Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94216146 . C A CCDS7421.1:NM_004969.3:c.2866Gtc>Ttc_NP_004960.2:p.956V>F Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 VAL A:956 A:956 0.0 0.0 E -112.6 125.9 NA NA NA
VAL B:956 B:956 0.0 0.0 E -104.2 126.5 0.0 0.0 0.0
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 VAL A:956 A:956 0.0 0.0 E -98.8 127.9 0.0 0.0 0.0 HOH
8.404
CA
O
VAL B:956 B:956 0.0 0.0 E -99.9 121.9 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 VAL A:956 A:956 0.0 0.0 E -113.5 122.1 0.0 0.0 0.0 HOH
7.700
C
O
VAL B:956 B:956 0.0 0.0 E -112.8 122.0 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 VAL A:927 A:956 0.0 0.0 E -112.5 117.0 0.0 0.0 0.0 HOH
6.999
C
O
VAL B:927 B:956 0.0 0.0 E -113.5 118.5 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 VAL A:927 A:956 0.0 0.0 E -120.8 115.3 0.0 0.0 0.0 HOH
7.020
C
O
VAL B:927 B:956 0.0 0.0 E -114.8 118.3 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 VAL A:927 A:956 0.0 0.0 E -118.1 115.5 0.0 0.0 0.0 HOH
7.132
C
O
VAL B:927 B:956 0.0 0.0 E -115.2 115.5 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 VAL A:927 A:956 0.0 0.0 E -114.6 119.9 0.0 0.0 0.0 HOH
6.963
C
O
VAL B:927 B:956 0.0 0.0 E -114.7 119.3 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 VAL A:927 A:956 0.0 0.0 E -113.2 118.4 0.0 0.0 0.0 HOH
6.972
C
O
VAL B:927 B:956 0.0 0.0 E -115.2 117.6 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 VAL A:927 A:956 0.0 0.0 E -126.1 123.7 0.0 0.0 0.0
VAL B:927 B:956 0.0 0.0 E -101.4 131.1 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 VAL A:927 A:956 0.0 0.0 E -110.6 123.7 0.0 0.0 0.0 HOH
7.773
CG1
O
VAL B:927 B:956 0.0 0.0 E -106.5 124.3 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 VAL A:956 A:956 0.0 0.0 E -109.3 120.2 0.0 0.0 0.0 HOH
8.229
CG1
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 VAL A:927 A:956 0.0 0.0 E -112.6 118.6 0.0 0.0 0.0 HOH
7.975
CA
O
VAL B:927 B:956 0.0 0.0 E -111.8 122.0 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 VAL A:956 A:956 0.0 0.0 E -104.1 126.0 0.0 0.0 0.0 HOH
8.092
CG2
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 VAL A:927 A:956 0.0 0.0 E -112.4 122.4 0.0 0.0 0.0 HOH
7.721
CG1
O
VAL B:927 B:956 0.0 0.0 E -108.3 122.1 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 VAL A:915 A:956 0.0 0.0 E -109.7 118.4 0.0 0.0 0.0 HOH
7.967
CG1
O
VAL B:915 B:956 0.0 0.0 E -110.0 118.4 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 VAL A:915 A:956 0.0 0.0 E -110.4 124.5 0.0 0.0 0.0
VAL B:915 B:956 0.0 0.0 E -110.6 122.4 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 VAL A:915 A:956 1.0 0.006 E -119.9 121.1 1.0 0.006 0.0
VAL B:915 B:956 0.0 0.0 E -120.8 121.3 0.0 0.0 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 VAL A:926 A:956 0.0 0.0 E -110.6 124.4 0.0 0.0 0.0 HOH
8.005
CG1
O
VAL B:926 B:956 0.0 0.0 E -119.5 125.5 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 VAL A:926 A:956 0.0 0.0 E -112.8 124.4 0.0 0.0 0.0 HOH
7.165
CG2
O
VAL B:926 B:956 0.0 0.0 E -113.3 124.1 0.0 0.0 0.0 HOH
7.247
C
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 VAL A:926 A:956 0.0 0.0 E -120.7 119.8 0.0 0.0 0.0 HOH
8.565
CG1
O
VAL B:926 B:956 0.0 0.0 E -117.1 121.5 0.0 0.0 0.0 HOH
8.034
CG1
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 VAL A:926 A:956 0.0 0.0 E -117.1 119.9 0.0 0.0 0.0 HOH
