Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr10 | 126094111 | . | G | A | CCDS7639.1:NM_000274.3:c.542aCg>aTg_NP_000265.1:p.181T>M | Homo sapiens ornithine aminotransferase (OAT), transcript variant 1, mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1oat | 1 | P04181 | 100.0 | 0.0 |
X-RAY |
1998-04-01 | THR | A:181 | A:181 | 48.0 | 0.343 | S | -69.6 | 168.7 | 6.0 | 0.043 | 0.3 |
B:P04181:0.3 |
PLP PLP HOH |
7.344 9.944 3.952 |
CG2 CG2 CG2 |
O2P O2P O |
|
| THR | B:181 | B:181 | 48.0 | 0.343 | S | -71.8 | 168.8 | 6.0 | 0.043 | 0.3 |
A:P04181:0.3 |
PLP PLP HOH |
9.977 7.401 3.816 |
CG2 CG2 CA |
O2P O2P O |
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| THR | C:181 | C:181 | 48.0 | 0.343 | S | -74.0 | 168.0 | NA | NA | NA | |||||||||||||
| 2oat | 1 | P04181 | 100.0 | 0.0 |
X-RAY |
1998-12-09 | THR | A:181 | A:181 | 44.0 | 0.314 | S | -72.3 | 169.0 | NA | NA | NA | ||||||
| THR | B:181 | B:181 | 43.0 | 0.307 | S | -71.2 | 166.8 | NA | NA | NA | |||||||||||||
| THR | C:181 | C:181 | 45.0 | 0.321 | S | -66.0 | 167.1 | 45.0 | 0.321 | 0.0 |
PFM PFM HOH |
7.006 7.006 4.453 |
N N CB |
OP1 OP1 O |
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| 2byj | 1 | P04181 | 99.77 | 0.0 |
X-RAY |
2005-09-07 | THR | A:181 | A:181 | 45.0 | 0.321 | S | -69.0 | 163.4 | 5.0 | 0.036 | 0.285 |
B:P04181:0.286 |
PLP PLP HOH |
7.355 9.879 8.809 |
N CG2 N |
O2P O2P O |
|
| THR | B:181 | B:181 | 44.0 | 0.314 | S | -68.9 | 163.8 | 3.0 | 0.021 | 0.293 |
A:P04181:0.293 |
PLP HOH |
7.373 8.795 |
N O |
O2P O |
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| THR | C:181 | C:181 | 45.0 | 0.321 | S | -68.2 | 164.0 | NA | NA | NA | |||||||||||||
| 2byl | 1 | P04181 | 99.32 | 0.0 |
X-RAY |
2005-09-07 | THR | A:181 | A:181 | 45.0 | 0.321 | S | -66.0 | 167.6 | 6.0 | 0.043 | 0.278 |
B:P04181:0.279 |
PLP HOH |
7.426 3.740 |
CG2 CB |
O2P O |
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| THR | B:181 | B:181 | 44.0 | 0.314 | S | -68.9 | 166.6 | 5.0 | 0.036 | 0.278 |
A:P04181:0.279 |
PLP HOH |
7.350 3.768 |
CG2 CB |
O2P O |
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| THR | C:181 | C:181 | 43.0 | 0.307 | S | -67.4 | 164.1 | NA | NA | NA | |||||||||||||
| 6hx7 | 1 | P04181 | 99.76 | 0.0 |
X-RAY |
2019-06-05 | THR | A:157 | A:181 | 44.0 | 0.314 | S | -67.3 | 168.0 | 4.0 | 0.029 | 0.285 |
A:P04181:0.286 |
PLP HOH |
7.414 3.785 |
N CB |
O3P O |
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| THR | B:157 | B:181 | 42.0 | 0.3 | S | -67.1 | 167.0 | NA | NA | NA | |||||||||||||
| THR | C:157 | C:181 | 46.0 | 0.329 | S | -68.9 | 167.4 | NA | NA | NA | |||||||||||||
| 5vwo | 1 | P04181 | 100.0 | 0.0 |
X-RAY |
2017-08-30 | THR | A:146 | A:181 | 46.0 | 0.329 | S | -67.9 | 167.5 | 5.0 | 0.036 | 0.293 |
B:P04181:0.293 |
9QJ HOH |
7.291 3.731 |
CG2 CB |
