Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr10 | 103343386 | . | T | A | CCDS7513.1:NM_001174084.1:c.944gAg>gTg_NP_001167555.1:p.315E>V | Homo sapiens DNA polymerase lambda (POLL), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 4xq8 | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2016-02-24 | GLU | A:74 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLU | B:74 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 5ca7 | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2016-02-24 | GLU | A:74 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLU | B:74 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 5iii | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2016-08-17 | GLU | A:74 | A:315 | 70.0 | 0.368 | H | -90.5 | -37.3 | 70.0 | 0.368 | 0.0 |
DG |
9.569 |
OE2 |
OP3 |
||
| 5iij | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2016-08-17 | GLU | A:74 | A:315 | 74.0 | 0.389 | H | -68.8 | -34.3 | 74.0 | 0.389 | 0.0 |
DG HOH |
9.687 2.704 |
OE2 OE1 |
OP3 O |
||
| 5iik | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2016-08-17 | GLU | A:74 | A:315 | 69.0 | 0.363 | H | -68.2 | -39.9 | 69.0 | 0.363 | 0.0 |
DG HOH |
9.503 2.745 |
OE2 OE2 |
OP2 O |
||
| 5iil | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2016-08-17 | GLU | A:74 | A:315 | 64.0 | 0.337 | H | -53.4 | -45.3 | 64.0 | 0.337 | 0.0 |
DG HOH |
9.443 2.958 |
OE2 OE2 |
OP2 O |
||
| 5iim | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2016-09-07 | GLU | A:74 | A:315 | 66.0 | 0.347 | H | -62.8 | -42.5 | 66.0 | 0.347 | 0.0 |
DG HOH |
9.307 2.987 |
OE1 OE2 |
OP3 O |
||
| 5iin | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2016-08-17 | GLU | A:74 | A:315 | 62.0 | 0.326 | H | -61.2 | -40.4 | 62.0 | 0.326 | 0.0 |
DG |
9.561 |
OE2 |
OP3 |
||
| 5iio | 4 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2016-08-17 | GLU | M:74 | A:315 | 36.0 | 0.189 | H | -61.2 | -44.1 | 36.0 | 0.189 | 0.0 |
DG HOH |
9.629 2.543 |
OE1 OE1 |
OP3 O |
||
| GLU | N:74 | E:315 | 43.0 | 0.226 | H | -68.5 | -44.4 | NA | NA | NA | |||||||||||||
| GLU | O:74 | I:315 | 32.0 | 0.168 | H | -64.1 | -42.3 | NA | NA | NA | |||||||||||||
| GLU | P:74 | M:315 | 34.0 | 0.179 | H | -59.7 | -45.7 | NA | NA | NA | |||||||||||||
| 1xsl | 4 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2005-01-18 | GLU | M:75 | A:315 | 65.0 | 0.342 | H | -63.1 | -43.8 | 65.0 | 0.342 | 0.0 |
DG HOH |
9.719 2.623 |
OE1 OE1 |
OP3 O |
||
| GLU | N:75 | E:315 | 61.0 | 0.321 | H | -67.7 | -42.7 | NA | NA | NA | |||||||||||||
| GLU | O:75 | I:315 | 70.0 | 0.368 | H | -71.2 | -42.8 | NA | NA | NA | |||||||||||||
