Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94291624 . C A CCDS7421.1:NM_004969.3:c.542aGa>aTa_NP_004960.2:p.181R>I Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 ARG A:181 A:181 53.0 0.236 H -79.7 -51.0 NA NA NA
ARG B:181 B:181 58.0 0.258 H -86.6 -53.1 58.0 0.258 0.0 HOH
5.523
O
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 ARG A:181 A:181 53.0 0.236 H -81.7 -52.4 53.0 0.236 0.0 QIX
HOH
7.984
5.708
NH1
O
C25
O
ARG B:181 B:181 52.0 0.231 H -87.9 -54.0 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 ARG A:181 A:181 79.0 0.351 H -72.1 -46.5 79.0 0.351 0.0 HOH
2.757
NH1
O
ARG B:181 B:181 63.0 0.28 H -73.6 -45.7 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 ARG A:152 A:181 53.0 0.236 H -86.1 -53.9 53.0 0.236 0.0 HOH
4.281
CG
O
ARG B:152 B:181 52.0 0.231 H -79.2 -52.3 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:152 A:181 51.0 0.227 H -83.5 -55.1 51.0 0.227 0.0 HOH
3.864
NE
O
ARG B:152 B:181 52.0 0.231 H -89.3 -57.3 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:152 A:181 54.0 0.24 H -77.3 -55.0 54.0 0.24 0.0 HOH
3.778
NH2
O
ARG B:152 B:181 52.0 0.231 H -90.2 -54.4 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:152 A:181 53.0 0.236 H -81.5 -55.5 53.0 0.236 0.0 HOH
3.178
NE
O
ARG B:152 B:181 52.0 0.231 H -88.7 -53.8 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:152 A:181 51.0 0.227 H -87.8 -54.2 51.0 0.227 0.0 HOH
3.685
NE
O
ARG B:152 B:181 51.0 0.227 H -79.8 -54.4 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 ARG A:152 A:181 54.0 0.24 H -65.4 -53.3 54.0 0.24 0.0 HOH
5.473
N
O
ARG B:152 B:181 58.0 0.258 H -100.4 -61.2 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 ARG A:152 A:181 55.0 0.244 H -71.4 -52.0 55.0 0.244 0.0 HOH
3.626
CG
O
ARG B:152 B:181 47.0 0.209 H -75.4 -55.1 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 ARG A:181 A:181 55.0 0.244 H -95.2 -46.4 55.0 0.244 0.0 HOH
3.560
NH2
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 ARG A:152 A:181 52.0 0.231 H -77.5 -57.3 52.0 0.231 0.0 HOH
5.671
O
O
ARG B:152 B:181 43.0 0.191 H -77.2 -57.8 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 ARG A:181 A:181 56.0 0.249 H -69.9 -60.4 56.0 0.249 0.0 HOH
9.933
NH1
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 ARG A:152 A:181 53.0 0.236 H -75.3 -53.4 53.0 0.236 0.0 HOH
3.808
NH2
O
ARG B:152 B:181 56.0 0.249 H -79.8 -51.9 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 ARG A:140 A:181 52.0 0.231 H -85.2 -53.9 52.0 0.231 0.0 HOH
3.707
CG
O
ARG B:140 B:181 52.0 0.231 H -86.0 -54.7 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 ARG A:140 A:181 56.0 0.249 H -89.9 -48.9 56.0 0.249 0.0
ARG B:140 B:181 60.0 0.267 H -90.1 -48.2 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 ARG A:140 A:181 56.0 0.249 H -92.0 -47.5 56.0 0.249 0.0
ARG B:140 B:181 57.0 0.253 H -92.1 -46.5 57.0 0.253 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:151 A:181 66.0 0.293 H -64.3 -48.8 66.0 0.293 0.0 ZN
HOH
9.532
4.942
O
N
ZN
O
ARG B:151 B:181 62.0 0.276 H -66.6 -40.0 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:151 A:181 82.0 0.364 H -63.2 -41.4 82.0 0.364 0.0 ZN
HOH
9.631
2.791
O
O
ZN
O
ARG B:151 B:181 86.0 0.382 H -66.9 -25.8 86.0 0.382 0.0 ZN
HOH
9.975
6.558
O
NH1
ZN
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:151 A:181 68.0 0.302 H -72.5 -37.7 68.0 0.302 0.0 ZN
HOH
9.487
5.203
O
N
ZN
O
ARG B:151 B:181 124.0 0.551 H -68.7 -36.3 124.0 0.551 0.0 ZN
HOH
9.629
3.200
O
CB
ZN
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:151 A:181 76.0 0.338 H -70.8 -32.2 76.0 0.338 0.0 ZN
