Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 75834615 . G A CCDS7340.1:NM_003373.3:c.737cGt>cAt_NP_003364.1:p.246R>H Homo sapiens vinculin (VCL), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
6upw 1 P18206 100.0 0.0 EM
 2020-09-30 ARG A:246 NA:NA DO NA DO DO DO NA NA NA
ARG C:246 NA:NA DO NA DO DO DO NA NA NA
7ktt 1 P18206 100.0 0.0 EM
 2021-01-27 ARG A:246 A:246 127.0 0.564 H -89.7 -8.7 127.0 0.564 0.0
7ktu 1 P18206 100.0 0.0 EM
 2021-01-27 ARG A:246 A:246 163.0 0.724 H -77.1 -29.8 163.0 0.724 0.0
7ktv 1 P18206 100.0 0.0 EM
 2021-01-27 ARG A:246 A:246 36.0 0.16 H -69.6 -29.6 36.0 0.16 0.0
7ktw 1 P18206 100.0 0.0 EM
 2021-01-27 ARG A:246 A:246 74.0 0.329 H -70.7 -23.0 74.0 0.329 0.0
1tr2 1 P18206 90.83 0.0 X-RAY
 2005-11-15 ARG A:246 A:246 67.0 0.298 H -58.0 -60.6 67.0 0.298 0.0 HOH
 6.393
 CD
 O
ARG B:246 B:246 36.0 0.16 H -50.2 -66.4 NA NA NA
6fuy 1 P18206 90.48 0.0 X-RAY
 2018-03-14 ARG A:246 A:246 71.0 0.316 H -68.5 -43.5 71.0 0.316 0.0 HOH
 7.402
 O
 O
6nr7 1 P12003 86.42 0.0 X-RAY
 2020-01-29 ARG A:266 A:246 34.0 0.151 H -62.0 -48.3 34.0 0.151 0.0 SO4
HOH
 7.666
5.647
 NH2
CD
 O3
O
1st6 1 P12003 86.42 0.0 X-RAY
 2004-08-03 ARG A:249 A:246 43.0 0.191 H -76.5 -40.4 43.0 0.191 0.0
2gdc 1 P12003 98.12 0.0 X-RAY
 2006-08-08 ARG A:246 A:246 111.0 0.493 H -61.2 -58.4 111.0 0.493 0.0 HOH
 7.193
 N
 O
3rf3 1 P18206 100.0 0.0 X-RAY
 2011-04-27 ARG A:246 A:246 110.0 0.489 H -63.4 -46.1 110.0 0.489 0.0 HOH
 2.211
 HH11
 O
ARG B:246 B:246 112.0 0.498 H -62.7 -46.4 NA NA NA
4dj9 1 P18206 100.0 0.0 X-RAY
 2012-02-29 ARG A:246 A:246 114.0 0.507 H -66.5 -46.3 114.0 0.507 0.0 HOH
 3.455
 NH1
 O
2gww 1 P18206 100.0 0.0 X-RAY
 2006-11-14 ARG A:254 A:246 163.0 0.724 H -51.6 -57.1 163.0 0.724 0.0 HOH
 2.762
 NH2
 O
2hsq 1 P18206 100.0 0.0 X-RAY
 2006-11-21 ARG A:254 A:246 162.0 0.72 H -49.1 -43.9 162.0 0.72 0.0
2ibf 1 P18206 100.0 0.0 X-RAY
 2007-09-18 ARG A:254 A:246 158.0 0.702 H -60.3 -44.0 158.0 0.702 0.0
1rkc 1 P18206 100.0 0.0 X-RAY
 2004-01-13 ARG A:250 A:246 156.0 0.693 H -60.1 -48.0 156.0 0.693 0.0
1rke 1 P18206 100.0 0.0 X-RAY
 2004-01-13 ARG A:250 A:246 104.0 0.462 H -67.1 -46.2 104.0 0.462 0.0 HOH
 2.585
 O
 O
1syq 1 P18206 100.0 0.0 X-RAY
