Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94297257 . A C CCDS7421.1:NM_004969.3:c.149aTa>aGa_NP_004960.2:p.50I>R Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 ILE A:50 A:50 89.0 0.509 E -113.2 132.7 NA NA NA
ILE B:50 B:50 90.0 0.514 E -105.1 139.7 90.0 0.514 0.0 HOH
4.318
O
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 ILE A:50 A:50 92.0 0.526 E -120.9 135.8 92.0 0.526 0.0 HOH
4.310
CG2
O
ILE B:50 B:50 84.0 0.48 E -130.1 116.5 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 ILE A:50 A:50 85.0 0.486 E -115.3 137.2 85.0 0.486 0.0 HOH
4.043
CG2
O
ILE B:50 B:50 85.0 0.486 E -128.4 134.8 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 ILE A:21 A:50 82.0 0.469 E -116.8 127.4 82.0 0.469 0.0 HOH
3.229
N
O
ILE B:21 B:50 91.0 0.52 E -116.0 122.7 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:21 A:50 94.0 0.537 E -108.7 111.6 94.0 0.537 0.0 HOH
4.303
CG2
O
ILE B:21 B:50 82.0 0.469 E -151.4 129.1 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:21 A:50 95.0 0.543 E -115.5 117.8 95.0 0.543 0.0 HOH
4.266
CG2
O
ILE B:21 B:50 77.0 0.44 E -152.2 134.3 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:21 A:50 96.0 0.549 E -113.2 113.2 96.0 0.549 0.0 HOH
2.982
O
O
ILE B:21 B:50 80.0 0.457 E -150.8 150.7 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:21 A:50 86.0 0.491 E -117.5 105.0 86.0 0.491 0.0 HOH
3.193
O
O
ILE B:21 B:50 88.0 0.503 E -115.9 113.8 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 ILE A:21 A:50 89.0 0.509 E -121.7 111.9 89.0 0.509 0.0
ILE B:21 B:50 72.0 0.411 -139.3 149.6 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 ILE A:21 A:50 86.0 0.491 E -105.9 132.6 86.0 0.491 0.0 HOH
3.165
N
O
ILE B:21 B:50 87.0 0.497 E -102.1 131.8 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 ILE A:50 A:50 47.0 0.269 E -115.8 122.2 47.0 0.269 0.0 HOH
3.100
N
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 ILE A:21 A:50 88.0 0.503 E -91.5 143.5 88.0 0.503 0.0 HOH
4.059
CG2
O
ILE B:21 B:50 87.0 0.497 E -103.8 141.4 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 ILE A:50 A:50 57.0 0.326 E -119.0 140.6 57.0 0.326 0.0 HOH
7.522
CD1
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 ILE A:21 A:50 98.0 0.56 E -107.5 129.0 98.0 0.56 0.0 HOH
4.446
CG2
O
ILE B:21 B:50 90.0 0.514 E -109.1 127.8 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 ILE A:9 A:50 95.0 0.543 E -118.4 131.0 95.0 0.543 0.0 HOH
4.451
CG2
O
ILE B:9 B:50 76.0 0.434 E -121.3 128.8 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 ILE A:9 A:50 88.0 0.503 E -132.1 137.7 88.0 0.503 0.0
ILE B:9 B:50 86.0 0.491 E -134.2 137.7 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 ILE A:9 A:50 94.0 0.537 E -127.8 128.4 94.0 0.537 0.0
ILE B:9 B:50 84.0 0.48 E -127.2 129.9 84.0 0.48 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:20 A:50 104.0 0.594 E -106.1 134.0 104.0 0.594 0.0 HOH
4.683
CG2
O
ILE B:20 B:50 90.0 0.514 E -113.0 134.0 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:20 A:50 101.0 0.577 E -114.2 128.3 101.0 0.577 0.0 HOH
4.707
CG2
O
ILE B:20 B:50 89.0 0.509 E -115.1 129.0 89.0 0.509 0.0 HOH
2.732
O
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:20 A:50 93.0 0.531 E -97.1 115.3 93.0 0.531 0.0 HOH
7.656
C
O
ILE B:20 B:50 113.0 0.646 E -117.4 130.2 113.0 0.646 0.0 HOH
7.376
CD1
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:20 A:50 91.0 0.52 E -100.8 127.8 91.0 0.52 0.0 HOH