7.299
C
O
VAL B:926 B:956 0.0 0.0 E -120.2 123.7 0.0 0.0 0.0 HOH
7.038
CG2
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 VAL A:927 A:956 1.0 0.006 E -112.4 123.5 1.0 0.006 0.0 HOH
7.992
CA
O
VAL B:927 B:956 0.0 0.0 E -96.7 138.1 0.0 0.0 0.0 HOH
7.149
C
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 VAL A:927 A:956 0.0 0.0 E -107.3 119.9 0.0 0.0 0.0
VAL B:927 B:956 0.0 0.0 E -108.1 130.0 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 VAL A:927 A:956 0.0 0.0 E -106.1 124.1 0.0 0.0 0.0 HOH
8.410
CA
O
VAL B:927 B:956 0.0 0.0 E -105.2 125.8 0.0 0.0 0.0 HOH
9.317
C
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 VAL A:927 A:956 0.0 0.0 E -114.1 122.4 0.0 0.0 0.0
VAL B:927 B:956 0.0 0.0 E -113.8 122.5 0.0 0.0 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 VAL A:927 A:956 0.0 0.0 E -110.5 126.9 0.0 0.0 0.0
VAL B:927 B:956 0.0 0.0 E -110.1 125.6 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 VAL A:927 A:956 0.0 0.0 E -108.6 120.7 0.0 0.0 0.0
VAL B:927 B:956 0.0 0.0 E -112.6 116.4 NA NA NA
VAL C:927 C:956 0.0 0.0 E -110.3 118.4 NA NA NA
VAL D:927 D:956 0.0 0.0 E -115.0 121.9 NA NA NA
VAL E:927 E:956 0.0 0.0 E -105.1 121.3 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 VAL A:927 A:956 0.0 0.0 E -119.7 123.5 0.0 0.0 0.0
VAL B:927 B:956 0.0 0.0 E -117.8 166.9 0.0 0.0 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 VAL A:927 A:956 0.0 0.0 E -108.2 129.8 0.0 0.0 0.0
VAL B:927 B:956 0.0 0.0 E -113.5 125.3 0.0 0.0 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 VAL A:927 A:956 0.0 0.0 E -108.1 122.6 0.0 0.0 0.0
VAL B:927 B:956 0.0 0.0 E -98.8 127.7 0.0 0.0 0.0
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 VAL A:927 A:956 0.0 0.0 E -106.6 124.9 0.0 0.0 0.0 HOH
7.631
CG1
O
VAL B:927 B:956 0.0 0.0 E -109.1 124.9 0.0 0.0 0.0 HOH
7.124
C
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 VAL A:927 A:956 0.0 0.0 E -113.5 123.2 0.0 0.0 0.0 HOH
7.226
C
O
VAL B:927 B:956 0.0 0.0 E -117.4 118.2 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 VAL A:927 A:956 0.0 0.0 E -110.2 124.0 0.0 0.0 0.0 HOH
7.591
CG1
O
VAL B:927 B:956 0.0 0.0 E -108.9 121.0 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 VAL A:927 A:956 0.0 0.0 E -106.0 122.0 0.0 0.0 0.0 HOH
8.026
CA
O
VAL B:927 B:956 0.0 0.0 E -107.6 122.3 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 VAL A:927 A:956 0.0 0.0 E -112.9 121.0 0.0 0.0 0.0 HOH
8.162
CA
O
VAL B:927 B:956 0.0 0.0 E -112.9 118.6 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 VAL A:927 A:956 0.0 0.0 E -108.9 116.9 0.0 0.0 0.0 HOH
9.232
CG1
O
VAL B:927 B:956 0.0 0.0 E -114.0 116.9 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 VAL A:927 A:956 0.0 0.0 E -107.9 121.6 0.0 0.0 0.0 HOH
8.742
CA
O
VAL B:927 B:956 0.0 0.0 E -113.9 120.5 0.0 0.0 0.0 HOH
8.812
C
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 VAL A:927 A:956 0.0 0.0 E -111.2 120.7 0.0 0.0 0.0 HOH
8.247
CA
O
VAL B:927 B:956 0.0 0.0 E -107.1 118.9 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 VAL A:927 A:956 0.0 0.0 E -118.0 122.2 0.0 0.0 0.0 HOH
8.159
CA
O
VAL B:927 B:956 0.0 0.0 E -105.4 132.0 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 VAL A:927 A:956 0.0 0.0 E -108.2 120.3 0.0 0.0 0.0 HOH
8.800
C
O