 2004-07-20 ARG A:252 A:246 158.0 0.702 H -70.1 -39.1 158.0 0.702 0.0 HOH
 2.565
 NE
 O
1ydi 1 P18206-2 100.0 0.0 X-RAY
 2005-07-19 ARG A:251 A:246 110.0 0.489 H -61.6 -50.8 110.0 0.489 0.0 HOH
 2.808
 O
 O
3tj6 1 P18206 100.0 0.0 X-RAY
 2011-09-07 ARG A:246 A:246 152.0 0.676 H -58.2 -39.3 152.0 0.676 0.0 HOH
 2.717
 NE
 O
1u6h 1 P12003 98.07 4e-180 X-RAY
 2005-01-18 ARG A:267 A:245 115.0 0.511 H -82.0 -55.7 115.0 0.511 0.0 HOH
 2.599
 O
 O
1xwj 1 P12003 98.07 4e-180 X-RAY
 2005-10-11 ARG A:267 A:245 108.0 0.48 H -56.7 -53.5 108.0 0.48 0.0 HOH
 2.672
 NH1
 O
3zdl 1 P12003 98.07 4e-180 X-RAY
 2013-02-13 ARG A:267 A:245 110.0 0.489 H -63.6 -42.1 110.0 0.489 0.0 HOH
 3.347
 NH2
 O
6fq4 1 P12003 98.07 4e-180 X-RAY
 2018-05-09 ARG A:267 A:246 94.0 0.418 H -76.7 -48.2 94.0 0.418 0.0
1zvz 1 P12003 98.07 4e-180 X-RAY
 2005-09-20 ARG A:266 A:245 111.0 0.493 H -61.2 -56.5 111.0 0.493 0.0 HOH
 2.942
 O
 O
1zw2 1 P12003 98.07 4e-180 X-RAY
 2005-09-20 ARG A:266 A:245 110.0 0.489 H -62.3 -44.8 110.0 0.489 0.0 HOH
 4.733
 NH2
 O
1zw3 1 P12003 98.07 4e-180 X-RAY
 2005-09-20 ARG A:266 A:245 106.0 0.471 H -52.5 -43.0 106.0 0.471 0.0
4e17 1 P12003 98.07 7e-180 X-RAY
 2012-05-16 ARG A:250 A:246 131.0 0.582 H -66.1 -51.3 131.0 0.582 0.0 HOH
 2.880
 NE
 O
4e18 1 P12003 98.07 7e-180 X-RAY
 2012-05-16 ARG A:250 A:246 113.0 0.502 H -65.1 -40.6 113.0 0.502 0.0 HOH
 2.954
 NH2
 O
3tj5 1 P18206 100.0 9e-180 X-RAY
 2011-09-07 ARG A:246 A:246 111.0 0.493 H -63.1 -47.5 111.0 0.493 0.0 HOH
 2.698
 O
 O
3s90 1 P18206 100.0 6e-177 X-RAY
 2011-06-22 ARG A:247 A:246 113.0 0.502 H -60.4 -49.5 113.0 0.502 0.0 HOH
 4.002
 CD
 O
ARG B:247 B:246 113.0 0.502 H -60.3 -49.4 NA NA NA
4ehp 1 P18206 100.0 6e-177 X-RAY
 2012-04-18 ARG A:247 A:246 123.0 0.547 H -67.7 -54.6 123.0 0.547 0.0 ACT
ACT
HOH
 7.378
5.078
4.061
 O
N
N
 C
O
O
1t01 1 P12003 98.03 3e-176 X-RAY
 2004-08-24 ARG A:247 A:246 106.0 0.471 H -65.0 -53.7 106.0 0.471 0.0 HOH
 2.685
 O
 O
5y04 1 Q64727 100.0 3e-175 X-RAY
 2018-03-28 ARG A:248 A:246 119.0 0.529 H -58.1 -55.9 119.0 0.529 0.0

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p18206-f1 1 P18206 100.0 0.0 ARG A:246 A:246 67.0 0.298 H -63.1 -50.8