Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94235650 . G A CCDS7421.1:NM_004969.3:c.1986atC>atT_NP_004960.2:p.662I>I Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 ILE A:662 A:662 17.0 0.097 H -68.0 -39.8 NA NA NA
ILE B:662 B:662 17.0 0.097 H -75.8 -33.7 17.0 0.097 0.0 HOH
5.008
O
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 ILE A:662 A:662 17.0 0.097 H -65.9 -36.8 17.0 0.097 0.0 HOH
4.864
O
O
ILE B:662 B:662 15.0 0.086 H -71.8 -40.6 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 ILE A:662 A:662 19.0 0.109 H -63.1 -40.5 19.0 0.109 0.0 HOH
6.311
N
O
ILE B:662 B:662 18.0 0.103 H -63.8 -39.4 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 ILE A:633 A:662 14.0 0.08 H -65.6 -34.3 14.0 0.08 0.0 HOH
4.696
N
O
ILE B:633 B:662 17.0 0.097 H -66.6 -32.1 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:633 A:662 19.0 0.109 H -66.9 -35.4 19.0 0.109 0.0 HOH
4.782
CD1
O
ILE B:633 B:662 16.0 0.091 H -70.9 -33.5 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:633 A:662 18.0 0.103 H -66.9 -27.9 18.0 0.103 0.0 HOH
4.805
CD1
O
ILE B:633 B:662 17.0 0.097 H -72.0 -34.2 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:633 A:662 15.0 0.086 H -64.2 -33.9 15.0 0.086 0.0 HOH
4.630
N
O
ILE B:633 B:662 15.0 0.086 H -66.7 -34.5 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:633 A:662 16.0 0.091 H -65.1 -36.3 16.0 0.091 0.0 HOH
4.686
N
O
ILE B:633 B:662 19.0 0.109 H -62.5 -35.1 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 ILE A:633 A:662 19.0 0.109 H -65.5 -42.5 19.0 0.109 0.0 HOH
8.533
N
O
ILE B:633 B:662 15.0 0.086 H -59.1 -49.0 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 ILE A:633 A:662 18.0 0.103 H -70.8 -36.2 18.0 0.103 0.0 HOH
4.672
CD1
O
ILE B:633 B:662 18.0 0.103 H -70.3 -33.2 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 ILE A:662 A:662 16.0 0.091 H -65.6 -38.7 16.0 0.091 0.0 HOH
4.724
N
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 ILE A:633 A:662 21.0 0.12 H -64.2 -42.0 21.0 0.12 0.0 HOH
4.902
CD1
O
ILE B:633 B:662 16.0 0.091 H -72.6 -42.8 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 ILE A:662 A:662 18.0 0.103 H -57.5 -40.7 18.0 0.103 0.0 HOH
5.460
CG1
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 ILE A:633 A:662 19.0 0.109 H -66.7 -36.1 19.0 0.109 0.0 HOH
4.705
N
O
ILE B:633 B:662 19.0 0.109 H -59.6 -44.4 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 ILE A:621 A:662 17.0 0.097 H -64.3 -40.9 17.0 0.097 0.0 HOH
3.530
O
O
ILE B:621 B:662 18.0 0.103 H -65.0 -41.3 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 ILE A:621 A:662 18.0 0.103 H -66.6 -39.9 18.0 0.103 0.0
ILE B:621 B:662 16.0 0.091 H -67.2 -40.9 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 ILE A:621 A:662 18.0 0.103 H -70.3 -38.2 18.0 0.103 0.0
ILE B:621 B:662 16.0 0.091 H -70.6 -38.4 16.0 0.091 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:632 A:662 17.0 0.097 H -71.5 -38.6 17.0 0.097 0.0 HOH
2.768
O
O
ILE B:632 B:662 16.0 0.091 H -68.5 -35.1 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:632 A:662 17.0 0.097 H -64.6 -38.8 17.0 0.097 0.0 HOH
3.586
O
O
ILE B:632 B:662 16.0 0.091 H -63.1 -39.1 16.0 0.091 0.0 HOH
4.741
O
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:632 A:662 19.0 0.109 H -65.5 -40.2 19.0 0.109 0.0 HOH
4.892
O
O
ILE B:632 B:662 16.0 0.091 H -63.4 -40.1 16.0 0.091 0.0 HOH
4.896
O
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:632 A:662 13.0 0.074 H -63.9 -37.3 13.0 0.074 0.0 HOH
