Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr10 | 131506228 | . | G | A | CCDS7660.2:NM_002412.3:c.288tgG>tgA_NP_002403.2:p.96W>* | Homo sapiens O-6-methylguanine-DNA methyltransferase (MGMT), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1eh6 | 1 | P16455 | 100.0 | 5e-151 |
X-RAY |
2000-04-12 | TRP | A:65 | A:65 | 18.0 | 0.071 | H | -66.5 | -46.2 | 18.0 | 0.071 | 0.0 |
HOH |
2.958 |
NE1 |
O |
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| 1eh7 | 1 | P16455 | 100.0 | 5e-151 |
X-RAY |
2000-04-12 | TRP | A:65 | A:65 | 20.0 | 0.078 | H | -64.0 | -49.8 | 20.0 | 0.078 | 0.0 |
HOH |
2.948 |
NE1 |
O |
||
| 1eh8 | 1 | P16455 | 100.0 | 5e-151 |
X-RAY |
2000-04-12 | TRP | A:65 | A:65 | 19.0 | 0.075 | H | -66.1 | -45.2 | 19.0 | 0.075 | 0.0 |
HOH |
3.093 |
NE1 |
O |
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| 1yfh | 3 | P16455 | 100.0 | 1e-130 |
X-RAY |
2005-12-13 | TRP | E:65 | A:65 | 23.0 | 0.09 | H | -50.1 | -54.8 | NA | NA | NA | ||||||
| TRP | F:65 | B:65 | 20.0 | 0.078 | H | -49.2 | -54.5 | NA | NA | NA | |||||||||||||
| TRP | G:65 | C:65 | 21.0 | 0.082 | H | -48.8 | -51.3 | 21.0 | 0.082 | 0.0 |
HOH |
8.445 |
CH2 |
O |
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| 1t39 | 3 | P16455 | 99.44 | 5e-129 |
X-RAY |
2004-07-13 | TRP | E:77 | A:65 | 22.0 | 0.086 | H | -54.6 | -46.2 | 22.0 | 0.086 | 0.0 | ||||||
| TRP | F:77 | B:65 | 21.0 | 0.082 | H | -55.1 | -47.0 | NA | NA | NA | |||||||||||||
| 1qnt | 1 | P16455 | 100.0 | 1e-128 |
X-RAY |
1999-12-16 | TRP | A:65 | A:65 | 16.0 | 0.063 | H | -63.9 | -51.4 | 16.0 | 0.063 | 0.0 |
HOH |
2.922 |
NE1 |
O |
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| 1t38 | 3 | P16455 | 98.88 | 6e-128 |
X-RAY |
2004-07-13 | TRP | C:77 | A:65 | 20.0 | 0.078 | H | -64.4 | -46.5 | 20.0 | 0.078 | 0.0 |
HOH |
8.699 |
CH2 |
O |
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| 3kzy | 1 | ? | 89.27 | 9e-112 |
X-RAY |
2010-12-15 | TRP | A:68 | A:65 | 20.0 | 0.078 | H | -62.9 | -46.0 | 20.0 | 0.078 | 0.0 |
HOH |
2.824 |
NE1 |
O |
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| TRP | B:68 | B:65 | 21.0 | 0.082 | H | -59.6 | -50.1 | NA | NA | NA | |||||||||||||
| 3l00 | 1 | ? | 89.27 | 9e-112 |
X-RAY |
2010-12-15 | TRP | A:68 | A:65 | 21.0 | 0.082 | H | -61.7 | -50.4 | 21.0 | 0.082 | 0.0 |
HOH |
2.871 |
NE1 |
O |
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| 6sc2 | 2 | E5BBQ0,B0I1S0 | 89.07 | 4e-111 |
EM |
2019-09-04 | TRP | B:65 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6sc2 | 1 | E5BBQ0,B0I1S0 | 89.07 | 4e-111 |
EM |
2019-09-04 | TRP | A:65 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6rla | 1 | E5BBQ0,B0I1S0 | 89.07 | 4e-111 |
EM |
2019-08-28 | TRP | A:65 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| TRP | B:65 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 6rlb | 1 | E5BBQ0,B0I1S0 | 89.07 | 4e-111 |
EM |
2019-08-28 | TRP | A:65 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| TRP | B:65 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 3kzz | 1 | ? | 88.7 | 7e-111 |
X-RAY |
2010-12-15 | TRP | A:68 | A:65 | 20.0 | 0.078 | H | -61.4 | -49.1 | 20.0 | 0.078 | 0.0 |
HOH |
3.047 |
NE1 |
O |
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| 6y8p | 1 | E5BBQ0 | 89.14 | 4e-110 |
X-RAY |
2021-03-31 | TRP | A:63 | A:65 | 22.0 | 0.086 | H | -61.0 | -45.8 | 22.0 | 0.086 | 0.0 |
HOH |
3.492 |
CH2 |
O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p16455-f1 | 1 | P16455 | 100.0 | 2e-151 | TRP | A:65 | A:65 | 19.0 | 0.075 | H | -62.4 | -45.2 | |