Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 103342563 . A C CCDS7513.1:NM_001174084.1:c.1151cTg>cGg_NP_001167555.1:p.384L>R Homo sapiens DNA polymerase lambda (POLL), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
4xq8 1 Q9UGP5 100.0 0.0 X-RAY
 2016-02-24 LEU A:143 B:384 85.0 0.5 H -67.5 -28.4 85.0 0.5 0.0 HOH
 3.710
 CB
 O
LEU B:143 A:384 78.0 0.459 T -85.4 -13.3 NA NA NA
5ca7 1 Q9UGP5 100.0 0.0 X-RAY
 2016-02-24 LEU A:143 B:384 85.0 0.5 H -80.8 -18.4 85.0 0.5 0.0 HOH
 3.517
 CG
 O
LEU B:143 A:384 78.0 0.459 G -93.2 -14.2 NA NA NA
5iii 1 Q9UGP5 100.0 0.0 X-RAY
 2016-08-17 LEU A:143 A:384 91.0 0.535 H -93.6 -6.9 91.0 0.535 0.0 DA
DTP
NA
HOH
 9.952
8.825
8.325
3.163
 CD2
O
CD2
O
 OP1
O2G
NA
O
5iij 1 Q9UGP5 100.0 0.0 X-RAY
 2016-08-17 LEU A:143 A:384 91.0 0.535 H -92.7 -6.9 91.0 0.535 0.0 DA
DCT
NA
HOH
 9.886
8.678
8.251
2.842
 CD2
O
CD2
O
 OP1
O2G
NA
O
5iik 1 Q9UGP5 100.0 0.0 X-RAY
 2016-08-17 LEU A:143 A:384 91.0 0.535 G -102.7 -8.2 91.0 0.535 0.0 DA
CIT
NA
HOH
 9.880
7.109
8.292
3.440
 CD2
O
CD2
CG
 OP1
O2
NA
O
5iil 1 Q9UGP5 100.0 0.0 X-RAY
 2016-08-17 LEU A:143 A:384 89.0 0.524 G -98.9 -5.1 89.0 0.524 0.0 DA
CIT
NA
HOH
 9.659
7.059
8.078
2.539
 CD2
O
CD2
O
 OP1
O2
NA
O
5iim 1 Q9UGP5 100.0 0.0 X-RAY
 2016-09-07 LEU A:143 A:384 89.0 0.524 H -91.7 -12.1 89.0 0.524 0.0 DUP
NA
HOH
 8.872
8.468
3.536
 O
CD2
CG
 O3G
NA
O
5iin 1 Q9UGP5 100.0 0.0 X-RAY
 2016-08-17 LEU A:143 A:384 94.0 0.553 H -91.0 -9.5 94.0 0.553 0.0 DUP
NA
HOH
 8.892
8.541
3.385
 O
CD2
CG
 O3G
NA
O
5iio 4 Q9UGP5 100.0 0.0 X-RAY
 2016-08-17 LEU M:143 A:384 84.0 0.494 H -81.4 -25.7 84.0 0.494 0.0 NA
HOH
 8.701
3.508
 CD1
CD1
 NA
O
LEU N:143 E:384 82.0 0.482 T -75.0 -11.3 NA NA NA
LEU O:143 I:384 89.0 0.524 H -82.5 -17.1 NA NA NA
LEU P:143 M:384 87.0 0.512 H -85.8 -13.4 NA NA NA
1xsl 4 Q9UGP5 100.0 0.0 X-RAY
 2005-01-18 LEU M:144 A:384 90.0 0.529 H -79.2 -33.6 90.0 0.529 0.0 NA
HOH
 8.993
3.939
 CD1
N
 NA
O
LEU N:144 E:384 77.0 0.453 H -68.6 -21.0 NA NA NA
LEU O:144 I:384 97.0 0.571 H -81.2 -28.0 NA NA NA
LEU P:144 M:384 82.0 0.482 H -76.9 -23.3 NA NA NA
2bcq 4 Q9UGP5 100.0 0.0 X-RAY
