Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94297209 . C A CCDS7421.1:NM_004969.3:c.197gGg>gTg_NP_004960.2:p.66G>V Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 GLY A:66 A:66 1.0 0.013 E -97.8 151.1 NA NA NA
GLY B:66 B:66 0.0 0.0 E -100.1 153.4 0.0 0.0 0.0 HOH
5.789
N
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 GLY A:66 A:66 1.0 0.013 E -97.2 161.7 1.0 0.013 0.0 HOH
3.133
N
O
GLY B:66 B:66 0.0 0.0 E -99.5 154.4 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 GLY A:66 A:66 1.0 0.013 E -116.1 149.6 1.0 0.013 0.0 HOH
2.863
N
O
GLY B:66 B:66 0.0 0.0 E -116.2 149.5 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 GLY A:37 A:66 0.0 0.0 E -103.1 149.1 0.0 0.0 0.0 HOH
2.831
N
O
GLY B:37 B:66 1.0 0.013 E -105.7 150.7 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLY A:37 A:66 0.0 0.0 E -94.5 159.0 0.0 0.0 0.0 HOH
3.122
N
O
GLY B:37 B:66 0.0 0.0 E -105.0 147.7 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLY A:37 A:66 1.0 0.013 E -101.1 154.3 1.0 0.013 0.0 HOH
2.916
N
O
GLY B:37 B:66 0.0 0.0 E -103.7 144.6 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLY A:37 A:66 1.0 0.013 E -100.8 150.4 1.0 0.013 0.0 HOH
2.823
N
O
GLY B:37 B:66 0.0 0.0 E -106.6 147.5 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLY A:37 A:66 0.0 0.0 E -100.6 146.3 0.0 0.0 0.0 HOH
2.826
N
O
GLY B:37 B:66 1.0 0.013 E -103.0 151.3 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 GLY A:37 A:66 0.0 0.0 E -97.2 156.0 0.0 0.0 0.0
GLY B:37 B:66 0.0 0.0 E -86.2 170.6 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 GLY A:37 A:66 1.0 0.013 E -101.3 149.6 1.0 0.013 0.0 HOH
2.833
N
O
GLY B:37 B:66 1.0 0.013 E -90.6 140.3 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 GLY A:66 A:66 0.0 0.0 E -99.7 145.8 0.0 0.0 0.0 HOH
6.502
N
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 GLY A:37 A:66 0.0 0.0 E -93.6 147.2 0.0 0.0 0.0 HOH
3.015
N
O
GLY B:37 B:66 0.0 0.0 E -87.0 154.7 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 GLY A:66 A:66 0.0 0.0 E -93.6 157.3 0.0 0.0 0.0 HOH
5.647
N
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 GLY A:37 A:66 1.0 0.013 E -99.4 147.3 1.0 0.013 0.0 HOH
3.042
N
O
GLY B:37 B:66 0.0 0.0 E -92.4 144.6 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 GLY A:25 A:66 1.0 0.013 E -104.4 147.9 1.0 0.013 0.0 HOH
2.879
N
O
GLY B:25 B:66 0.0 0.0 E -104.1 148.9 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 GLY A:25 A:66 0.0 0.0 E -102.3 141.4 0.0 0.0 0.0
GLY B:25 B:66 0.0 0.0 E -101.4 143.4 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 GLY A:25 A:66 0.0 0.0 E -106.4 141.7 0.0 0.0 0.0
GLY B:25 B:66 0.0 0.0 E -106.2 144.0 0.0 0.0 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLY A:36 A:66 0.0 0.0 E -102.9 148.5 0.0 0.0 0.0 HOH
2.761
N
O
GLY B:36 B:66 1.0 0.013 E -105.7 147.3 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLY A:36 A:66 1.0 0.013 E -104.1 137.0 1.0 0.013 0.0 HOH
2.923
N
O
GLY B:36 B:66 1.0 0.013 E -104.3 136.9 1.0 0.013 0.0 HOH
2.960
N
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLY A:36 A:66 0.0 0.0 E -106.9 146.0 0.0 0.0 0.0 HOH
6.091
N
O
GLY B:36 B:66 1.0 0.013 E -108.1 144.5 1.0 0.013 0.0 HOH
5.840
N
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLY A:36 A:66 0.0 0.0 E -103.7 143.4 0.0 0.0 0.0 HOH
