Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94274683 . C A CCDS7421.1:NM_004969.3:c.778Ggt>Tgt_NP_004960.2:p.260G>C Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 GLY A:260 A:260 0.0 0.0 E -166.8 177.5 NA NA NA
GLY B:260 B:260 0.0 0.0 E -151.5 -168.8 0.0 0.0 0.0 HOH
7.615
C
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 GLY A:260 A:260 0.0 0.0 E -151.6 -176.7 0.0 0.0 0.0 HOH
3.490
CA
O
GLY B:260 B:260 0.0 0.0 E -159.6 -173.5 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 GLY A:260 A:260 0.0 0.0 E -162.7 177.7 0.0 0.0 0.0 HOH
3.141
CA
O
GLY B:260 B:260 0.0 0.0 E -162.7 178.5 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 GLY A:231 A:260 0.0 0.0 E -159.1 179.7 0.0 0.0 0.0 HOH
3.661
CA
O
GLY B:231 B:260 0.0 0.0 E -157.2 179.8 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLY A:231 A:260 0.0 0.0 E -166.3 174.9 0.0 0.0 0.0 HOH
3.588
CA
O
GLY B:231 B:260 0.0 0.0 E -162.0 -178.3 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLY A:231 A:260 0.0 0.0 E -159.4 174.0 0.0 0.0 0.0 HOH
3.592
CA
O
GLY B:231 B:260 0.0 0.0 E -164.0 -177.2 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLY A:231 A:260 0.0 0.0 E -161.0 176.2 0.0 0.0 0.0 HOH
3.686
CA
O
GLY B:231 B:260 0.0 0.0 E -157.0 -176.1 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLY A:231 A:260 0.0 0.0 E -165.0 179.5 0.0 0.0 0.0 HOH
3.632
CA
O
GLY B:231 B:260 0.0 0.0 E -157.5 178.1 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 GLY A:231 A:260 0.0 0.0 E -172.7 -179.5 0.0 0.0 0.0 HOH
7.575
N
O
GLY B:231 B:260 0.0 0.0 E 178.5 -178.0 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 GLY A:231 A:260 0.0 0.0 E -154.1 172.4 0.0 0.0 0.0 HOH
3.754
CA
O
GLY B:231 B:260 0.0 0.0 E -157.5 177.4 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 GLY A:260 A:260 0.0 0.0 E -155.6 168.5 0.0 0.0 0.0 HOH
3.689
CA
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 GLY A:231 A:260 0.0 0.0 E -163.7 178.7 0.0 0.0 0.0 HOH
3.415
CA
O
GLY B:231 B:260 0.0 0.0 E -156.7 -175.9 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 GLY A:260 A:260 0.0 0.0 E -157.0 175.8 0.0 0.0 0.0 HOH
3.558
CA
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 GLY A:231 A:260 0.0 0.0 E -154.6 175.0 0.0 0.0 0.0 HOH
3.684
CA
O
GLY B:231 B:260 0.0 0.0 E -157.9 179.1 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 GLY A:219 A:260 0.0 0.0 E -155.1 178.6 0.0 0.0 0.0 HOH
3.668
CA
O
GLY B:219 B:260 0.0 0.0 E -155.4 179.4 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 GLY A:219 A:260 0.0 0.0 E -152.7 174.7 0.0 0.0 0.0
GLY B:219 B:260 0.0 0.0 E -153.4 176.1 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 GLY A:219 A:260 0.0 0.0 E -158.1 169.4 0.0 0.0 0.0
GLY B:219 B:260 0.0 0.0 E -157.0 169.1 0.0 0.0 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLY A:230 A:260 0.0 0.0 E -153.8 167.8 0.0 0.0 0.0
GLY B:230 B:260 0.0 0.0 E -152.3 173.6 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLY A:230 A:260 0.0 0.0 E -157.3 171.1 0.0 0.0 0.0 HOH
6.290
C
O
GLY B:230 B:260 0.0 0.0 E -158.5 171.5 0.0 0.0 0.0 HOH
3.507
CA
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLY A:230 A:260 0.0 0.0 E -162.0 171.9 0.0 0.0 0.0 HOH
8.414
N
O
GLY B:230 B:260 0.0 0.0 E -157.2 165.8 0.0 0.0 0.0 HOH
7.397
O
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLY A:230 A:260 0.0 0.0 E -156.1 176.0 0.0 0.0 0.0 HOH
