Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94247039 . G A CCDS7421.1:NM_004969.3:c.1570Ctt>Ttt_NP_004960.2:p.524L>F Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 LEU A:524 A:524 31.0 0.182 -47.9 158.2 NA NA NA
LEU B:524 B:524 30.0 0.176 -77.1 161.1 30.0 0.176 0.0 HOH
2.676
O
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 LEU A:524 A:524 30.0 0.176 -59.1 155.8 30.0 0.176 0.0 HOH
2.822
O
O
LEU B:524 B:524 31.0 0.182 -71.6 158.8 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 LEU A:524 A:524 29.0 0.171 -61.9 158.1 29.0 0.171 0.0 HOH
3.470
CA
O
LEU B:524 B:524 31.0 0.182 -62.7 158.4 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 LEU A:495 A:524 30.0 0.176 -71.9 154.8 30.0 0.176 0.0 HOH
2.796
O
O
LEU B:495 B:524 26.0 0.153 -67.7 154.7 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 LEU A:495 A:524 28.0 0.165 -65.7 159.1 28.0 0.165 0.0 HOH
2.677
O
O
LEU B:495 B:524 29.0 0.171 -81.6 161.5 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 LEU A:495 A:524 26.0 0.153 -68.2 160.4 26.0 0.153 0.0 HOH
2.806
O
O
LEU B:495 B:524 25.0 0.147 -62.4 157.6 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 LEU A:495 A:524 27.0 0.159 -63.1 156.1 27.0 0.159 0.0 HOH
2.631
O
O
LEU B:495 B:524 28.0 0.165 -67.7 156.7 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 LEU A:495 A:524 31.0 0.182 -74.1 155.3 31.0 0.182 0.0 HOH
2.726
O
O
LEU B:495 B:524 29.0 0.171 -65.6 156.0 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 LEU A:495 A:524 27.0 0.159 -60.2 158.1 27.0 0.159 0.0 HOH
4.359
C
O
LEU B:495 B:524 25.0 0.147 -67.4 168.1 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 LEU A:495 A:524 28.0 0.165 -54.1 149.5 28.0 0.165 0.0 HOH
4.626
C
O
LEU B:495 B:524 27.0 0.159 -60.8 150.0 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 LEU A:524 A:524 29.0 0.171 -56.5 147.2 29.0 0.171 0.0 HOH
2.978
N
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 LEU A:495 A:524 26.0 0.153 -56.9 155.7 26.0 0.153 0.0 HOH
2.682
O
O
LEU B:495 B:524 25.0 0.147 -69.3 158.0 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 LEU A:524 A:524 29.0 0.171 -79.3 163.9 29.0 0.171 0.0 HOH
2.757
N
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 LEU A:495 A:524 29.0 0.171 -60.6 152.9 29.0 0.171 0.0 HOH
2.690
O
O
LEU B:495 B:524 29.0 0.171 -59.0 153.0 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 LEU A:483 A:524 32.0 0.188 -61.6 156.6 32.0 0.188 0.0 HOH
2.601
O
O
LEU B:483 B:524 29.0 0.171 -60.9 157.1 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 LEU A:483 A:524 30.0 0.176 -64.3 157.5 30.0 0.176 0.0
LEU B:483 B:524 32.0 0.188 -64.1 159.2 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 LEU A:483 A:524 35.0 0.206 -66.4 145.5 35.0 0.206 0.0
LEU B:483 B:524 37.0 0.218 -65.2 146.6 37.0 0.218 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 LEU A:494 A:524 33.0 0.194 -62.3 150.2 33.0 0.194 0.0 HOH
2.948
O
O
LEU B:494 B:524 31.0 0.182 -67.7 152.6 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 LEU A:494 A:524 32.0 0.188 -70.3 153.4 32.0 0.188 0.0 HOH
2.760
O
O
LEU B:494 B:524 32.0 0.188 -71.6 153.2 32.0 0.188 0.0 HOH
2.949
O
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 LEU A:494 A:524 27.0 0.159 -68.8 148.4 27.0 0.159 0.0 HOH
4.583
C
O
LEU B:494 B:524 30.0 0.176 -61.4 147.7 30.0 0.176 0.0 HOH
2.893
N