 2006-03-07 LEU D:144 A:384 86.0 0.506 G -104.0 -2.9 86.0 0.506 0.0 DA
NA
PPV
HOH
 9.833
8.227
8.672
2.768
 CD2
CD2
O
O
 OP1
NA
O21
O
2bcr 4 Q9UGP5 100.0 0.0 X-RAY
 2006-03-07 LEU D:144 A:384 93.0 0.547 G -103.8 -3.9 93.0 0.547 0.0 DA
NA
PPV
HOH
 9.833
8.271
8.637
2.908
 CD2
CD2
O
O
 OP1
NA
O21
O
2bcs 4 Q9UGP5 100.0 0.0 X-RAY
 2006-03-07 LEU D:144 A:384 91.0 0.535 G -104.4 -9.3 91.0 0.535 0.0 NA
PPV
HOH
 8.681
8.693
2.758
 CD2
O
O
 NA
O21
O
2bcu 4 Q9UGP5 100.0 0.0 X-RAY
 2006-03-07 LEU D:144 A:384 93.0 0.547 G -99.9 -8.9 93.0 0.547 0.0 NA
PPV
HOH
 8.774
9.166
3.651
 CD2
O
CG
 NA
O31
O
2bcv 4 Q9UGP5 100.0 0.0 X-RAY
 2006-03-07 LEU D:144 A:384 92.0 0.541 G -98.3 -5.3 92.0 0.541 0.0 DA
NA
TTP
HOH
 9.901
8.305
8.918
3.186
 CD2
CD2
O
O
 OP1
NA
O2G
O
2gws 4 Q9UGP5 100.0 0.0 X-RAY
 2006-09-05 LEU M:144 A:384 89.0 0.524 H -83.9 -20.7 89.0 0.524 0.0 NA
HOH
 8.659
3.498
 CD1
O
 NA
O
LEU N:144 E:384 74.0 0.435 G -102.9 -7.9 NA NA NA
LEU O:144 I:384 94.0 0.553 H -78.4 -13.5 NA NA NA
LEU P:144 M:384 91.0 0.535 H -76.1 -18.4 NA NA NA
4xrh 1 Q9UGP5 100.0 0.0 X-RAY
 2016-02-24 LEU A:144 B:384 85.0 0.5 T -78.5 -16.7 85.0 0.5 0.0
LEU B:144 A:384 76.0 0.447 G -88.6 -29.1 NA NA NA
5ddm 1 Q9UGP5 100.0 0.0 X-RAY
 2016-02-24 LEU A:144 B:384 90.0 0.529 H -72.7 -21.5 90.0 0.529 0.0 NA
HOH
 8.469
3.862
 CD2
CG
 NA
O
LEU B:144 A:384 74.0 0.435 T -75.4 -25.6 NA NA NA
5ddy 1 Q9UGP5 100.0 0.0 X-RAY
 2016-02-24 LEU A:144 A:384 68.0 0.4 S -75.4 -22.5 68.0 0.4 0.0 DCP
MN
HOH
 9.728
8.264
9.225
 O
CD1
N
 O1G
MN
O
LEU B:144 C:384 58.0 0.341 T -77.2 -9.0 NA NA NA
LEU C:144 E:384 87.0 0.512 T -66.7 -38.8 NA NA NA
LEU D:144 G:384 98.0 0.576 S -78.1 -31.6 NA NA NA
3c5g 1 Q9UGP5 99.7 0.0 X-RAY
 2008-07-29 LEU A:144 A:384 89.0 0.524 H -77.9 -31.8 89.0 0.524 0.0 NA
D3T
HOH
 8.788
8.693
3.757
 CD1
O
CD2
 NA
O2G
O
LEU E:144 B:384 90.0 0.529 H -72.0 -39.8 NA NA NA
5chg 1 Q9UGP5 99.7 0.0 X-RAY
 2016-02-24 LEU A:143 A:384 80.0 0.471 H -79.6 -21.0 80.0 0.471 0.0 MG
HOH
 8.794
6.257
 CD2
N
 MG
O
LEU B:143 B:384 77.0 0.453 G -93.7 -17.0 NA NA NA
5cj7 1 Q9UGP5 99.7 0.0 X-RAY
 2016-02-24 LEU A:143 A:384 86.0 0.506 H -69.6 -22.8 86.0 0.506 0.0 HOH