6.405
O
O
GLY B:230 B:260 0.0 0.0 E -165.8 170.6 0.0 0.0 0.0 HOH
6.004
C
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 GLY A:231 A:260 0.0 0.0 E -156.5 174.6 0.0 0.0 0.0 HOH
9.918
O
O
GLY B:231 B:260 0.0 0.0 E -155.8 -176.6 0.0 0.0 0.0 HOH
3.582
CA
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 GLY A:231 A:260 0.0 0.0 E -158.2 171.9 0.0 0.0 0.0 HOH
9.713
O
O
GLY B:231 B:260 0.0 0.0 E -161.2 179.5 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 GLY A:231 A:260 0.0 0.0 E -158.7 -179.6 0.0 0.0 0.0 HOH
3.442
CA
O
GLY B:231 B:260 0.0 0.0 E -157.7 179.8 0.0 0.0 0.0 HOH
8.417
O
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 GLY A:231 A:260 0.0 0.0 E -162.4 166.0 0.0 0.0 0.0
GLY B:231 B:260 0.0 0.0 E -163.4 165.8 0.0 0.0 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 GLY A:231 A:260 0.0 0.0 E -157.4 -179.6 0.0 0.0 0.0
GLY B:231 B:260 0.0 0.0 E -157.3 178.6 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 GLY A:231 A:260 0.0 0.0 E -174.3 177.5 0.0 0.0 0.0
GLY B:231 B:260 0.0 0.0 E -171.1 174.5 NA NA NA
GLY C:231 C:260 0.0 0.0 E -171.1 170.8 NA NA NA
GLY D:231 D:260 0.0 0.0 E -166.3 -179.2 NA NA NA
GLY E:231 E:260 0.0 0.0 E -174.6 177.0 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 GLY A:231 A:260 0.0 0.0 E -96.2 159.1 0.0 0.0 0.0
GLY B:231 B:260 0.0 0.0 E -107.3 174.3 0.0 0.0 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLY A:231 A:260 0.0 0.0 E -155.9 178.4 0.0 0.0 0.0
GLY B:231 B:260 0.0 0.0 E -159.8 169.4 0.0 0.0 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLY A:231 A:260 0.0 0.0 E -155.0 172.7 0.0 0.0 0.0 HOH
7.259
O
O
GLY B:231 B:260 0.0 0.0 E -154.3 179.9 0.0 0.0 0.0 HOH
3.562
CA
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLY A:231 A:260 0.0 0.0 E -160.1 178.5 0.0 0.0 0.0 HOH
3.278
CA
O
GLY B:231 B:260 0.0 0.0 E -158.0 179.1 0.0 0.0 0.0 HOH
3.490
CA
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 GLY A:231 A:260 0.0 0.0 E -163.1 166.3 0.0 0.0 0.0 HOH
3.464
CA
O
GLY B:231 B:260 0.0 0.0 E -158.1 -176.1 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 GLY A:231 A:260 0.0 0.0 E -166.3 169.9 0.0 0.0 0.0 HOH
3.411
CA
O
GLY B:231 B:260 0.0 0.0 E -159.5 -172.0 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 GLY A:231 A:260 0.0 0.0 E -158.0 177.3 0.0 0.0 0.0 HOH
3.415
CA
O
GLY B:231 B:260 0.0 0.0 E -165.5 -173.8 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 GLY A:231 A:260 0.0 0.0 E -169.3 176.8 0.0 0.0 0.0 DIO
HOH
8.657
7.810
CA
N
C2
O
GLY B:231 B:260 0.0 0.0 E -151.3 -176.3 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 GLY A:231 A:260 0.0 0.0 E -166.1 -177.6 0.0 0.0 0.0
GLY B:231 B:260 0.0 0.0 E -158.0 179.4 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 GLY A:231 A:260 0.0 0.0 E -164.4 -177.8 0.0 0.0 0.0 HOH
8.579
O
O
GLY B:231 B:260 0.0 0.0 E -161.9 179.1 0.0 0.0 0.0 HOH
3.519
CA
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 GLY A:231 A:260 0.0 0.0 E -155.5 168.9 0.0 0.0 0.0 HOH
3.533
CA
O
GLY B:231 B:260 0.0 0.0 E -158.1 179.8 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 GLY A:231 A:260 0.0 0.0 E -161.7 169.4 0.0 0.0 0.0 HOH
8.437
O
O
GLY B:231 B:260 0.0 0.0 E -167.8 180.0 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLY A:231 A:260 0.0 0.0 E -165.6 173.1 0.0 0.0 0.0 HOH
3.457
