Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94267880 . C A CCDS7421.1:NM_004969.3:c.1143gaG>gaT_NP_004960.2:p.381E>D Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 GLU A:381 A:381 125.0 0.658 H -55.4 -37.7 NA NA NA
GLU B:381 B:381 122.0 0.642 H -63.7 -35.4 122.0 0.642 0.0 HOH
2.618
O
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 GLU A:381 A:381 123.0 0.647 H -53.1 -41.1 123.0 0.647 0.0 HOH
4.234
OE2
O
GLU B:381 B:381 120.0 0.632 H -64.7 -38.8 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 GLU A:381 A:381 123.0 0.647 H -54.2 -43.8 123.0 0.647 0.0 HOH
3.147
N
O
GLU B:381 B:381 126.0 0.663 H -54.6 -43.4 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 GLU A:352 A:381 125.0 0.658 H -58.6 -42.5 125.0 0.658 0.0 HOH
2.549
O
O
GLU B:352 B:381 124.0 0.653 H -58.8 -46.9 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLU A:352 A:381 127.0 0.668 H -59.4 -46.6 127.0 0.668 0.0 HOH
3.401
OE1
O
GLU B:352 B:381 122.0 0.642 T -59.5 -43.1 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLU A:352 A:381 125.0 0.658 H -62.6 -46.7 125.0 0.658 0.0 HOH
3.494
N
O
GLU B:352 B:381 124.0 0.653 H -60.9 -41.1 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLU A:352 A:381 121.0 0.637 H -58.5 -46.5 121.0 0.637 0.0 HOH
2.792
O
O
GLU B:352 B:381 119.0 0.626 T -62.7 -39.8 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLU A:352 A:381 124.0 0.653 H -58.2 -42.0 124.0 0.653 0.0 HOH
2.566
O
O
GLU B:352 B:381 128.0 0.674 H -63.7 -46.5 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 GLU A:352 A:381 122.0 0.642 H -62.3 -49.1 122.0 0.642 0.0 HOH
3.535
N
O
GLU B:352 B:381 122.0 0.642 H -54.7 -38.8 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 GLU A:352 A:381 114.0 0.6 H -56.7 -37.7 114.0 0.6 0.0 HOH
3.043
N
O
GLU B:352 B:381 119.0 0.626 H -56.5 -43.7 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 GLU A:381 A:381 123.0 0.647 H -58.2 -43.7 123.0 0.647 0.0 HOH
2.760
OE2
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 GLU A:352 A:381 120.0 0.632 H -51.4 -47.5 120.0 0.632 0.0 HOH
2.918
OE2
O
GLU B:352 B:381 122.0 0.642 H -64.8 -41.2 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 GLU A:381 A:381 124.0 0.653 H -60.9 -46.4 124.0 0.653 0.0 HOH
7.146
C
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 GLU A:352 A:381 120.0 0.632 H -56.2 -42.8 120.0 0.632 0.0 HOH
2.983
O
O
GLU B:352 B:381 126.0 0.663 H -54.3 -44.7 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 GLU A:340 A:381 118.0 0.621 H -62.8 -34.0 118.0 0.621 0.0 HOH
2.338
OE2
O
GLU B:340 B:381 121.0 0.637 H -62.2 -34.5 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 GLU A:340 A:381 126.0 0.663 H -52.0 -40.4 126.0 0.663 0.0
GLU B:340 B:381 129.0 0.679 H -51.3 -41.5 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 GLU A:340 A:381 128.0 0.674 H -57.1 -44.7 128.0 0.674 0.0
GLU B:340 B:381 126.0 0.663 H -57.1 -45.1 126.0 0.663 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLU A:351 A:381 118.0 0.621 T -64.9 -35.5 118.0 0.621 0.0 HOH
2.839
O
O
GLU B:351 B:381 120.0 0.632 T -65.2 -41.5 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLU A:351 A:381 115.0 0.605 H -65.4 -39.1 115.0 0.605 0.0 HOH
2.993
N
O
GLU B:351 B:381 114.0 0.6 T -65.8 -39.4 114.0 0.6 0.0 HOH
2.564
O
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLU A:351 A:381 122.0 0.642 T -53.0 -35.6 122.0 0.642 0.0 HOH
3.556
OE2
O
GLU B:351 B:381 117.0 0.616 T -65.2 -31.0 117.0 0.616 0.0 HOH
2.717
O
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLU A:351 A:381 119.0 0.626 T -60.4 -39.0 119.0 0.626 0.0 HOH
