Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr10 | 131557522 | . | G | A | CCDS7660.2:NM_002412.3:c.424Gtg>Atg_NP_002403.2:p.142V>M | Homo sapiens O-6-methylguanine-DNA methyltransferase (MGMT), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1eh6 | 1 | P16455 | 100.0 | 5e-151 |
X-RAY |
2000-04-12 | VAL | A:111 | A:111 | 64.0 | 0.413 | -131.5 | 161.1 | 64.0 | 0.413 | 0.0 |
HOH |
3.962 |
CG1 |
O |
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| 1eh7 | 1 | P16455 | 100.0 | 5e-151 |
X-RAY |
2000-04-12 | VAL | A:111 | A:111 | 64.0 | 0.413 | -140.2 | 163.3 | 64.0 | 0.413 | 0.0 |
HOH |
2.941 |
O |
O |
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| 1eh8 | 1 | P16455 | 100.0 | 5e-151 |
X-RAY |
2000-04-12 | VAL | A:111 | A:111 | 63.0 | 0.406 | -132.1 | 165.7 | 63.0 | 0.406 | 0.0 |
HOH |
2.819 |
N |
O |
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| 1yfh | 3 | P16455 | 100.0 | 1e-130 |
X-RAY |
2005-12-13 | VAL | E:111 | A:111 | 47.0 | 0.303 | -152.4 | 152.0 | NA | NA | NA | |||||||
| VAL | F:111 | B:111 | 69.0 | 0.445 | -154.4 | 158.6 | NA | NA | NA | ||||||||||||||
| VAL | G:111 | C:111 | 63.0 | 0.406 | -154.9 | 160.4 | 63.0 | 0.406 | 0.0 | ||||||||||||||
| 1t39 | 3 | P16455 | 99.44 | 5e-129 |
X-RAY |
2004-07-13 | VAL | E:123 | A:111 | 61.0 | 0.394 | -133.5 | 148.7 | 61.0 | 0.394 | 0.0 |
E1X |
9.628 |
CG1 |
O2 |
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| VAL | F:123 | B:111 | 63.0 | 0.406 | -133.9 | 148.7 | NA | NA | NA | ||||||||||||||
| 1qnt | 1 | P16455 | 100.0 | 1e-128 |
X-RAY |
1999-12-16 | VAL | A:111 | A:111 | 55.0 | 0.355 | -129.4 | 157.5 | 55.0 | 0.355 | 0.0 |
HOH |
2.901 |
O |
O |
|||
| 1t38 | 3 | P16455 | 98.88 | 6e-128 |
X-RAY |
2004-07-13 | VAL | C:123 | A:111 | 61.0 | 0.394 | -155.4 | 143.7 | 61.0 | 0.394 | 0.0 |
6OG DT HOH |
9.715 9.965 9.000 |
CB C CG1 |
N2 OP1 O |
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| 3kzy | 1 | ? | 89.27 | 9e-112 |
X-RAY |
2010-12-15 | VAL | A:114 | A:111 | 40.0 | 0.258 | -132.4 | 168.2 | 40.0 | 0.258 | 0.0 |
HOH |
2.921 |
N |
O |
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| VAL | B:114 | B:111 | 40.0 | 0.258 | -131.8 | 164.3 | NA | NA | NA | ||||||||||||||
| 3l00 | 1 | ? | 89.27 | 9e-112 |
X-RAY |
2010-12-15 | VAL | A:114 | A:111 | 40.0 | 0.258 | -128.3 | 167.3 | 40.0 | 0.258 | 0.0 |
HOH |
4.346 |
CG1 |
O |
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| 6sc2 | 2 | E5BBQ0,B0I1S0 | 89.07 | 4e-111 |
EM |
2019-09-04 | VAL | B:111 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6sc2 | 1 | E5BBQ0,B0I1S0 | 89.07 | 4e-111 |
EM |
2019-09-04 | VAL | A:111 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6rla | 1 | E5BBQ0,B0I1S0 | 89.07 | 4e-111 |
EM |
2019-08-28 | VAL | A:111 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:111 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 6rlb | 1 | E5BBQ0,B0I1S0 | 89.07 | 4e-111 |
EM |
2019-08-28 | VAL | A:111 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| VAL | B:111 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 3kzz | 1 | ? | 88.7 | 7e-111 |
X-RAY |
2010-12-15 | VAL | A:114 | A:111 | 40.0 | 0.258 | -129.7 | 164.0 | 40.0 | 0.258 | 0.0 |
OBG HOH |
9.287 2.805 |
CB O |
N1 O |
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| 6y8p | 1 | E5BBQ0 | 89.14 | 4e-110 |
X-RAY |
2021-03-31 | VAL | A:109 | A:111 | 41.0 | 0.265 | -142.8 | 174.0 | 41.0 | 0.265 | 0.0 |
HOH |
3.105 |
N |
O |
|||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p16455-f1 | 1 | P16455 | 100.0 | 2e-151 | VAL | A:111 | A:111 | 49.0 | 0.316 | -130.2 | 155.0 | ||