HOH
9.509
9.478
O
N
ZN
O
ARG B:151 B:181 117.0 0.52 H -68.1 -33.6 117.0 0.52 0.0 ZN
HOH
9.457
2.726
O
O
ZN
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 ARG A:152 A:181 56.0 0.249 H -78.6 -48.1 56.0 0.249 0.0 HOH
4.433
NH2
O
ARG B:152 B:181 57.0 0.253 H -94.1 -50.6 57.0 0.253 0.0 HOH
6.277
N
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 ARG A:152 A:181 55.0 0.244 H -72.5 -54.3 55.0 0.244 0.0
ARG B:152 B:181 57.0 0.253 H -92.5 -52.3 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 ARG A:152 A:181 51.0 0.227 H -78.2 -57.6 51.0 0.227 0.0
ARG B:152 B:181 55.0 0.244 H -78.1 -57.3 55.0 0.244 0.0 HOH
9.051
NH1
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 ARG A:152 A:181 65.0 0.289 H -79.8 -47.0 65.0 0.289 0.0
ARG B:152 NA:NA DO NA DO DO DO NA NA NA
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 ARG A:152 A:181 49.0 0.218 H -85.9 -53.0 49.0 0.218 0.0 HOH
4.779
N
O
ARG B:152 B:181 51.0 0.227 H -86.3 -53.2 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 ARG A:152 A:181 39.0 0.173 H -98.6 -57.0 39.0 0.173 0.0
ARG B:152 B:181 64.0 0.284 H -97.8 -41.3 NA NA NA
ARG C:152 C:181 58.0 0.258 H -104.8 -41.5 NA NA NA
ARG D:152 D:181 67.0 0.298 H -101.6 -47.6 NA NA NA
ARG E:152 E:181 61.0 0.271 H -102.1 -51.1 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 ARG A:152 A:181 58.0 0.258 H -118.6 14.8 58.0 0.258 0.0
ARG B:152 B:181 94.0 0.418 T -84.6 -31.3 94.0 0.418 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 ARG A:152 A:181 51.0 0.227 H -76.5 -59.1 51.0 0.227 0.0 VQD
9.091
NH1
C13
ARG B:152 B:181 51.0 0.227 H -80.6 -51.3 51.0 0.227 0.0 VQD
8.823
NH1
C12
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 ARG A:152 A:181 60.0 0.267 H -81.0 -61.3 60.0 0.267 0.0 VQG
HOH
8.374
4.944
NH1
N
C12
O
ARG B:152 B:181 47.0 0.209 H -79.5 -59.7 47.0 0.209 0.0 VQG
HOH
8.275
4.902
NH1
N
C13
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 ARG A:152 A:181 48.0 0.213 H -75.9 -58.1 48.0 0.213 0.0 VQJ
HOH
8.625
5.035
NH1
N
C13
O
ARG B:152 B:181 51.0 0.227 H -84.6 -53.7 51.0 0.227 0.0 VQJ
HOH
8.732
3.725
NH1
CG
C13
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 ARG A:152 A:181 54.0 0.24 H -79.2 -47.8 54.0 0.24 0.0 HOH
5.568
O
O
ARG B:152 B:181 58.0 0.258 H -82.7 -53.6 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 ARG A:152 A:181 58.0 0.258 H -79.4 -48.9 58.0 0.258 0.0 HOH
3.566
CG
O
ARG B:152 B:181 58.0 0.258 H -81.2 -60.3 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 ARG A:152 A:181 46.0 0.204 H -85.2 -53.9 46.0 0.204 0.0 HOH
7.628
NH1
O
ARG B:152 B:181 59.0 0.262 H -85.1 -57.4 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 ARG A:152 A:181 58.0 0.258 H -73.3 -61.7 58.0 0.258 0.0 HOH
9.675
NH2
O
ARG B:152 B:181 56.0 0.249 H -82.6 -57.2 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 ARG A:152 A:181 62.0 0.276 H -87.4 -60.8 62.0 0.276 0.0
ARG B:152 B:181 53.0 0.236 H -85.6 -51.2 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 ARG A:152 A:181 63.0 0.28 H -81.5 -53.8 63.0 0.28 0.0
ARG B:152 B:181 55.0 0.244 H -78.5 -47.8 55.0 0.244 0.0
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 ARG A:152 A:181 51.0 0.227 H -80.0 -48.4 51.0 0.227 0.0 HOH
4.832
NH1
O
ARG B:152 B:181 54.0 0.24 H -82.7 -54.2 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 ARG A:152 A:181 52.0 0.231 H -76.4 -50.3 52.0 0.231 0.0 HOH
6.271
O
O
ARG B:152 B:181 58.0 0.258 H -89.6 -56.5 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 ARG A:152 A:181 52.0 0.231 H -79.9 -54.1 52.0 0.231 0.0 HOH
