Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94264654 . A C CCDS7421.1:NM_004969.3:c.1327Tat>Gat_NP_004960.2:p.443Y>D Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 TYR A:443 A:443 55.0 0.239 T -111.5 -11.5 NA NA NA
TYR B:443 B:443 55.0 0.239 T -118.0 -16.1 55.0 0.239 0.0 HOH
5.893
OH
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 TYR A:443 A:443 57.0 0.248 T -118.4 -13.5 57.0 0.248 0.0 HOH
2.575
O
O
TYR B:443 B:443 60.0 0.261 T -124.1 -12.4 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 TYR A:443 A:443 55.0 0.239 T -123.7 -12.6 55.0 0.239 0.0 HOH
2.552
OH
O
TYR B:443 B:443 58.0 0.252 T -122.4 -11.3 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 TYR A:414 A:443 48.0 0.209 T -113.0 -16.6 48.0 0.209 0.0 HOH
2.700
O
O
TYR B:414 B:443 52.0 0.226 T -115.0 -17.4 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 TYR A:414 A:443 46.0 0.2 T -109.1 -20.2 46.0 0.2 0.0 HOH
2.600
O
O
TYR B:414 B:443 56.0 0.243 T -109.3 -11.0 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 TYR A:414 A:443 44.0 0.191 T -112.9 -17.4 44.0 0.191 0.0 HOH
2.672
O
O
TYR B:414 B:443 56.0 0.243 T -108.0 -18.0 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 TYR A:414 A:443 44.0 0.191 T -116.8 -17.1 44.0 0.191 0.0 HOH
2.630
O
O
TYR B:414 B:443 60.0 0.261 T -112.3 -17.2 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 TYR A:414 A:443 49.0 0.213 T -113.8 -12.6 49.0 0.213 0.0 HOH
2.618
O
O
TYR B:414 B:443 50.0 0.217 T -113.9 -19.5 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 TYR A:414 A:443 49.0 0.213 T -122.5 -13.3 49.0 0.213 0.0 HOH
5.247
O
O
TYR B:414 B:443 46.0 0.2 T -119.0 -12.9 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 TYR A:414 A:443 52.0 0.226 T -116.2 -20.3 52.0 0.226 0.0 HOH
2.657
O
O
TYR B:414 B:443 54.0 0.235 T -116.5 -16.2 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 TYR A:443 A:443 46.0 0.2 T -115.2 -24.9 46.0 0.2 0.0 HOH
4.041
CE2
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 TYR A:414 A:443 52.0 0.226 T -120.0 -18.8 52.0 0.226 0.0 HOH
3.316
CE1
O
TYR B:414 B:443 58.0 0.252 T -115.7 -17.1 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 TYR A:443 A:443 48.0 0.209 T -113.9 -15.8 48.0 0.209 0.0 HOH
4.152
CD1
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 TYR A:414 A:443 51.0 0.222 T -116.7 -22.5 51.0 0.222 0.0 HOH
2.617
OH
O
TYR B:414 B:443 59.0 0.257 T -116.1 -14.8 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 TYR A:402 A:443 60.0 0.261 T -117.6 -14.8 60.0 0.261 0.0 HOH
2.776
O
O
TYR B:402 B:443 60.0 0.261 T -117.7 -15.7 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 TYR A:402 A:443 57.0 0.248 T -118.3 -11.4 57.0 0.248 0.0
TYR B:402 B:443 53.0 0.23 T -117.3 -10.7 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 TYR A:402 A:443 59.0 0.257 T -107.3 -18.4 59.0 0.257 0.0
TYR B:402 B:443 58.0 0.252 T -105.7 -18.2 58.0 0.252 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 TYR A:413 A:443 64.0 0.278 T -111.1 -19.8 64.0 0.278 0.0 HOH
4.005
CG
O
TYR B:413 B:443 64.0 0.278 T -110.5 -17.1 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 TYR A:413 A:443 63.0 0.274 T -113.0 -20.4 63.0 0.274 0.0 HOH
4.221
CG
O
TYR B:413 B:443 64.0 0.278 T -114.3 -20.0 64.0 0.278 0.0 HOH
3.357
CE1
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 TYR A:413 A:443 55.0 0.239 T -101.9 -16.8 55.0 0.239 0.0 HOH
6.046
N
O
TYR B:413 B:443 55.0 0.239 T -91.9 -24.8 55.0 0.239 0.0 HOH
5.078
CE2
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 TYR A:413 A:443 63.0 0.274 T -114.0 -18.3 63.0 0.274 0.0 HOH
