Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94269878 . A C CCDS7421.1:NM_004969.3:c.826Tct>Gct_NP_004960.2:p.276S>A Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 SER A:276 A:276 45.0 0.391 T -70.8 -7.6 NA NA NA
SER B:276 B:276 35.0 0.304 T -74.5 -14.8 35.0 0.304 0.0 HOH
7.509
O
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 SER A:276 A:276 47.0 0.409 T -76.1 -7.3 47.0 0.409 0.0
SER B:276 B:276 48.0 0.417 T -75.8 -17.8 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 SER A:276 A:276 48.0 0.417 T -65.0 -27.5 48.0 0.417 0.0 HOH
6.282
O
O
SER B:276 B:276 40.0 0.348 S -64.9 -31.9 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 SER A:247 A:276 47.0 0.409 T -64.7 -19.3 47.0 0.409 0.0 HOH
3.393
O
O
SER B:247 B:276 46.0 0.4 T -60.3 -27.7 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 SER A:247 A:276 51.0 0.443 T -63.9 -12.7 51.0 0.443 0.0 HOH
5.912
O
O
SER B:247 B:276 35.0 0.304 T -72.2 -9.3 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 SER A:247 A:276 53.0 0.461 T -67.0 -9.5 53.0 0.461 0.0 HOH
4.581
O
O
SER B:247 B:276 31.0 0.27 T -68.7 -4.8 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 SER A:247 A:276 49.0 0.426 T -63.3 -15.8 49.0 0.426 0.0 HOH
3.361
O
O
SER B:247 B:276 31.0 0.27 T -67.2 -14.5 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 SER A:247 A:276 47.0 0.409 T -59.4 -20.0 47.0 0.409 0.0 HOH
3.343
O
O
SER B:247 B:276 45.0 0.391 T -62.1 -29.0 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 SER A:247 A:276 48.0 0.417 T -67.2 -12.8 48.0 0.417 0.0
SER B:247 B:276 32.0 0.278 T -66.5 -16.8 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 SER A:247 A:276 48.0 0.417 T -75.2 -11.2 48.0 0.417 0.0 HOH
7.766
O
O
SER B:247 B:276 32.0 0.278 T -71.6 -12.8 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 SER A:276 A:276 44.0 0.383 T -64.6 -28.8 44.0 0.383 0.0 HOH
3.462
O
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 SER A:247 A:276 46.0 0.4 T -73.3 -8.7 46.0 0.4 0.0 HOH
8.092
O
O
SER B:247 B:276 37.0 0.322 T -64.5 -13.3 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 SER A:276 A:276 41.0 0.357 T -57.3 -24.9 41.0 0.357 0.0 HOH
3.409
O
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 SER A:247 A:276 44.0 0.383 T -62.4 -28.4 44.0 0.383 0.0 HOH
3.250
N
O
SER B:247 B:276 43.0 0.374 T -59.0 -29.1 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 SER A:235 A:276 48.0 0.417 T -80.4 -9.0 48.0 0.417 0.0 HOH
8.008
O
O
SER B:235 B:276 44.0 0.383 T -80.7 -9.4 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 SER A:235 A:276 46.0 0.4 T -68.6 -12.8 46.0 0.4 0.0
SER B:235 B:276 43.0 0.374 T -69.2 -13.2 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 SER A:235 A:276 48.0 0.417 T -63.5 -14.8 48.0 0.417 0.0
SER B:235 B:276 46.0 0.4 T -63.6 -14.1 46.0 0.4 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 SER A:246 A:276 40.0 0.348 T -66.8 -19.6 40.0 0.348 0.0
SER B:246 B:276 35.0 0.304 T -70.8 -17.4 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 SER A:246 A:276 45.0 0.391 T -67.5 -23.0 45.0 0.391 0.0 HOH
3.132
O
O
SER B:246 B:276 32.0 0.278 T -67.4 -23.7 32.0 0.278 0.0 HOH
7.640
O
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 SER A:246 A:276 34.0 0.296 S -83.3 -16.4 34.0 0.296 0.0
SER B:246 B:276 42.0 0.365 T -72.3 -15.1 42.0 0.365 0.0
