Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94294443 . C A CCDS7421.1:NM_004969.3:c.383aGc>aTc_NP_004960.2:p.128S>I Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 SER A:128 A:128 44.0 0.383 H -64.8 -40.5 NA NA NA
SER B:128 B:128 40.0 0.348 H -75.1 -28.8 40.0 0.348 0.0 HOH
2.948
N
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 SER A:128 A:128 43.0 0.374 H -61.2 -46.8 43.0 0.374 0.0 QIX
HOH
3.402
2.843
OG
N
C23
O
SER B:128 B:128 40.0 0.348 H -64.2 -37.1 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 SER A:128 A:128 40.0 0.348 H -54.5 -48.9 40.0 0.348 0.0 HOH
2.643
OG
O
SER B:128 B:128 49.0 0.426 H -54.7 -48.1 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 SER A:99 A:128 40.0 0.348 H -63.5 -39.3 40.0 0.348 0.0 HOH
3.019
OG
O
SER B:99 B:128 41.0 0.357 H -60.6 -44.1 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 SER A:99 A:128 40.0 0.348 H -57.8 -53.9 40.0 0.348 0.0 HOH
2.910
N
O
SER B:99 B:128 45.0 0.391 H -68.9 -31.6 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 SER A:99 A:128 41.0 0.357 H -63.0 -41.8 41.0 0.357 0.0 HOH
2.530
OG
O
SER B:99 B:128 46.0 0.4 H -62.9 -28.6 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 SER A:99 A:128 42.0 0.365 H -63.4 -42.0 42.0 0.365 0.0 HOH
2.564
OG
O
SER B:99 B:128 44.0 0.383 H -64.7 -30.3 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 SER A:99 A:128 40.0 0.348 H -62.7 -36.5 40.0 0.348 0.0 HOH
2.923
OG
O
SER B:99 B:128 42.0 0.365 H -59.5 -42.5 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 SER A:99 A:128 44.0 0.383 H -54.6 -49.0 44.0 0.383 0.0 HOH
9.552
N
O
SER B:99 B:128 48.0 0.417 H -53.0 -12.7 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 SER A:99 A:128 42.0 0.365 H -66.5 -35.8 42.0 0.365 0.0 HOH
3.011
N
O
SER B:99 B:128 45.0 0.391 H -75.7 -33.0 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 SER A:128 A:128 39.0 0.339 H -62.7 -40.9 39.0 0.339 0.0 HOH
3.281
OG
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 SER A:99 A:128 41.0 0.357 H -63.0 -43.7 41.0 0.357 0.0 HOH
2.784
N
O
SER B:99 B:128 45.0 0.391 H -67.7 -20.3 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 SER A:128 A:128 39.0 0.339 H -66.1 -37.0 39.0 0.339 0.0 HOH
2.894
OG
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 SER A:99 A:128 42.0 0.365 H -69.7 -37.3 24.0 0.209 0.156 C:P01344:0.157
HOH
2.908
O
O
SER B:99 B:128 45.0 0.391 H -68.9 -37.4 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 SER A:87 A:128 44.0 0.383 H -54.0 -47.9 44.0 0.383 0.0 HOH
2.870
N
O
SER B:87 B:128 42.0 0.365 H -53.9 -46.7 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 SER A:87 A:128 44.0 0.383 H -56.7 -44.1 38.0 0.33 0.053 C:P01275:0.052
SER B:87 B:128 47.0 0.409 H -57.6 -43.9 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 SER A:87 A:128 49.0 0.426 H -58.7 -44.3 49.0 0.426 0.0
SER B:87 B:128 43.0 0.374 H -58.0 -43.7 43.0 0.374 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 SER A:98 A:128 70.0 0.609 H -63.6 -42.2 70.0 0.609 0.0 HOH
8.756
N
O
SER B:98 B:128 70.0 0.609 H -57.8 -42.4 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 SER A:98 A:128 74.0 0.643 H -64.5 -35.4 74.0 0.643 0.0 HOH
8.401
N
O
SER B:98 B:128 61.0 0.53 H -60.7 -48.4 61.0 0.53 0.0 HOH
2.605
OG
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 SER A:98 A:128 65.0 0.565 H -60.4 -44.9 65.0 0.565 0.0 HOH
7.115
C
O
SER B:98 B:128 78.0 0.678 H -63.4 -38.5 78.0 0.678 0.0 HOH
3.941
OG
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 SER A:98 A:128 59.0 0.513 H -61.2 -56.2 59.0 0.513 0.0 HOH
