Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94234654 . C A CCDS7421.1:NM_004969.3:c.2060cGc>cTc_NP_004960.2:p.687R>L Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
 2009-11-03 ARG A:687 A:687 129.0 0.573 H -54.3 -47.0 NA NA NA
ARG B:687 B:687 40.0 NA H -58.7 -36.2 40.0 NA NA HOH
 5.371
 O
 O
3e4a 1 P14735 98.63 0.0 X-RAY
 2009-05-19 ARG A:687 A:687 127.0 0.564 H -60.4 -45.2 127.0 0.564 0.0 DIO
HOH
 9.503
3.839
 CG
NH2
 C2
O
ARG B:687 B:687 125.0 0.556 H -53.1 -53.2 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
 2019-04-03 ARG A:687 A:687 136.0 0.604 H -65.7 -34.3 136.0 0.604 0.0 EPE
HOH
 9.538
4.604
 CD
NH2
 O3S
O
ARG B:687 B:687 130.0 0.578 H -64.8 -35.2 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
 2006-10-24 ARG A:658 A:687 118.0 0.524 H -60.6 -46.3 118.0 0.524 0.0 HOH
 2.855
 NH2
 O
ARG B:658 B:687 127.0 0.564 H -59.0 -48.1 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
 2006-10-24 ARG A:658 A:687 129.0 0.573 H -59.7 -52.9 129.0 0.573 0.0 HOH
 3.007
 NH2
 O
ARG B:658 B:687 90.0 0.4 H -64.2 -41.4 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
 2006-10-24 ARG A:658 A:687 125.0 0.556 H -60.8 -52.4 125.0 0.556 0.0 HOH
 2.979
 NH2
 O
ARG B:658 B:687 91.0 0.404 H -66.0 -39.7 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
 2006-10-24 ARG A:658 A:687 117.0 0.52 H -60.9 -47.6 117.0 0.52 0.0 HOH
 2.834
 NH2
 O
ARG B:658 B:687 98.0 0.436 H -59.8 -41.2 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
 2006-10-24 ARG A:658 A:687 115.0 0.511 H -59.6 -45.0 114.0 0.507 0.004 C:P01308:0.004
 HOH
 3.956
 CA
 O
ARG B:658 B:687 89.0 0.396 H -65.2 -47.5 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
 2007-07-03 ARG A:658 A:687 131.0 0.582 H -70.0 -46.6 131.0 0.582 0.0
ARG B:658 B:687 124.0 0.551 H -55.9 -57.2 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
 2009-08-18 ARG A:658 A:687 124.0 0.551 H -50.7 -53.1 124.0 0.551 0.0 HOH
 3.719
 CA
 O
ARG B:658 B:687 83.0 0.369 H -61.1 -42.8 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
 2011-10-26 ARG A:687 A:687 124.0 0.551 H -56.0 -38.8 124.0 0.551 0.0 HOH
 3.079
 O
 O
2jg4 1 P14735 99.9 0.0 X-RAY
 2007-07-03 ARG A:658 A:687 131.0 0.582 H -44.6 -55.9 131.0 0.582 0.0 DIO
HOH
 9.305
3.417
 CD
CG
 C2
O
ARG B:658 B:687 86.0 0.382 H -56.7 -46.2 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
 2011-07-27 ARG A:687 A:687 126.0 0.56 H -58.3 -41.7 126.0 0.56 0.0 HOH
 3.694
 O
 O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
 2009-08-18 ARG A:658 A:687 124.0 0.551 H -57.9 -52.2 124.0 0.551 0.0 HOH
 2.995
 NH2
 O
ARG B:658 B:687 122.0 0.542 H -55.4 -46.7 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
 2014-05-21 ARG A:646 A:687 130.0 0.578 H -58.1 -42.7 130.0 0.578 0.0 HOH
 3.569
 O
 O
ARG B:646 B:687 39.0 NA H -58.2 -42.3 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
