Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94297255 . C A CCDS7421.1:NM_004969.3:c.151Gga>Tga_NP_004960.2:p.51G>* Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 GLY A:51 A:51 14.0 0.187 -68.2 170.7 NA NA NA
GLY B:51 B:51 12.0 0.16 -94.6 159.5 12.0 0.16 0.0 HOH
3.793
CA
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 GLY A:51 A:51 15.0 0.2 -72.7 168.6 15.0 0.2 0.0 HOH
3.026
O
O
GLY B:51 B:51 7.0 0.093 -65.6 155.0 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 GLY A:51 A:51 14.0 0.187 -81.1 172.6 14.0 0.187 0.0 HOH
2.917
O
O
GLY B:51 B:51 3.0 0.04 E -102.1 107.5 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 GLY A:22 A:51 12.0 0.16 -62.1 150.8 12.0 0.16 0.0 HOH
2.516
O
O
GLY B:22 B:51 16.0 0.213 -65.8 168.5 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLY A:22 A:51 13.0 0.173 -55.7 162.1 13.0 0.173 0.0 HOH
2.607
O
O
GLY B:22 B:51 4.0 0.053 E -118.9 118.4 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLY A:22 A:51 14.0 0.187 -59.6 170.1 14.0 0.187 0.0 HOH
2.874
O
O
GLY B:22 B:51 5.0 0.067 E -126.8 113.6 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLY A:22 A:51 13.0 0.173 -56.9 166.5 13.0 0.173 0.0 HOH
2.722
O
O
GLY B:22 B:51 9.0 0.12 E -140.7 113.4 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLY A:22 A:51 10.0 0.133 -47.8 160.4 10.0 0.133 0.0 HOH
2.582
O
O
GLY B:22 B:51 14.0 0.187 -57.4 171.1 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 GLY A:22 A:51 10.0 0.133 -60.9 166.0 10.0 0.133 0.0
GLY B:22 B:51 6.0 0.08 -74.3 118.0 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 GLY A:22 A:51 14.0 0.187 -71.6 167.4 14.0 0.187 0.0 HOH
2.964
O
O
GLY B:22 B:51 8.0 0.107 E -86.2 122.5 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 GLU A:51 A:51 29.0 0.153 E -95.1 102.2 29.0 0.153 0.0 HOH
3.129
OE1
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 GLY A:22 A:51 14.0 0.187 -81.2 166.8 14.0 0.187 0.0 HOH
2.692
O
O
GLY B:22 B:51 9.0 0.12 -80.1 119.5 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 GLU A:51 A:51 47.0 0.247 53.5 -128.0 47.0 0.247 0.0 HOH
3.348
OE1
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 GLY A:22 A:51 14.0 0.187 -71.0 165.7 14.0 0.187 0.0 HOH
2.766
O
O
GLY B:22 B:51 14.0 0.187 -73.9 142.4 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 GLY A:10 A:51 14.0 0.187 -48.6 143.0 14.0 0.187 0.0 HOH
2.896
O
O
GLY B:10 B:51 1.0 0.013 E -99.0 92.0 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 GLY A:10 A:51 12.0 0.16 E -85.3 133.7 12.0 0.16 0.0
GLY B:10 B:51 8.0 0.107 E -87.0 134.3 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 GLY A:10 A:51 9.0 0.12 -74.6 148.7 9.0 0.12 0.0
GLY B:10 B:51 8.0 0.107 -74.5 146.9 8.0 0.107 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLY A:21 A:51 11.0 0.147 -70.1 162.2 11.0 0.147 0.0 HOH
3.254
O
O
GLY B:21 B:51 13.0 0.173 -65.4 160.2 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLY A:21 A:51 13.0 0.173 -69.2 163.9 13.0 0.173 0.0 HOH
3.028
O
O
GLY B:21 B:51 14.0 0.187 -69.5 164.9 14.0 0.187 0.0 HOH
3.005
O
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLY A:21 A:51 14.0 0.187 -55.2 157.0 14.0 0.187 0.0 HOH
5.869
CA
O
GLY B:21 B:51 15.0 0.2 -73.9 163.6 15.0 0.2 0.0 HOH
6.124
O
