Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94223617 . T A CCDS7421.1:NM_004969.3:c.2632Aca>Tca_NP_004960.2:p.878T>S Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 THR A:878 A:878 95.0 0.679 -66.5 153.3 NA NA NA
THR B:878 B:878 86.0 0.614 -73.0 153.8 86.0 0.614 0.0 HOH
4.519
C
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 THR A:878 A:878 93.0 0.664 -62.1 159.5 93.0 0.664 0.0 HOH
2.934
N
O
THR B:878 B:878 79.0 0.564 -72.5 151.7 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 THR A:878 A:878 90.0 0.643 -66.7 165.9 90.0 0.643 0.0 HOH
2.834
N
O
THR B:878 B:878 84.0 0.6 -69.2 163.2 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 THR A:849 A:878 83.0 0.593 -75.7 154.5 83.0 0.593 0.0 HOH
2.949
N
O
THR B:849 B:878 89.0 0.636 -71.4 159.4 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 THR A:849 A:878 88.0 0.629 -68.2 163.9 88.0 0.629 0.0 HOH
3.063
N
O
THR B:849 B:878 85.0 0.607 -78.3 155.6 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 THR A:849 A:878 91.0 0.65 -71.0 159.6 91.0 0.65 0.0 HOH
2.994
N
O
THR B:849 B:878 86.0 0.614 -78.2 157.0 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 THR A:849 A:878 91.0 0.65 -71.8 161.9 91.0 0.65 0.0 HOH
2.835
N
O
THR B:849 B:878 84.0 0.6 -81.5 153.3 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 THR A:849 A:878 87.0 0.621 -79.6 156.4 87.0 0.621 0.0 HOH
3.023
N
O
THR B:849 B:878 90.0 0.643 -70.4 162.5 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 THR A:849 A:878 93.0 0.664 -67.3 161.8 93.0 0.664 0.0
THR B:849 B:878 94.0 0.671 -58.9 147.0 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 THR A:849 A:878 95.0 0.679 -62.9 163.6 95.0 0.679 0.0 HOH
3.042
N
O
THR B:849 B:878 56.0 NA -56.3 154.2 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 THR A:878 A:878 89.0 0.636 -67.7 157.6 89.0 0.636 0.0 HOH
6.904
O
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 THR A:849 A:878 90.0 0.643 -67.8 163.6 90.0 0.643 0.0 HOH
2.832
N
O
THR B:849 B:878 59.0 NA -58.9 152.3 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 THR A:878 A:878 92.0 0.657 -59.5 148.9 92.0 0.657 0.0 HOH
2.960
N
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 THR A:849 A:878 90.0 0.643 -69.0 156.1 90.0 0.643 0.0 HOH
5.159
C
O
THR B:849 B:878 95.0 0.679 -76.1 160.0 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 THR A:837 A:878 82.0 0.586 -73.6 160.5 82.0 0.586 0.0 HOH
2.984
N
O
THR B:837 B:878 84.0 0.6 -74.4 159.5 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 THR A:837 A:878 72.0 0.514 -61.8 159.0 72.0 0.514 0.0
THR B:837 B:878 77.0 0.55 -62.4 155.6 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 THR A:837 A:878 63.0 0.45 -62.2 156.3 11.0 0.079 0.371 B:P14735:0.371
THR B:837 B:878 77.0 0.55 -60.8 155.4 77.0 0.55 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 THR A:848 A:878 83.0 0.593 -78.1 147.6 83.0 0.593 0.0 HOH
7.675
C
O
THR B:848 B:878 83.0 0.593 -65.4 156.6 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 THR A:848 A:878 83.0 0.593 -70.4 156.5 83.0 0.593 0.0 HOH
7.510
O
O
THR B:848 B:878 83.0 0.593 -69.7 156.6 83.0 0.593 0.0
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 THR A:848 A:878 86.0 0.614 -77.7 164.9 86.0 0.614 0.0 HOH
6.428
OG1
O
THR B:848 B:878 84.0 0.6 -79.7 166.5 84.0 0.6 0.0 HOH
5.817
N
