Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94250290 . G A CCDS7421.1:NM_004969.3:c.1493aCc>aTc_NP_004960.2:p.498T>I Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
 2009-11-03 THR A:498 A:498 1.0 0.007 -67.9 123.0 NA NA NA
THR B:498 B:498 1.0 0.007 -54.6 128.6 1.0 0.007 0.0 HOH
 2.598
 OG1
 O
3e4a 1 P14735 98.63 0.0 X-RAY
 2009-05-19 THR A:498 A:498 1.0 0.007 -56.4 125.3 1.0 0.007 0.0 ACY
HOH
 7.391
2.504
 CG2
OG1
 OXT
O
THR B:498 B:498 1.0 0.007 -53.6 126.8 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
 2019-04-03 THR A:498 A:498 1.0 0.007 -60.4 133.7 1.0 0.007 0.0 J18
HOH
 7.106
3.568
 CG2
CA
 H23
O
THR B:498 B:498 1.0 0.007 -60.4 140.5 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
 2006-10-24 THR A:469 A:498 1.0 0.007 -49.7 126.3 1.0 0.007 0.0 DIO
HOH
 7.809
2.737
 CG2
OG1
 C2'
O
THR B:469 B:498 1.0 0.007 -60.4 129.2 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
 2006-10-24 THR A:469 A:498 1.0 0.007 -64.4 132.4 1.0 0.007 0.0 DIO
HOH
 7.538
2.706
 CG2
OG1
 C2'
O
THR B:469 B:498 1.0 0.007 -54.2 129.4 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
 2006-10-24 THR A:469 A:498 1.0 0.007 -64.3 132.5 1.0 0.007 0.0 DIO
HOH
 7.334
2.385
 CG2
OG1
 C2'
O
THR B:469 B:498 0.0 0.0 -51.8 128.6 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
 2006-10-24 THR A:469 A:498 0.0 0.0 -59.8 130.3 0.0 0.0 0.0 DIO
HOH
 7.814
2.698
 CG2
OG1
 C2'
O
THR B:469 B:498 1.0 0.007 -54.1 128.2 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
 2006-10-24 THR A:469 A:498 1.0 0.007 -52.8 127.6 1.0 0.007 0.0 DIO
HOH
 7.883
2.725
 CG2
OG1
 C2'
O
THR B:469 B:498 0.0 0.0 -60.8 125.0 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
 2007-07-03 THR A:469 A:498 0.0 0.0 -55.2 127.1 0.0 0.0 0.0 DIO
 7.534
 CG2
 C2
THR B:469 B:498 1.0 0.007 -49.3 136.0 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
 2009-08-18 THR A:469 A:498 1.0 0.007 -54.8 125.8 1.0 0.007 0.0 HOH
 3.545
 CG2
 O
THR B:469 B:498 1.0 0.007 -62.1 130.6 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
 2011-10-26 THR A:498 A:498 1.0 0.007 -52.1 131.7 1.0 0.007 0.0 HOH
 5.796
 N
 O
2jg4 1 P14735 99.9 0.0 X-RAY
 2007-07-03 THR A:469 A:498 1.0 0.007 -57.7 123.8 1.0 0.007 0.0 HOH
 3.319
 CG2
 O
THR B:469 B:498 1.0 0.007 -59.9 126.0 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
 2011-07-27 THR A:498 A:498 1.0 0.007 -47.5 121.2 1.0 0.007 0.0 HOH
 3.203
 CG2
 O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
 2009-08-18 THR A:469 A:498 1.0 0.007 -53.9 129.2 1.0 0.007 0.0 HOH
 2.498
 OG1
 O
THR B:469 B:498 1.0 0.007 -62.6 126.7 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
 2014-05-21 THR A:457 A:498 1.0 0.007 -58.6 124.2 1.0 0.007 0.0 HOH