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLY A:21 A:51 12.0 0.16 -61.2 163.6 12.0 0.16 0.0 HOH
5.464
CA
O
GLY B:21 B:51 14.0 0.187 -70.6 170.7 14.0 0.187 0.0 HOH
3.212
O
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 GLY A:22 A:51 12.0 0.16 -91.1 172.6 12.0 0.16 0.0 HOH
2.882
O
O
GLY B:22 B:51 0.0 0.0 E -96.1 124.2 0.0 0.0 0.0 HOH
6.208
O
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 GLY A:22 A:51 9.0 0.12 49.2 -158.4 9.0 0.12 0.0 HOH
6.686
O
O
GLY B:22 B:51 13.0 0.173 -54.9 -52.6 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 GLY A:22 A:51 23.0 0.307 44.1 -123.8 23.0 0.307 0.0 HOH
7.676
C
O
GLY B:22 B:51 12.0 0.16 -99.2 -58.2 12.0 0.16 0.0 HOH
7.829
O
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 GLY A:22 A:51 23.0 0.307 E -124.2 98.0 23.0 0.307 0.0
GLY B:22 B:51 21.0 0.28 -86.9 172.3 21.0 0.28 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 GLY A:22 A:51 2.0 0.027 E -82.1 105.7 2.0 0.027 0.0
GLY B:22 B:51 13.0 0.173 -66.8 171.0 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 GLY A:22 A:51 9.0 0.12 E -99.1 99.0 9.0 0.12 0.0
GLY B:22 B:51 14.0 0.187 -79.5 166.1 NA NA NA
GLY C:22 C:51 3.0 0.04 E -94.4 107.0 NA NA NA
GLY D:22 D:51 14.0 0.187 -78.6 165.0 NA NA NA
GLY E:22 E:51 1.0 0.013 E -91.5 77.1 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 GLY A:22 A:51 12.0 0.16 -87.7 148.0 12.0 0.16 0.0
GLY B:22 B:51 35.0 0.467 145.1 151.7 35.0 0.467 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLY A:22 A:51 10.0 0.133 -63.4 158.6 10.0 0.133 0.0
GLY B:22 B:51 15.0 0.2 -67.0 168.2 15.0 0.2 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLY A:22 A:51 12.0 0.16 -56.0 155.3 12.0 0.16 0.0 HOH
6.043
O
O
GLY B:22 B:51 16.0 0.213 -82.9 166.9 16.0 0.213 0.0 HOH
6.398
O
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLY A:22 A:51 11.0 0.147 -59.8 165.5 11.0 0.147 0.0 HOH
2.760
O
O
GLY B:22 B:51 15.0 0.2 -74.5 169.9 15.0 0.2 0.0 HOH
2.908
O
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 GLY A:22 A:51 14.0 0.187 -87.0 172.3 14.0 0.187 0.0 HOH
2.805
O
O
GLY B:22 B:51 6.0 0.08 -80.7 113.6 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 GLY A:22 A:51 11.0 0.147 -87.2 177.9 11.0 0.147 0.0 HOH
3.738
CA
O
GLY B:22 B:51 7.0 0.093 B -96.2 134.4 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 GLY A:22 A:51 14.0 0.187 -70.0 170.9 14.0 0.187 0.0 HOH
3.570
CA
O
GLY B:22 B:51 8.0 0.107 E -97.9 138.6 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 GLY A:22 A:51 14.0 0.187 -81.4 166.7 14.0 0.187 0.0 HOH
6.376
O
O
GLY B:22 B:51 9.0 0.12 -105.8 148.7 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 GLY A:22 A:51 10.0 0.133 -60.8 124.7 10.0 0.133 0.0 HOH
3.703
O
O
GLY B:22 B:51 12.0 0.16 -94.3 132.1 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 GLY A:22 A:51 7.0 0.093 E -116.1 119.6 7.0 0.093 0.0 HOH
5.044
O
O
GLY B:22 B:51 12.0 0.16 -54.5 151.0 12.0 0.16 0.0 HOH
4.128
CA
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 GLY A:22 A:51 13.0 0.173 -76.4 163.3 13.0 0.173 0.0 HOH
2.708
O
O
GLY B:22 B:51 6.0 0.08 E -158.2 -162.1 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 GLY A:22 A:51 26.0 0.347 -57.0 171.8 26.0 0.347 0.0 HOH
6.314
C
O
GLY B:22 B:51 7.0 0.093 -68.1 140.7 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLY A:22 A:51 13.0 0.173 -75.6 168.4 13.0 0.173 0.0 HOH