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 THR A:848 A:878 81.0 0.579 -70.7 159.1 81.0 0.579 0.0 HOH
3.208
N
O
THR B:848 B:878 82.0 0.586 -78.3 154.8 82.0 0.586 0.0 HOH
7.477
O
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 THR A:849 A:878 95.0 0.679 -62.0 150.9 95.0 0.679 0.0 HOH
2.603
N
O
THR B:849 B:878 80.0 0.571 -63.5 156.9 80.0 0.571 0.0
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 THR A:849 A:878 90.0 0.643 -66.7 158.9 90.0 0.643 0.0 HOH
8.702
N
O
THR B:849 B:878 82.0 0.586 -65.6 167.4 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 THR A:849 A:878 84.0 0.6 -70.6 163.6 84.0 0.6 0.0
THR B:849 B:878 83.0 0.593 -73.2 165.7 83.0 0.593 0.0
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 THR A:849 A:878 92.0 0.657 -78.8 155.0 92.0 0.657 0.0
THR B:849 B:878 96.0 0.686 -78.4 155.0 96.0 0.686 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 THR A:849 A:878 88.0 0.629 -64.5 159.5 88.0 0.629 0.0
THR B:849 B:878 91.0 0.65 -64.6 160.8 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 THR A:849 A:878 69.0 0.493 -70.7 157.9 69.0 0.493 0.0
THR B:849 B:878 76.0 0.543 -66.2 163.3 NA NA NA
THR C:849 C:878 77.0 0.55 -71.9 161.0 NA NA NA
THR D:849 D:878 88.0 0.629 -65.2 139.6 NA NA NA
THR E:849 E:878 70.0 0.5 -74.0 152.5 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 THR A:849 A:878 93.0 0.664 -85.5 175.2 93.0 0.664 0.0
THR B:849 B:878 87.0 0.621 -87.3 168.2 87.0 0.621 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 THR A:849 A:878 79.0 0.564 -66.0 156.9 79.0 0.564 0.0
THR B:849 B:878 86.0 0.614 -71.0 157.5 86.0 0.614 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 THR A:849 A:878 81.0 0.579 -71.1 163.6 81.0 0.579 0.0
THR B:849 B:878 90.0 0.643 -64.9 159.5 90.0 0.643 0.0 HOH
6.631
N
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 THR A:849 A:878 78.0 0.557 -72.9 163.9 78.0 0.557 0.0 HOH
5.566
N
O
THR B:849 B:878 85.0 0.607 -67.7 158.7 85.0 0.607 0.0 HOH
9.810
N
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 THR A:849 A:878 93.0 0.664 -78.8 154.4 93.0 0.664 0.0 HOH
2.813
N
O
THR B:849 B:878 88.0 0.629 -71.3 152.7 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 THR A:849 A:878 95.0 0.679 -72.3 161.0 95.0 0.679 0.0 HOH
7.472
O
O
THR B:849 B:878 88.0 0.629 -75.3 162.5 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 THR A:849 A:878 93.0 0.664 -66.1 157.4 93.0 0.664 0.0 HOH
3.030
N
O
THR B:849 B:878 88.0 0.629 -78.2 155.0 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 THR A:849 A:878 90.0 0.643 -59.4 143.4 90.0 0.643 0.0
THR B:849 B:878 79.0 0.564 -58.8 164.2 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 THR A:849 A:878 89.0 0.636 -71.5 143.6 89.0 0.636 0.0
THR B:849 B:878 92.0 0.657 -59.1 156.6 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 THR A:849 A:878 93.0 0.664 -69.2 147.3 93.0 0.664 0.0
THR B:849 B:878 91.0 0.65 -72.0 166.5 15.0 0.107 0.543 A:P14735:0.543
HOH
7.564
N
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 THR A:849 A:878 90.0 0.643 -72.3 159.8 90.0 0.643 0.0 HOH
3.032
N
O
THR B:849 B:878 91.0 0.65 -63.1 156.0 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 THR A:849 A:878 90.0 0.643 -64.2 155.3 90.0 0.643 0.0
THR B:849 B:878 85.0 0.607 -67.5 150.6 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 THR A:849 A:878 96.0 0.686 -55.3 151.2 96.0 0.686 0.0
