Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94235704 . C A CCDS7421.1:NM_004969.3:c.1932aaG>aaT_NP_004960.2:p.644K>N Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 LYS A:644 A:644 70.0 0.35 H -54.0 -38.6 NA NA NA
LYS B:644 B:644 80.0 0.4 H -58.0 -41.4 80.0 0.4 0.0 HOH
2.693
NZ
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 LYS A:644 A:644 58.0 0.29 H -61.9 -38.9 58.0 0.29 0.0 ACY
HOH
7.498
8.032
CE
N
O
O
LYS B:644 B:644 82.0 0.41 H -75.4 -40.9 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 LYS A:644 A:644 70.0 0.35 H -65.2 -37.9 70.0 0.35 0.0 HOH
2.576
NZ
O
LYS B:644 B:644 81.0 0.405 H -67.0 -38.8 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 LYS A:615 A:644 78.0 0.39 H -62.2 -43.5 78.0 0.39 0.0 HOH
3.634
N
O
LYS B:615 B:644 62.0 0.31 H -58.4 -40.3 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 LYS A:615 A:644 70.0 0.35 H -59.1 -42.7 70.0 0.35 0.0 HOH
6.317
CE
O
LYS B:615 B:644 77.0 0.385 H -67.3 -46.9 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 LYS A:615 A:644 75.0 0.375 H -60.5 -43.6 75.0 0.375 0.0 HOH
2.700
NZ
O
LYS B:615 B:644 77.0 0.385 H -65.0 -44.7 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 LYS A:615 A:644 70.0 0.35 H -59.3 -42.4 70.0 0.35 0.0 HOH
6.318
CE
O
LYS B:615 B:644 76.0 0.38 H -58.3 -43.2 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 LYS A:615 A:644 72.0 0.36 H -58.8 -47.4 72.0 0.36 0.0 HOH
3.580
N
O
LYS B:615 B:644 51.0 0.255 H -58.4 -42.7 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 LYS A:615 A:644 76.0 0.38 H -63.7 -42.0 76.0 0.38 0.0 HOH
3.029
NZ
O
LYS B:615 B:644 74.0 0.37 H -67.3 -43.7 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 LYS A:615 A:644 55.0 0.275 H -61.1 -41.7 55.0 0.275 0.0 HOH
3.646
N
O
LYS B:615 B:644 77.0 0.385 H -57.3 -41.9 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 LYS A:644 A:644 68.0 0.34 H -66.4 -36.5 68.0 0.34 0.0 HOH
6.330
CE
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 LYS A:615 A:644 68.0 0.34 H -54.8 -39.1 68.0 0.34 0.0 HOH
8.578
NZ
O
LYS B:615 B:644 75.0 0.375 H -61.9 -40.9 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 LYS A:644 A:644 73.0 0.365 H -61.0 -45.8 73.0 0.365 0.0 HOH
6.514
CE
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 LYS A:615 A:644 54.0 0.27 H -58.1 -42.1 54.0 0.27 0.0 HOH
2.692
NZ
O
LYS B:615 B:644 75.0 0.375 H -58.3 -45.7 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 LYS A:603 A:644 75.0 0.375 H -61.2 -42.6 75.0 0.375 0.0 HOH
6.425
CE
O
LYS B:603 B:644 80.0 0.4 H -61.1 -42.8 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 LYS A:603 A:644 60.0 0.3 H -55.6 -32.9 60.0 0.3 0.0 DIO
7.030
CD
H1'1
LYS B:603 B:644 64.0 0.32 H -58.4 -35.0 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 LYS A:603 A:644 62.0 0.31 H -62.8 -29.9 62.0 0.31 0.0
LYS B:603 B:644 67.0 0.335 H -63.2 -29.9 67.0 0.335 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 LYS A:614 A:644 80.0 0.4 H -63.8 -37.3 80.0 0.4 0.0 HOH
3.608
N
O
LYS B:614 B:644 76.0 0.38 H -61.9 -39.4 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 LYS A:614 A:644 67.0 0.335 H -63.4 -37.4 67.0 0.335 0.0 HOH
3.587
CE
O
LYS B:614 B:644 68.0 0.34 H -62.2 -39.1 68.0 0.34 0.0 HOH
3.798
N
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 LYS A:614 A:644 60.0 0.3 H -60.1 -42.2 60.0 0.3 0.0 HOH
6.082
CE
O
LYS B:614 B:644 76.0 0.38 H -64.9 -44.1 76.0 0.38 0.0 HOH
5.013
CE
