Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94243073 . A C CCDS7421.1:NM_004969.3:c.1678Tgg>Ggg_NP_004960.2:p.560W>G Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 TRP A:560 A:560 26.0 0.102 E -98.4 140.0 NA NA NA
TRP B:560 B:560 9.0 0.035 E -98.7 135.3 9.0 0.035 0.0 HOH
8.189
NE1
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 TRP A:560 A:560 26.0 0.102 E -92.4 143.4 26.0 0.102 0.0 ACY
HOH
4.404
4.494
CZ2
CZ3
O
O
TRP B:560 B:560 26.0 0.102 E -104.8 143.4 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 TRP A:560 A:560 28.0 0.11 E -101.7 133.6 28.0 0.11 0.0 HOH
4.400
CZ3
O
TRP B:560 B:560 27.0 0.106 E -101.0 135.2 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 TRP A:531 A:560 9.0 0.035 E -101.8 134.9 9.0 0.035 0.0 HOH
4.143
CZ2
O
TRP B:531 B:560 7.0 0.027 E -98.6 135.5 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 TRP A:531 A:560 7.0 0.027 E -96.9 134.4 7.0 0.027 0.0 HOH
4.036
CZ3
O
TRP B:531 B:560 10.0 0.039 E -99.5 140.5 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 TRP A:531 A:560 7.0 0.027 E -97.7 135.6 7.0 0.027 0.0 HOH
4.058
CZ3
O
TRP B:531 B:560 6.0 0.024 E -100.3 134.9 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 TRP A:531 A:560 7.0 0.027 E -99.3 135.0 7.0 0.027 0.0 HOH
4.147
CZ3
O
TRP B:531 B:560 6.0 0.024 E -103.7 134.4 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 TRP A:531 A:560 8.0 0.031 E -99.7 135.6 8.0 0.031 0.0 HOH
4.423
CZ3
O
TRP B:531 B:560 7.0 0.027 E -99.6 137.2 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 TRP A:531 A:560 5.0 0.02 E -98.5 136.6 5.0 0.02 0.0
TRP B:531 B:560 4.0 0.016 E -101.1 125.4 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 TRP A:531 A:560 27.0 0.106 E -97.7 137.3 27.0 0.106 0.0 HOH
4.246
CZ3
O
TRP B:531 B:560 25.0 0.098 E -93.4 135.4 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 TRP A:560 A:560 27.0 0.106 E -98.0 134.7 27.0 0.106 0.0 HOH
4.109
CZ2
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 TRP A:531 A:560 27.0 0.106 E -95.2 137.6 27.0 0.106 0.0 HOH
4.077
CZ3
O
TRP B:531 B:560 29.0 0.114 E -95.0 135.0 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 TRP A:560 A:560 24.0 0.094 E -103.0 140.8 24.0 0.094 0.0 HOH
6.760
C
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 TRP A:531 A:560 28.0 0.11 E -97.2 133.1 28.0 0.11 0.0 HOH
4.422
CZ3
O
TRP B:531 B:560 28.0 0.11 E -96.7 137.8 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 TRP A:519 A:560 25.0 0.098 E -95.9 135.5 25.0 0.098 0.0 HOH
4.500
CZ3
O
TRP B:519 B:560 27.0 0.106 E -95.6 136.6 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 TRP A:519 A:560 18.0 0.071 E -93.5 133.2 18.0 0.071 0.0
TRP B:519 B:560 23.0 0.09 E -93.0 132.7 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 TRP A:519 A:560 25.0 0.098 E -99.5 134.4 25.0 0.098 0.0
TRP B:519 B:560 27.0 0.106 E -99.5 134.8 27.0 0.106 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 TRP A:530 A:560 20.0 0.078 E -98.8 134.3 20.0 0.078 0.0 HOH
4.285
CZ3
O
TRP B:530 B:560 1.0 0.004 E -101.2 138.0 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 TRP A:530 A:560 22.0 0.086 E -101.4 129.7 22.0 0.086 0.0 HOH
4.306
CZ3
O
TRP B:530 B:560 1.0 0.004 E -101.3 129.5 1.0 0.004 0.0 HOH
3.848
CZ3
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 TRP A:530 A:560 2.0 0.008 E -100.6 128.9 2.0 0.008 0.0 HOH
4.267
CZ2
O
TRP B:530 B:560 20.0 0.078 E -102.9 129.9 20.0 0.078 0.0 HOH
6.642
C
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 TRP A:530 A:560 1.0 0.004 E -97.5 133.1 1.0 0.004 0.0 HOH