VAL B:927 B:956 0.0 0.0 E -106.3 131.0 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 VAL A:927 A:956 0.0 0.0 E -92.0 123.9 0.0 0.0 0.0
VAL B:927 B:956 0.0 0.0 E -101.6 118.8 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 VAL A:927 A:956 0.0 0.0 E -111.7 122.4 0.0 0.0 0.0 HOH
8.248
CA
O
VAL B:927 B:956 0.0 0.0 E -108.1 128.4 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 VAL A:927 A:956 0.0 0.0 E -127.6 113.2 0.0 0.0 0.0
VAL B:927 B:956 0.0 0.0 E -125.4 120.3 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 VAL A:927 A:956 0.0 0.0 E -107.3 124.5 0.0 0.0 0.0 HOH
8.829
CG2
O
VAL B:927 B:956 0.0 0.0 E -106.4 123.9 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 VAL A:927 A:956 0.0 0.0 E -102.2 120.1 0.0 0.0 0.0
VAL B:927 B:956 0.0 0.0 E -113.1 125.6 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 VAL A:927 A:956 0.0 0.0 E -104.9 122.6 0.0 0.0 0.0 HOH
8.683
CG2
O
VAL B:927 B:956 0.0 0.0 E -105.7 120.8 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 VAL A:927 A:956 0.0 0.0 E -111.1 125.1 0.0 0.0 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 VAL A:927 A:956 0.0 0.0 E -117.8 118.7 0.0 0.0 0.0
VAL B:927 B:956 0.0 0.0 E -115.7 116.0 0.0 0.0 0.0
VAL C:927 C:956 0.0 0.0 E -114.5 117.0 NA NA NA
VAL D:927 D:956 0.0 0.0 E -114.5 120.2 NA NA NA
VAL E:927 E:956 0.0 0.0 E -116.2 114.7 NA NA NA
VAL F:927 F:956 0.0 0.0 E -116.9 116.6 NA NA NA
VAL G:927 G:956 0.0 0.0 E -115.6 118.3 NA NA NA
VAL H:927 H:956 0.0 0.0 E -119.0 116.1 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 VAL A:914 A:956 0.0 0.0 E -107.1 122.0 0.0 0.0 0.0 HOH
7.506
CG1
O
VAL B:914 B:956 0.0 0.0 E -103.1 124.9 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 VAL A:911 A:956 1.0 0.006 E -136.1 127.3 1.0 0.006 0.0
VAL B:911 B:956 1.0 0.006 E -138.1 122.7 1.0 0.006 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 VAL A:911 A:956 15.0 0.097 E -141.1 132.7 15.0 0.097 0.0
VAL B:911 B:956 5.0 0.032 E -136.8 124.9 5.0 0.032 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 VAL A:911 A:956 25.0 0.161 E -142.7 132.3 25.0 0.161 0.0
VAL B:911 B:956 17.0 0.11 -136.0 124.3 17.0 0.11 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 VAL A:911 A:956 14.0 0.09 E -137.9 128.9 14.0 0.09 0.0
VAL B:911 B:956 19.0 0.123 E -137.5 128.4 19.0 0.123 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 VAL A:911 A:956 19.0 0.123 E -138.4 128.2 19.0 0.123 0.0
VAL B:911 B:956 22.0 0.142 E -137.1 126.9 22.0 0.142 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 VAL A:911 A:956 1.0 0.006 E -134.2 123.1 1.0 0.006 0.0
VAL B:911 B:956 0.0 0.0 E -130.5 122.3 0.0 0.0 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 VAL A:911 A:956 10.0 0.065 E -135.1 123.7 10.0 0.065 0.0
VAL B:911 B:956 1.0 0.006 E -131.7 124.1 1.0 0.006 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 VAL A:911 A:956 1.0 0.006 E -118.7 123.2 1.0 0.006 0.0
VAL B:911 B:956 0.0 0.0 E -118.7 166.1 0.0 0.0 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 VAL A:915 A:956 0.0 0.0 E -116.8 114.8 0.0 0.0 0.0 HOH
7.302
CG2
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 VAL A:927 A:956 0.0 0.0 E -108.1 121.9 0.0 0.0 0.0 HOH
7.337
CG2
O
VAL B:927 B:956 0.0 0.0 E -111.4 123.4 0.0 0.0 0.0 DIO
HOH
9.689
7.615
CG1
CG2
C2
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 VAL A:956 A:956 0.0 0.0 E -109.2 118.2