3.306
CE1
O
TYR B:413 B:443 65.0 0.283 T -113.8 -18.0 65.0 0.283 0.0 HOH
3.923
CD1
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 TYR A:414 A:443 54.0 0.235 T -95.0 -26.8 54.0 0.235 0.0 HOH
5.742
N
O
TYR B:414 B:443 52.0 0.226 T -128.0 -14.3 52.0 0.226 0.0 HOH
4.311
CE2
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 TYR A:414 A:443 65.0 0.283 T -134.1 -21.6 65.0 0.283 0.0 HOH
3.685
C
O
TYR B:414 B:443 56.0 0.243 T -114.2 -8.4 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 TYR A:414 A:443 63.0 0.274 T -114.8 -12.1 63.0 0.274 0.0 HOH
4.653
CD2
O
TYR B:414 B:443 57.0 0.248 T -114.8 -12.3 57.0 0.248 0.0 HOH
4.156
C
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 TYR A:414 A:443 65.0 0.283 T -121.9 -12.8 65.0 0.283 0.0
TYR B:414 B:443 28.0 0.122 T -123.7 -13.6 28.0 0.122 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 TYR A:414 A:443 69.0 0.3 T -109.1 -14.8 69.0 0.3 0.0 1PE
3.938
CE2
H161
TYR B:414 B:443 70.0 0.304 T -109.4 -15.1 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 TYR A:414 A:443 57.0 0.248 T -100.7 -8.8 57.0 0.248 0.0
TYR B:414 B:443 51.0 0.222 T -100.4 -14.7 NA NA NA
TYR C:414 C:443 48.0 0.209 T -100.2 -12.5 NA NA NA
TYR D:414 D:443 66.0 0.287 T -97.8 -13.6 NA NA NA
TYR E:414 E:443 54.0 0.235 T -101.7 -9.6 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 TYR A:414 A:443 58.0 0.252 T -98.5 -33.3 58.0 0.252 0.0
TYR B:414 B:443 79.0 0.343 T -112.8 -17.2 79.0 0.343 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 TYR A:414 A:443 62.0 0.27 T -114.1 -13.0 62.0 0.27 0.0
TYR B:414 B:443 57.0 0.248 T -114.8 -6.2 57.0 0.248 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 TYR A:414 A:443 66.0 0.287 T -106.5 -18.0 66.0 0.287 0.0 HOH
6.413
O
O
TYR B:414 B:443 52.0 0.226 T -111.3 -6.4 52.0 0.226 0.0 HOH
2.909
O
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 TYR A:414 A:443 62.0 0.27 T -118.6 -17.6 62.0 0.27 0.0 HOH
2.734
O
O
TYR B:414 B:443 56.0 0.243 T -112.6 -5.4 56.0 0.243 0.0 HOH
3.609
CE1
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 TYR A:414 A:443 59.0 0.257 T -122.0 -13.4 59.0 0.257 0.0 HOH
2.774
O
O
TYR B:414 B:443 58.0 0.252 T -116.4 -14.5 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 TYR A:414 A:443 53.0 0.23 T -135.2 -20.7 53.0 0.23 0.0 HOH
2.944
O
O
TYR B:414 B:443 61.0 0.265 T -125.7 -13.1 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 TYR A:414 A:443 61.0 0.265 T -121.1 -8.0 61.0 0.265 0.0 HOH
2.764
O
O
TYR B:414 B:443 57.0 0.248 T -127.2 -16.1 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 TYR A:414 A:443 46.0 0.2 T -142.7 -14.3 46.0 0.2 0.0 HOH
6.071
N
O
TYR B:414 B:443 44.0 0.191 T -128.8 -21.5 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 TYR A:414 A:443 63.0 0.274 T -119.1 -15.2 63.0 0.274 0.0 HOH
6.299
N
O
TYR B:414 B:443 61.0 0.265 T -126.6 -17.7 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 TYR A:414 A:443 57.0 0.248 T -123.1 -19.4 57.0 0.248 0.0 HOH
6.388
N
O
TYR B:414 B:443 50.0 0.217 T -122.4 -24.4 50.0 0.217 0.0 HOH
6.354
N
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 TYR A:414 A:443 51.0 0.222 T -117.2 -21.4 51.0 0.222 0.0 HOH
3.498
CE1
O
TYR B:414 B:443 55.0 0.239 T -112.7 -16.1 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 TYR A:414 A:443 56.0 0.243 T -125.4 -22.5 56.0 0.243 0.0 HOH
2.911
O
O
TYR B:414 B:443 60.0 0.261 T -129.7 -9.7 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 TYR A:414 A:443 47.0 0.204 T -119.7 -16.1 47.0 0.204 0.0 HOH
4.164
CE1
O
