.0 68.0 0.302 0.0 HOH
 6.239
 CG
 O
2gww 1 P18206 100.0 0.0 X-RAY
 2006-11-14 ARG A:196 A:188 47.0 0.209 H -63.3 -38.6 47.0 0.209 0.0 HOH
 3.495
 CD
 O
2hsq 1 P18206 100.0 0.0 X-RAY
 2006-11-21 ARG A:196 A:188 63.0 0.28 H -48.4 -44.5 63.0 0.28 0.0
2ibf 1 P18206 100.0 0.0 X-RAY
 2007-09-18 ARG A:196 A:188 72.0 0.32 H -55.0 -41.8 72.0 0.32 0.0
1rkc 1 P18206 100.0 0.0 X-RAY
 2004-01-13 ARG A:192 A:188 81.0 0.36 H -42.8 -47.2 81.0 0.36 0.0
1rke 1 P18206 100.0 0.0 X-RAY
 2004-01-13 ARG A:192 A:188 56.0 0.249 H -61.3 -37.6 54.0 0.24 0.009 B:P18206:0.009
 HOH
 3.511
 O
 O
1syq 1 P18206 100.0 0.0 X-RAY
 2004-07-20 ARG A:194 A:188 61.0 0.271 H -60.0 -51.2 61.0 0.271 0.0 HOH
 6.356
 N
 O
1ydi 1 P18206-2 100.0 0.0 X-RAY
 2005-07-19 ARG A:193 A:188 60.0 0.267 H -61.4 -45.2 60.0 0.267 0.0 HOH
 2.714
 NH2
 O
3tj6 1 P18206 100.0 0.0 X-RAY
 2011-09-07 ARG A:188 A:188 59.0 0.262 H -57.2 -44.1 59.0 0.262 0.0 HOH
 3.284
 NH1
 O
1u6h 1 P12003 98.07 4e-180 X-RAY
 2005-01-18 ARG A:209 A:187 60.0 0.267 H -59.6 -33.7 60.0 0.267 0.0 HOH
 6.248
 N
 O
1xwj 1 P12003 98.07 4e-180 X-RAY
 2005-10-11 ARG A:209 A:187 73.0 0.324 H -58.6 -53.9 73.0 0.324 0.0 HOH
 4.049
 NE
 O
3zdl 1 P12003 98.07 4e-180 X-RAY
 2013-02-13 ARG A:209 A:187 74.0 0.329 H -58.5 -41.7 74.0 0.329 0.0 HOH
 6.025
 NH1
 O
6fq4 1 P12003 98.07 4e-180 X-RAY
 2018-05-09 ARG A:209 A:188 84.0 0.373 H -50.9 -49.9 84.0 0.373 0.0
1zvz 1 P12003 98.07 4e-180 X-RAY
 2005-09-20 ARG A:208 A:187 78.0 0.347 H -58.2 -45.7 78.0 0.347 0.0 HOH
 3.127
 NE
 O
1zw2 1 P12003 98.07 4e-180 X-RAY
 2005-09-20 ARG A:208 A:187 65.0 0.289 H -67.1 -46.5 65.0 0.289 0.0 HOH
 6.261
 NH2
 O
1zw3 1 P12003 98.07 4e-180 X-RAY
 2005-09-20 ARG A:208 A:187 62.0 0.276 H -57.7 -37.2 62.0 0.276 0.0
4e17 1 P12003 98.07 7e-180 X-RAY
 2012-05-16 ARG A:192 A:188 81.0 0.36 H -61.7 -40.0 81.0 0.36 0.0 HOH
 6.470
 NH1
 O
4e18 1 P12003 98.07 7e-180 X-RAY
 2012-05-16 ARG A:192 A:188 75.0 0.333 H -62.2 -48.6 75.0 0.333 0.0 HOH
 3.033
 NE
 O
3tj5 1 P18206 100.0 9e-180 X-RAY
 2011-09-07 ARG A:188 A:188 49.0 0.218 H -61.8 -45.0 49.0 0.218 0.0 HOH
 3.987
 O
 O
3s90 1 P18206 100.0 6e-177 X-RAY
 2011-06-22 ARG A:189 A:188 54.0 0.24 H -61.6 -42.1 54.0 0.24 0.0 HOH
 5.956
 N
 O
ARG B:189 B:188 54.0 0.24 H -60.9 -43.0 NA NA NA
4ehp 1 P18206 100.0 6e-177 X-RAY
 2012-04-18 ARG A:189 A:188 66.0 0.293 H -62.9 -46.0 66.0 0.293 0.0 ACT
HOH
 7.309
6.316
 CD
CG
 OXT
O
1t01 1 P12003 98.03 3e-176 X-RAY
 2004-08-24 ARG A:189 A:188 81.0 0.36 H -63.2 -46.2 81.0 0.36 0.0 HOH
 4.073
 CB
 O
5y04 1 Q64727 100.0 3e-175 X-RAY
 2018-03-28 ARG A:190 A:188 69.0 0.307 H -55.9 -47.9 69.0 0.307 0.0 HOH
 9.289
 NH2
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p18206-f1 1 P18206 100.0 0.0 ARG A:188 A:188 52.0 0.231 H -58.8 -48.0