3.189
N
O
GLU B:351 B:381 114.0 0.6 T -66.6 -30.9 114.0 0.6 0.0 HOH
2.684
O
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 GLU A:352 A:381 125.0 0.658 H -61.6 -48.1 125.0 0.658 0.0 HOH
3.010
CG
O
GLU B:352 B:381 124.0 0.653 H -64.4 -51.9 124.0 0.653 0.0 HOH
2.722
N
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 GLU A:352 A:381 126.0 0.663 H -73.8 -42.8 126.0 0.663 0.0 HOH
8.156
N
O
GLU B:352 B:381 122.0 0.642 H -53.8 -44.3 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 GLU A:352 A:381 123.0 0.647 T -58.5 -46.6 123.0 0.647 0.0 HOH
7.782
N
O
GLU B:352 B:381 128.0 0.674 H -57.3 -47.2 128.0 0.674 0.0 HOH
7.451
N
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 GLU A:352 A:381 117.0 0.616 H -55.5 -43.0 117.0 0.616 0.0
GLU B:352 B:381 116.0 0.611 H -55.8 -43.6 116.0 0.611 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 GLU A:352 A:381 120.0 0.632 H -56.3 -39.5 120.0 0.632 0.0 HOH
5.833
CG
O
GLU B:352 B:381 123.0 0.647 T -57.0 -42.4 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 GLU A:352 A:381 123.0 0.647 T -60.9 -34.2 123.0 0.647 0.0
GLU B:352 B:381 125.0 0.658 T -62.4 -31.0 NA NA NA
GLU C:352 C:381 122.0 0.642 T -64.3 -43.0 NA NA NA
GLU D:352 D:381 98.0 0.516 T -62.2 -40.6 NA NA NA
GLU E:352 E:381 121.0 0.637 T -60.1 -32.0 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 GLU A:352 A:381 142.0 0.747 T -61.2 -49.5 142.0 0.747 0.0
GLU B:352 B:381 126.0 0.663 T -60.3 -37.6 126.0 0.663 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLU A:352 A:381 123.0 0.647 H -57.7 -41.5 123.0 0.647 0.0
GLU B:352 B:381 119.0 0.626 H -67.1 -45.4 119.0 0.626 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLU A:352 A:381 125.0 0.658 H -60.4 -44.9 125.0 0.658 0.0 HOH
2.716
O
O
GLU B:352 B:381 119.0 0.626 H -64.0 -45.2 119.0 0.626 0.0 HOH
5.279
CG
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLU A:352 A:381 117.0 0.616 H -62.1 -41.3 117.0 0.616 0.0 HOH
2.745
O
O
GLU B:352 B:381 120.0 0.632 H -63.0 -47.4 120.0 0.632 0.0 HOH
2.752
N
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 GLU A:352 A:381 116.0 0.611 H -56.0 -43.2 116.0 0.611 0.0 HOH
3.372
OE2
O
GLU B:352 B:381 121.0 0.637 H -59.8 -47.9 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 GLU A:352 A:381 116.0 0.611 H -69.8 -33.4 116.0 0.611 0.0 HOH
3.830
N
O
GLU B:352 B:381 120.0 0.632 H -67.1 -48.2 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 GLU A:352 A:381 121.0 0.637 H -60.1 -32.3 121.0 0.637 0.0 HOH
2.948
OE1
O
GLU B:352 B:381 119.0 0.626 H -57.1 -44.5 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 GLU A:352 A:381 123.0 0.647 H -60.7 -42.1 123.0 0.647 0.0 HOH
3.424
N
O
GLU B:352 B:381 120.0 0.632 H -48.6 -40.0 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 GLU A:352 A:381 126.0 0.663 H -57.6 -46.5 126.0 0.663 0.0 HOH
5.790
OE2
O
GLU B:352 B:381 124.0 0.653 H -56.5 -42.2 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 GLU A:352 A:381 124.0 0.653 H -50.5 -49.7 124.0 0.653 0.0
GLU B:352 B:381 126.0 0.663 H -53.4 -44.6 126.0 0.663 0.0 HOH
3.000
OE1
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 GLU A:352 A:381 123.0 0.647 H -58.7 -35.8 123.0 0.647 0.0 HOH
2.640
OE2
O
GLU B:352 B:381 124.0 0.653 H -55.3 -45.0 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 GLU A:352 A:381 118.0 0.621 H -54.5 -44.6 118.0 0.621 0.0 HOH
8.802
CG
O
GLU B:352 B:381 122.0 0.642 H -48.3 -47.9 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLU A:352 A:381 120.0 0.632 H -59.2 -31.7 120.0 0.632 0.0 HOH