| GLU | P:75 | M:315 | 35.0 | 0.184 | H | -61.8 | -34.9 | NA | NA | NA | |||||||||||||
| 2bcq | 4 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2006-03-07 | GLU | D:75 | A:315 | 30.0 | 0.158 | H | -60.3 | -26.3 | 30.0 | 0.158 | 0.0 |
DG HOH |
9.785 3.250 |
OE2 OE2 |
OP3 O |
||
| 2bcr | 4 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2006-03-07 | GLU | D:75 | A:315 | 61.0 | 0.321 | H | -59.3 | -37.9 | 61.0 | 0.321 | 0.0 |
HOH |
2.740 |
OE1 |
O |
||
| 2bcs | 4 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2006-03-07 | GLU | D:75 | A:315 | 57.0 | 0.3 | H | -43.5 | -66.2 | 57.0 | 0.3 | 0.0 | ||||||
| 2bcu | 4 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2006-03-07 | GLU | D:75 | A:315 | 62.0 | 0.326 | H | -48.2 | -28.4 | 62.0 | 0.326 | 0.0 |
HOH |
6.794 |
OE2 |
O |
||
| 2bcv | 4 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2006-03-07 | GLU | D:75 | A:315 | 62.0 | 0.326 | H | -60.0 | -39.4 | 62.0 | 0.326 | 0.0 |
HOH |
2.790 |
OE1 |
O |
||
| 2gws | 4 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2006-09-05 | GLU | M:75 | A:315 | 69.0 | 0.363 | H | -66.9 | -42.0 | 69.0 | 0.363 | 0.0 |
DG HOH |
9.601 3.882 |
OE1 N |
OP3 O |
||
| GLU | N:75 | E:315 | 36.0 | NA | H | -64.5 | -32.9 | NA | NA | NA | |||||||||||||
| GLU | O:75 | I:315 | 62.0 | 0.326 | H | -68.2 | -45.4 | NA | NA | NA | |||||||||||||
| GLU | P:75 | M:315 | 41.0 | 0.216 | H | -54.8 | -41.0 | NA | NA | NA | |||||||||||||
| 4xrh | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2016-02-24 | GLU | A:75 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLU | B:75 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 5ddm | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2016-02-24 | GLU | A:75 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLU | B:75 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 5ddy | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2016-02-24 | GLU | A:75 | A:315 | 58.0 | 0.305 | H | -56.4 | -46.0 | 58.0 | 0.305 | 0.0 |
MN HOH |
6.896 3.690 |
OE2 OE1 |
MN O |
||
| GLU | B:75 | C:315 | 75.0 | 0.395 | H | -54.7 | -35.8 | NA | NA | NA | |||||||||||||
| GLU | C:75 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| GLU | D:75 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 3c5g | 1 | Q9UGP5 | 99.7 | 0.0 |
X-RAY |
2008-07-29 | GLU | A:75 | A:315 | 38.0 | 0.2 | H | -59.6 | -45.4 | 38.0 | 0.2 | 0.0 |
DG HOH |
9.806 2.621 |
OE2 OE1 |
OP3 O |
||
| GLU | E:75 | B:315 | 30.0 | 0.158 | H | -61.0 | -39.7 | NA | NA | NA | |||||||||||||
| 5chg | 1 | Q9UGP5 | 99.7 | 0.0 |
X-RAY |
