Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94214232 . G A CCDS7421.1:NM_004969.3:c.3029cCa>cTa_NP_004960.2:p.1010P>L Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 PRO A:1010 A:1010 82.0 0.566 -51.8 152.7 NA NA NA
PRO B:1010 B:1010 84.0 0.579 -84.4 174.3 84.0 0.579 0.0
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 PRO A:1010 A:1010 85.0 0.586 -48.3 150.0 85.0 0.586 0.0 ACY
HOH
4.536
5.824
CB
N
O
O
PRO B:1010 B:1010 85.0 0.586 -52.8 176.0 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 PRO A:1010 A:1010 88.0 0.607 -66.2 154.8 88.0 0.607 0.0 HOH
6.130
N
O
PRO B:1010 B:1010 85.0 0.586 -65.8 151.6 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 PRO A:981 A:1010 68.0 0.469 -70.5 144.7 68.0 0.469 0.0 HOH
5.713
CB
O
PRO B:981 B:1010 73.0 0.503 -64.9 161.2 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 PRO A:981 A:1010 82.0 0.566 -63.7 150.5 82.0 0.566 0.0 HOH
4.341
C
O
PRO B:981 B:1010 69.0 0.476 -64.9 152.4 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 PRO A:981 A:1010 87.0 0.6 -59.0 179.6 87.0 0.6 0.0 HOH
4.138
O
O
PRO B:981 B:1010 74.0 0.51 -62.8 165.2 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 PRO A:981 A:1010 85.0 0.586 -60.9 154.7 85.0 0.586 0.0 HOH
4.209
C
O
PRO B:981 B:1010 77.0 0.531 -72.3 163.9 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 PRO A:981 A:1010 72.0 0.497 -70.0 136.9 72.0 0.497 0.0 HOH
2.863
CG
O
PRO B:981 B:1010 85.0 0.586 -63.4 133.2 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 PRO A:981 A:1010 62.0 0.428 -57.8 135.9 62.0 0.428 0.0
PRO B:981 B:1010 74.0 0.51 -66.2 146.8 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 PRO A:981 A:1010 78.0 0.538 -60.9 148.3 78.0 0.538 0.0 HOH
4.537
CD
O
PRO B:981 B:1010 80.0 0.552 -55.1 162.2 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 PRO A:1010 A:1010 93.0 0.641 -74.7 137.7 93.0 0.641 0.0 HOH
6.213
CB
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 PRO A:981 A:1010 79.0 0.545 -56.8 154.6 79.0 0.545 0.0 HOH
6.024
N
O
PRO B:981 B:1010 87.0 0.6 -54.6 173.3 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 PRO A:1010 A:1010 87.0 0.6 -68.9 134.0 72.0 0.497 0.103 A:P35559:0.103
HOH
4.809
N
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 PRO A:981 A:1010 89.0 0.614 -65.8 143.2 89.0 0.614 0.0 HOH
3.994
C
O
PRO B:981 B:1010 85.0 0.586 -54.2 142.4 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 PRO A:969 A:1010 85.0 0.586 -59.0 158.7 85.0 0.586 0.0 HOH
8.901
CG
O
PRO B:969 B:1010 83.0 0.572 -59.2 159.4 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 PRO A:969 A:1010 85.0 0.586 -85.9 151.2 85.0 0.586 0.0
PRO B:969 B:1010 76.0 0.524 -87.0 153.6 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 PRO A:969 A:1010 80.0 0.552 -89.5 164.0 80.0 0.552 0.0
PRO B:969 B:1010 78.0 0.538 -89.0 166.3 78.0 0.538 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 PRO A:980 A:1010 73.0 0.503 -71.5 141.8 73.0 0.503 0.0 HOH
6.316
N
O
PRO B:980 B:1010 75.0 0.517 -72.0 155.2 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 PRO A:980 A:1010 77.0 0.531 -69.3 163.6 60.0 0.414 0.117 B:P14735:0.117
HOH
6.585
N
O
PRO B:980 B:1010 74.0 0.51 -68.4 159.3 60.0 0.414 0.096 A:P14735:0.097
HOH
7.041
CD
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 PRO A:980 A:1010 75.0 0.517 -65.9 159.0 62.0 0.428 0.089 B:P14735:0.09
HOH
5.492
CB
O
PRO B:980 B:1010 75.0 0.517 -70.3 144.6 55.0 0.379 0.138 A:P14735:0.138
HOH
4.643
CD
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 PRO A:980 A:1010 73.0 0.503 -69.1 163.8 58.0 0.4 0.103 B:P14735:0.103
HOH
6.718
CG
O
PRO B:980 B:1010 69.0 0.476 -67.7 144.2 51.0 0.352 0.124 A:P14735:0.124