8.141
N
O
GLY B:22 B:51 9.0 0.12 -82.8 161.1 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLY A:22 A:51 14.0 0.187 -65.1 166.8 14.0 0.187 0.0 HOH
2.953
O
O
GLY B:22 B:51 8.0 0.107 -94.7 147.8 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLY A:22 A:51 26.0 0.347 74.9 150.2 26.0 0.347 0.0 HOH
2.924
O
O
GLY B:22 B:51 18.0 0.24 -105.9 -71.9 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 GLY A:22 A:51 4.0 0.053 E -95.7 85.1 4.0 0.053 0.0
GLY B:22 B:51 2.0 0.027 -65.2 120.8 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 GLY A:22 A:51 8.0 0.107 -54.1 152.6 8.0 0.107 0.0
GLY B:22 B:51 9.0 0.12 -53.1 155.6 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 GLY A:22 A:51 16.0 0.213 -73.7 171.0 16.0 0.213 0.0
GLY B:22 B:51 12.0 0.16 -64.2 150.1 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 GLY A:22 A:51 7.0 0.093 74.9 -144.4 7.0 0.093 0.0 HOH
3.188
CA
O
GLY B:22 B:51 4.0 0.053 -66.3 123.0 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 GLY A:22 A:51 14.0 0.187 -64.9 165.9 14.0 0.187 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 GLY A:22 A:51 12.0 0.16 -67.6 153.1 12.0 0.16 0.0
GLY B:22 B:51 10.0 0.133 -77.7 146.9 10.0 0.133 0.0
GLY C:22 C:51 16.0 0.213 -75.4 164.0 NA NA NA
GLY D:22 D:51 11.0 0.147 -70.8 152.9 NA NA NA
GLY E:22 E:51 7.0 0.093 -72.3 163.9 NA NA NA
GLY F:22 F:51 9.0 0.12 -69.1 140.9 NA NA NA
GLY G:22 G:51 8.0 0.107 -72.9 154.0 NA NA NA
GLY H:22 H:51 12.0 0.16 -71.9 146.9 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 GLY A:9 A:51 12.0 0.16 -78.3 176.4 12.0 0.16 0.0 HOH
3.126
CA
O
GLY B:9 B:51 10.0 0.133 -88.4 153.9 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 GLY A:6 A:51 64.0 0.853 -141.9 140.5 64.0 0.853 0.0
GLY B:6 B:51 56.0 0.747 -145.8 144.9 56.0 0.747 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 GLY A:6 A:51 40.0 0.533 -158.0 176.1 40.0 0.533 0.0
GLY B:6 B:51 31.0 0.413 -168.3 -179.3 31.0 0.413 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 GLY A:6 A:51 40.0 0.533 160.1 169.0 40.0 0.533 0.0
GLY B:6 B:51 68.0 0.907 159.8 -148.8 68.0 0.907 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 GLY A:6 A:51 50.0 0.667 -158.3 173.6 50.0 0.667 0.0
GLY B:6 B:51 45.0 0.6 -158.5 174.7 45.0 0.6 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 GLY A:6 A:51 54.0 0.72 -157.5 176.6 54.0 0.72 0.0
GLY B:6 B:51 48.0 0.64 -158.8 173.4 48.0 0.64 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 GLY A:6 A:51 39.0 0.52 -157.5 166.1 39.0 0.52 0.0
GLY B:6 B:51 54.0 0.72 -156.9 161.8 54.0 0.72 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 GLY A:6 A:51 45.0 0.6 -155.3 163.3 45.0 0.6 0.0
GLY B:6 B:51 47.0 0.627 -161.6 172.7 47.0 0.627 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 GLY A:6 A:51 10.0 0.133 -86.9 146.0 10.0 0.133 0.0
GLY B:6 B:51 35.0 0.467 145.6 150.7 35.0 0.467 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 GLU A:10 A:51 21.0 0.111 E -98.0 114.0 21.0 0.111 0.0 HOH
2.872
OE1
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 GLY A:22 A:51 14.0 0.187 -70.2 162.3 14.0 0.187 0.0 HOH
2.859
O
O
GLY B:22 B:51 13.0 0.173 -67.0 143.8 13.0 0.173 0.0 HOH
2.297
O
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 GLY A:51 A:51 12.0 0.16 -63.1 159.0