CA
O
GLY B:231 B:260 0.0 0.0 E -152.0 -170.0 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLY A:231 A:260 0.0 0.0 E -144.9 176.1 0.0 0.0 0.0 HOH
3.688
CA
O
GLY B:231 B:260 0.0 0.0 E -147.9 171.8 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLY A:231 A:260 0.0 0.0 E -164.4 173.7 0.0 0.0 0.0 HOH
3.436
CA
O
GLY B:231 B:260 0.0 0.0 E -166.2 -170.8 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 GLY A:231 A:260 0.0 0.0 E -168.8 -178.1 0.0 0.0 0.0
GLY B:231 B:260 0.0 0.0 E -171.5 174.5 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 GLY A:231 A:260 0.0 0.0 E -155.7 -177.8 0.0 0.0 0.0 HOH
7.282
O
O
GLY B:231 B:260 0.0 0.0 E -156.6 -178.1 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 GLY A:231 A:260 0.0 0.0 E -155.2 174.8 0.0 0.0 0.0
GLY B:231 B:260 0.0 0.0 E -154.9 177.7 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 GLY A:231 A:260 0.0 0.0 E -158.2 176.7 0.0 0.0 0.0 HOH
3.607
CA
O
GLY B:231 B:260 0.0 0.0 E -158.3 175.8 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 GLY A:231 A:260 0.0 0.0 E -148.9 168.7 0.0 0.0 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 GLY A:231 A:260 0.0 0.0 E -162.3 179.7 0.0 0.0 0.0
GLY B:231 B:260 0.0 0.0 E -164.4 173.9 0.0 0.0 0.0
GLY C:231 C:260 0.0 0.0 E -163.9 178.3 NA NA NA
GLY D:231 D:260 0.0 0.0 E -162.5 176.6 NA NA NA
GLY E:231 E:260 0.0 0.0 E -164.5 -177.8 NA NA NA
GLY F:231 F:260 0.0 0.0 E -160.9 177.0 NA NA NA
GLY G:231 G:260 0.0 0.0 E -163.6 -173.7 NA NA NA
GLY H:231 H:260 0.0 0.0 E -161.4 174.8 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 GLY A:218 A:260 0.0 0.0 E -164.7 176.3 0.0 0.0 0.0 HOH
3.107
CA
O
GLY B:218 B:260 0.0 0.0 E -159.3 -175.0 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 GLY A:215 A:260 2.0 0.027 E -102.5 166.1 2.0 0.027 0.0
GLY B:215 B:260 1.0 0.013 E -86.9 175.4 1.0 0.013 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 GLY A:215 A:260 0.0 0.0 E -107.1 174.5 0.0 0.0 0.0
GLY B:215 B:260 0.0 0.0 E -118.5 166.5 0.0 0.0 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 GLY A:215 A:260 2.0 0.027 E -86.8 170.4 2.0 0.027 0.0
GLY B:215 B:260 1.0 0.013 E -94.2 173.6 1.0 0.013 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 GLY A:215 A:260 2.0 0.027 E -114.3 159.4 2.0 0.027 0.0
GLY B:215 B:260 0.0 0.0 E -114.3 161.1 0.0 0.0 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 GLY A:215 A:260 0.0 0.0 E -116.2 158.3 0.0 0.0 0.0
GLY B:215 B:260 0.0 0.0 E -115.7 162.2 0.0 0.0 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 GLY A:215 A:260 1.0 0.013 E -114.0 155.0 1.0 0.013 0.0
GLY B:215 B:260 0.0 0.0 E -117.7 164.5 0.0 0.0 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 GLY A:215 A:260 0.0 0.0 E -114.3 155.5 0.0 0.0 0.0
GLY B:215 B:260 3.0 0.04 E -117.5 164.5 3.0 0.04 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 GLY A:215 A:260 0.0 0.0 E -94.3 160.3 0.0 0.0 0.0
GLY B:215 B:260 0.0 0.0 E -106.4 175.7 0.0 0.0 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 GLY A:219 A:260 0.0 0.0 E -148.5 174.2 0.0 0.0 0.0 HOH
3.475
CA
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 GLY A:231 A:260 0.0 0.0 E -153.8 177.6 0.0 0.0 0.0 HOH
3.527
CA
O
GLY B:231 B:260 0.0 0.0 E -156.4 178.1 0.0 0.0 0.0 HOH
3.520
CA
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 GLY A:260 A:260 0.0 0.0 E -151.9 178.3