5.935
CD1
O
ILE B:20 B:50 96.0 0.549 E -119.7 127.8 96.0 0.549 0.0 HOH
4.541
CG2
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 ILE A:21 A:50 88.0 0.503 E -85.3 143.9 88.0 0.503 0.0 HOH
4.384
CG2
O
ILE B:21 B:50 66.0 0.377 E -130.0 130.8 66.0 0.377 0.0 HOH
5.166
N
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 ILE A:21 A:50 87.0 0.497 -112.4 21.3 87.0 0.497 0.0 HOH
5.321
CG2
O
ILE B:21 B:50 81.0 0.463 -131.3 96.6 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 ILE A:21 A:50 89.0 0.509 -105.7 18.0 89.0 0.509 0.0 HOH
5.157
CG2
O
ILE B:21 B:50 87.0 0.497 E -108.2 149.4 87.0 0.497 0.0 HOH
8.466
N
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 ILE A:21 A:50 77.0 0.44 E -117.8 134.4 77.0 0.44 0.0
ILE B:21 B:50 102.0 0.583 B -113.8 135.4 102.0 0.583 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 ILE A:21 A:50 74.0 0.423 E -130.4 106.1 74.0 0.423 0.0
ILE B:21 B:50 90.0 0.514 E -125.1 112.2 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 ILE A:21 A:50 74.0 0.423 E -130.8 115.6 74.0 0.423 0.0
ILE B:21 B:50 97.0 0.554 E -122.2 118.7 NA NA NA
ILE C:21 C:50 76.0 0.434 E -130.2 118.9 NA NA NA
ILE D:21 D:50 89.0 0.509 E -115.7 119.7 NA NA NA
ILE E:21 E:50 88.0 0.503 E -95.5 130.8 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 ILE A:21 A:50 111.0 0.634 E -130.3 132.9 111.0 0.634 0.0
ILE B:21 B:50 71.0 0.406 -90.1 161.2 71.0 0.406 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 ILE A:21 A:50 77.0 0.44 E -131.3 118.6 77.0 0.44 0.0
ILE B:21 B:50 92.0 0.526 E -113.5 128.9 92.0 0.526 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 ILE A:21 A:50 91.0 0.52 E -120.2 107.6 91.0 0.52 0.0 HOH
8.755
CG2
O
ILE B:21 B:50 87.0 0.497 E -103.1 141.3 87.0 0.497 0.0 HOH
8.592
CG2
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 ILE A:21 A:50 91.0 0.52 E -119.3 117.4 91.0 0.52 0.0 HOH
4.566
CG2
O
ILE B:21 B:50 94.0 0.537 E -110.7 135.6 94.0 0.537 0.0 HOH
4.485
CG2
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 ILE A:21 A:50 91.0 0.52 E -112.9 134.8 91.0 0.52 0.0 HOH
3.094
N
O
ILE B:21 B:50 70.0 0.4 E -131.9 149.3 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 ILE A:21 A:50 87.0 0.497 E -123.6 144.1 87.0 0.497 0.0 HOH
4.493
O
O
ILE B:21 B:50 67.0 0.383 -172.7 135.4 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 ILE A:21 A:50 91.0 0.52 E -113.8 132.9 91.0 0.52 0.0 HOH
4.103
O
O
ILE B:21 B:50 85.0 0.486 E -121.0 140.4 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 ILE A:21 A:50 90.0 0.514 E -115.1 134.5 90.0 0.514 0.0 HOH
7.720
CD1
O
ILE B:21 B:50 99.0 0.566 E -110.6 152.8 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 ILE A:21 A:50 72.0 0.411 E -127.1 134.1 72.0 0.411 0.0 HOH
4.698
CG2
O
ILE B:21 B:50 92.0 0.526 E -125.8 147.2 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 ILE A:21 A:50 104.0 0.594 E -132.7 116.8 104.0 0.594 0.0 HOH
6.145
CG2
O
ILE B:21 B:50 86.0 0.491 E -112.9 107.9 86.0 0.491 0.0 HOH
4.226
CG1
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 ILE A:21 A:50 98.0 0.56 E -107.8 132.3 98.0 0.56 0.0 HOH
4.264
CG2
O
ILE B:21 B:50 70.0 0.4 E -120.8 147.6 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 ILE A:21 A:50 79.0 0.451 -139.5 1.1 79.0 0.451 0.0 HOH
4.701
CG2
O
ILE B:21 B:50 78.0 0.446 E -122.8 123.9 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 ILE A:21 A:50 89.0 0.509 E -109.7 132.0 89.0 0.509 0.0 HOH