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 LYS A:614 A:644 54.0 0.27 H -64.1 -43.2 54.0 0.27 0.0 HOH
3.878
N
O
LYS B:614 B:644 65.0 0.325 H -59.8 -39.7 65.0 0.325 0.0 HOH
3.678
CE
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 LYS A:615 A:644 75.0 0.375 H -59.6 -41.5 75.0 0.375 0.0 HOH
9.400
CG
O
LYS B:615 B:644 79.0 0.395 H -60.3 -49.2 79.0 0.395 0.0 HOH
8.690
O
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 LYS A:615 A:644 79.0 0.395 H -64.5 -32.2 79.0 0.395 0.0 HOH
7.816
N
O
LYS B:615 B:644 78.0 0.39 H -56.9 -39.5 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 LYS A:615 A:644 66.0 0.33 H -64.2 -40.6 66.0 0.33 0.0 HOH
8.260
O
O
LYS B:615 B:644 63.0 0.315 H -61.1 -42.4 63.0 0.315 0.0 HOH
8.972
CD
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 LYS A:615 A:644 54.0 0.27 H -64.6 -39.0 54.0 0.27 0.0
LYS B:615 B:644 84.0 0.42 H -65.1 -38.2 84.0 0.42 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 LYS A:615 A:644 81.0 0.405 H -57.2 -43.1 81.0 0.405 0.0
LYS B:615 B:644 79.0 0.395 H -56.7 -42.9 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 LYS A:615 A:644 85.0 0.425 H -65.7 -27.8 85.0 0.425 0.0
LYS B:615 B:644 75.0 0.375 H -60.3 -26.7 NA NA NA
LYS C:615 C:644 85.0 0.425 H -58.1 -28.0 NA NA NA
LYS D:615 D:644 72.0 0.36 H -64.1 -28.0 NA NA NA
LYS E:615 E:644 59.0 0.295 H -69.3 -26.8 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 LYS A:615 A:644 63.0 0.315 H -54.3 -34.1 63.0 0.315 0.0
LYS B:615 B:644 45.0 0.225 H -65.4 -39.4 45.0 0.225 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 LYS A:615 A:644 83.0 0.415 H -63.1 -38.1 83.0 0.415 0.0
LYS B:615 B:644 78.0 0.39 H -62.0 -42.7 78.0 0.39 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 LYS A:615 A:644 85.0 0.425 H -61.4 -39.9 85.0 0.425 0.0
LYS B:615 B:644 78.0 0.39 H -59.7 -39.6 78.0 0.39 0.0 HOH
6.959
CD
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 LYS A:615 A:644 87.0 0.435 H -54.6 -45.0 87.0 0.435 0.0 HOH
6.519
CE
O
LYS B:615 B:644 79.0 0.395 H -62.4 -40.1 79.0 0.395 0.0 HOH
3.703
N
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 LYS A:615 A:644 59.0 0.295 H -64.9 -38.1 59.0 0.295 0.0 HOH
2.354
NZ
O
LYS B:615 B:644 82.0 0.41 H -59.4 -41.8 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 LYS A:615 A:644 73.0 0.365 H -54.5 -42.9 73.0 0.365 0.0 DIO
DIO
HOH
6.162
7.409
5.801
N
CE
NZ
C2
O1
O
LYS B:615 B:644 83.0 0.415 H -65.8 -41.1 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 LYS A:615 A:644 69.0 0.345 H -60.8 -35.6 69.0 0.345 0.0 HOH
8.349
NZ
O
LYS B:615 B:644 83.0 0.415 H -63.2 -34.2 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 LYS A:615 A:644 66.0 0.33 H -66.1 -36.2 66.0 0.33 0.0 HOH
8.067
NZ
O
LYS B:615 B:644 76.0 0.38 H -55.1 -42.4 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 LYS A:615 A:644 77.0 0.385 H -59.8 -42.0 77.0 0.385 0.0 HOH
3.210
NZ
O
LYS B:615 B:644 80.0 0.4 H -63.1 -41.6 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 LYS A:615 A:644 79.0 0.395 H -58.5 -43.5 79.0 0.395 0.0
LYS B:615 B:644 75.0 0.375 H -60.9 -40.6 75.0 0.375 0.0 HOH
3.164
NZ
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 LYS A:615 A:644 54.0 0.27 H -58.6 -41.5 54.0 0.27 0.0 HOH
8.463
CE
O
LYS B:615 B:644 74.0 0.37 H -60.6 -42.0 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 LYS A:615 A:644 73.0 0.365 H -56.6 -43.7 73.0 0.365 0.0 HOH
8.593
O
O
LYS B:615 B:644 77.0 0.385 H -68.3 -40.0 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 LYS A:615 A:644 71.0 0.355 H -64.3 -34.9 71.0 0.355 0.0 HOH