2016-02-24 | GLU | A:74 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLU | B:74 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 5cj7 | 1 | Q9UGP5 | 99.7 | 0.0 |
X-RAY |
2016-02-24 | GLU | A:74 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLU | B:74 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 5cp2 | 1 | Q9UGP5 | 99.7 | 0.0 |
X-RAY |
2016-02-24 | GLU | A:74 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLU | B:74 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 5cr0 | 1 | Q9UGP5 | 99.7 | 0.0 |
X-RAY |
2016-02-24 | GLU | A:74 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| GLU | B:74 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 3c5f | 4 | Q9UGP5 | 99.7 | 0.0 |
X-RAY |
2008-09-02 | GLU | G:75 | A:315 | 36.0 | 0.189 | H | -58.0 | -44.0 | 36.0 | 0.189 | 0.0 |
DG HOH |
9.754 2.735 |
OE2 OE2 |
OP3 O |
||
| GLU | H:75 | B:315 | 33.0 | 0.174 | H | -58.8 | -40.3 | NA | NA | NA | |||||||||||||
| 1xsn | 4 | Q9UGP5 | 99.7 | 0.0 |
X-RAY |
2005-01-18 | GLU | D:75 | A:315 | 65.0 | 0.342 | T | -81.9 | -15.6 | 65.0 | 0.342 | 0.0 | ||||||
| 1xsp | 4 | Q9UGP5 | 99.7 | 0.0 |
X-RAY |
2005-01-18 | GLU | D:75 | A:315 | 59.0 | 0.311 | H | -42.8 | -41.5 | 59.0 | 0.311 | 0.0 |
DG HOH |
9.155 6.026 |
OE2 O |
OP3 O |
||
| 2pfn | 4 | Q9UGP5 | 99.7 | 0.0 |
X-RAY |
2007-05-15 | GLU | D:75 | A:315 | 66.0 | 0.347 | H | -60.5 | -31.2 | 66.0 | 0.347 | 0.0 |
DG HOH |
9.868 2.954 |
OE2 OE2 |
OP3 O |
||
| 2pfo | 4 | Q9UGP5 | 99.7 | 0.0 |
X-RAY |
2007-05-15 | GLU | D:75 | A:315 | 59.0 | 0.311 | H | -52.5 | -30.9 | 59.0 | 0.311 | 0.0 |
DG HOH |
9.743 7.432 |
OE2 O |
OP3 O |
||
| 2pfp | 4 | Q9UGP5 | 99.7 | 0.0 |
X-RAY |
2007-05-15 | GLU | D:75 | A:315 | 69.0 | 0.363 | H | -54.7 | -28.6 | 69.0 | 0.363 | 0.0 |
DG HOH |
9.757 2.816 |
OE1 OE1 |
OP3 O |
||
| 2pfq | 4 | Q9UGP5 | 99.7 | 0.0 |
X-RAY |
2007-05-15 | GLU | D:75 | A:315 | 29.0 | 0.153 | I | -44.8 | -42.9 | 29.0 | 0.153 | 0.0 |
DG HOH |
9.330 4.154 |
OE2 OE2 |
OP3 O |
||
| 3hw8 | 1 | Q9UGP5 | 99.7 | 0.0 |
X-RAY |
2009-08-25 | GLU | A:75 | A:315 | 57.0 | 0.3 | H | -72.9 | -31.7 | 57.0 | 0.3 | 0.0 | ||||||
| 3hwt | 1 | Q9UGP5 | 99.7 | 0.0 |
X-RAY |
2009-08-25 | GLU | A:75 | A:315 | 68.0 | 0.358 | H | -93.3 | -43.9 | 68.0 | 0.358 | 0.0 | ||||||
| 1rzt | 4 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2004-03-02 | GLU | M:71 | A:315 | 67.0 | 0.353 | H | -60.3 | -51.0 | 67.0 | 0.353 | 0.0 |
DG HOH |
9.549 2.712 |
OE1 OE1 |
OP3 O |
||
| GLU | N:71 | E:315 | 71.0 | 0.374 | H | -62.5 | -44.0 | NA | NA | NA | |||||||||||||
| GLU | O:71 | I:315 | 76.0 | 0.4 | H | -73.0 | -42.8 | NA | NA | NA | |||||||||||||
| GLU | P:71 | M:315 | 32.0 | 0.168 | H | -61.9 | -43.2 | NA | NA | NA | |||||||||||||