6.079
N
O
GLY B:36 B:66 1.0 0.013 E -97.1 141.0 1.0 0.013 0.0 HOH
2.904
N
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 GLY A:37 A:66 0.0 0.0 E -96.4 140.9 0.0 0.0 0.0 HOH
2.750
N
O
GLY B:37 B:66 0.0 0.0 E -105.0 169.6 0.0 0.0 0.0 HOH
6.733
N
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 GLY A:37 A:66 0.0 0.0 E -112.8 160.2 0.0 0.0 0.0 HOH
5.928
N
O
GLY B:37 B:66 0.0 0.0 E -100.9 156.4 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 GLY A:37 A:66 0.0 0.0 E -103.8 152.1 0.0 0.0 0.0 HOH
5.899
N
O
GLY B:37 B:66 0.0 0.0 E -102.4 153.1 0.0 0.0 0.0 HOH
9.993
N
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 GLY A:37 A:66 0.0 0.0 E -98.4 139.3 0.0 0.0 0.0
GLY B:37 B:66 1.0 0.013 E -97.5 140.1 1.0 0.013 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 GLY A:37 A:66 0.0 0.0 E -97.8 155.5 0.0 0.0 0.0
GLY B:37 B:66 0.0 0.0 E -99.5 155.2 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 GLY A:37 A:66 0.0 0.0 E -96.2 147.7 0.0 0.0 0.0
GLY B:37 B:66 0.0 0.0 E -96.8 143.5 NA NA NA
GLY C:37 C:66 0.0 0.0 E -99.5 149.8 NA NA NA
GLY D:37 D:66 1.0 0.013 E -98.1 143.5 NA NA NA
GLY E:37 E:66 1.0 0.013 E -97.3 146.0 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 GLY A:37 A:66 8.0 0.107 E -113.1 152.9 8.0 0.107 0.0
GLY B:37 B:66 2.0 0.027 E -123.1 147.2 2.0 0.027 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLY A:37 A:66 0.0 0.0 E -87.6 160.9 0.0 0.0 0.0
GLY B:37 B:66 1.0 0.013 E -104.6 157.5 1.0 0.013 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLY A:37 A:66 0.0 0.0 E -104.7 159.6 0.0 0.0 0.0 HOH
5.696
N
O
GLY B:37 B:66 0.0 0.0 E -109.5 152.0 0.0 0.0 0.0 HOH
5.882
N
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLY A:37 A:66 0.0 0.0 E -104.6 159.0 0.0 0.0 0.0 HOH
2.906
N
O
GLY B:37 B:66 1.0 0.013 E -101.4 152.0 1.0 0.013 0.0 HOH
2.980
N
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 GLY A:37 A:66 0.0 0.0 E -98.3 139.2 0.0 0.0 0.0 HOH
2.974
N
O
GLY B:37 B:66 0.0 0.0 E -100.0 146.3 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 GLY A:37 A:66 0.0 0.0 E -99.7 158.3 0.0 0.0 0.0 HOH
7.395
O
O
GLY B:37 B:66 0.0 0.0 E -94.0 146.8 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 GLY A:37 A:66 1.0 0.013 E -101.1 153.1 1.0 0.013 0.0 HOH
6.957
O
O
GLY B:37 B:66 0.0 0.0 E -103.5 147.4 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 GLY A:37 A:66 1.0 0.013 E -105.4 150.5 1.0 0.013 0.0 HOH
6.001
N
O
GLY B:37 B:66 0.0 0.0 E -98.4 155.9 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 GLY A:37 A:66 0.0 0.0 E -90.2 147.2 0.0 0.0 0.0 HOH
5.990
N
O
GLY B:37 B:66 0.0 0.0 E -101.4 148.9 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 GLY A:37 A:66 0.0 0.0 E -90.5 152.1 0.0 0.0 0.0 HOH
5.913
N
O
GLY B:37 B:66 0.0 0.0 E -102.8 148.0 0.0 0.0 0.0 HOH
7.075
O
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 GLY A:37 A:66 1.0 0.013 E -100.1 146.7 1.0 0.013 0.0 HOH
2.876
N
O
GLY B:37 B:66 0.0 0.0 E -93.6 140.9 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 GLY A:37 A:66 2.0 0.027 E -88.5 146.1 2.0 0.027 0.0 HOH
5.478
N
O
GLY B:37 B:66 0.0 0.0 E -91.7 161.0 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLY A:37 A:66 1.0 0.013 E -100.6 154.0 1.0 0.013 0.0 HOH
8.327