6.493
CZ3
O
TRP B:530 B:560 21.0 0.082 E -99.1 130.7 21.0 0.082 0.0 HOH
6.893
NE1
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 TRP A:531 A:560 27.0 0.106 E -97.7 132.3 27.0 0.106 0.0 HOH
8.224
CZ3
O
TRP B:531 B:560 30.0 0.118 E -89.3 134.1 30.0 0.118 0.0
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 TRP A:531 A:560 14.0 0.055 E -100.8 134.6 14.0 0.055 0.0 HOH
7.910
CZ3
O
TRP B:531 B:560 25.0 0.098 E -93.4 144.4 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 TRP A:531 A:560 28.0 0.11 E -103.4 134.3 28.0 0.11 0.0 HOH
8.056
CZ3
O
TRP B:531 B:560 31.0 0.122 E -103.8 135.0 31.0 0.122 0.0 HOH
8.738
CZ3
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 TRP A:531 A:560 25.0 0.098 E -93.4 135.5 25.0 0.098 0.0
TRP B:531 B:560 23.0 0.09 E -93.3 134.4 23.0 0.09 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 TRP A:531 A:560 27.0 0.106 E -97.8 131.7 27.0 0.106 0.0 HOH
7.255
CH2
O
TRP B:531 B:560 28.0 0.11 E -98.0 130.7 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 TRP A:531 A:560 23.0 0.09 E -107.5 127.9 23.0 0.09 0.0
TRP B:531 B:560 28.0 0.11 E -105.3 129.7 NA NA NA
TRP C:531 C:560 20.0 0.078 E -104.8 132.2 NA NA NA
TRP D:531 D:560 22.0 0.086 E -106.7 132.9 NA NA NA
TRP E:531 E:560 30.0 0.118 E -105.7 133.5 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 TRP A:531 A:560 28.0 0.11 -145.1 120.2 28.0 0.11 0.0
TRP B:531 B:560 25.0 0.098 E -126.8 139.2 25.0 0.098 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 TRP A:531 A:560 9.0 0.035 E -97.4 130.7 9.0 0.035 0.0
TRP B:531 B:560 24.0 0.094 E -96.6 139.4 24.0 0.094 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 TRP A:531 A:560 9.0 0.035 E -99.4 132.2 9.0 0.035 0.0 HOH
4.510
CZ2
O
TRP B:531 B:560 26.0 0.102 E -103.9 137.4 26.0 0.102 0.0 HOH
6.608
C
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 TRP A:531 A:560 8.0 0.031 E -99.0 131.1 8.0 0.031 0.0 HOH
6.808
C
O
TRP B:531 B:560 25.0 0.098 E -99.8 134.4 25.0 0.098 0.0 HOH
3.973
CZ3
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 TRP A:531 A:560 28.0 0.11 E -93.8 134.5 28.0 0.11 0.0 HOH
4.165
CZ3
O
TRP B:531 B:560 29.0 0.114 E -103.4 135.2 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 TRP A:531 A:560 25.0 0.098 E -97.5 138.5 25.0 0.098 0.0 HOH
4.540
CZ3
O
TRP B:531 B:560 28.0 0.11 E -94.1 143.9 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 TRP A:531 A:560 26.0 0.102 E -97.3 134.6 26.0 0.102 0.0 HOH
6.295
C
O
TRP B:531 B:560 27.0 0.106 E -101.5 143.5 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 TRP A:531 A:560 23.0 0.09 E -100.5 136.0 23.0 0.09 0.0 HOH
8.325
CH2
O
TRP B:531 B:560 23.0 0.09 E -106.5 136.3 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 TRP A:531 A:560 25.0 0.098 E -102.0 141.0 25.0 0.098 0.0 HOH
5.678
CH2
O
TRP B:531 B:560 26.0 0.102 E -98.4 133.2 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 TRP A:531 A:560 25.0 0.098 E -98.3 140.0 25.0 0.098 0.0 HOH
9.685
CA
O
TRP B:531 B:560 27.0 0.106 E -92.1 134.5 27.0 0.106 0.0
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 TRP A:531 A:560 28.0 0.11 E -101.7 136.0 28.0 0.11 0.0 HOH
4.468
CZ3
O
TRP B:531 B:560 23.0 0.09 E -98.6 136.4 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 TRP A:531 A:560 26.0 0.102 E -98.3 130.7 26.0 0.102 0.0 HOH
4.160
CZ3
O
TRP B:531 B:560 30.0 0.118 E -98.0 133.2 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 TRP A:531 A:560 24.0 0.094 E -91.1 138.0 24.0 0.094 0.0