4.312
CG1
O
ILE B:21 B:50 90.0 0.514 E -122.8 126.8 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 ILE A:21 A:50 91.0 0.52 E -119.8 118.5 91.0 0.52 0.0 HOH
4.275
CG2
O
ILE B:21 B:50 85.0 0.486 E -105.1 140.1 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 ILE A:21 A:50 80.0 0.457 -109.0 -36.3 80.0 0.457 0.0 HOH
3.401
O
O
ILE B:21 B:50 95.0 0.543 E -97.5 153.7 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 ILE A:21 A:50 78.0 0.446 E -129.6 123.9 78.0 0.446 0.0
ILE B:21 B:50 78.0 0.446 E -123.8 129.0 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 ILE A:21 A:50 85.0 0.486 E -113.5 112.1 85.0 0.486 0.0
ILE B:21 B:50 91.0 0.52 E -113.4 112.6 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 ILE A:21 A:50 91.0 0.52 E -108.3 132.9 91.0 0.52 0.0
ILE B:21 B:50 66.0 0.377 E -114.3 132.2 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 ILE A:21 A:50 89.0 0.509 E -129.1 141.0 89.0 0.509 0.0 HOH
5.257
C
O
ILE B:21 B:50 75.0 0.429 E -121.4 138.7 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 ILE A:21 A:50 92.0 0.526 E -131.6 114.1 92.0 0.526 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 ILE A:21 A:50 92.0 0.526 E -131.7 134.6 92.0 0.526 0.0
ILE B:21 B:50 92.0 0.526 E -122.0 140.5 92.0 0.526 0.0
ILE C:21 C:50 96.0 0.549 E -129.6 139.0 NA NA NA
ILE D:21 D:50 70.0 0.4 E -129.2 132.2 NA NA NA
ILE E:21 E:50 89.0 0.509 E -123.5 119.7 NA NA NA
ILE F:21 F:50 91.0 0.52 E -128.8 136.8 NA NA NA
ILE G:21 G:50 83.0 0.474 E -128.9 131.5 NA NA NA
ILE H:21 H:50 94.0 0.537 E -123.6 134.9 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 ILE A:8 A:50 100.0 0.571 E -104.6 140.6 100.0 0.571 0.0 HOH
4.039
O
O
ILE B:8 B:50 88.0 0.503 E -110.4 142.8 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 ILE A:5 A:50 69.0 0.394 -147.1 114.4 69.0 0.394 0.0
ILE B:5 B:50 81.0 0.463 -143.8 103.1 81.0 0.463 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 ILE A:5 A:50 103.0 0.589 -147.9 115.5 103.0 0.589 0.0
ILE B:5 B:50 110.0 0.629 -139.7 98.6 110.0 0.629 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 ILE A:5 A:50 105.0 0.6 -134.7 162.2 105.0 0.6 0.0
ILE B:5 B:50 84.0 0.48 -142.3 128.2 84.0 0.48 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 ILE A:5 A:50 93.0 0.531 -147.6 113.0 93.0 0.531 0.0
ILE B:5 B:50 98.0 0.56 -145.7 109.5 98.0 0.56 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 ILE A:5 A:50 138.0 0.789 -150.0 112.8 138.0 0.789 0.0
ILE B:5 B:50 86.0 0.491 -144.8 107.8 86.0 0.491 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 ILE A:5 A:50 99.0 0.566 -147.3 111.5 99.0 0.566 0.0
ILE B:5 B:50 84.0 0.48 -142.0 114.8 84.0 0.48 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 ILE A:5 A:50 80.0 0.457 -149.7 122.7 80.0 0.457 0.0
ILE B:5 B:50 93.0 0.531 -144.7 103.8 93.0 0.531 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 ILE A:5 A:50 107.0 0.611 E -130.5 132.8 107.0 0.611 0.0
ILE B:5 B:50 70.0 0.4 -88.9 160.5 70.0 0.4 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 ILE A:9 A:50 55.0 0.314 E -123.5 123.0 55.0 0.314 0.0 HOH
3.131
N
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 ILE A:21 A:50 91.0 0.52 E -111.2 133.9 91.0 0.52 0.0 HOH
2.906
N
O
ILE B:21 B:50 88.0 0.503 E -109.4 129.3 88.0 0.503 0.0 HOH
4.202
CG2
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 ILE A:50 A:50 57.0 0.326 E -101.4 129.6