N
O
GLY B:37 B:66 0.0 0.0 E -99.2 157.5 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLY A:37 A:66 1.0 0.013 E -105.5 163.0 1.0 0.013 0.0 HOH
2.917
O
O
GLY B:37 B:66 0.0 0.0 E -92.8 154.4 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLY A:37 A:66 1.0 0.013 E -94.8 148.5 1.0 0.013 0.0 HOH
2.952
N
O
GLY B:37 B:66 0.0 0.0 E -99.9 148.8 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 GLY A:37 A:66 1.0 0.013 E -88.7 151.6 1.0 0.013 0.0
GLY B:37 B:66 0.0 0.0 E -93.6 152.4 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 GLY A:37 A:66 0.0 0.0 E -97.8 149.5 0.0 0.0 0.0 HOH
9.246
N
O
GLY B:37 B:66 0.0 0.0 E -98.5 148.7 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 GLY A:37 A:66 2.0 0.027 E -103.0 143.3 2.0 0.027 0.0
GLY B:37 B:66 0.0 0.0 E -95.0 159.6 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 GLY A:37 A:66 0.0 0.0 E -100.7 142.3 0.0 0.0 0.0 HOH
3.401
N
O
GLY B:37 B:66 0.0 0.0 E -95.1 148.1 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 GLY A:37 A:66 1.0 0.013 E -105.2 143.4 1.0 0.013 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 GLY A:37 A:66 1.0 0.013 E -101.7 147.0 1.0 0.013 0.0
GLY B:37 B:66 1.0 0.013 E -100.3 139.3 1.0 0.013 0.0
GLY C:37 C:66 2.0 0.027 E -102.0 145.4 NA NA NA
GLY D:37 D:66 1.0 0.013 E -99.8 143.4 NA NA NA
GLY E:37 E:66 0.0 0.0 E -98.5 152.8 NA NA NA
GLY F:37 F:66 0.0 0.0 E -97.3 148.1 NA NA NA
GLY G:37 G:66 1.0 0.013 E -100.2 154.0 NA NA NA
GLY H:37 H:66 1.0 0.013 E -97.2 144.8 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 GLY A:24 A:66 0.0 0.0 E -95.7 149.2 0.0 0.0 0.0 HOH
6.676
O
O
GLY B:24 B:66 0.0 0.0 E -90.2 149.7 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 GLY A:21 A:66 14.0 0.187 E -111.4 160.1 14.0 0.187 0.0
GLY B:21 B:66 0.0 0.0 E -117.1 150.5 0.0 0.0 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 GLY A:21 A:66 0.0 0.0 E -101.6 149.5 0.0 0.0 0.0
GLY B:21 B:66 0.0 0.0 E -105.7 148.7 0.0 0.0 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 GLY A:21 A:66 1.0 0.013 E -117.4 149.2 1.0 0.013 0.0
GLY B:21 B:66 3.0 0.04 E -117.5 133.3 3.0 0.04 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 GLY A:21 A:66 0.0 0.0 E -105.0 152.8 0.0 0.0 0.0
GLY B:21 B:66 0.0 0.0 E -102.9 154.6 0.0 0.0 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 GLY A:21 A:66 2.0 0.027 E -104.1 150.8 2.0 0.027 0.0
GLY B:21 B:66 4.0 0.053 E -104.7 151.9 4.0 0.053 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 GLY A:21 A:66 2.0 0.027 E -132.0 163.0 2.0 0.027 0.0
GLY B:21 B:66 6.0 0.08 E -97.9 152.9 6.0 0.08 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 GLY A:21 A:66 1.0 0.013 E -133.3 146.7 1.0 0.013 0.0
GLY B:21 B:66 6.0 0.08 E -103.5 142.3 6.0 0.08 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 GLY A:21 A:66 8.0 0.107 E -112.5 152.0 8.0 0.107 0.0
GLY B:21 B:66 2.0 0.027 E -122.8 147.9 2.0 0.027 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 GLY A:25 A:66 0.0 0.0 E -100.1 141.8 0.0 0.0 0.0 HOH
5.951
N
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 GLY A:37 A:66 0.0 0.0 E -103.5 148.8 0.0 0.0 0.0 HOH
2.840
N
O
GLY B:37 B:66 0.0 0.0 E -100.7 149.1 0.0 0.0 0.0 HOH
2.896
N
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 GLY A:66 A:66 0.0 0.0 E -88.5 144.0