Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94297206 . A C CCDS7421.1:NM_004969.3:c.200cTa>cGa_NP_004960.2:p.67L>R Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 LEU A:67 A:67 2.0 0.012 E -163.4 170.2 NA NA NA
LEU B:67 B:67 0.0 0.0 E -160.1 159.8 0.0 0.0 0.0 HOH
7.028
CA
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 LEU A:67 A:67 1.0 0.006 E -169.2 159.4 1.0 0.006 0.0 HOH
5.382
N
O
LEU B:67 B:67 1.0 0.006 E -165.8 165.6 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 LEU A:67 A:67 2.0 0.012 E -162.8 163.5 2.0 0.012 0.0 HOH
5.233
N
O
LEU B:67 B:67 2.0 0.012 E -161.1 160.4 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 LEU A:38 A:67 0.0 0.0 E -157.1 166.6 0.0 0.0 0.0 HOH
5.294
N
O
LEU B:38 B:67 2.0 0.012 E -161.7 171.2 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 LEU A:38 A:67 2.0 0.012 E -172.9 167.6 2.0 0.012 0.0 HOH
5.434
N
O
LEU B:38 B:67 2.0 0.012 E -158.5 156.8 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 LEU A:38 A:67 1.0 0.006 E -168.5 165.1 1.0 0.006 0.0 HOH
5.314
N
O
LEU B:38 B:67 1.0 0.006 E -155.3 152.9 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 LEU A:38 A:67 1.0 0.006 E -166.8 163.1 1.0 0.006 0.0 HOH
5.221
N
O
LEU B:38 B:67 2.0 0.012 E -156.9 161.1 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 LEU A:38 A:67 1.0 0.006 E -160.5 161.7 1.0 0.006 0.0 HOH
5.121
N
O
LEU B:38 B:67 2.0 0.012 E -164.1 170.0 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 LEU A:38 A:67 3.0 0.018 E -175.4 153.2 3.0 0.018 0.0
LEU B:38 B:67 0.0 0.0 E 171.9 140.3 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 LEU A:38 A:67 1.0 0.006 E -158.7 166.5 1.0 0.006 0.0 HOH
5.335
N
O
LEU B:38 B:67 0.0 0.0 E -138.2 151.2 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 LEU A:67 A:67 0.0 0.0 E -133.7 145.3 0.0 0.0 0.0 HOH
5.763
C
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 LEU A:38 A:67 1.0 0.006 E -159.3 162.4 1.0 0.006 0.0 HOH
5.248
N
O
LEU B:38 B:67 1.0 0.006 E -163.7 150.0 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 LEU A:67 A:67 0.0 0.0 E -151.0 150.0 0.0 0.0 0.0 HOH
6.305
O
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 LEU A:38 A:67 3.0 0.018 E -158.6 165.5 3.0 0.018 0.0 HOH
5.419
N
O
LEU B:38 B:67 0.0 0.0 E -139.9 141.2 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 LEU A:26 A:67 0.0 0.0 E -142.7 156.6 0.0 0.0 0.0 HOH
5.432
N
O
LEU B:26 B:67 0.0 0.0 E -141.9 155.5 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 LEU A:26 A:67 0.0 0.0 E -137.9 153.5 0.0 0.0 0.0
LEU B:26 B:67 0.0 0.0 E -135.9 151.4 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 LEU A:26 A:67 0.0 0.0 E -138.5 157.6 0.0 0.0 0.0
LEU B:26 B:67 0.0 0.0 E -137.3 156.1 0.0 0.0 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 LEU A:37 A:67 2.0 0.012 E -159.0 166.9 2.0 0.012 0.0 HOH
5.433
N
O
LEU B:37 B:67 1.0 0.006 E -160.7 166.4 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 LEU A:37 A:67 1.0 0.006 E -154.6 162.7 1.0 0.006 0.0 HOH
5.352
N
O
LEU B:37 B:67 1.0 0.006 E -154.7 163.2 1.0 0.006 0.0 HOH
5.381
N
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 LEU A:37 A:67 1.0 0.006 E -163.6 154.4 1.0 0.006 0.0 HOH
7.776
N
O
LEU B:37 B:67 1.0 0.006 E -161.8 154.0 1.0 0.006 0.0 HOH
9.165
N
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 LEU A:37 A:67 1.0 0.006 E -159.7 165.6 1.0 0.006 0.0 HOH