| 4k4g | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2014-07-16 | GLU | A:72 | A:315 | 43.0 | 0.226 | H | -37.3 | -51.7 | 43.0 | 0.226 | 0.0 |
HOH |
3.048 |
OE1 |
O |
||
| GLU | E:72 | E:315 | 59.0 | 0.311 | H | -64.6 | -43.2 | NA | NA | NA | |||||||||||||
| GLU | I:72 | I:315 | 43.0 | 0.226 | H | -69.3 | -30.7 | NA | NA | NA | |||||||||||||
| GLU | M:72 | M:315 | 34.0 | 0.179 | H | -60.6 | -50.9 | NA | NA | NA | |||||||||||||
| 4k4h | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2014-07-16 | GLU | A:72 | A:315 | 36.0 | 0.189 | H | -39.5 | -47.9 | 36.0 | 0.189 | 0.0 |
HOH |
3.407 |
OE1 |
O |
||
| GLU | E:72 | E:315 | 32.0 | 0.168 | H | -60.2 | -44.7 | NA | NA | NA | |||||||||||||
| GLU | I:72 | I:315 | 51.0 | 0.268 | H | -59.4 | -40.0 | NA | NA | NA | |||||||||||||
| GLU | M:72 | M:315 | 29.0 | 0.153 | H | -59.3 | -45.1 | NA | NA | NA | |||||||||||||
| 4k4i | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2014-07-16 | GLU | A:72 | A:315 | 43.0 | 0.226 | H | -33.6 | -47.7 | 43.0 | 0.226 | 0.0 |
DG HOH |
9.714 2.426 |
OE1 CG |
OP3 O |
||
| GLU | E:72 | E:315 | 57.0 | 0.3 | H | -59.0 | -47.1 | NA | NA | NA | |||||||||||||
| GLU | I:72 | I:315 | 48.0 | 0.253 | H | -61.8 | -36.0 | NA | NA | NA | |||||||||||||
| GLU | M:72 | M:315 | 32.0 | 0.168 | H | -60.0 | -44.4 | NA | NA | NA | |||||||||||||
| 3hx0 | 1 | Q9UGP5 | 98.8 | 0.0 |
X-RAY |
2009-08-25 | GLU | A:75 | A:315 | 73.0 | 0.384 | H | -62.5 | -50.5 | 73.0 | 0.384 | 0.0 |
DG |
9.814 |
OE2 |
OP3 |
||
| GLU | E:75 | F:315 | 68.0 | 0.358 | H | -57.3 | -25.1 | NA | NA | NA | |||||||||||||
| GLU | I:75 | K:315 | 59.0 | 0.311 | H | -59.0 | -23.8 | NA | NA | NA | |||||||||||||
| GLU | M:75 | P:315 | 77.0 | 0.405 | H | -66.9 | 9.1 | NA | NA | NA | |||||||||||||
| 5dkw | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2016-02-24 | GLU | A:67 | A:315 | 34.0 | 0.179 | H | -64.4 | -38.8 | 34.0 | 0.179 | 0.0 |
DG HOH |
9.967 8.274 |
OE1 OE2 |
OP1 O |
||
| GLU | B:67 | B:315 | 30.0 | 0.158 | H | -63.7 | -43.1 | NA | NA | NA | |||||||||||||
| 5cb1 | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2016-02-24 | GLU | A:66 | A:315 | 70.0 | 0.368 | H | -54.2 | -44.1 | 70.0 | 0.368 | 0.0 | ||||||
| GLU | B:66 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 4x5v | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2015-10-28 | GLU | A:65 | A:315 | 73.0 | 0.384 | H | -66.4 | -34.3 | 73.0 | 0.384 | 0.0 |
DG |
9.377 |
OE1 |
OP3 |
||
| 4xa5 | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2016-02-10 | GLU | A:65 | A:315 | 78.0 | 0.411 | H | -69.3 | -45.4 | 78.0 | 0.411 | 0.0 |
DG HOH |
9.613 3.186 |