 7.634
 CD1
 O
LEU B:143 B:384 78.0 0.459 G -89.9 -17.9 NA NA NA
5cp2 1 Q9UGP5 99.7 0.0 X-RAY
 2016-02-24 LEU A:143 A:384 74.0 0.435 G -100.6 -2.5 74.0 0.435 0.0 SO4
HOH
 9.891
5.198
 O
N
 O1
O
LEU B:143 B:384 85.0 0.5 H -86.0 -15.7 NA NA NA
5cr0 1 Q9UGP5 99.7 0.0 X-RAY
 2016-02-24 LEU A:143 A:384 80.0 0.471 T -86.0 -11.9 80.0 0.471 0.0 HOH
 5.924
 CD2
 O
LEU B:143 B:384 91.0 0.535 T -101.0 20.4 NA NA NA
3c5f 4 Q9UGP5 99.7 0.0 X-RAY
 2008-09-02 LEU G:144 A:384 89.0 0.524 H -76.3 -22.6 89.0 0.524 0.0 NA
HOH
 9.203
3.672
 CD2
CD1
 NA
O
LEU H:144 B:384 91.0 0.535 H -71.0 -29.9 NA NA NA
1xsn 4 Q9UGP5 99.7 0.0 X-RAY
 2005-01-18 LEU D:144 A:384 83.0 0.488 G -95.7 -13.8 83.0 0.488 0.0 NA
D3T
HOH
 8.436
8.911
3.485
 CD2
O
CG
 NA
O2G
O
1xsp 4 Q9UGP5 99.7 0.0 X-RAY
 2005-01-18 LEU D:144 A:384 88.0 0.518 G -104.5 -11.7 88.0 0.518 0.0 DA
NA
PPV
HOH
 9.942
8.210
9.211
2.659
 CD2
CD2
O
O
 OP1
NA
O31
O
2pfn 4 Q9UGP5 99.7 0.0 X-RAY
 2007-05-15 LEU D:144 A:384 89.0 0.524 H -93.9 -7.6 89.0 0.524 0.0 DA
NA
NA
DUP
HOH
 9.952
7.955
8.421
9.017
3.466
 CD2
CD2
CD2
O
CG
 OP1
NA
NA
O1G
O
2pfo 4 Q9UGP5 99.7 0.0 X-RAY
 2007-05-15 LEU D:144 A:384 90.0 0.529 G -97.6 -8.3 90.0 0.529 0.0 NA
NA
DUP
EDO
HOH
 8.652
7.046
9.060
8.403
3.534
 CD2
CD2
O
C
CG
 NA
NA
O1G
O2
O
2pfp 4 Q9UGP5 99.7 0.0 X-RAY
 2007-05-15 LEU D:144 A:384 91.0 0.535 H -95.5 -7.6 91.0 0.535 0.0 DA
NA
DCP
HOH
 9.934
8.376
8.937
3.000
 CD2
CD2
O
O
 OP1
NA
O1G
O
2pfq 4 Q9UGP5 99.7 0.0 X-RAY
 2007-05-15 LEU D:144 A:384 91.0 0.535 G -108.3 -13.7 91.0 0.535 0.0 NA
DCP
PPV
HOH
 8.578
9.245
9.186
3.001
 CD2
O
O
O
 NA
O1G
O22
O
3hw8 1 Q9UGP5 99.7 0.0 X-RAY
 2009-08-25 LEU A:144 A:384 84.0 0.494 T -95.0 -5.6 84.0 0.494 0.0 DA
NA
D3T
EDO
HOH
 9.933
8.276
8.789
9.369
3.477
 CD2
CD2
O
C
O
 OP1
NA
O2G
O1
O
3hwt 1 Q9UGP5 99.7 0.0 X-RAY
 2009-08-25 LEU A:144 A:384 82.0 0.482 G -98.0 -10.5 82.0 0.482 0.0 DA
D3T
NA
EDO
HOH
 9.771
8.866
8.155
8.782
3.381
 CD2
O
CD2
C
O
 OP1
O2G
NA
O1
O
1rzt 4 Q9UGP5 100.0 0.0 X-RAY
 2004-03-02 LEU M:140 A:384 88.0 0.518 H -84.1 -22.0 88.0 0.518 0.0 NA
HOH
 8.802
3.676
 CD1
CD2
 NA
O