 2.577
 OG1
 O
THR B:457 B:498 1.0 0.007 -58.1 124.9 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
 2019-04-03 THR A:457 A:498 1.0 0.007 -56.1 132.3 1.0 0.007 0.0 J22
 7.309
 CG2
 H271
THR B:457 B:498 1.0 0.007 -56.2 134.7 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
 2019-04-03 THR A:457 A:498 1.0 0.007 -55.8 130.5 1.0 0.007 0.0 J22
 7.373
 CG2
 H271
THR B:457 B:498 1.0 0.007 -56.0 130.7 1.0 0.007 0.0 J22
 7.808
 CG2
 H271
4pes 1 P14735 98.57 0.0 X-RAY
 2015-06-17 THR A:468 A:498 1.0 0.007 -62.6 137.5 1.0 0.007 0.0 2PJ
HOH
 7.690
2.884
 CG2
OG1
 C5
O
THR B:468 B:498 1.0 0.007 E -59.5 135.7 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
 2015-06-17 THR A:468 A:498 3.0 0.021 -57.5 128.2 3.0 0.021 0.0 HOH
 2.805
 OG1
 O
THR B:468 B:498 2.0 0.014 E -54.8 131.3 2.0 0.014 0.0 HOH
 2.660
 OG1
 O
4pf9 1 P14735 98.57 0.0 X-RAY
 2015-06-17 THR A:468 A:498 2.0 0.014 -56.1 129.2 2.0 0.014 0.0 2Q6
HOH
 7.978
2.665
 CG2
OG1
 C38
O
THR B:468 B:498 3.0 0.021 -63.7 123.5 3.0 0.021 0.0 2Q6
HOH
 7.589
4.081
 CG2
CG2
 C38
O
4pfc 1 P14735 98.57 0.0 X-RAY
 2015-06-17 THR A:468 A:498 2.0 0.014 E -58.8 128.0 2.0 0.014 0.0 2QX
HOH
 7.756
7.195
 CG2
O
 C3
O
THR B:468 B:498 2.0 0.014 -52.5 127.5 2.0 0.014 0.0 2QX
HOH
 7.792
2.892
 CG2
OG1
 C3
O
3qz2 1 P14735 98.67 0.0 X-RAY
 2012-01-25 THR A:469 A:498 0.0 0.0 -54.6 121.1 0.0 0.0 0.0 HOH
 4.127
 CG2
 O
THR B:469 B:498 1.0 0.007 -42.2 128.6 1.0 0.007 0.0 HOH
 9.446
 N
 O
4dtt 1 P14735 98.67 0.0 X-RAY
 2013-02-27 THR A:469 A:498 0.0 0.0 -67.8 131.9 0.0 0.0 0.0 HOH
 8.587
 CG2
 O
THR B:469 B:498 1.0 0.007 -65.7 134.2 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
 2013-12-18 THR A:469 A:498 1.0 0.007 -53.7 132.1 1.0 0.007 0.0 HOH
 8.856
 CG2
 O
THR B:469 B:498 1.0 0.007 -50.4 136.8 1.0 0.007 0.0 HOH
 8.772
 CG2
 O
4iof 1 P14735 98.67 0.0 X-RAY
 2013-07-24 THR A:469 A:498 1.0 0.007 -60.1 131.5 1.0 0.007 0.0
THR B:469 B:498 84.0 0.6 -153.7 132.3 84.0 0.6 0.0
4re9 1 P14735 98.67 0.0 X-RAY
 2015-09-30 THR A:469 A:498 1.0 0.007 -53.9 131.1 1.0 0.007 0.0 PEG
 8.104
 CG2
 H11
THR B:469 B:498 1.0 0.007 -53.1 127.5 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
 2018-02-07 THR A:469 A:498 1.0 0.007 -72.1 118.1 1.0 0.007 0.0
THR B:469 B:498 0.0 0.0 -76.5 128.5 NA NA NA
THR C:469 C:498 1.0 0.007 -70.0 125.0 NA NA NA
THR D:469 D:498 1.0 0.007 -87.5 136.0 NA NA NA
THR E:469 E:498 1.0 0.007 -72.3 114.0 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
 2017-11-22 THR A:469 A:498 6.0 0.043 -102.1 159.7 6.0 0.043 0.0
THR B:469 B:498 3.0 0.021 -69.2 145.5 3.0 0.021 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
 2021-09-22 THR A:469 A:498 1.0 0.007 -55.7 135.7 1.0 0.007 0.0