O2P O |
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| THR | B:146 | B:181 | 46.0 | 0.329 | S | -66.6 | 167.5 | 5.0 | 0.036 | 0.293 |
A:P04181:0.293 |
9QJ 9QJ HOH |
9.911 7.323 3.637 |
CG2 N CB |
O2P O2P O |
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| THR | C:146 | C:181 | 44.0 | 0.314 | S | -65.6 | 163.0 | 44.0 | 0.314 | 0.0 |
9QJ HOH |
7.304 3.772 |
CG2 CB |
O2P O |
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| 6oia | 1 | P04181 | 100.0 | 0.0 |
X-RAY |
2019-09-18 | THR | A:146 | A:181 | 45.0 | 0.321 | S | -62.8 | 168.7 | 5.0 | 0.036 | 0.285 |
B:P04181:0.286 |
PLP PLP HOH |
7.225 9.932 3.761 |
CG2 CG2 CB |
O2P O2P O |
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| THR | B:146 | B:181 | 45.0 | 0.321 | S | -66.0 | 167.4 | 5.0 | 0.036 | 0.285 |
A:P04181:0.286 |
PLP PLP MQ4 HOH |
9.949 7.260 9.935 3.711 |
CG2 CG2 N CB |
O2P O2P C2 O |
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| THR | C:146 | C:181 | 44.0 | 0.314 | S | -64.7 | 166.2 | NA | NA | NA | |||||||||||||
| 6v8c | 1 | P04181 | 100.0 | 0.0 |
X-RAY |
2020-12-16 | THR | A:146 | A:181 | 46.0 | 0.329 | S | -63.3 | 169.9 | 5.0 | 0.036 | 0.293 |
A:P04181:0.293 |
PLP QRM PLP HOH |
7.172 9.289 9.802 3.615 |
CG2 N CG2 N |
O3P O9 O3P O |
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| THR | B:146 | B:181 | 47.0 | 0.336 | S | -64.9 | 169.3 | NA | NA | NA | |||||||||||||
| THR | C:146 | C:181 | 46.0 | 0.329 | S | -63.6 | 169.5 | NA | NA | NA | |||||||||||||
| 6v8d | 1 | P04181 | 100.0 | 0.0 |
X-RAY |
2020-12-16 | THR | A:146 | A:181 | 48.0 | 0.343 | S | -64.0 | 169.9 | 5.0 | 0.036 | 0.307 |
B:P04181:0.307 |
PLP O78 PLP HOH |
7.303 8.132 9.895 3.859 |
CG2 N CG2 CB |
O1P O8 O3P O |
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| THR | B:146 | B:181 | 48.0 | 0.343 | S | -69.1 | 172.2 | 5.0 | 0.036 | 0.307 |
A:P04181:0.307 |
PLP PLP O78 HOH |
9.875 7.267 7.863 3.718 |
CG2 CG2 N CB |
O1P O3P O9 O |
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| THR | C:146 | C:181 | 46.0 | 0.329 | S | -66.5 | 169.4 | NA | NA | NA | |||||||||||||
| 7jx9 | 1 | P04181 | 100.0 | 0.0 |
X-RAY |
2021-01-06 | THR | A:146 | A:181 | 45.0 | 0.321 | S | -67.1 | 166.1 | 6.0 | 0.043 | 0.278 |
A:P04181:0.279 |
IF1 VLS IF1 HOH |
7.180 9.987 9.818 3.690 |
N O CG2 CB |
O17 O05 O17 O |
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| THR | B:146 | B:181 | 46.0 | 0.329 | S | -68.4 | 166.3 | NA | NA | NA | |||||||||||||
| THR | C:146 | C:181 | 46.0 | 0.329 | S | -65.4 | 167.7 | NA | NA | NA | |||||||||||||
| 7lnm | 1 | P04181 | 100.0 | 0.0 |
X-RAY |
2021-08-25 | THR | A:146 | B:181 | 43.0 | 0.307 | S | -66.7 | 166.5 | 6.0 | 0.043 | 0.264 |
B:P04181:0.264 |
Y7S HOH |
7.162 3.720 |
CG2 CB |
O43 O |
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| THR | B:146 | C:181 | 46.0 | 0.329 | S | -63.8 | 164.7 | 6.0 | 0.043 | 0.286 |