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 LEU A:494 A:524 28.0 0.165 -67.2 152.5 28.0 0.165 0.0 HOH
3.843
CA
O
LEU B:494 B:524 30.0 0.176 -61.7 148.2 30.0 0.176 0.0 HOH
3.936
C
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 LEU A:495 A:524 30.0 0.176 -49.1 149.1 30.0 0.176 0.0 HOH
3.804
CA
O
LEU B:495 B:524 24.0 0.141 -69.9 159.1 24.0 0.141 0.0 HOH
8.393
CD2
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 LEU A:495 A:524 19.0 0.112 -58.5 157.5 19.0 0.112 0.0 HOH
4.278
N
O
LEU B:495 B:524 26.0 0.153 -74.4 166.2 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 LEU A:495 A:524 15.0 0.088 -67.3 160.3 15.0 0.088 0.0
LEU B:495 B:524 28.0 0.165 -69.5 161.1 28.0 0.165 0.0 HOH
4.194
N
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 LEU A:495 A:524 24.0 0.141 -58.6 156.6 24.0 0.141 0.0
LEU B:495 B:524 33.0 0.194 -58.6 156.9 33.0 0.194 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 LEU A:495 A:524 34.0 0.2 -63.3 154.4 34.0 0.2 0.0 HOH
3.808
CA
O
LEU B:495 B:524 29.0 0.171 -63.7 154.3 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 LEU A:495 A:524 14.0 0.082 -59.8 145.7 14.0 0.082 0.0
LEU B:495 B:524 39.0 0.229 -62.5 145.3 NA NA NA
LEU C:495 C:524 29.0 0.171 -63.8 148.5 NA NA NA
LEU D:495 D:524 27.0 0.159 -61.9 152.1 NA NA NA
LEU E:495 E:524 31.0 0.182 -66.1 150.9 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 LEU A:495 A:524 31.0 0.182 -79.6 151.0 31.0 0.182 0.0
LEU B:495 B:524 51.0 0.3 -71.2 147.8 51.0 0.3 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 LEU A:495 A:524 23.0 0.135 -56.4 160.7 23.0 0.135 0.0
LEU B:495 B:524 28.0 0.165 -62.1 158.9 28.0 0.165 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 LEU A:495 A:524 31.0 0.182 -58.9 156.0 31.0 0.182 0.0 HOH
3.097
O
O
LEU B:495 B:524 31.0 0.182 -55.8 161.8 31.0 0.182 0.0 HOH
3.874
CA
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 LEU A:495 A:524 31.0 0.182 -59.7 155.8 31.0 0.182 0.0 HOH
2.842
O
O
LEU B:495 B:524 26.0 0.153 -55.6 157.1 26.0 0.153 0.0 HOH
2.642
O
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 LEU A:495 A:524 28.0 0.165 -58.8 156.9 28.0 0.165 0.0 HOH
2.813
O
O
LEU B:495 B:524 26.0 0.153 -62.8 158.6 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 LEU A:495 A:524 28.0 0.165 -52.7 158.6 28.0 0.165 0.0 HOH
4.538
C
O
LEU B:495 B:524 25.0 0.147 -79.4 159.5 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 LEU A:495 A:524 11.0 0.065 -54.3 164.2 11.0 0.065 0.0 HOH
6.187
CD1
O
LEU B:495 B:524 23.0 0.135 -67.7 160.6 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 LEU A:495 A:524 32.0 0.188 -53.2 153.1 32.0 0.188 0.0 HOH
4.353
C
O
LEU B:495 B:524 28.0 0.165 -67.5 164.1 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 LEU A:495 A:524 28.0 0.165 -71.2 161.9 28.0 0.165 0.0
LEU B:495 B:524 26.0 0.153 -62.9 158.0 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 LEU A:495 A:524 26.0 0.153 -61.8 163.0 26.0 0.153 0.0 HOH
3.277
N
O
LEU B:495 B:524 19.0 0.112 -64.9 156.5 19.0 0.112 0.0
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 LEU A:495 A:524 27.0 0.159 -53.0 150.1 27.0 0.159 0.0 HOH
2.617
O
O
LEU B:495 B:524 29.0 0.171 -58.1 152.7 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 LEU A:495 A:524 27.0 0.159 -48.8 153.0 27.0 0.159 0.0
LEU B:495 B:524 22.0 0.129 -71.4 166.6 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 LEU A:495 A:524 32.0 0.188 -52.1 152.1 32.0 0.188 0.0