HOH
6.041
N
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 PRO A:981 A:1010 79.0 0.545 -75.9 166.6 64.0 0.441 0.104 B:P14735:0.103
HOH
4.410
CD
O
PRO B:981 B:1010 79.0 0.545 -73.4 78.8 58.0 0.4 0.145 A:P14735:0.145
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 PRO A:981 A:1010 71.0 0.49 -63.5 -172.4 71.0 0.49 0.0
PRO B:981 B:1010 71.0 0.49 -51.5 -174.3 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 PRO A:981 A:1010 76.0 0.524 -62.1 -173.1 58.0 0.4 0.124 B:P14735:0.124
HOH
6.611
CB
O
PRO B:981 B:1010 112.0 0.772 -65.7 360.0 97.0 0.669 0.103 A:P14735:0.103
HOH
3.973
O
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 PRO A:981 A:1010 115.0 0.793 -56.2 360.0 107.0 0.738 0.055 B:P14735:0.055
PRO B:981 B:1010 77.0 0.531 -68.3 -150.7 53.0 0.366 0.165 A:P14735:0.166
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 PRO A:981 A:1010 63.0 0.434 -58.0 161.1 63.0 0.434 0.0 HOH
5.004
C
O
PRO B:981 B:1010 66.0 0.455 -58.9 161.0 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 PRO A:981 A:1010 84.0 0.579 -71.4 167.1 84.0 0.579 0.0
PRO B:981 B:1010 102.0 0.703 -63.0 158.4 NA NA NA
PRO C:981 C:1010 87.0 0.6 -68.0 153.9 NA NA NA
PRO D:981 D:1010 76.0 0.524 -71.1 -174.0 NA NA NA
PRO E:981 E:1010 71.0 0.49 -71.9 163.6 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 PRO A:981 A:1010 79.0 0.545 -69.7 165.5 57.0 0.393 0.152 B:P14735:0.152
PRO B:981 B:1010 93.0 0.641 -70.6 140.7 80.0 0.552 0.089 A:P14735:0.09
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 PRO A:981 A:1010 63.0 0.434 -62.0 162.0 44.0 0.303 0.131 B:P14735:0.131
PRO B:981 B:1010 87.0 0.6 -67.0 158.8 63.0 0.434 0.166 A:P14735:0.166
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 PRO A:981 A:1010 72.0 0.497 -60.2 166.7 56.0 0.386 0.111 B:P14735:0.11
HOH
4.874
CB
O
PRO B:981 B:1010 90.0 0.621 -66.4 174.5 65.0 0.448 0.173 A:P14735:0.172
HOH
6.630
N
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 PRO A:981 A:1010 69.0 0.476 -57.7 159.1 51.0 0.352 0.124 B:P14735:0.124
HOH
6.097
N
O
PRO B:981 B:1010 87.0 0.6 -68.8 161.1 71.0 0.49 0.11 A:P14735:0.11
HOH
6.628
C
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 PRO A:981 A:1010 88.0 0.607 -55.9 151.2 88.0 0.607 0.0 HOH
5.038
CB
O
PRO B:981 B:1010 82.0 0.566 -43.5 162.0 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 PRO A:981 A:1010 84.0 0.579 -54.4 132.9 84.0 0.579 0.0 HOH
5.844
N
O
PRO B:981 B:1010 82.0 0.566 -46.2 138.4 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 PRO A:981 A:1010 81.0 0.559 -54.2 165.9 81.0 0.559 0.0 HOH
6.192
C
O
PRO B:981 B:1010 80.0 0.552 -53.3 -170.5 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 PRO A:981 A:1010 86.0 0.593 -58.1 132.2 60.0 0.414 0.179 B:P14735:0.179
HOH
5.311
O
O
PRO B:981 B:1010 84.0 0.579 -70.1 167.4 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 PRO A:981 A:1010 78.0 0.538 -72.9 103.7 78.0 0.538 0.0 HOH
5.054
O
O
PRO B:981 B:1010 88.0 0.607 -47.2 133.8 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 PRO A:981 A:1010 79.0 0.545 -69.0 77.9 79.0 0.545 0.0
PRO B:981 B:1010 75.0 0.517 -61.4 162.2 75.0 0.517 0.0
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 PRO A:981 A:1010 89.0 0.614 -56.1 148.1 89.0 0.614 0.0 HOH
4.342
C
O
PRO B:981 B:1010 84.0 0.579 -52.0 165.9 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 PRO A:981 A:1010 71.0 0.49 -69.8 169.6 71.0 0.49 0.0 HOH
5.874
N
O
PRO B:981 B:1010 75.0 0.517 -58.7 -172.9 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 PRO A:981 A:1010 80.0 0.552 -53.8 150.3 80.0 0.552 0.0 HOH
6.201
N
O
PRO B:981 B:1010 84.0 0.579 -58.0 150.8 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 PRO A:981 A:1010 79.0 0.545 -62.8 -167.6 79.0 0.545 0.0 HOH