LEU N:140 E:384 86.0 0.506 H -62.9 -19.2 NA NA NA
LEU O:140 I:384 93.0 0.547 H -82.7 -20.4 NA NA NA
LEU P:140 M:384 90.0 0.529 H -83.6 -17.8 NA NA NA
4k4g 1 Q9UGP5 100.0 0.0 X-RAY
 2014-07-16 LEU A:141 A:384 83.0 0.488 H -75.3 -19.0 83.0 0.488 0.0 1S0
CA
HOH
 8.926
8.973
3.890
 O
CD1
N
 OAO
CA
O
LEU E:141 E:384 80.0 0.471 H -84.4 -11.1 NA NA NA
LEU I:141 I:384 92.0 0.541 H -64.1 -35.7 NA NA NA
LEU M:141 M:384 98.0 0.576 T -63.1 -14.3 NA NA NA
4k4h 1 Q9UGP5 100.0 0.0 X-RAY
 2014-07-16 LEU A:141 A:384 79.0 0.465 H -76.3 -17.2 79.0 0.465 0.0 1RZ
CA
HOH
 8.894
9.063
3.845
 O
CD1
N
 O1G
CA
O
LEU E:141 E:384 82.0 0.482 H -79.5 -14.3 NA NA NA
LEU I:141 I:384 94.0 0.553 H -71.1 -34.9 NA NA NA
LEU M:141 M:384 93.0 0.547 H -74.3 -27.5 NA NA NA
4k4i 1 Q9UGP5 100.0 0.0 X-RAY
 2014-07-16 LEU A:141 A:384 84.0 0.494 H -70.7 -29.0 84.0 0.494 0.0 1RY
CA
HOH
 8.632
9.019
3.464
 O
CD1
CD1
 OAG
CA
O
LEU E:141 E:384 84.0 0.494 H -89.9 -11.4 NA NA NA
LEU I:141 I:384 95.0 0.559 H -70.5 -30.8 NA NA NA
LEU M:141 M:384 94.0 0.553 H -73.7 -22.1 NA NA NA
3hx0 1 Q9UGP5 98.8 0.0 X-RAY
 2009-08-25 LEU A:144 A:384 81.0 0.476 H -84.2 -25.0 81.0 0.476 0.0 D3T
HOH
 9.407
4.078
 O
C
 O2G
O
LEU E:144 F:384 86.0 0.506 H -76.3 -27.1 NA NA NA
LEU I:144 K:384 83.0 0.488 H -79.3 -12.6 NA NA NA
LEU M:144 P:384 89.0 0.524 H -44.4 -36.8 NA NA NA
5dkw 1 Q9UGP5 100.0 0.0 X-RAY
 2016-02-24 LEU A:136 A:384 93.0 0.547 H -84.0 -20.4 93.0 0.547 0.0 DTP
HOH
 9.344
3.953
 O
CB
 O2G
O
LEU B:136 B:384 95.0 0.559 H -94.8 -23.5 NA NA NA
5cb1 1 Q9UGP5 100.0 0.0 X-RAY
 2016-02-24 LEU A:135 A:384 37.0 0.218 H -70.7 -29.7 37.0 0.218 0.0
LEU B:135 B:384 87.0 0.512 S -69.9 -36.1 NA NA NA
4x5v 1 Q9UGP5 100.0 0.0 X-RAY
 2015-10-28 LEU A:134 A:384 93.0 0.547 H -85.4 -14.5 93.0 0.547 0.0 MG
CIT
HOH
 8.734
7.052
3.563
 CD2
O
CG
 MG
O1
O
4xa5 1 Q9UGP5 100.0 0.0 X-RAY
 2016-02-10 LEU A:134 A:384 89.0 0.524 H -88.6 -13.5 89.0 0.524 0.0 8DG
MG
HOH
 8.804
8.599
3.603
 O
CD2
CG
 O3G
MG
O
4xus 1 Q9UGP5 100.0 0.0 X-RAY
 2016-02-03 LEU A:134 A:384 96.0 0.565 H -93.0 0.7 96.0 0.565 0.0 DA
TTP
MG
HOH
 9.909
9.092
8.194
3.627
 CD2
O
CD2
CG
 OP1
O3G