8.723
N
O
GLU B:352 B:381 122.0 0.642 H -53.6 -42.7 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLU A:352 A:381 125.0 0.658 T -43.6 -55.0 125.0 0.658 0.0 HOH
8.313
N
O
GLU B:352 B:381 120.0 0.632 H -54.4 -47.3 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLU A:352 A:381 121.0 0.637 H -58.7 -33.7 121.0 0.637 0.0 HOH
3.646
N
O
GLU B:352 B:381 124.0 0.653 H -57.2 -38.2 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 GLU A:352 A:381 108.0 0.568 T -36.9 -55.1 108.0 0.568 0.0
GLU B:352 B:381 108.0 0.568 T -61.0 -49.7 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 GLU A:352 A:381 128.0 0.674 T -54.1 -35.3 128.0 0.674 0.0 HOH
3.053
N
O
GLU B:352 B:381 123.0 0.647 T -56.0 -35.2 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 GLU A:352 A:381 121.0 0.637 T -64.9 -31.9 121.0 0.637 0.0
GLU B:352 B:381 125.0 0.658 T -50.3 -41.2 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 GLU A:352 A:381 104.0 0.547 T -69.3 -35.9 104.0 0.547 0.0
GLU B:352 B:381 90.0 0.474 T -66.4 -35.7 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 GLU A:352 A:381 126.0 0.663 T -67.8 -35.7 126.0 0.663 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 GLU A:352 A:381 117.0 0.616 T -65.6 -28.8 117.0 0.616 0.0
GLU B:352 B:381 120.0 0.632 T -66.6 -35.9 120.0 0.632 0.0
GLU C:352 C:381 118.0 0.621 T -65.7 -28.9 NA NA NA
GLU D:352 D:381 118.0 0.621 T -67.0 -34.4 NA NA NA
GLU E:352 E:381 127.0 0.668 T -72.3 -26.4 NA NA NA
GLU F:352 F:381 119.0 0.626 T -68.6 -35.8 NA NA NA
GLU G:352 G:381 126.0 0.663 T -70.1 -26.9 NA NA NA
GLU H:352 H:381 114.0 0.6 T -67.0 -31.5 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 GLU A:339 A:381 119.0 0.626 H -56.7 -38.1 119.0 0.626 0.0 HOH
6.061
OE1
O
GLU B:339 B:381 121.0 0.637 H -48.5 -49.1 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 GLU A:336 A:381 106.0 0.558 T -66.0 -45.0 106.0 0.558 0.0
GLU B:336 B:381 124.0 0.653 S -55.6 -53.5 124.0 0.653 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 GLU A:336 A:381 121.0 0.637 H -66.5 -44.6 121.0 0.637 0.0
GLU B:336 B:381 131.0 0.689 H -63.6 -49.4 131.0 0.689 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 GLU A:336 A:381 107.0 0.563 H -73.0 -44.3 107.0 0.563 0.0
GLU B:336 B:381 132.0 0.695 S -76.0 -30.3 132.0 0.695 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 GLU A:336 A:381 111.0 0.584 H -60.7 -45.7 111.0 0.584 0.0
GLU B:336 B:381 121.0 0.637 S -59.3 -56.0 121.0 0.637 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 GLU A:336 A:381 105.0 0.553 H -59.3 -43.0 105.0 0.553 0.0
GLU B:336 B:381 99.0 0.521 T -56.2 -57.5 99.0 0.521 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 GLU A:336 A:381 108.0 0.568 H -54.2 -60.2 108.0 0.568 0.0
GLU B:336 B:381 152.0 0.8 T -58.5 -56.1 152.0 0.8 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 GLU A:336 A:381 96.0 0.505 H -55.1 -64.6 96.0 0.505 0.0
GLU B:336 B:381 143.0 0.753 S -64.0 -56.4 143.0 0.753 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 GLU A:336 A:381 140.0 0.737 T -63.7 -48.2 140.0 0.737 0.0
GLU B:336 B:381 123.0 0.647 T -61.4 -38.6 123.0 0.647 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 GLU A:340 A:381 121.0 0.637 H -65.0 -38.1 121.0 0.637 0.0 HOH
7.109
N
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 GLU A:352 A:381 121.0 0.637 H -60.3 -46.0 121.0 0.637 0.0 HOH
2.506
OE1
O
GLU B:352 B:381 120.0 0.632 H -59.2 -43.8 120.0 0.632 0.0 HOH
2.370
OE1
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 GLU A:381 A:381 125.0 0.658 H -57.4 -47.2