THR B:469 B:498 0.0 0.0 -64.0 133.7 0.0 0.0 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
 2021-09-22 THR A:469 A:498 1.0 0.007 -30.6 125.7 1.0 0.007 0.0 HOH
 2.435
 OG1
 O
THR B:469 B:498 0.0 0.0 -58.6 133.6 0.0 0.0 0.0 HOH
 3.737
 CA
 O
7k1f 1 P14735 98.67 0.0 X-RAY
 2021-09-22 THR A:469 A:498 1.0 0.007 -46.8 131.5 1.0 0.007 0.0 HOH
 2.539
 OG1
 O
THR B:469 B:498 1.0 0.007 -58.1 132.9 1.0 0.007 0.0 HOH
 3.486
 CA
 O
2wby 1 P14735 98.57 0.0 X-RAY
 2009-03-24 THR A:469 A:498 1.0 0.007 -59.7 132.2 1.0 0.007 0.0 HOH
 2.553
 OG1
 O
THR B:469 B:498 1.0 0.007 -53.1 131.0 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
 2009-03-24 THR A:469 A:498 1.0 0.007 -50.3 126.3 1.0 0.007 0.0 DIO
HOH
 7.657
2.586
 CG2
OG1
 C1'
O
THR B:469 B:498 1.0 0.007 -70.0 132.7 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
 2012-11-28 THR A:469 A:498 0.0 0.0 -59.5 125.7 0.0 0.0 0.0 HOH
 2.695
 OG1
 O
THR B:469 B:498 1.0 0.007 -44.5 124.4 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
 2010-04-14 THR A:469 A:498 1.0 0.007 -73.1 123.7 1.0 0.007 0.0 DIO
DIO
 9.850
8.069
 CG2
CG2
 O1
O1
THR B:469 B:498 1.0 0.007 -48.1 121.0 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
 2010-11-17 THR A:469 A:498 1.0 0.007 -62.0 123.6 1.0 0.007 0.0 DIO
 7.868
 CG2
 C2'
THR B:469 B:498 1.0 0.007 -55.5 129.9 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
 2010-11-17 THR A:469 A:498 1.0 0.007 -58.7 131.7 1.0 0.007 0.0 HOH
 7.753
 C
 O
THR B:469 B:498 1.0 0.007 -55.9 133.8 1.0 0.007 0.0
3ofi 1 P14735 98.57 0.0 X-RAY
 2010-09-08 THR A:469 A:498 1.0 0.007 -55.4 132.1 1.0 0.007 0.0 HOH
 3.386
 CG2
 O
THR B:469 B:498 1.0 0.007 -56.2 128.2 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
 2013-04-03 THR A:469 A:498 1.0 0.007 -51.1 123.9 1.0 0.007 0.0 HOH
 4.029
 CG2
 O
THR B:469 B:498 1.0 0.007 -49.6 117.5 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
 2013-08-28 THR A:469 A:498 1.0 0.007 -52.4 124.2 1.0 0.007 0.0 HOH
 3.487
 CG2
 O
THR B:469 B:498 1.0 0.007 -51.3 123.5 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
 2013-08-28 THR A:469 A:498 0.0 0.0 -68.6 131.5 0.0 0.0 0.0 HOH
 2.724
 OG1
 O
THR B:469 B:498 1.0 0.007 -70.2 125.6 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
 2013-08-28 THR A:469 A:498 1.0 0.007 -61.8 135.7 1.0 0.007 0.0 HOH
 3.526
 CG2
 O
THR B:469 B:498 1.0 0.007 -55.8 130.4 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
 2014-08-06 THR A:469 A:498 1.0 0.007 -84.8 127.3 1.0 0.007 0.0
THR B:469 B:498 1.0 0.007 -97.8 128.6 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
 2015-10-07 THR A:469 A:498 1.0 0.007 -59.9 123.8 1.0 0.007 0.0 HOH
 8.928
 CG2