MG
O
5cwr 1 Q9UGP5 99.69 0.0 X-RAY
 2016-02-24 LEU A:135 A:384 89.0 0.524 H -78.9 -22.7 89.0 0.524 0.0 DCP
HOH
 8.738
3.532
 O
CD2
 O3G
O
LEU D:135 B:384 88.0 0.518 H -73.1 -32.6 NA NA NA
3mda 1 Q9UGP5 100.0 0.0 X-RAY
 2010-04-28 LEU A:134 A:384 90.0 0.529 G -97.1 -8.8 90.0 0.529 0.0 PPV
NA
HOH
 8.606
8.564
2.701
 O
CD2
O
 O32
NA
O
3mdc 1 Q9UGP5 100.0 0.0 X-RAY
 2010-04-28 LEU A:134 A:384 97.0 0.571 G -102.8 0.6 97.0 0.571 0.0 GTF
NA
HOH
 8.670
8.458
3.585
 O
CD2
CG
 O2G
NA
O
3mgh 1 Q9UGP5 97.6 0.0 X-RAY
 2010-05-19 LEU A:143 A:384 87.0 0.512 H -83.0 -27.6 87.0 0.512 0.0 NA
HOH
 8.508
3.634
 CD2
CG
 NA
O
LEU E:143 C:384 78.0 0.459 G -99.6 -28.6 NA NA NA
3mgi 1 Q9UGP5 97.6 0.0 X-RAY
 2010-05-19 LEU A:143 A:384 86.0 0.506 G -93.5 -12.5 86.0 0.506 0.0 DA
D3T
NA
HOH
 9.737
8.608
7.430
3.485
 CD2
O
CD2
CG
 OP1
O2G
NA
O
3pml 1 Q9UGP5 97.6 0.0 X-RAY
 2011-01-26 LEU A:143 A:384 81.0 0.476 H -95.3 -14.3 81.0 0.476 0.0 1GC
NA
HOH
 9.149
8.218
3.576
 O
CD2
CG
 O2G
NA
O
LEU B:143 B:384 86.0 0.506 S -89.0 -3.7 NA NA NA
3pmn 1 Q9UGP5 97.6 0.0 X-RAY
 2011-02-02 LEU A:143 A:384 81.0 0.476 G -90.2 -13.7 81.0 0.476 0.0 1GC
NA
MN
HOH
 9.475
8.749
9.874
3.724
 O
CD2
N
CD2
 O2G
NA
MN
O
3pnc 1 Q9UGP5 97.6 0.0 X-RAY
 2011-02-02 LEU A:143 A:384 79.0 0.465 H -90.0 -13.5 79.0 0.465 0.0 1GC
NA
TRS
HOH
 9.122
8.405
7.254
3.616
 O
CD2
N
CG
 O2G
NA
C3
O
3upq 1 Q9UGP5 97.6 0.0 X-RAY
 2012-05-23 LEU A:143 A:384 93.0 0.547 H -84.7 -11.6 93.0 0.547 0.0 ZAN
MN
NA
HOH
 9.051
9.819
8.428
3.534
 O
N
CD2
CD2
 O1G
MN
NA
O
3uq0 1 Q9UGP5 97.6 0.0 X-RAY
 2012-05-23 LEU A:143 A:384 93.0 0.547 H -85.3 -8.7 93.0 0.547 0.0 DC
NA
SO4
HOH
 9.138
8.456
8.754
3.593
 CD2
CD2
O
CG
 OP2
NA
O4
O
3uq2 1 Q9UGP5 97.31 0.0 X-RAY
 2012-05-23 LEU A:143 A:384 96.0 0.565 T -86.3 -0.9 96.0 0.565 0.0 PPV
NA
HOH
 9.097
8.693
3.702
 O
CD2
CG
 O12
NA
O
4fo6 1 Q9UGP5 97.31 0.0 X-RAY
 2012-07-11 LEU A:143 A:384 92.0 0.541 G -92.8 -5.1 92.0 0.541 0.0 DA
NA
F2A
HOH
 9.735
8.217
9.110
3.552
 CD2
CD2
O
CG
 OP1
NA
O1G
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-q9ugp5-f1 1 Q9UGP5 100.0 0.0 LEU A:384 A:384 86.0 0.506 H -84.8 -26.6