TYR B:414 B:443 59.0 0.257 T -120.8 -17.1 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 TYR A:414 A:443 49.0 0.213 T -133.7 -19.8 49.0 0.213 0.0 HOH
5.704
N
O
TYR B:414 B:443 59.0 0.257 T -124.8 -25.7 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 TYR A:414 A:443 60.0 0.261 T -123.0 -11.0 60.0 0.261 0.0 HOH
3.342
CE1
O
TYR B:414 B:443 60.0 0.261 T -123.6 -13.2 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 TYR A:414 A:443 62.0 0.27 T -90.6 -44.7 62.0 0.27 0.0
TYR B:414 B:443 33.0 0.143 T -112.7 -23.8 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 TYR A:414 A:443 59.0 0.257 T -104.4 -15.6 59.0 0.257 0.0 1PE
EDO
HOH
6.924
3.079
2.806
CD2
CE1
O
H121
H11
O
TYR B:414 B:443 62.0 0.27 T -102.3 -16.7 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 TYR A:414 A:443 53.0 0.23 T -109.4 -19.3 53.0 0.23 0.0
TYR B:414 B:443 62.0 0.27 T -117.8 -13.2 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 TYR A:414 A:443 44.0 0.191 T -109.8 -17.6 44.0 0.191 0.0 HOH
6.410
N
O
TYR B:414 B:443 56.0 0.243 T -109.4 -18.6 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 TYR A:414 A:443 71.0 0.309 T -73.2 -17.9 71.0 0.309 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 TYR A:414 A:443 35.0 0.152 T -92.9 -24.5 35.0 0.152 0.0
TYR B:414 B:443 44.0 0.191 T -102.8 -15.4 44.0 0.191 0.0
TYR C:414 C:443 35.0 0.152 T -99.8 -27.8 NA NA NA
TYR D:414 D:443 44.0 0.191 T -110.2 -24.2 NA NA NA
TYR E:414 E:443 41.0 0.178 T -105.2 -20.4 NA NA NA
TYR F:414 F:443 33.0 0.143 T -101.6 -17.3 NA NA NA
TYR G:414 G:443 45.0 0.196 T -107.6 -22.6 NA NA NA
TYR H:414 H:443 34.0 0.148 S -95.2 -15.7 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 TYR A:401 A:443 60.0 0.261 T -133.3 -12.2 60.0 0.261 0.0 HOH
4.920
CA
O
TYR B:401 B:443 55.0 0.239 T -129.8 -29.2 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 TYR A:398 A:443 61.0 0.265 T -88.2 -15.9 61.0 0.265 0.0
TYR B:398 B:443 69.0 0.3 T -111.8 -14.8 69.0 0.3 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 TYR A:398 A:443 67.0 0.291 G -102.2 -5.4 67.0 0.291 0.0
TYR B:398 B:443 53.0 0.23 H -101.9 -5.9 53.0 0.23 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 TYR A:398 A:443 54.0 0.235 T -102.2 0.1 54.0 0.235 0.0
TYR B:398 B:443 67.0 0.291 H -72.6 -16.2 67.0 0.291 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 TYR A:398 A:443 67.0 0.291 T -104.7 -6.1 67.0 0.291 0.0
TYR B:398 B:443 41.0 0.178 T -103.4 -5.5 41.0 0.178 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 TYR A:398 A:443 52.0 0.226 T -103.8 -4.6 52.0 0.226 0.0
TYR B:398 B:443 45.0 0.196 T -103.4 -4.5 45.0 0.196 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 TYR A:398 A:443 61.0 0.265 G -100.3 -1.1 61.0 0.265 0.0
TYR B:398 B:443 58.0 0.252 T -102.2 -8.3 58.0 0.252 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 TYR A:398 A:443 65.0 0.283 G -102.2 3.1 65.0 0.283 0.0
TYR B:398 B:443 66.0 0.287 T -102.0 -5.3 66.0 0.287 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 TYR A:398 A:443 60.0 0.261 T -96.9 -34.5 51.0 0.222 0.039 C:P01308:0.039
TYR B:398 B:443 77.0 0.335 T -112.9 -18.6 77.0 0.335 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 TYR A:402 A:443 67.0 0.291 T -117.4 -12.5 67.0 0.291 0.0 HOH
2.794
O
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 TYR A:414 A:443 61.0 0.265 T -119.3 -18.7 61.0 0.265 0.0 HOH
2.578
OH
O
TYR B:414 B:443 60.0 0.261 T -114.4 -16.5 60.0 0.261 0.0 HOH
2.553
OH
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 TYR A:443 A:443 71.0 0.309 T -104.3 -27.5