OE2 OE2 |
OP3 O |
||
| 4xus | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2016-02-03 | GLU | A:65 | A:315 | 67.0 | 0.353 | H | -71.9 | -42.8 | 67.0 | 0.353 | 0.0 |
HOH |
7.235 |
O |
O |
||
| 5cwr | 1 | Q9UGP5 | 99.69 | 0.0 |
X-RAY |
2016-02-24 | GLU | A:66 | A:315 | 36.0 | 0.189 | H | -62.3 | -45.1 | 36.0 | 0.189 | 0.0 |
DG HOH |
9.579 2.402 |
OE1 OE1 |
OP1 O |
||
| GLU | D:66 | B:315 | 35.0 | 0.184 | H | -54.7 | -48.2 | NA | NA | NA | |||||||||||||
| 3mda | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2010-04-28 | GLU | A:65 | A:315 | 31.0 | 0.163 | H | -65.7 | -29.6 | 31.0 | 0.163 | 0.0 |
DG HOH |
9.635 3.098 |
OE2 OE2 |
OP3 O |
||
| 3mdc | 1 | Q9UGP5 | 100.0 | 0.0 |
X-RAY |
2010-04-28 | GLU | A:65 | A:315 | 66.0 | 0.347 | H | -80.0 | -27.6 | 66.0 | 0.347 | 0.0 |
DG HOH |
9.526 7.300 |
OE2 O |
OP2 O |
||
| 3mgh | 1 | Q9UGP5 | 97.6 | 0.0 |
X-RAY |
2010-05-19 | GLU | A:74 | A:315 | 50.0 | 0.263 | H | -57.9 | -44.9 | 50.0 | 0.263 | 0.0 |
HOH |
2.640 |
OE2 |
O |
||
| GLU | E:74 | C:315 | 33.0 | 0.174 | H | -57.8 | -47.8 | NA | NA | NA | |||||||||||||
| 3mgi | 1 | Q9UGP5 | 97.6 | 0.0 |
X-RAY |
2010-05-19 | GLU | A:74 | A:315 | 68.0 | 0.358 | H | -63.7 | -29.2 | 68.0 | 0.358 | 0.0 |
DG |
9.390 |
OE1 |
OP3 |
||
| 3pml | 1 | Q9UGP5 | 97.6 | 0.0 |
X-RAY |
2011-01-26 | GLU | A:74 | A:315 | 52.0 | 0.274 | H | -51.8 | -34.1 | 52.0 | 0.274 | 0.0 |
HOH |
7.080 |
O |
O |
||
| GLU | B:74 | B:315 | 34.0 | 0.179 | H | -50.1 | -40.4 | NA | NA | NA | |||||||||||||
| 3pmn | 1 | Q9UGP5 | 97.6 | 0.0 |
X-RAY |
2011-02-02 | GLU | A:74 | A:315 | 55.0 | 0.289 | H | -45.1 | -32.7 | 55.0 | 0.289 | 0.0 |
HOH |
7.029 |
OE2 |
O |
||
| 3pnc | 1 | Q9UGP5 | 97.6 | 0.0 |
X-RAY |
2011-02-02 | GLU | A:74 | A:315 | 66.0 | 0.347 | H | -52.0 | -32.5 | 66.0 | 0.347 | 0.0 |
HOH |
2.854 |
OE1 |
O |
||
| 3upq | 1 | Q9UGP5 | 97.6 | 0.0 |
X-RAY |
2012-05-23 | GLU | A:74 | A:315 | 75.0 | 0.395 | H | -78.7 | -34.8 | 75.0 | 0.395 | 0.0 |
DG |
9.872 |
OE1 |
OP3 |
||
| 3uq0 | 1 | Q9UGP5 | 97.6 | 0.0 |
X-RAY |
2012-05-23 | GLU | A:74 | A:315 | 69.0 | 0.363 | H | -65.3 | -35.3 | 69.0 | 0.363 | 0.0 |
DG |
9.954 |
OE1 |
OP3 |
||
| 3uq2 | 1 | Q9UGP5 | 97.31 | 0.0 |
X-RAY |
2012-05-23 | GLU | A:74 | A:315 | 65.0 | 0.342 | H | -60.3 | -39.1 | 65.0 | 0.342 | 0.0 |
DG |
9.476 |
OE1 |
OP3 |
||
| 4fo6 | 1 | Q9UGP5 | 97.31 | 0.0 |
X-RAY |
2012-07-11 | GLU | A:74 | A:315 | 72.0 | 0.379 | H | -64.3 | -41.4 | 72.0 | 0.379 | 0.0 |
DG HOH |
9.039 2.766 |
OE1 OE2 |
OP3 O |
||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-q9ugp5-f1 | 1 | Q9UGP5 | 100.0 | 0.0 | GLU | A:315 | A:315 | 36.0 | 0.189 | H | -54.5 | -41.3 | |