TRP B:531 B:560 25.0 0.098 E -90.1 138.6 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 TRP A:531 A:560 27.0 0.106 E -88.3 142.1 27.0 0.106 0.0 HOH
4.233
CH2
O
TRP B:531 B:560 26.0 0.102 E -105.0 139.9 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 TRP A:531 A:560 27.0 0.106 E -98.5 137.3 27.0 0.106 0.0 HOH
4.096
CZ3
O
TRP B:531 B:560 13.0 0.051 E -95.3 143.4 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 TRP A:531 A:560 21.0 0.082 E -113.0 131.1 21.0 0.082 0.0
TRP B:531 B:560 26.0 0.102 E -91.5 134.8 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 TRP A:531 A:560 29.0 0.114 E -94.7 134.4 29.0 0.114 0.0 HOH
4.273
CZ2
O
TRP B:531 B:560 26.0 0.102 E -94.5 132.8 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 TRP A:531 A:560 29.0 0.114 E -100.2 135.1 29.0 0.114 0.0
TRP B:531 B:560 25.0 0.098 E -100.5 134.3 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 TRP A:531 A:560 13.0 0.051 E -98.8 132.2 13.0 0.051 0.0
TRP B:531 B:560 17.0 0.067 E -98.0 134.2 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 TRP A:531 A:560 10.0 0.039 E -97.7 135.6 10.0 0.039 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 TRP A:531 A:560 26.0 0.102 E -103.7 140.9 26.0 0.102 0.0
TRP B:531 B:560 27.0 0.106 E -101.6 138.8 27.0 0.106 0.0
TRP C:531 C:560 26.0 0.102 E -111.2 144.9 NA NA NA
TRP D:531 D:560 28.0 0.11 E -104.8 137.4 NA NA NA
TRP E:531 E:560 21.0 0.082 E -101.8 143.5 NA NA NA
TRP F:531 F:560 25.0 0.098 E -113.6 139.4 NA NA NA
TRP G:531 G:560 29.0 0.114 E -97.4 142.6 NA NA NA
TRP H:531 H:560 26.0 0.102 E -111.8 138.3 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 TRP A:518 A:560 25.0 0.098 E -96.5 132.4 25.0 0.098 0.0 HOH
4.134
CZ3
O
TRP B:518 B:560 25.0 0.098 E -97.7 137.7 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 TRP A:515 A:560 28.0 0.11 E -114.1 153.3 28.0 0.11 0.0
TRP B:515 B:560 29.0 0.114 E -109.5 148.7 29.0 0.114 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 TRP A:515 A:560 29.0 0.114 E -117.2 134.3 29.0 0.114 0.0
TRP B:515 B:560 27.0 0.106 E -112.7 144.4 27.0 0.106 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 TRP A:515 A:560 30.0 0.118 E -139.6 119.3 30.0 0.118 0.0
TRP B:515 B:560 23.0 0.09 E -74.2 129.5 23.0 0.09 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 TRP A:515 A:560 30.0 0.118 E -117.6 141.4 30.0 0.118 0.0
TRP B:515 B:560 36.0 0.141 E -115.4 143.7 36.0 0.141 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 TRP A:515 A:560 39.0 0.153 E -117.0 143.9 39.0 0.153 0.0
TRP B:515 B:560 41.0 0.161 E -116.0 143.8 41.0 0.161 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 TRP A:515 A:560 35.0 0.137 E -119.4 137.7 35.0 0.137 0.0
TRP B:515 B:560 33.0 0.129 E -111.6 147.3 33.0 0.129 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 TRP A:515 A:560 50.0 0.196 E -117.4 141.1 50.0 0.196 0.0
TRP B:515 B:560 30.0 0.118 E -113.1 148.8 30.0 0.118 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 TRP A:515 A:560 28.0 0.11 E -144.9 120.1 28.0 0.11 0.0
TRP B:515 B:560 26.0 0.102 E -126.4 139.5 26.0 0.102 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 TRP A:519 A:560 26.0 0.102 E -101.6 136.8 26.0 0.102 0.0 HOH
6.174
CZ3
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 TRP A:531 A:560 28.0 0.11 E -99.8 131.7 28.0 0.11 0.0 HOH
3.913
CZ3
O
TRP B:531 B:560 26.0 0.102 E -98.3 135.0 26.0 0.102 0.0 HOH
4.206
CH2
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 TRP A:560 A:560 4.0 0.016 E -92.3 131.7