A:P04181:0.286 |
Y7S Y7S HOH |
9.948 7.140 3.927 |
CG2 CG2 CB |
O43 O42 O |
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| THR | C:146 | E:181 | 45.0 | 0.321 | S | -67.1 | 167.2 | NA | NA | NA | |||||||||||||
| THR | D:146 | F:181 | 47.0 | 0.336 | S | -64.8 | 166.4 | NA | NA | NA | |||||||||||||
| THR | E:146 | I:181 | 45.0 | 0.321 | S | -68.5 | 169.5 | NA | NA | NA | |||||||||||||
| THR | F:146 | J:181 | 45.0 | 0.321 | S | -67.9 | 168.8 | NA | NA | NA | |||||||||||||
| 7lom | 1 | P04181 | 100.0 | 0.0 |
X-RAY |
2021-08-25 | THR | A:146 | A:181 | 44.0 | 0.314 | S | -72.0 | 172.6 | 4.0 | 0.029 | 0.285 |
A:P04181:0.286 |
Y8P Y8P HOH |
7.302 9.915 3.789 |
CG2 CG2 CB |
O44 O44 O |
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| THR | B:146 | B:181 | 46.0 | 0.329 | S | -67.8 | 167.7 | NA | NA | NA | |||||||||||||
| THR | C:146 | C:181 | 46.0 | 0.329 | S | -67.4 | 174.0 | NA | NA | NA | |||||||||||||
| 7lon | 1 | P04181 | 100.0 | 0.0 |
X-RAY |
2021-08-25 | THR | A:146 | B:181 | 50.0 | 0.357 | S | -64.9 | 169.6 | 5.0 | 0.036 | 0.321 |
A:P04181:0.321 |
7QP 7QP HOH |
7.359 9.860 3.715 |
N CG2 CB |
O44 O44 O |
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| THR | B:146 | A:181 | 48.0 | 0.343 | S | -65.8 | 168.4 | NA | NA | NA | |||||||||||||
| THR | C:146 | C:181 | 50.0 | 0.357 | S | -64.0 | 167.1 | NA | NA | NA | |||||||||||||
| 1gbn | 1 | P04181 | 100.0 | 0.0 |
X-RAY |
1998-06-03 | THR | A:144 | A:181 | 48.0 | 0.343 | S | -77.2 | 162.6 | 6.0 | 0.043 | 0.3 |
B:P04181:0.3 |
GAB PLP PLP HOH |
8.927 6.835 9.907 3.354 |
H H CG2 CB |
O1' O1P O1P O |
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| THR | B:144 | B:181 | 48.0 | 0.343 | S | -76.9 | 163.0 | 6.0 | 0.043 | 0.3 |
A:P04181:0.3 |
PLP GBC PLP HOH |
9.978 8.737 6.973 3.717 |
CG2 H H CB |
O1P O2 O1P O |
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| THR | C:144 | C:181 | 48.0 | 0.343 | S | -77.0 | 163.1 | 48.0 | 0.343 | 0.0 |
GBC PLP HOH |
9.087 6.758 4.383 |
H H CB |
O1 O1P O |
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| 2can | 1 | P04181 | 100.0 | 0.0 |
X-RAY |
1998-06-03 | THR | A:144 | A:181 | 48.0 | 0.343 | S | -75.1 | 165.4 | 7.0 | 0.05 | 0.293 |
B:P04181:0.293 |
CAN PLP HOH |
7.598 6.942 3.650 |
H H CB |
O O1P O |
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| THR | B:144 | B:181 | 50.0 | 0.357 | S | -74.9 | 164.9 | 7.0 | 0.05 | 0.307 |
A:P04181:0.307 |
CAN PLP HOH |
7.652 6.873 3.744 |
H H CB |
O O1P O |
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| THR | C:144 | C:181 | 48.0 | 0.343 | S | -74.6 | 164.2 | NA | NA | NA | |||||||||||||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p04181-f1 | 1 | P04181 | 100.0 | 0.0 | THR | A:181 | A:181 | 46.0 | 0.329 | S | -71.8 | 165.3 | |