6.709
C
O
SER B:98 B:128 79.0 0.687 H -68.5 -36.6 79.0 0.687 0.0 HOH
8.615
N
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 SER A:99 A:128 44.0 0.383 H -59.8 -30.6 44.0 0.383 0.0 HOH
3.581
N
O
SER B:99 B:128 45.0 0.391 H -70.4 -15.3 45.0 0.391 0.0 HOH
2.880
N
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 SER A:99 A:128 40.0 0.348 H -39.4 -55.4 40.0 0.348 0.0 I41
HOH
6.535
8.204
OG
O
N09
O
SER B:99 B:128 50.0 0.435 H -39.3 -37.5 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 SER A:99 A:128 34.0 0.296 H -39.5 -42.6 34.0 0.296 0.0 HOH
7.243
C
O
SER B:99 B:128 46.0 0.4 H -39.4 -41.6 46.0 0.4 0.0 1EF
HOH
2.985
3.490
OG
OG
CAO
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 SER A:99 A:128 46.0 0.4 H -76.7 -29.7 46.0 0.4 0.0
SER B:99 B:128 56.0 0.487 H -55.7 -37.2 56.0 0.487 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 SER A:99 A:128 45.0 0.391 H -64.1 -37.5 45.0 0.391 0.0 3M9
HOH
3.060
2.454
OG
OG
O27
O
SER B:99 B:128 41.0 0.357 H -64.1 -38.1 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 SER A:99 A:128 47.0 0.409 H -71.2 -40.2 47.0 0.409 0.0
SER B:99 B:128 33.0 0.287 H -74.5 -48.0 NA NA NA
SER C:99 C:128 32.0 0.278 H -68.7 -43.5 NA NA NA
SER D:99 D:128 40.0 0.348 H -66.0 -40.6 NA NA NA
SER E:99 E:128 34.0 0.296 H -68.5 -39.5 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 SER A:99 A:128 34.0 0.296 H -73.0 -35.0 31.0 0.27 0.026 C:P01308:0.026
SER B:99 B:128 33.0 0.287 H -80.3 -10.0 33.0 0.287 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 SER A:99 A:128 37.0 0.322 H -64.8 -36.0 37.0 0.322 0.0 VQD
3.093
OG
C11
SER B:99 B:128 39.0 0.339 H -56.6 -43.3 39.0 0.339 0.0 VQD
3.071
OG
C11
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 SER A:99 A:128 38.0 0.33 H -64.2 -43.8 38.0 0.33 0.0 VQG
HOH
3.088
2.500
OG
OG
C11
O
SER B:99 B:128 37.0 0.322 H -55.6 -51.1 37.0 0.322 0.0 VQG
HOH
3.114
2.768
OG
N
C11
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 SER A:99 A:128 33.0 0.287 H -59.8 -45.6 33.0 0.287 0.0 VQJ
HOH
3.140
2.623
OG
OG
C11
O
SER B:99 B:128 35.0 0.304 H -58.1 -48.3 35.0 0.304 0.0 VQJ
HOH
3.066
2.812
OG
OG
C11
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 SER A:99 A:128 43.0 0.374 H -77.2 -28.5 43.0 0.374 0.0 HOH
2.614
O
O
SER B:99 B:128 41.0 0.357 H -76.6 -24.2 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 SER A:99 A:128 40.0 0.348 H -73.9 -34.8 40.0 0.348 0.0 HOH
2.870
N
O
SER B:99 B:128 45.0 0.391 H -50.5 -42.6 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 SER A:99 A:128 44.0 0.383 H -44.6 -48.9 44.0 0.383 0.0 HOH
2.799
N
O
SER B:99 B:128 42.0 0.365 H -69.0 -22.5 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 SER A:99 A:128 47.0 0.409 H -66.4 -26.9 47.0 0.409 0.0 HOH
7.028
C
O
SER B:99 B:128 47.0 0.409 H -68.6 -30.0 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 SER A:99 A:128 46.0 0.4 H -64.4 -26.1 46.0 0.4 0.0
SER B:99 B:128 47.0 0.409 H -52.5 -46.3 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 SER A:99 A:128 43.0 0.374 H -60.3 -44.8 43.0 0.374 0.0
SER B:99 B:128 40.0 0.348 H -61.9 -43.5 40.0 0.348 0.0 HOH
6.848
C
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 SER A:99 A:128 43.0 0.374 H -69.9 -37.8 43.0 0.374 0.0 HOH
3.066
O
O
SER B:99 B:128 45.0 0.391 H -71.2 -35.0 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 SER A:99 A:128 45.0 0.391 H -69.1 -32.4 45.0 0.391 0.0 HOH
2.970
CB
O
SER B:99 B:128 40.0 0.348 H -63.5 -27.6 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 SER A:99 A:128 44.0 0.383 H -67.8 -28.1 44.0 0.383 0.0 HOH