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 SER A:246 A:276 31.0 0.27 T -71.9 -21.9 31.0 0.27 0.0 HOH
7.021
OG
O
SER B:246 B:276 47.0 0.409 T -70.1 -20.4 47.0 0.409 0.0 HOH
2.706
O
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 SER A:247 A:276 43.0 0.374 T -75.7 -32.5 43.0 0.374 0.0
SER B:247 B:276 45.0 0.391 T -58.0 -32.4 45.0 0.391 0.0
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 SER A:247 A:276 42.0 0.365 H -69.3 -33.2 42.0 0.365 0.0
SER B:247 B:276 41.0 0.357 T -78.0 -9.8 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 SER A:247 A:276 49.0 0.426 T -74.6 -12.6 49.0 0.426 0.0 HOH
9.977
O
O
SER B:247 B:276 48.0 0.417 T -76.0 -12.9 48.0 0.417 0.0
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 SER A:247 A:276 41.0 0.357 T -50.2 -33.8 41.0 0.357 0.0
SER B:247 B:276 45.0 0.391 T -50.4 -34.0 45.0 0.391 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 SER A:247 A:276 48.0 0.417 T -67.0 -18.2 48.0 0.417 0.0
SER B:247 B:276 50.0 0.435 T -66.2 -15.8 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 SER A:247 A:276 37.0 0.322 T -71.6 -23.4 37.0 0.322 0.0
SER B:247 B:276 20.0 0.174 T -70.3 -15.9 NA NA NA
SER C:247 C:276 23.0 0.2 T -66.4 -14.2 NA NA NA
SER D:247 D:276 42.0 0.365 T -71.1 -20.2 NA NA NA
SER E:247 E:276 36.0 0.313 T -66.7 -19.3 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 SER A:247 A:276 75.0 0.652 -77.9 -10.6 75.0 0.652 0.0
SER B:247 B:276 74.0 0.643 S -83.8 -14.0 74.0 0.643 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 SER A:247 A:276 42.0 0.365 T -64.4 -22.4 42.0 0.365 0.0
SER B:247 B:276 40.0 0.348 T -60.6 -29.1 40.0 0.348 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 SER A:247 A:276 48.0 0.417 T -73.3 -21.7 48.0 0.417 0.0
SER B:247 B:276 43.0 0.374 T -57.6 -25.2 43.0 0.374 0.0
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 SER A:247 A:276 44.0 0.383 T -64.4 -20.1 44.0 0.383 0.0
SER B:247 B:276 45.0 0.391 T -57.2 -33.9 45.0 0.391 0.0 HOH
5.599
O
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 SER A:247 A:276 45.0 0.391 T -49.0 -32.8 45.0 0.391 0.0 HOH
7.548
O
O
SER B:247 B:276 43.0 0.374 T -75.8 -11.7 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 SER A:247 A:276 48.0 0.417 T -55.1 -29.9 48.0 0.417 0.0 HOH
2.875
N
O
SER B:247 B:276 37.0 0.322 T -78.7 -10.7 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 SER A:247 A:276 44.0 0.383 T -66.7 -22.7 44.0 0.383 0.0 HOH
7.988
O
O
SER B:247 B:276 45.0 0.391 T -73.5 -22.6 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 SER A:247 A:276 46.0 0.4 T -68.1 -27.3 46.0 0.4 0.0
SER B:247 B:276 44.0 0.383 T -62.9 -29.7 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 SER A:247 A:276 43.0 0.374 T -70.5 -13.2 43.0 0.374 0.0 HOH
9.851
CB
O
SER B:247 B:276 45.0 0.391 T -67.3 -27.8 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 SER A:247 A:276 44.0 0.383 T -74.6 -9.5 44.0 0.383 0.0
SER B:247 B:276 39.0 0.339 T -63.6 -15.5 39.0 0.339 0.0 HOH
8.228
C
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 SER A:247 A:276 45.0 0.391 T -57.2 -28.5 45.0 0.391 0.0 HOH
9.766
N
O
SER B:247 B:276 44.0 0.383 T -50.8 -35.4 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 SER A:247 A:276 44.0 0.383 T -67.7 -27.5 44.0 0.383 0.0
SER B:247 B:276 44.0 0.383 T -62.0 -37.7 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 SER A:247 A:276 45.0 0.391 T -66.8 -24.5 45.0 0.391 0.0