 2019-04-03 ARG A:646 A:687 133.0 0.591 H -59.7 -41.8 133.0 0.591 0.0 EPE
 9.985
 CD
 O2S
ARG B:646 B:687 133.0 0.591 H -61.4 -41.4 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
 2019-04-03 ARG A:646 A:687 134.0 0.596 H -57.4 -40.6 134.0 0.596 0.0 EPE
 9.928
 CD
 O3S
ARG B:646 B:687 135.0 0.6 H -58.2 -42.0 135.0 0.6 0.0 EPE
 9.735
 CD
 O2S
4pes 1 P14735 98.57 0.0 X-RAY
 2015-06-17 ARG A:657 A:687 126.0 0.56 H -56.8 -43.2 126.0 0.56 0.0 HOH
 2.777
 NE
 O
ARG B:657 B:687 128.0 0.569 H -55.9 -38.9 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
 2015-06-17 ARG A:657 A:687 129.0 0.573 H -60.7 -43.0 129.0 0.573 0.0 HOH
 3.010
 NH2
 O
ARG B:657 B:687 123.0 0.547 H -60.0 -42.4 123.0 0.547 0.0 HOH
 2.998
 NH1
 O
4pf9 1 P14735 98.57 0.0 X-RAY
 2015-06-17 ARG A:657 A:687 126.0 0.56 H -59.6 -42.5 126.0 0.56 0.0 HOH
 3.457
 NH1
 O
ARG B:657 B:687 125.0 0.556 H -68.0 -40.0 125.0 0.556 0.0 HOH
 4.860
 O
 O
4pfc 1 P14735 98.57 0.0 X-RAY
 2015-06-17 ARG A:657 A:687 123.0 0.547 H -64.8 -37.6 123.0 0.547 0.0 HOH
 3.313
 NH1
 O
ARG B:657 B:687 121.0 0.538 H -62.4 -40.9 121.0 0.538 0.0 HOH
 3.584
 CG
 O
3qz2 1 P14735 98.67 0.0 X-RAY
 2012-01-25 ARG A:658 A:687 128.0 0.569 H -53.4 -42.6 128.0 0.569 0.0 HOH
 5.370
 NH2
 O
ARG B:658 B:687 126.0 0.56 H -55.5 -45.7 126.0 0.56 0.0 HOH
 3.293
 CG
 O
4dtt 1 P14735 98.67 0.0 X-RAY
 2013-02-27 ARG A:658 A:687 130.0 0.578 H -51.3 -41.6 130.0 0.578 0.0
ARG B:658 B:687 124.0 0.551 H -45.5 -44.8 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
 2013-12-18 ARG A:658 A:687 124.0 0.551 H -56.6 -34.7 124.0 0.551 0.0 HOH
 3.331
 CG
 O
ARG B:658 B:687 124.0 0.551 H -56.2 -37.4 124.0 0.551 0.0 HOH
 3.885
 NH2
 O
4iof 1 P14735 98.67 0.0 X-RAY
 2013-07-24 ARG A:658 A:687 120.0 0.533 H -61.7 -53.5 120.0 0.533 0.0
ARG B:658 B:687 134.0 0.596 H -62.2 -53.2 134.0 0.596 0.0
4re9 1 P14735 98.67 0.0 X-RAY
 2015-09-30 ARG A:658 A:687 129.0 0.573 H -60.4 -40.6 129.0 0.573 0.0 EPE
PEG
PEG
HOH
 9.730
8.533
7.228
9.747
 CD
NH1
NE
O
 O1S
H41
HO1
O
ARG B:658 B:687 128.0 0.569 H -58.9 -41.5 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
 2018-02-07 ARG A:658 A:687 105.0 0.467 H -63.7 -33.9 105.0 0.467 0.0
ARG B:658 B:687 118.0 0.524 H -56.2 -34.5 NA NA NA
ARG C:658 C:687 99.0 0.44 H -63.4 -30.5 NA NA NA
ARG D:658 D:687 98.0 0.436 H -60.3 -25.8 NA NA NA
ARG E:658 E:687 90.0 0.4 H -61.1 -37.7 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
 2017-11-22 ARG A:658 A:687 123.0 0.547 H -73.9 -13.7 76.0 0.338 0.209 C:P01308:0.209
ARG B:658 B:687 155.0 0.689 H -73.9 -25.0 155.0 0.689 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
 2021-09-22 ARG A:658 A:687 131.0 0.582 H -66.4 -35.3 131.0 0.582 0.0 DIO
EPE
 9.578
9.719
 NH1
CD
 H12
O1S
ARG B:658 B:687 122.0 0.542 H -54.6 -41.7 122.0 0.542 0.0 DIO
EPE
 7.768
9.717
 NH1
CD
 H1'1
O3S
7k1e 1 P14735 98.67 0.0 X-RAY