8.339
O
O
LYS B:615 B:644 80.0 0.4 H -59.8 -37.9 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 LYS A:615 A:644 76.0 0.38 H -59.7 -39.2 76.0 0.38 0.0 HOH
2.720
NZ
O
LYS B:615 B:644 75.0 0.375 H -61.7 -34.9 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 LYS A:615 A:644 64.0 0.32 H -60.9 -38.0 64.0 0.32 0.0 HOH
2.816
NZ
O
LYS B:615 B:644 79.0 0.395 H -63.3 -33.4 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 LYS A:615 A:644 60.0 0.3 H -70.1 -30.7 60.0 0.3 0.0
LYS B:615 B:644 77.0 0.385 H -67.3 -32.8 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 LYS A:615 A:644 71.0 0.355 H -60.5 -35.6 71.0 0.355 0.0
LYS B:615 B:644 55.0 0.275 H -63.9 -33.0 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 LYS A:615 A:644 66.0 0.33 H -62.4 -43.6 66.0 0.33 0.0
LYS B:615 B:644 79.0 0.395 H -55.3 -52.7 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 LYS A:615 A:644 59.0 0.295 H -65.6 -33.2 59.0 0.295 0.0 HOH
2.464
NZ
O
LYS B:615 B:644 62.0 0.31 H -66.4 -33.5 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 LYS A:615 A:644 67.0 0.335 H -68.2 -11.0 67.0 0.335 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 LYS A:615 A:644 63.0 0.315 H -64.7 -40.1 63.0 0.315 0.0
LYS B:615 B:644 87.0 0.435 H -61.0 -34.4 87.0 0.435 0.0
LYS C:615 C:644 79.0 0.395 H -64.2 -37.9 NA NA NA
LYS D:615 D:644 93.0 0.465 H -61.5 -36.6 NA NA NA
LYS E:615 E:644 86.0 0.43 H -64.1 -36.8 NA NA NA
LYS F:615 F:644 91.0 0.455 H -60.2 -39.8 NA NA NA
LYS G:615 G:644 87.0 0.435 H -62.6 -39.4 NA NA NA
LYS H:615 H:644 87.0 0.435 H -61.2 -39.5 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 LYS A:602 A:644 76.0 0.38 H -62.6 -40.0 76.0 0.38 0.0 HOH
5.636
NZ
O
LYS B:602 B:644 84.0 0.42 H -60.2 -43.1 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 LYS A:599 A:644 71.0 0.355 H -71.8 -34.0 71.0 0.355 0.0
LYS B:599 B:644 77.0 0.385 H -71.3 -32.1 77.0 0.385 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 LYS A:599 A:644 80.0 0.4 H -65.4 -31.4 80.0 0.4 0.0
LYS B:599 B:644 91.0 0.455 H -68.8 -31.8 91.0 0.455 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 LYS A:599 A:644 75.0 0.375 H -65.1 -43.6 75.0 0.375 0.0
LYS B:599 B:644 87.0 0.435 H -63.2 -39.7 87.0 0.435 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 LYS A:599 A:644 81.0 0.405 H -66.3 -28.8 81.0 0.405 0.0
LYS B:599 B:644 86.0 0.43 H -65.5 -30.2 86.0 0.43 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 LYS A:599 A:644 90.0 0.45 H -66.9 -29.0 90.0 0.45 0.0
LYS B:599 B:644 86.0 0.43 H -67.9 -29.7 86.0 0.43 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 LYS A:599 A:644 82.0 0.41 H -69.2 -28.6 82.0 0.41 0.0
LYS B:599 B:644 89.0 0.445 H -71.6 -29.6 89.0 0.445 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 LYS A:599 A:644 93.0 0.465 H -63.9 -51.9 93.0 0.465 0.0
LYS B:599 B:644 85.0 0.425 H -70.9 -23.2 85.0 0.425 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 LYS A:599 A:644 60.0 0.3 H -56.2 -33.8 60.0 0.3 0.0
LYS B:599 B:644 43.0 0.215 H -66.2 -39.7 43.0 0.215 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 LYS A:603 A:644 77.0 0.385 H -68.1 -37.9 77.0 0.385 0.0 HOH
3.096
NZ
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 LYS A:615 A:644 70.0 0.35 H -60.7 -40.2 70.0 0.35 0.0 HOH
3.747
N
O
LYS B:615 B:644 78.0 0.39 H -60.5 -43.3 78.0 0.39 0.0 HOH
3.662
N
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 LYS A:644 A:644 80.0 0.4 H -61.9 -39.9