LEU B:495 B:524 27.0 0.159 -67.7 168.4 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 LEU A:495 A:524 33.0 0.194 -64.2 159.4 33.0 0.194 0.0 HOH
8.862
N
O
LEU B:495 B:524 25.0 0.147 -65.3 166.6 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 LEU A:495 A:524 20.0 0.118 -55.1 159.1 20.0 0.118 0.0 HOH
2.748
O
O
LEU B:495 B:524 25.0 0.147 -65.9 160.4 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 LEU A:495 A:524 24.0 0.141 -69.4 133.4 24.0 0.141 0.0
LEU B:495 B:524 27.0 0.159 -60.0 144.6 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 LEU A:495 A:524 32.0 0.188 -65.1 151.1 32.0 0.188 0.0
LEU B:495 B:524 33.0 0.194 -62.6 150.8 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 LEU A:495 A:524 30.0 0.176 -58.3 146.3 30.0 0.176 0.0
LEU B:495 B:524 35.0 0.206 -65.4 152.8 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 LEU A:495 A:524 26.0 0.153 -62.9 144.1 26.0 0.153 0.0 HOH
3.902
N
O
LEU B:495 B:524 31.0 0.182 -66.3 143.7 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 LEU A:495 A:524 32.0 0.188 -63.1 150.3 32.0 0.188 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 LEU A:495 A:524 37.0 0.218 -69.7 142.7 37.0 0.218 0.0
LEU B:495 B:524 47.0 0.276 -67.4 150.5 47.0 0.276 0.0
LEU C:495 C:524 32.0 0.188 -72.0 143.5 NA NA NA
LEU D:495 D:524 41.0 0.241 -70.1 152.1 NA NA NA
LEU E:495 E:524 36.0 0.212 -74.4 144.7 NA NA NA
LEU F:495 F:524 28.0 0.165 -68.8 147.3 NA NA NA
LEU G:495 G:524 38.0 0.224 -67.2 140.7 NA NA NA
LEU H:495 H:524 36.0 0.212 -65.7 146.8 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 LEU A:482 A:524 28.0 0.165 -56.4 151.7 28.0 0.165 0.0 HOH
7.319
O
O
LEU B:482 B:524 30.0 0.176 -65.8 154.0 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 LEU A:479 A:524 49.0 0.288 -73.9 150.7 49.0 0.288 0.0
LEU B:479 B:524 54.0 0.318 -70.9 142.2 54.0 0.318 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 LEU A:479 A:524 56.0 0.329 -60.5 127.0 56.0 0.329 0.0
LEU B:479 B:524 41.0 0.241 -62.0 138.2 41.0 0.241 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 LEU A:479 A:524 65.0 0.382 -77.7 125.1 65.0 0.382 0.0
LEU B:479 B:524 51.0 0.3 -71.1 153.9 51.0 0.3 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 LEU A:479 A:524 56.0 0.329 -75.6 148.5 56.0 0.329 0.0
LEU B:479 B:524 68.0 0.4 -76.4 146.6 68.0 0.4 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 LEU A:479 A:524 65.0 0.382 -77.4 146.7 65.0 0.382 0.0
LEU B:479 B:524 79.0 0.465 -74.1 147.1 79.0 0.465 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 LEU A:479 A:524 62.0 0.365 -71.0 148.6 62.0 0.365 0.0
LEU B:479 B:524 77.0 0.453 -66.2 156.3 77.0 0.453 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 LEU A:479 A:524 60.0 0.353 -69.6 147.3 60.0 0.353 0.0
LEU B:479 B:524 40.0 0.235 -68.0 163.2 40.0 0.235 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 LEU A:479 A:524 30.0 0.176 -78.7 150.5 30.0 0.176 0.0
LEU B:479 B:524 55.0 0.324 -70.8 148.0 55.0 0.324 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 LEU A:483 A:524 25.0 0.147 -64.4 138.7 25.0 0.147 0.0 HOH
3.194
N
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 LEU A:495 A:524 32.0 0.188 -60.9 150.6 32.0 0.188 0.0 HOH
2.644
O
O
LEU B:495 B:524 30.0 0.176 -57.5 153.3 30.0 0.176 0.0 HOH
2.667
O
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 LEU A:524 A:524 30.0 0.176 -63.1 153.7