 2021-09-22 ARG A:658 A:687 106.0 0.471 H -76.8 -21.4 106.0 0.471 0.0 HOH
 4.202
 NH2
 O
ARG B:658 B:687 117.0 0.52 H -53.5 -46.6 117.0 0.52 0.0 DIO
EPE
HOH
 8.616
9.961
5.506
 NH2
CG
O
 H1'1
O3S
O
7k1f 1 P14735 98.67 0.0 X-RAY
 2021-09-22 ARG A:658 A:687 130.0 0.578 H -59.7 -39.5 130.0 0.578 0.0 DIO
EPE
HOH
 9.597
9.949
3.710
 NH1
CD
CA
 O1
O1S
O
ARG B:658 B:687 113.0 0.502 H -54.1 -45.6 113.0 0.502 0.0 DIO
HOH
 8.179
2.199
 NH2
NH2
 H11
O
2wby 1 P14735 98.57 0.0 X-RAY
 2009-03-24 ARG A:658 A:687 125.0 0.556 H -62.1 -53.6 125.0 0.556 0.0 HOH
 4.320
 CD
 O
ARG B:658 B:687 126.0 0.56 H -61.3 -41.8 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
 2009-03-24 ARG A:658 A:687 129.0 0.573 H -63.5 -50.3 105.0 0.467 0.106 D:P01308:0.107
 HOH
 2.890
 CD
 O
ARG B:658 B:687 128.0 0.569 H -67.5 -40.7 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
 2012-11-28 ARG A:658 A:687 130.0 0.578 H -56.7 -48.0 130.0 0.578 0.0 HOH
 5.651
 O
 O
ARG B:658 B:687 130.0 0.578 H -59.3 -38.7 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
 2010-04-14 ARG A:658 A:687 126.0 0.56 H -47.2 -54.8 126.0 0.56 0.0 HOH
 4.824
 NH1
 O
ARG B:658 B:687 129.0 0.573 H -67.3 -40.6 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
 2010-11-17 ARG A:658 A:687 127.0 0.564 H -55.3 -42.0 127.0 0.564 0.0 HOH
 7.618
 O
 O
ARG B:658 B:687 126.0 0.56 H -58.9 -47.8 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
 2010-11-17 ARG A:658 A:687 126.0 0.56 H -59.4 -54.7 126.0 0.56 0.0
ARG B:658 B:687 133.0 0.591 H -52.0 -50.8 133.0 0.591 0.0 HOH
 6.688
 O
 O
3ofi 1 P14735 98.57 0.0 X-RAY
 2010-09-08 ARG A:658 A:687 127.0 0.564 H -52.6 -50.0 127.0 0.564 0.0 DIO
HOH
 9.822
4.451
 CG
CG
 C2
O
ARG B:658 B:687 126.0 0.56 H -54.5 -48.8 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
 2013-04-03 ARG A:658 A:687 128.0 0.569 H -56.7 -50.2 128.0 0.569 0.0 HOH
 5.358
 NH2
 O
ARG B:658 B:687 121.0 0.538 H -55.6 -49.4 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
 2013-08-28 ARG A:658 A:687 122.0 0.542 H -53.8 -50.3 122.0 0.542 0.0 HOH
 7.350
 O
 O
ARG B:658 B:687 127.0 0.564 H -54.5 -51.7 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
 2013-08-28 ARG A:658 A:687 128.0 0.569 H -53.5 -50.8 128.0 0.569 0.0 HOH
 5.482
 O
 O
ARG B:658 B:687 126.0 0.56 H -52.0 -47.2 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
 2013-08-28 ARG A:658 A:687 130.0 0.578 H -58.7 -46.2 130.0 0.578 0.0 HOH
 5.316
 NH2
 O
ARG B:658 B:687 131.0 0.582 H -63.1 -37.0 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
 2014-08-06 ARG A:658 A:687 128.0 0.569 H -65.5 -35.7 128.0 0.569 0.0
ARG B:658 B:687 134.0 0.596 H -70.7 -18.7 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
 2015-10-07 ARG A:658 A:687 125.0 0.556 H -59.1 -42.3 125.0 0.556 0.0 PEG
EDO
HOH
 5.149
7.869
2.555
 NH2
NH2
NH2
 O4
O1
O