2.777
O
O
ILE B:632 B:662 14.0 0.08 H -66.1 -37.8 14.0 0.08 0.0 HOH
6.135
N
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 ILE A:633 A:662 20.0 0.114 H -68.3 -35.4 20.0 0.114 0.0
ILE B:633 B:662 15.0 0.086 H -66.7 -46.2 15.0 0.086 0.0 HOH
6.647
N
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 ILE A:633 A:662 19.0 0.109 H -62.2 -36.2 19.0 0.109 0.0
ILE B:633 B:662 16.0 0.091 H -63.3 -23.2 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 ILE A:633 A:662 13.0 0.074 H -55.2 -39.2 13.0 0.074 0.0 HOH
9.850
C
O
ILE B:633 B:662 13.0 0.074 H -55.6 -41.3 13.0 0.074 0.0 HOH
4.613
O
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 ILE A:633 A:662 15.0 0.086 H -70.1 -35.9 15.0 0.086 0.0
ILE B:633 B:662 13.0 0.074 H -69.5 -35.0 13.0 0.074 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 ILE A:633 A:662 21.0 0.12 H -66.9 -43.4 21.0 0.12 0.0
ILE B:633 B:662 20.0 0.114 H -67.8 -41.8 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 ILE A:633 A:662 15.0 0.086 H -72.4 -37.9 15.0 0.086 0.0
ILE B:633 B:662 16.0 0.091 H -70.3 -40.3 NA NA NA
ILE C:633 C:662 17.0 0.097 H -73.8 -36.2 NA NA NA
ILE D:633 D:662 17.0 0.097 H -68.9 -33.3 NA NA NA
ILE E:633 E:662 17.0 0.097 H -68.1 -38.1 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 ILE A:633 A:662 16.0 0.091 H -68.6 -33.4 16.0 0.091 0.0
ILE B:633 B:662 16.0 0.091 H -66.7 -36.5 16.0 0.091 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 ILE A:633 A:662 17.0 0.097 H -71.9 -39.6 17.0 0.097 0.0
ILE B:633 B:662 19.0 0.109 H -72.6 -37.4 19.0 0.109 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 ILE A:633 A:662 19.0 0.109 H -73.5 -36.8 19.0 0.109 0.0 HOH
4.027
CG2
O
ILE B:633 B:662 17.0 0.097 H -68.9 -32.7 17.0 0.097 0.0 HOH
7.106
O
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 ILE A:633 A:662 19.0 0.109 H -71.7 -34.9 19.0 0.109 0.0 HOH
4.503
CD1
O
ILE B:633 B:662 18.0 0.103 H -75.1 -32.7 18.0 0.103 0.0 HOH
4.621
CD1
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 ILE A:633 A:662 17.0 0.097 H -70.0 -35.4 17.0 0.097 0.0 HOH
4.771
CG1
O
ILE B:633 B:662 16.0 0.091 H -69.9 -34.6 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 ILE A:633 A:662 21.0 0.12 H -61.4 -43.5 21.0 0.12 0.0 HOH
5.773
CG1
O
ILE B:633 B:662 16.0 0.091 H -66.9 -38.1 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 ILE A:633 A:662 18.0 0.103 H -70.3 -43.9 18.0 0.103 0.0 HOH
5.973
N
O
ILE B:633 B:662 18.0 0.103 H -71.3 -36.1 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 ILE A:633 A:662 19.0 0.109 H -57.0 -47.2 19.0 0.109 0.0 HOH
4.784
O
O
ILE B:633 B:662 18.0 0.103 H -68.8 -38.7 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 ILE A:633 A:662 16.0 0.091 H -62.6 -43.2 16.0 0.091 0.0 HOH
8.927
O
O
ILE B:633 B:662 15.0 0.086 H -60.8 -38.0 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 ILE A:633 A:662 14.0 0.08 H -66.7 -34.7 14.0 0.08 0.0
ILE B:633 B:662 16.0 0.091 H -65.2 -37.5 16.0 0.091 0.0 HOH
7.080
N
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 ILE A:633 A:662 20.0 0.114 H -71.8 -32.1 20.0 0.114 0.0 HOH
3.500
O
O
ILE B:633 B:662 18.0 0.103 H -71.1 -39.7 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 ILE A:633 A:662 20.0 0.114 H -54.3 -45.4 20.0 0.114 0.0 HOH
9.496
CD1
O
ILE B:633 B:662 17.0 0.097 H -69.2 -41.3 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 ILE A:633 A:662 20.0 0.114 H -55.3 -43.7 20.0 0.114 0.0