6.607
O
O
LEU B:37 B:67 1.0 0.006 E -158.3 164.9 1.0 0.006 0.0 HOH
5.327
N
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 LEU A:38 A:67 2.0 0.012 E -151.3 154.7 2.0 0.012 0.0 HOH
5.066
N
O
LEU B:38 B:67 1.0 0.006 E -172.5 157.0 1.0 0.006 0.0 HOH
5.420
C
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 LEU A:38 A:67 3.0 0.018 E -171.4 147.3 3.0 0.018 0.0 HOH
7.465
CD2
O
LEU B:38 B:67 2.0 0.012 E -167.1 141.2 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 LEU A:38 A:67 2.0 0.012 E -161.3 160.1 2.0 0.012 0.0 HOH
7.225
O
O
LEU B:38 B:67 1.0 0.006 E -161.1 159.7 1.0 0.006 0.0
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 LEU A:38 A:67 2.0 0.012 E -145.4 167.8 2.0 0.012 0.0
LEU B:38 B:67 4.0 0.024 E -144.7 168.7 4.0 0.024 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 LEU A:38 A:67 1.0 0.006 E -163.0 159.2 1.0 0.006 0.0
LEU B:38 B:67 1.0 0.006 E -165.6 161.3 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 LEU A:38 A:67 1.0 0.006 E -156.2 153.9 1.0 0.006 0.0
LEU B:38 B:67 2.0 0.012 E -154.3 161.8 NA NA NA
LEU C:38 C:67 2.0 0.012 E -158.7 157.1 NA NA NA
LEU D:38 D:67 1.0 0.006 E -155.1 163.4 NA NA NA
LEU E:38 E:67 2.0 0.012 E -162.0 159.8 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 LEU A:38 A:67 18.0 0.106 E -159.2 178.1 18.0 0.106 0.0
LEU B:38 B:67 4.0 0.024 E -170.5 163.5 4.0 0.024 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 LEU A:38 A:67 0.0 0.0 E -173.7 152.9 0.0 0.0 0.0
LEU B:38 B:67 2.0 0.012 E -172.8 162.3 2.0 0.012 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 LEU A:38 A:67 2.0 0.012 E -173.1 153.4 2.0 0.012 0.0 HOH
9.157
N
O
LEU B:38 B:67 2.0 0.012 E -163.9 160.9 2.0 0.012 0.0 HOH
8.290
O
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 LEU A:38 A:67 1.0 0.006 E -172.4 154.6 1.0 0.006 0.0 HOH
5.376
N
O
LEU B:38 B:67 2.0 0.012 E -163.5 165.1 2.0 0.012 0.0 HOH
5.237
N
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 LEU A:38 A:67 3.0 0.018 E -145.7 168.5 3.0 0.018 0.0 HOH
5.489
N
O
LEU B:38 B:67 0.0 0.0 E -138.2 147.5 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 LEU A:38 A:67 3.0 0.018 E -171.5 166.8 3.0 0.018 0.0 HOH
7.486
CA
O
LEU B:38 B:67 0.0 0.0 E -145.7 158.9 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 LEU A:38 A:67 1.0 0.006 E -162.8 168.7 1.0 0.006 0.0 HOH
6.869
O
O
LEU B:38 B:67 1.0 0.006 E -152.9 161.2 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 LEU A:38 A:67 3.0 0.018 E -167.7 164.5 3.0 0.018 0.0 HOH
9.495
N
O
LEU B:38 B:67 3.0 0.018 E -157.6 153.2 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 LEU A:38 A:67 0.0 0.0 E -136.9 158.3 0.0 0.0 0.0 HOH
7.082
CD1
O
LEU B:38 B:67 0.0 0.0 E -156.5 172.4 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 LEU A:38 A:67 0.0 0.0 E -147.1 148.8 0.0 0.0 0.0 HOH
6.985
CD1
O
LEU B:38 B:67 0.0 0.0 E -147.2 159.4 0.0 0.0 0.0 HOH
7.511
C
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 LEU A:38 A:67 1.0 0.006 E -158.9 164.0 1.0 0.006 0.0 HOH
5.323
N
O
LEU B:38 B:67 0.0 0.0 E -136.5 151.8 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 LEU A:38 A:67 2.0 0.012 E -165.6 168.6 2.0 0.012 0.0 HOH
7.787
CB
O
LEU B:38 B:67 0.0 0.0 E -168.4 156.3 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 LEU A:38 A:67 2.0 0.012 E -169.3 166.2 2.0 0.012 0.0 HOH
7.256