 O
THR B:469 B:498 1.0 0.007 -58.8 123.4 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
 2015-05-13 THR A:469 A:498 0.0 0.0 -69.7 128.9 0.0 0.0 0.0
THR B:469 B:498 0.0 0.0 -72.3 121.5 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
 2015-05-13 THR A:469 A:498 0.0 0.0 -70.5 120.6 0.0 0.0 0.0 HOH
 3.677
 CA
 O
THR B:469 B:498 2.0 0.014 -72.2 120.9 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
 2016-07-20 THR A:469 A:498 1.0 0.007 -63.4 125.7 1.0 0.007 0.0
5wob 1 P14735 98.57 0.0 X-RAY
 2018-04-18 THR A:469 A:498 1.0 0.007 -75.2 127.7 1.0 0.007 0.0
THR B:469 B:498 1.0 0.007 -71.6 117.4 1.0 0.007 0.0
THR C:469 C:498 0.0 0.0 -75.5 125.0 NA NA NA
THR D:469 D:498 0.0 0.0 -71.2 122.5 NA NA NA
THR E:469 E:498 1.0 0.007 -73.4 130.0 NA NA NA
THR F:469 F:498 1.0 0.007 -80.4 134.2 NA NA NA
THR G:469 G:498 0.0 0.0 -71.2 128.5 NA NA NA
THR H:469 H:498 0.0 0.0 -70.6 118.7 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
 2009-12-08 THR A:456 A:498 1.0 0.007 -63.1 118.6 1.0 0.007 0.0 HOH
 3.208
 CA
 O
THR B:456 B:498 1.0 0.007 -50.2 128.2 NA NA NA
6b70 1 P14735 98.86 0.0 EM
 2017-12-27 THR A:453 A:498 3.0 0.021 -75.4 169.2 3.0 0.021 0.0
THR B:453 B:498 3.0 0.021 -66.0 150.8 3.0 0.021 0.0
6b7y 1 P14735 98.86 0.0 EM
 2017-11-08 THR A:453 A:498 2.0 0.014 -72.8 161.8 2.0 0.014 0.0
THR B:453 B:498 6.0 0.043 -75.2 168.4 6.0 0.043 0.0
6b7z 1 P14735 98.86 0.0 EM
 2018-01-10 THR A:453 A:498 6.0 0.043 -81.8 149.1 6.0 0.043 0.0
THR B:453 B:498 21.0 0.15 -73.3 153.7 21.0 0.15 0.0
6bf6 1 P14735 98.86 0.0 EM
 2018-02-07 THR A:453 A:498 4.0 0.029 -74.9 161.3 4.0 0.029 0.0
THR B:453 B:498 6.0 0.043 -73.2 159.9 6.0 0.043 0.0
6bf7 1 P14735 98.86 0.0 EM
 2018-02-07 THR A:453 A:498 15.0 0.107 -74.3 161.7 15.0 0.107 0.0
THR B:453 B:498 12.0 0.086 -74.0 161.5 12.0 0.086 0.0
6bf8 1 P14735 98.86 0.0 EM
 2018-04-04 THR A:453 A:498 2.0 0.014 -72.2 160.6 2.0 0.014 0.0
THR B:453 B:498 35.0 0.25 -77.4 170.1 35.0 0.25 0.0
6bf9 1 P14735 98.86 0.0 EM
 2018-02-07 THR A:453 A:498 20.0 0.143 -75.0 163.1 20.0 0.143 0.0
THR B:453 B:498 21.0 0.15 -74.6 165.1 21.0 0.15 0.0
6bfc 1 P14735 98.86 0.0 EM
 2017-12-27 THR A:453 A:498 4.0 0.029 -101.4 160.0 4.0 0.029 0.0
THR B:453 B:498 3.0 0.021 -69.3 145.1 3.0 0.021 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
 2011-07-20 THR A:457 A:498 2.0 0.014 -45.5 141.1 2.0 0.014 0.0 HOH
 2.799
 OG1
 O
3cww 1 P14735 97.34 0.0 X-RAY
 2008-11-25 THR A:469 A:498 1.0 0.007 -53.4 126.7 1.0 0.007 0.0 DIO
HOH
 7.713
2.702
 CG2
OG1
 O1
O
THR B:469 B:498 1.0 0.007 -55.8 127.0 1.0 0.007 0.0 DIO
HOH
 7.662
2.572
 CG2
OG1
 C1'
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 THR A:498 A:498 1.0 0.007 E -75.5 117.5