5.686
O
O
ARG B:152 B:181 58.0 0.258 H -86.1 -55.7 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 ARG A:152 A:181 60.0 0.267 H -82.2 -53.7 60.0 0.267 0.0 HOH
6.286
O
O
ARG B:152 B:181 53.0 0.236 H -88.8 -52.7 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 ARG A:152 A:181 55.0 0.244 H -85.3 -51.0 55.0 0.244 0.0 HOH
7.669
NH1
O
ARG B:152 B:181 56.0 0.249 H -89.1 -55.9 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 ARG A:152 A:181 57.0 0.253 H -99.6 -35.5 57.0 0.253 0.0
ARG B:152 B:181 48.0 0.213 H -106.4 -42.8 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 ARG A:152 A:181 49.0 0.218 H -79.2 -55.6 49.0 0.218 0.0 HOH
4.515
NE
O
ARG B:152 B:181 51.0 0.227 H -82.4 -56.3 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 ARG A:152 A:181 49.0 0.218 H -87.9 -54.7 49.0 0.218 0.0
ARG B:152 B:181 53.0 0.236 H -87.4 -48.2 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 ARG A:152 A:181 40.0 0.178 H -93.8 -55.5 40.0 0.178 0.0 HOH
7.517
C
O
ARG B:152 B:181 58.0 0.258 H -94.4 -55.7 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 ARG A:152 A:181 56.0 0.249 H -92.5 -54.7 56.0 0.249 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 ARG A:152 A:181 42.0 0.187 H -80.8 -46.3 42.0 0.187 0.0
ARG B:152 B:181 71.0 0.316 H -92.5 -46.5 71.0 0.316 0.0
ARG C:152 C:181 45.0 0.2 H -78.1 -43.4 NA NA NA
ARG D:152 D:181 63.0 0.28 H -90.2 -41.4 NA NA NA
ARG E:152 E:181 55.0 0.244 H -87.5 -47.2 NA NA NA
ARG F:152 F:181 81.0 0.36 T -84.9 -38.4 NA NA NA
ARG G:152 G:181 57.0 0.253 H -80.5 -47.4 NA NA NA
ARG H:152 H:181 85.0 0.378 H -83.7 -46.1 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 ARG A:139 A:181 58.0 0.258 H -75.8 -59.6 58.0 0.258 0.0 HOH
7.044
NH2
O
ARG B:139 B:181 58.0 0.258 H -81.8 -61.0 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 ARG A:136 A:181 40.0 0.178 H -83.5 -35.2 40.0 0.178 0.0
ARG B:136 B:181 56.0 0.249 H -99.4 -34.5 56.0 0.249 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 ARG A:136 A:181 110.0 0.489 H -93.9 -34.1 110.0 0.489 0.0
ARG B:136 B:181 88.0 0.391 H -92.9 -32.6 88.0 0.391 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 ARG A:136 A:181 114.0 0.507 H -82.9 -35.6 114.0 0.507 0.0
ARG B:136 B:181 107.0 0.476 H -66.8 -36.3 107.0 0.476 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 ARG A:136 A:181 163.0 0.724 H -93.2 -33.8 163.0 0.724 0.0
ARG B:136 B:181 115.0 0.511 H -93.7 -32.7 115.0 0.511 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 ARG A:136 A:181 161.0 0.716 H -94.7 -33.9 161.0 0.716 0.0
ARG B:136 B:181 118.0 0.524 H -93.6 -35.7 118.0 0.524 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 ARG A:136 A:181 86.0 0.382 H -100.7 -36.5 86.0 0.382 0.0
ARG B:136 B:181 75.0 0.333 H -96.4 -34.2 75.0 0.333 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 ARG A:136 A:181 140.0 0.622 H -96.1 -33.1 140.0 0.622 0.0
ARG B:136 B:181 104.0 0.462 H -92.5 -39.8 104.0 0.462 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 ARG A:136 A:181 58.0 0.258 H -117.6 14.3 58.0 0.258 0.0
ARG B:136 B:181 91.0 0.404 T -82.7 -31.0 91.0 0.404 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 ARG A:140 A:181 56.0 0.249 H -66.1 -46.3 56.0 0.249 0.0 HOH
5.507
O
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 ARG A:152 A:181 53.0 0.236 H -79.5 -51.2 53.0 0.236 0.0 HOH
3.282
NE
O
ARG B:152 B:181 56.0 0.249 H -80.6 -55.4 56.0 0.249 0.0 HOH
2.997
NE
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 ARG A:181 A:181 49.0 0.218 H -80.5 -55.0