ARG B:658 B:687 130.0 0.578 H -60.6 -42.2 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
 2015-05-13 ARG A:658 A:687 118.0 0.524 H -54.2 -51.2 118.0 0.524 0.0
ARG B:658 B:687 96.0 0.427 H -59.1 -48.5 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
 2015-05-13 ARG A:658 A:687 124.0 0.551 H -66.6 -34.4 124.0 0.551 0.0 HOH
 5.823
 NH2
 O
ARG B:658 B:687 130.0 0.578 H -67.6 -35.5 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
 2016-07-20 ARG A:658 A:687 129.0 0.573 H -66.0 -30.8 129.0 0.573 0.0
5wob 1 P14735 98.57 0.0 X-RAY
 2018-04-18 ARG A:658 A:687 144.0 0.64 H -60.0 -49.3 144.0 0.64 0.0
ARG B:658 B:687 140.0 0.622 H -59.4 -45.3 140.0 0.622 0.0
ARG C:658 C:687 147.0 0.653 H -61.6 -46.8 NA NA NA
ARG D:658 D:687 142.0 0.631 H -60.9 -43.9 NA NA NA
ARG E:658 E:687 143.0 0.636 H -62.7 -45.4 NA NA NA
ARG F:658 F:687 144.0 0.64 H -63.1 -43.8 NA NA NA
ARG G:658 G:687 147.0 0.653 H -61.2 -45.8 NA NA NA
ARG H:658 H:687 145.0 0.644 H -60.3 -44.7 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
 2009-12-08 ARG A:645 A:687 125.0 0.556 H -58.7 -46.9 125.0 0.556 0.0 HOH
 5.473
 NH1
 O
ARG B:645 B:687 124.0 0.551 H -61.1 -42.5 NA NA NA
6b70 1 P14735 98.86 0.0 EM
 2017-12-27 ARG A:642 A:687 141.0 0.627 H -77.0 -8.2 127.0 0.564 0.063 G:P01308:0.062
ARG B:642 B:687 159.0 0.707 H -72.0 -13.8 159.0 0.707 0.0
6b7y 1 P14735 98.86 0.0 EM
 2017-11-08 ARG A:642 A:687 136.0 0.604 H -77.6 -14.2 136.0 0.604 0.0
ARG B:642 B:687 128.0 0.569 H -74.4 -14.0 128.0 0.569 0.0
6b7z 1 P14735 98.86 0.0 EM
 2018-01-10 ARG A:642 A:687 157.0 0.698 H -71.4 -16.3 157.0 0.698 0.0
ARG B:642 B:687 157.0 0.698 H -81.0 -13.7 157.0 0.698 0.0
6bf6 1 P14735 98.86 0.0 EM
 2018-02-07 ARG A:642 A:687 142.0 0.631 H -74.2 -13.8 142.0 0.631 0.0
ARG B:642 B:687 141.0 0.627 H -76.0 -13.4 141.0 0.627 0.0
6bf7 1 P14735 98.86 0.0 EM
 2018-02-07 ARG A:642 A:687 135.0 0.6 H -76.3 -13.8 135.0 0.6 0.0
ARG B:642 B:687 135.0 0.6 H -76.5 -12.6 135.0 0.6 0.0
6bf8 1 P14735 98.86 0.0 EM
 2018-04-04 ARG A:642 A:687 108.0 0.48 H -77.6 -7.3 108.0 0.48 0.0
ARG B:642 B:687 158.0 0.702 H -67.5 -18.5 158.0 0.702 0.0
6bf9 1 P14735 98.86 0.0 EM
 2018-02-07 ARG A:642 A:687 169.0 0.751 H -74.4 -13.5 169.0 0.751 0.0
ARG B:642 B:687 125.0 0.556 H -72.4 -13.3 125.0 0.556 0.0
6bfc 1 P14735 98.86 0.0 EM
 2017-12-27 ARG A:642 A:687 135.0 0.6 H -74.3 -13.6 97.0 0.431 0.169 C:P01308:0.169
ARG B:642 B:687 150.0 0.667 H -73.8 -23.9 140.0 0.622 0.045 D:P01308:0.044
3p7l 1 P35559 96.63 0.0 X-RAY
 2011-07-20 ARG A:646 A:687 122.0 0.542 H -51.9 -53.2 122.0 0.542 0.0 HOH
 3.185
 O
 O
3cww 1 P14735 97.34 0.0 X-RAY
 2008-11-25 ARG A:658 A:687 125.0 0.556 H -57.8 -48.1 125.0 0.556 0.0 HOH
 3.305
 NH1
 O
ARG B:658 B:687 122.0 0.542 H -57.2 -49.0 122.0 0.542 0.0 ACT
DIO
HOH
 6.683
9.601
3.215
 O
C
NH1
 OXT
C2
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 ARG A:687 A:687 147.0 0.653 H -61.0 -40.1