CD1
O
LEU B:38 B:67 1.0 0.006 E -167.1 159.8 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 LEU A:38 A:67 2.0 0.012 E -174.3 168.9 2.0 0.012 0.0 HOH
4.903
N
O
LEU B:38 B:67 0.0 0.0 E -165.4 156.1 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 LEU A:38 A:67 2.0 0.012 E -162.2 175.1 2.0 0.012 0.0 HOH
5.382
N
O
LEU B:38 B:67 0.0 0.0 E -155.4 153.3 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 LEU A:38 A:67 2.0 0.012 E -158.8 143.1 2.0 0.012 0.0
LEU B:38 B:67 2.0 0.012 E -161.8 153.4 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 LEU A:38 A:67 1.0 0.006 E -159.9 159.7 1.0 0.006 0.0
LEU B:38 B:67 0.0 0.0 E -159.7 159.1 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 LEU A:38 A:67 1.0 0.006 E -159.9 144.6 1.0 0.006 0.0
LEU B:38 B:67 1.0 0.006 E -168.7 146.0 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 LEU A:38 A:67 1.0 0.006 E -149.8 153.5 1.0 0.006 0.0 HOH
6.166
N
O
LEU B:38 B:67 1.0 0.006 E -142.6 149.5 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 LEU A:38 A:67 2.0 0.012 E -157.1 162.5 2.0 0.012 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 LEU A:38 A:67 3.0 0.018 E -158.2 163.8 3.0 0.018 0.0
LEU B:38 B:67 2.0 0.012 E -138.0 156.1 2.0 0.012 0.0
LEU C:38 C:67 4.0 0.024 E -154.3 170.9 NA NA NA
LEU D:38 D:67 2.0 0.012 E -158.2 162.4 NA NA NA
LEU E:38 E:67 2.0 0.012 E -160.0 169.5 NA NA NA
LEU F:38 F:67 2.0 0.012 E -157.1 166.4 NA NA NA
LEU G:38 G:67 4.0 0.024 E -161.8 165.6 NA NA NA
LEU H:38 H:67 4.0 0.024 E -156.5 159.9 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 LEU A:25 A:67 3.0 0.018 E -164.3 167.4 3.0 0.018 0.0 HOH
6.692
O
O
LEU B:25 B:67 0.0 0.0 E -160.3 153.1 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 LEU A:22 A:67 11.0 0.065 E -163.2 -177.8 11.0 0.065 0.0
LEU B:22 B:67 15.0 0.088 E -159.7 -165.9 15.0 0.088 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 LEU A:22 A:67 4.0 0.024 E -160.3 154.3 4.0 0.024 0.0
LEU B:22 B:67 0.0 0.0 E -160.9 152.7 0.0 0.0 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 LEU A:22 A:67 8.0 0.047 E -163.5 -178.3 8.0 0.047 0.0
LEU B:22 B:67 10.0 0.059 E -150.8 -174.4 10.0 0.059 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 LEU A:22 A:67 3.0 0.018 E -163.3 152.1 3.0 0.018 0.0
LEU B:22 B:67 6.0 0.035 E -161.5 152.3 6.0 0.035 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 LEU A:22 A:67 9.0 0.053 E -162.8 150.7 9.0 0.053 0.0
LEU B:22 B:67 13.0 0.076 E -162.1 151.3 13.0 0.076 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 LEU A:22 A:67 7.0 0.041 E -160.6 158.4 7.0 0.041 0.0
LEU B:22 B:67 27.0 0.159 E -157.8 154.6 27.0 0.159 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 LEU A:22 A:67 6.0 0.035 E -152.2 177.4 6.0 0.035 0.0
LEU B:22 B:67 13.0 0.076 E -156.0 178.5 13.0 0.076 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 LEU A:22 A:67 16.0 0.094 E -158.9 176.8 16.0 0.094 0.0
LEU B:22 B:67 4.0 0.024 E -170.1 163.5 4.0 0.024 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 LEU A:26 A:67 0.0 0.0 E -125.7 151.9 0.0 0.0 0.0 HOH
5.147
CD2
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 LEU A:38 A:67 3.0 0.018 E -157.6 170.5 3.0 0.018 0.0 HOH
5.321
N
O
LEU B:38 B:67 0.0 0.0 E -151.2 163.0 0.0 0.0 0.0 HOH
5.436
N
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 LEU A:67 A:67 1.0 0.006 E -151.5 159.4