SER B:247 B:276 44.0 0.383 T -75.5 -28.1 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 SER A:247 A:276 44.0 0.383 T -77.6 -25.7 44.0 0.383 0.0 HOH
6.068
O
O
SER B:247 B:276 39.0 0.339 T -56.8 -36.5 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 SER A:247 A:276 46.0 0.4 T -59.2 -24.9 46.0 0.4 0.0
SER B:247 B:276 44.0 0.383 T -75.2 -16.7 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 SER A:247 A:276 47.0 0.409 T -87.3 -3.1 47.0 0.409 0.0
SER B:247 B:276 44.0 0.383 T -98.4 -15.6 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 SER A:247 A:276 45.0 0.391 T -74.3 -18.9 45.0 0.391 0.0
SER B:247 B:276 46.0 0.4 T -74.4 -18.5 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 SER A:247 A:276 50.0 0.435 T -77.3 -13.8 50.0 0.435 0.0
SER B:247 B:276 42.0 0.365 T -73.8 -19.3 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 SER A:247 A:276 53.0 0.461 S -78.4 -13.7 53.0 0.461 0.0
SER B:247 B:276 42.0 0.365 S -80.0 -16.2 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 SER A:247 A:276 45.0 0.391 T -70.0 -15.2 45.0 0.391 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 SER A:247 A:276 45.0 0.391 T -67.5 -21.2 45.0 0.391 0.0
SER B:247 B:276 55.0 0.478 T -71.9 -20.3 55.0 0.478 0.0
SER C:247 C:276 41.0 0.357 T -68.8 -21.9 NA NA NA
SER D:247 D:276 51.0 0.443 T -70.3 -20.9 NA NA NA
SER E:247 E:276 45.0 0.391 T -71.0 -10.7 NA NA NA
SER F:247 F:276 42.0 0.365 T -69.4 -15.4 NA NA NA
SER G:247 G:276 51.0 0.443 T -68.8 -13.3 NA NA NA
SER H:247 H:276 45.0 0.391 T -68.0 -21.1 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 SER A:234 A:276 43.0 0.374 T -80.0 -8.8 43.0 0.374 0.0
SER B:234 B:276 43.0 0.374 T -60.0 -15.9 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 SER A:231 A:276 74.0 0.643 -136.1 -11.1 74.0 0.643 0.0
SER B:231 B:276 73.0 0.635 -123.3 -5.7 73.0 0.635 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 SER A:231 A:276 37.0 0.322 T -78.2 -4.7 37.0 0.322 0.0
SER B:231 B:276 32.0 0.278 G -79.8 3.2 32.0 0.278 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 SER A:231 A:276 54.0 0.47 T -76.1 -10.5 54.0 0.47 0.0
SER B:231 B:276 69.0 0.6 -86.7 22.6 69.0 0.6 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 SER A:231 A:276 58.0 0.504 -128.6 1.0 58.0 0.504 0.0
SER B:231 B:276 62.0 0.539 -126.1 -3.8 62.0 0.539 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 SER A:231 A:276 62.0 0.539 -128.4 1.6 62.0 0.539 0.0
SER B:231 B:276 51.0 0.443 -128.3 -2.8 51.0 0.443 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 SER A:231 A:276 52.0 0.452 -132.3 -3.0 52.0 0.452 0.0
SER B:231 B:276 65.0 0.565 -126.3 0.9 65.0 0.565 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 SER A:231 A:276 52.0 0.452 -131.9 -8.8 52.0 0.452 0.0
SER B:231 B:276 61.0 0.53 -131.3 -9.7 61.0 0.53 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 SER A:231 A:276 74.0 0.643 -78.8 -9.8 74.0 0.643 0.0
SER B:231 B:276 71.0 0.617 S -83.8 -13.3 71.0 0.617 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 SER A:235 A:276 42.0 0.365 T -60.5 -16.1 42.0 0.365 0.0 HOH
3.199
O
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 SER A:247 A:276 51.0 0.443 T -68.1 -14.7 51.0 0.443 0.0 HOH
2.714
O
O
SER B:247 B:276 48.0 0.417 T -69.2 -17.8 48.0 0.417 0.0 HOH
3.184
O
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 SER A:276 A:276 46.0 0.4 T -68.7 -18.0