THR B:849 B:878 79.0 0.564 -67.2 169.1 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 THR A:849 A:878 88.0 0.629 -70.2 166.0 88.0 0.629 0.0 HOH
3.798
CB
O
THR B:849 B:878 83.0 0.593 -71.2 178.6 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 THR A:849 A:878 91.0 0.65 -74.7 158.1 91.0 0.65 0.0 HOH
2.804
N
O
THR B:849 B:878 84.0 0.6 -75.5 165.0 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 THR A:849 A:878 99.0 0.707 -72.5 175.9 99.0 0.707 0.0
THR B:849 B:878 84.0 0.6 -68.4 162.4 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 THR A:849 A:878 88.0 0.629 -68.2 157.8 88.0 0.629 0.0
THR B:849 B:878 89.0 0.636 -68.9 158.6 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 THR A:849 A:878 88.0 0.629 -81.1 157.8 88.0 0.629 0.0
THR B:849 B:878 87.0 0.621 -75.0 161.7 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 THR A:849 A:878 97.0 0.693 -61.0 150.2 97.0 0.693 0.0
THR B:849 B:878 80.0 0.571 -61.3 144.3 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 THR A:849 A:878 81.0 0.579 -67.3 162.5 81.0 0.579 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 THR A:849 A:878 89.0 0.636 -82.5 155.9 89.0 0.636 0.0
THR B:849 B:878 86.0 0.614 -82.1 157.1 86.0 0.614 0.0
THR C:849 C:878 92.0 0.657 -79.2 154.9 NA NA NA
THR D:849 D:878 89.0 0.636 -87.5 152.6 NA NA NA
THR E:849 E:878 88.0 0.629 -85.1 156.2 NA NA NA
THR F:849 F:878 164.0 1.0 360.0 168.1 NA NA NA
THR G:849 G:878 92.0 0.657 -75.0 160.6 NA NA NA
THR H:849 NA:NA DO NA DO DO DO NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 THR A:836 A:878 90.0 0.643 -61.6 169.9 90.0 0.643 0.0 HOH
4.208
CB
O
THR B:836 B:878 82.0 0.586 -75.8 155.3 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 THR A:833 A:878 79.0 0.564 -75.4 167.2 79.0 0.564 0.0
THR B:833 B:878 74.0 0.529 -76.5 -177.5 74.0 0.529 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 THR A:833 A:878 83.0 0.593 -85.3 -175.2 83.0 0.593 0.0
THR B:833 B:878 75.0 0.536 -79.9 -177.9 75.0 0.536 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 THR A:833 A:878 75.0 0.536 -81.3 -167.1 75.0 0.536 0.0
THR B:833 B:878 79.0 0.564 -77.3 -171.1 79.0 0.564 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 THR A:833 A:878 79.0 0.564 -85.8 -177.3 79.0 0.564 0.0
THR B:833 B:878 69.0 0.493 -87.3 -173.7 69.0 0.493 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 THR A:833 A:878 81.0 0.579 -84.2 -178.6 81.0 0.579 0.0
THR B:833 B:878 77.0 0.55 -87.5 -175.1 77.0 0.55 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 THR A:833 A:878 94.0 0.671 -79.6 -177.7 94.0 0.671 0.0
THR B:833 B:878 88.0 0.629 -80.8 -176.3 88.0 0.629 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 THR A:833 A:878 87.0 0.621 -85.8 -168.7 87.0 0.621 0.0
THR B:833 B:878 78.0 0.557 -84.0 -176.7 78.0 0.557 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 THR A:833 A:878 91.0 0.65 -82.9 176.2 91.0 0.65 0.0
THR B:833 B:878 88.0 0.629 -85.9 167.8 88.0 0.629 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 THR A:837 A:878 84.0 0.6 -60.9 152.8 84.0 0.6 0.0 HOH
5.617
C
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 THR A:849 A:878 91.0 0.65 -69.4 160.2 13.0 0.093 0.557 B:P14735:0.557
HOH
2.997
N
O
THR B:849 B:878 87.0 0.621 -71.6 154.4 87.0 0.621 0.0 HOH
2.759
OG1
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 THR A:878 A:878 87.0 0.621 -71.2 155.5