Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr10 | 131506283 | . | C | A | CCDS7660.2:NM_002412.3:c.343Ctt>Att_NP_002403.2:p.115L>I | Homo sapiens O-6-methylguanine-DNA methyltransferase (MGMT), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1eh6 | 1 | P16455 | 100.0 | 5e-151 |
X-RAY |
2000-04-12 | LEU | A:84 | A:84 | 31.0 | 0.182 | B | -108.4 | 135.0 | 31.0 | 0.182 | 0.0 |
ZN HOH |
6.768 2.854 |
C N |
ZN O |
||
| 1eh7 | 1 | P16455 | 100.0 | 5e-151 |
X-RAY |
2000-04-12 | LEU | A:84 | A:84 | 32.0 | 0.188 | B | -110.2 | 135.4 | 32.0 | 0.188 | 0.0 |
ZN HOH |
6.750 3.066 |
C N |
ZN O |
||
| 1eh8 | 1 | P16455 | 100.0 | 5e-151 |
X-RAY |
2000-04-12 | LEU | A:84 | A:84 | 31.0 | 0.182 | B | -100.2 | 137.0 | 31.0 | 0.182 | 0.0 |
ZN HOH |
6.757 3.874 |
C CG |
ZN O |
||
| 1yfh | 3 | P16455 | 100.0 | 1e-130 |
X-RAY |
2005-12-13 | LEU | E:84 | A:84 | 36.0 | 0.212 | B | -101.0 | 133.1 | NA | NA | NA | ||||||
| LEU | F:84 | B:84 | 33.0 | 0.194 | B | -96.4 | 131.8 | NA | NA | NA | |||||||||||||
| LEU | G:84 | C:84 | 40.0 | 0.235 | B | -99.5 | 131.7 | 40.0 | 0.235 | 0.0 |
ZN |
6.983 |
C |
ZN |
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| 1t39 | 3 | P16455 | 99.44 | 5e-129 |
X-RAY |
2004-07-13 | LEU | E:96 | A:84 | 26.0 | 0.153 | -96.9 | 83.9 | 26.0 | 0.153 | 0.0 | |||||||
| LEU | F:96 | B:84 | 24.0 | 0.141 | -97.7 | 82.7 | NA | NA | NA | ||||||||||||||
| 1qnt | 1 | P16455 | 100.0 | 1e-128 |
X-RAY |
1999-12-16 | LEU | A:84 | A:84 | 35.0 | 0.206 | B | -111.4 | 139.5 | 35.0 | 0.206 | 0.0 |
HOH |
2.924 |
N |
O |
||
| 1t38 | 3 | P16455 | 98.88 | 6e-128 |
X-RAY |
2004-07-13 | LEU | C:96 | A:84 | 36.0 | 0.212 | B | -97.9 | 123.2 | 36.0 | 0.212 | 0.0 | ||||||
| 3kzy | 1 | ? | 89.27 | 9e-112 |
X-RAY |
2010-12-15 | LEU | A:87 | A:84 | 28.0 | 0.165 | B | -120.5 | 132.6 | 28.0 | 0.165 | 0.0 |
ZN HOH |
6.715 3.001 |
C N |
ZN O |
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| LEU | B:87 | B:84 | 33.0 | 0.194 | B | -112.6 | 125.5 | NA | NA | NA | |||||||||||||
| 3l00 | 1 | ? | 89.27 | 9e-112 |
X-RAY |
2010-12-15 | LEU | A:87 | A:84 | 30.0 | 0.176 | B | -114.7 | 134.6 | 30.0 | 0.176 | 0.0 |
ZN HOH |
6.740 3.010 |
C N |
ZN O |
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| 6sc2 | 2 | E5BBQ0,B0I1S0 | 89.07 | 4e-111 |
EM |
2019-09-04 | LEU | B:84 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6sc2 | 1 | E5BBQ0,B0I1S0 | 89.07 | 4e-111 |
EM |
2019-09-04 | LEU | A:84 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6rla | 1 | E5BBQ0,B0I1S0 | 89.07 | 4e-111 |
EM |
2019-08-28 | LEU | A:84 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| LEU | B:84 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 6rlb | 1 | E5BBQ0,B0I1S0 | 89.07 | 4e-111 |
EM |
2019-08-28 | LEU | A:84 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| LEU | B:84 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 3kzz | 1 | ? | 88.7 | 7e-111 |
X-RAY |
2010-12-15 | LEU | A:87 | A:84 | 30.0 | 0.176 | B | -116.7 | 136.0 | 30.0 | 0.176 | 0.0 |
ZN HOH |
6.661 3.126 |
C N |
ZN O |
||
| 6y8p | 1 | E5BBQ0 | 89.14 | 4e-110 |
X-RAY |
2021-03-31 | LEU | A:82 | A:84 | 31.0 | 0.182 | B | -120.8 | 130.5 | 31.0 | 0.182 | 0.0 |
ZN HOH |
6.816 9.222 |
C O |
ZN O |
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AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p16455-f1 | 1 | P16455 | 100.0 | 2e-151 | LEU | A:84 | A:84 | 32.0 | 0.188 | B | -112.5 | 129.1 | |