Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr10 | 101163497 | . | C | A | CCDS7479.1:NM_002079.2:c.777aaG>aaT_NP_002070.1:p.259K>N | Homo sapiens glutamic-oxaloacetic transaminase 1 (GOT1), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 3wzf | 1 | P17174 | 100.0 | 0.0 |
X-RAY |
2015-10-07 | LYS | A:258 | A:258 | 45.0 | 0.225 | T | -84.9 | -31.0 | 23.0 | 0.115 | 0.11 |
A:P17174:0.11 |
HOH |
7.463 |
O |
O |
|
| 6dnd | 1 | P17174 | 100.0 | 0.0 |
X-RAY |
2018-11-14 | LYS | A:257 | A:259 | 35.0 | 0.175 | T | -93.8 | -47.3 | 35.0 | 0.175 | 0.0 |
PLP HOH |
2.736 2.675 |
NZ O |
C4A O |
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| LYS | B:257 | B:259 | 31.0 | 0.155 | T | -82.2 | -47.9 | NA | NA | NA | |||||||||||||
| 6lig | 1 | P17174 | 100.0 | 0.0 |
X-RAY |
2020-12-16 | LYS | A:257 | A:259 | 30.0 | 0.15 | S | -100.4 | -55.1 | 15.0 | 0.075 | 0.075 |
B:P17174:0.075 |
EE6 HOH |
1.431 2.697 |
NZ O |
C30 O |
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| LYS | B:257 | B:259 | 22.0 | 0.11 | T | -111.1 | -52.7 | 11.0 | 0.055 | 0.055 |
A:P17174:0.055 |
PLP HOH |
3.175 2.842 |
CE O |
O4A O |
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| 6dnb | 1 | P17174 | 99.27 | 0.0 |
X-RAY |
2018-11-14 | LYS | A:257 | A:259 | 36.0 | 0.18 | T | -76.7 | -47.7 | 36.0 | 0.18 | 0.0 |
GOL PO4 HOH |
4.623 9.494 2.654 |
NZ O O |
O1 O2 O |
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| 6dna | 1 | P17174 | 99.75 | 0.0 |
X-RAY |
2018-11-14 | LYS | A:254 | A:259 | 32.0 | 0.16 | T | -90.4 | -48.2 | 32.0 | 0.16 | 0.0 |
PLP |
2.951 |
NZ |
C4A |
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| LYS | B:254 | B:259 | 35.0 | 0.175 | T | -89.2 | -49.0 | NA | NA | NA | |||||||||||||
| LYS | C:254 | C:259 | 38.0 | 0.19 | T | -88.6 | -47.9 | NA | NA | NA | |||||||||||||
| LYS | D:254 | D:259 | 37.0 | 0.185 | T | -89.2 | -47.7 | NA | NA | NA | |||||||||||||
| LYS | E:254 | E:259 | 30.0 | 0.15 | T | -87.8 | -49.4 | NA | NA | NA | |||||||||||||
| LYS | F:254 | F:259 | 38.0 | 0.19 | T | -89.9 | -48.9 | NA | NA | NA | |||||||||||||
| 3ii0 | 1 | P17174 | 100.0 | 0.0 |
X-RAY |
2009-08-11 | LYS | A:247 | A:259 | 31.0 | 0.155 | T | -94.7 | -57.5 | 31.0 | 0.155 | 0.0 |
PLP TAR HOH |
2.263 2.755 2.757 |
NZ NZ O |
O4A O2 O |
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| LYS | B:247 | B:259 | 30.0 | 0.15 | T | -95.3 | -52.1 | NA | NA | NA | |||||||||||||
| LYS | C:247 | C:259 | 30.0 | 0.15 | T | -97.9 | -51.6 | NA | NA | NA | |||||||||||||
| LYS | D:247 | D:259 | 28.0 | 0.14 | T | -103.3 | -49.1 | NA | NA | NA | |||||||||||||
| 5toq | 1 | P00503 | 92.01 | 0.0 |
X-RAY |
2017-03-01 | LLP | A:260 | A:258 | NA | NA | NA | NA | NA | NA | NA | NA |
HOH |
2.773 |
O |
O |
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| LLP | B:260 | B:258 | NA | NA | NA | NA | NA | NA | NA | NA |
HOH |
2.759 |
O |
O |