2.762
N
O
SER B:99 B:128 44.0 0.383 H -60.6 -26.9 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 SER A:99 A:128 43.0 0.374 H -71.2 -18.4 43.0 0.374 0.0 HOH
2.711
O
O
SER B:99 B:128 42.0 0.365 H -50.4 -49.6 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 SER A:99 A:128 42.0 0.365 H -49.8 -53.7 42.0 0.365 0.0 HOH
3.057
N
O
SER B:99 B:128 42.0 0.365 H -67.7 -26.7 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 SER A:99 A:128 33.0 0.287 H -71.2 -40.8 30.0 0.261 0.026 G:P05067:0.026
SER B:99 B:128 34.0 0.296 H -72.1 -38.0 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 SER A:99 A:128 45.0 0.391 H -60.2 -43.2 45.0 0.391 0.0 2H7
HOH
3.471
5.136
OG
OG
C16
O
SER B:99 B:128 38.0 0.33 H -59.9 -44.6 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 SER A:99 A:128 42.0 0.365 H -64.1 -33.7 42.0 0.365 0.0
SER B:99 B:128 47.0 0.409 H -59.8 -39.3 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 SER A:99 A:128 35.0 0.304 H -68.6 -32.4 18.0 0.157 0.147 C:P13236:0.148
HOH
8.212
OG
O
SER B:99 B:128 45.0 0.391 H -68.5 -32.0 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 SER A:99 A:128 41.0 0.357 H -68.1 -37.3 41.0 0.357 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 SER A:99 A:128 31.0 0.27 H -65.8 -28.2 31.0 0.27 0.0
SER B:99 B:128 30.0 0.261 H -65.0 -30.1 30.0 0.261 0.0
SER C:99 C:128 29.0 0.252 H -67.2 -26.2 NA NA NA
SER D:99 D:128 29.0 0.252 H -99.7 -43.8 NA NA NA
SER E:99 NA:NA DO NA DO DO DO NA NA NA
SER F:99 F:128 28.0 0.243 H -64.6 -30.5 NA NA NA
SER G:99 NA:NA DO NA DO DO DO NA NA NA
SER H:99 H:128 28.0 0.243 H -64.8 -27.6 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 SER A:86 A:128 46.0 0.4 H -44.7 -52.8 46.0 0.4 0.0 HOH
7.018
C
O
SER B:86 B:128 45.0 0.391 H -37.7 -45.9 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 SER A:83 A:128 39.0 0.339 H -63.3 -58.3 37.0 0.322 0.017 G:P01308:0.017
SER B:83 B:128 37.0 0.322 H -71.2 -27.0 35.0 0.304 0.018 H:P01308:0.017
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 SER A:83 A:128 71.0 0.617 H -65.1 -39.8 71.0 0.617 0.0
SER B:83 B:128 69.0 0.6 H -63.6 -33.5 69.0 0.6 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 SER A:83 A:128 68.0 0.591 H -66.6 -31.1 68.0 0.591 0.0
SER B:83 B:128 77.0 0.67 H -66.6 -40.6 77.0 0.67 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 SER A:83 A:128 68.0 0.591 H -65.0 -38.3 68.0 0.591 0.0
SER B:83 B:128 67.0 0.583 H -75.2 -33.7 67.0 0.583 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 SER A:83 A:128 68.0 0.591 H -64.6 -40.1 68.0 0.591 0.0
SER B:83 B:128 70.0 0.609 H -63.2 -38.8 70.0 0.609 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 SER A:83 A:128 70.0 0.609 H -64.4 -32.9 70.0 0.609 0.0
SER B:83 B:128 64.0 0.557 H -61.0 -35.8 64.0 0.557 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 SER A:83 A:128 74.0 0.643 H -63.7 -40.3 74.0 0.643 0.0
SER B:83 B:128 65.0 0.565 H -63.7 -38.2 65.0 0.565 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 SER A:83 A:128 33.0 0.287 H -72.1 -36.5 32.0 0.278 0.009 C:P01308:0.009
SER B:83 B:128 32.0 0.278 H -78.8 -12.0 30.0 0.261 0.017 D:P01308:0.017
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 SER A:87 A:128 40.0 0.348 H -61.8 -36.9 40.0 0.348 0.0 HOH
3.177
N
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 SER A:99 A:128 40.0 0.348 H -60.3 -43.7 40.0 0.348 0.0 HOH
2.883
O
O
SER B:99 B:128 39.0 0.339 H -60.4 -45.0 39.0 0.339 0.0 HOH
2.878
O
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 SER A:128 A:128 42.0 0.365 H -63.4 -43.7