ILE B:633 B:662 18.0 0.103 H -74.5 -41.7 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 ILE A:633 A:662 17.0 0.097 H -69.7 -41.2 17.0 0.097 0.0 HOH
5.144
CD1
O
ILE B:633 B:662 15.0 0.086 H -76.4 -29.2 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 ILE A:633 A:662 17.0 0.097 H -67.7 -38.8 17.0 0.097 0.0 HOH
4.918
CD1
O
ILE B:633 B:662 17.0 0.097 H -77.2 -30.1 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 ILE A:633 A:662 14.0 0.08 H -65.6 -39.2 14.0 0.08 0.0
ILE B:633 B:662 15.0 0.086 H -67.0 -40.8 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 ILE A:633 A:662 21.0 0.12 H -61.0 -38.3 21.0 0.12 0.0 EDO
HOH
8.889
8.436
O
CG2
H22
O
ILE B:633 B:662 22.0 0.126 H -60.8 -37.1 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 ILE A:633 A:662 18.0 0.103 H -59.2 -42.9 18.0 0.103 0.0
ILE B:633 B:662 18.0 0.103 H -66.4 -34.6 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 ILE A:633 A:662 9.0 0.051 H -64.1 -37.9 9.0 0.051 0.0
ILE B:633 B:662 13.0 0.074 H -65.6 -39.8 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 ILE A:633 A:662 14.0 0.08 H -60.7 -42.9 14.0 0.08 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 ILE A:633 A:662 12.0 0.069 H -65.8 -38.4 12.0 0.069 0.0
ILE B:633 B:662 11.0 0.063 H -64.5 -35.9 11.0 0.063 0.0
ILE C:633 C:662 12.0 0.069 H -67.7 -36.8 NA NA NA
ILE D:633 D:662 13.0 0.074 H -64.0 -39.0 NA NA NA
ILE E:633 E:662 8.0 0.046 H -66.9 -37.4 NA NA NA
ILE F:633 F:662 14.0 0.08 H -65.7 -36.8 NA NA NA
ILE G:633 G:662 8.0 0.046 H -66.9 -35.8 NA NA NA
ILE H:633 H:662 14.0 0.08 H -65.9 -37.9 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 ILE A:620 A:662 22.0 0.126 H -54.8 -44.4 22.0 0.126 0.0 HOH
8.687
O
O
ILE B:620 B:662 19.0 0.109 H -64.1 -42.1 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 ILE A:617 A:662 15.0 0.086 H -72.4 -32.1 15.0 0.086 0.0
ILE B:617 B:662 11.0 0.063 H -69.3 -36.9 11.0 0.063 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 ILE A:617 A:662 12.0 0.069 H -65.5 -35.8 12.0 0.069 0.0
ILE B:617 B:662 29.0 0.166 H -64.0 -33.7 29.0 0.166 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 ILE A:617 A:662 17.0 0.097 H -60.1 -37.7 17.0 0.097 0.0
ILE B:617 B:662 38.0 0.217 H -64.8 -38.6 38.0 0.217 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 ILE A:617 A:662 20.0 0.114 H -69.0 -34.1 20.0 0.114 0.0
ILE B:617 B:662 21.0 0.12 H -68.7 -32.9 21.0 0.12 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 ILE A:617 A:662 28.0 0.16 H -70.2 -35.4 28.0 0.16 0.0
ILE B:617 B:662 22.0 0.126 H -68.5 -35.0 22.0 0.126 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 ILE A:617 A:662 10.0 0.057 H -65.6 -38.2 10.0 0.057 0.0
ILE B:617 B:662 26.0 0.149 H -68.3 -35.7 26.0 0.149 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 ILE A:617 A:662 10.0 0.057 H -66.5 -36.7 10.0 0.057 0.0
ILE B:617 B:662 21.0 0.12 H -68.4 -37.0 21.0 0.12 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 ILE A:617 A:662 16.0 0.091 H -68.9 -32.6 16.0 0.091 0.0
ILE B:617 B:662 17.0 0.097 H -66.8 -35.8 17.0 0.097 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 ILE A:621 A:662 16.0 0.091 H -56.6 -43.7 16.0 0.091 0.0 HOH
5.596
CG1
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 ILE A:633 A:662 19.0 0.109 H -69.1 -32.9 19.0 0.109 0.0 HOH
3.085
O
O
ILE B:633 B:662 15.0 0.086 H -65.9 -35.8 15.0 0.086 0.0 HOH
2.981
O
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 ILE A:662 A:662 17.0 0.097 H -72.8 -36.2