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| 5vk7 | 1 | P00503 | 92.01 | 0.0 |
X-RAY |
2017-11-01 | LLP | A:260 | A:258 | NA | NA | NA | NA | NA | NA | NA | NA |
HOH |
2.783 |
OP2 |
O |
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| LLP | B:260 | B:258 | NA | NA | NA | NA | NA | NA | NA | NA |
HOH |
2.766 |
OP1 |
O |
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| 1ajr | 1 | P00503 | 91.99 | 0.0 |
X-RAY |
1997-08-20 | LLP | A:258 | A:258 | NA | NA | NA | NA | NA | NA | NA | NA |
HOH |
2.752 |
OP1 |
O |
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| LLP | B:258 | B:258 | NA | NA | NA | NA | NA | NA | NA | NA |
HOH |
2.756 |
O |
O |
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| 1ajs | 1 | P00503 | 91.99 | 0.0 |
X-RAY |
1997-08-20 | LYS | A:258 | A:258 | 0.0 | 0.0 | T | -87.7 | -47.2 | 0.0 | 0.0 | 0.0 |
PLA HOH |
2.867 2.756 |
NZ O |
C4A O |
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| 1ajs | 2 | P00503 | 91.99 | 0.0 |
X-RAY |
1997-08-20 | LLP | B:258 | B:258 | NA | NA | NA | NA | NA | NA | NA | NA |
HOH |
2.759 |
O |
O |
||
| 5vjz | 1 | P00503 | 91.99 | 0.0 |
NEUTRON DIFFRACTION X-RAY |
2017-11-01 | LYS | A:258 | A:258 | 0.0 | 0.0 | T | -92.4 | -47.4 | 0.0 | 0.0 | 0.0 | ||||||
| 5vjz | 2 | P00503 | 91.99 | 0.0 |
NEUTRON DIFFRACTION X-RAY |
2017-11-01 | LLP | B:258 | B:258 | NA | NA | NA | NA | NA | NA | NA | NA | ||||||
| 5tor | 1 | P00503 | 91.77 | 0.0 |
X-RAY |
2017-03-01 | LLP | A:260 | A:258 | NA | NA | NA | NA | NA | NA | NA | NA |
HOH |
2.760 |
OP1 |
O |
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| LLP | B:260 | B:258 | NA | NA | NA | NA | NA | NA | NA | NA |
HOH |
2.670 |
N1 |
O |
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| 5ton | 1 | P00503 | 91.77 | 0.0 |
X-RAY |
2017-03-01 | LLP | A:260 | A:258 | NA | NA | NA | NA | NA | NA | NA | NA |
HOH |
2.734 |
OP1 |
O |
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| LLP | B:260 | B:258 | NA | NA | NA | NA | NA | NA | NA | NA |
HOH |
2.732 |
O |
O |
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| 5tot | 1 | P00503 | 91.53 | 0.0 |
X-RAY |
2017-03-01 | LLP | A:260 | A:258 | NA | NA | NA | NA | NA | NA | NA | NA |
HOH |
2.730 |
OP1 |
O |
||
| LLP | B:260 | B:258 | NA | NA | NA | NA | NA | NA | NA | NA |
HOH |
2.751 |
OP1 |
O |
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| 2cst | 1 | P00504 | 80.44 | 0.0 |
X-RAY |
1994-11-30 | LYS | A:257 | A:258 | 34.0 | 0.17 | T | -92.1 | -45.4 | 20.0 | 0.1 | 0.07 |
B:P00504:0.07 |
PLP MAE HOH |
1.293 3.746 2.699 |
NZ NZ O |
C4A C2 O |
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| LYS | B:257 | B:258 | 34.0 | 0.17 | T | -89.7 | -47.2 | 18.0 | 0.09 | 0.08 |
A:P00504:0.08 |
PLP MAE HOH |
1.293 3.729 2.751 |
NZ NZ O |
C4A C2 O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p17174-f1 | 1 | P17174 | 100.0 | 0.0 | LYS | A:259 | A:259 | 39.0 | 0.195 | T | -97.5 | -45.8 | |