6.969
C
O
PRO B:981 B:1010 73.0 0.503 -75.4 -144.6 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 PRO A:981 A:1010 78.0 0.538 -57.0 173.3 78.0 0.538 0.0 HOH
6.863
C
O
PRO B:981 B:1010 73.0 0.503 -54.4 179.1 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 PRO A:981 A:1010 67.0 0.462 -62.6 173.4 67.0 0.462 0.0
PRO B:981 B:1010 122.0 0.841 -60.1 360.0 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 PRO A:981 A:1010 84.0 0.579 -60.1 169.4 84.0 0.579 0.0 HOH
5.875
CB
O
PRO B:981 B:1010 83.0 0.572 -62.0 167.8 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 PRO A:981 A:1010 122.0 0.841 -64.8 360.0 122.0 0.841 0.0
PRO B:981 B:1010 109.0 0.752 -63.0 360.0 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 PRO A:981 A:1010 65.0 0.448 -64.8 166.8 65.0 0.448 0.0 HOH
5.759
N
O
PRO B:981 B:1010 64.0 0.441 -66.9 164.4 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 PRO A:981 A:1010 36.0 0.248 -60.4 141.5 36.0 0.248 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 PRO A:981 A:1010 100.0 0.69 -70.6 168.0 75.0 0.517 0.173 B:P14735:0.172
PRO B:981 NA:NA DO NA DO DO DO NA NA NA
PRO C:981 C:1010 87.0 0.6 -67.1 172.7 NA NA NA
PRO D:981 D:1010 110.0 0.759 -58.1 360.0 NA NA NA
PRO E:981 E:1010 113.0 0.779 -60.3 360.0 NA NA NA
PRO F:981 F:1010 98.0 0.676 -66.5 168.1 NA NA NA
PRO G:981 G:1010 102.0 0.703 -61.0 360.0 NA NA NA
PRO H:981 H:1010 125.0 0.862 -59.8 360.0 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 PRO A:968 A:1010 74.0 0.51 -59.8 133.5 74.0 0.51 0.0 HOH
5.637
CB
O
PRO B:968 B:1010 79.0 0.545 -57.0 146.2 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 PRO A:965 A:1010 79.0 0.545 -68.1 146.3 67.0 0.462 0.083 B:P14735:0.083
PRO B:965 B:1010 83.0 0.572 -74.4 124.9 62.0 0.428 0.144 A:P14735:0.145
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 PRO A:965 A:1010 91.0 0.628 -73.6 139.4 84.0 0.579 0.049 B:P14735:0.048
PRO B:965 B:1010 84.0 0.579 -72.8 132.7 81.0 0.559 0.02 A:P14735:0.021
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 PRO A:965 A:1010 122.0 0.841 -74.2 163.5 118.0 0.814 0.027 B:P14735:0.028
PRO B:965 B:1010 102.0 0.703 -75.9 -173.4 90.0 0.621 0.082 A:P14735:0.083
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 PRO A:965 A:1010 87.0 0.6 -73.5 136.0 80.0 0.552 0.048 B:P14735:0.048
PRO B:965 B:1010 81.0 0.559 -76.8 137.5 76.0 0.524 0.035 A:P14735:0.034
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 PRO A:965 A:1010 90.0 0.621 -73.9 136.4 68.0 0.469 0.152 B:P14735:0.152
PRO B:965 B:1010 85.0 0.586 -74.5 135.3 79.0 0.545 0.041 A:P14735:0.041
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 PRO A:965 A:1010 86.0 0.593 -73.4 138.4 83.0 0.572 0.021 B:P14735:0.021
PRO B:965 B:1010 81.0 0.559 -73.4 134.9 70.0 0.483 0.076 A:P14735:0.076
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 PRO A:965 A:1010 87.0 0.6 -74.3 136.7 80.0 0.552 0.048 B:P14735:0.048
PRO B:965 B:1010 108.0 0.745 -72.5 132.7 99.0 0.683 0.062 A:P14735:0.062
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 PRO A:965 A:1010 77.0 0.531 -69.1 166.1 55.0 0.379 0.152 B:P14735:0.152
PRO B:965 B:1010 91.0 0.628 -71.8 141.3 79.0 0.545 0.083 A:P14735:0.083
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 PRO A:969 A:1010 80.0 0.552 -82.0 177.3 74.0 0.51 0.042 A:P35559:0.041
HOH
4.828
CG
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 PRO A:981 A:1010 84.0 0.579 -59.2 142.4 84.0 0.579 0.0 HOH
4.429
C
O
PRO B:981 B:1010 83.0 0.572 -60.5 147.5 83.0 0.572 0.0 HOH
5.999
N
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 PRO A:1010 A:1010 59.0 0.407 -53.7 136.3