Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 131557574 . G A CCDS7660.2:NM_002412.3:c.476cGa>cAa_NP_002403.2:p.159R>Q Homo sapiens O-6-methylguanine-DNA methyltransferase (MGMT), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1eh6 1 P16455 100.0 5e-151 X-RAY
 2000-04-12 ARG A:128 A:128 231.0 1.0 H -66.7 -38.3 231.0 1.0 0.0 HOH
 2.781
 NH2
 O
1eh7 1 P16455 100.0 5e-151 X-RAY
 2000-04-12 ARG A:128 A:128 229.0 1.0 H -65.7 -42.8 229.0 1.0 0.0 HOH
 2.838
 NE
 O
1eh8 1 P16455 100.0 5e-151 X-RAY
 2000-04-12 ARG A:128 A:128 230.0 1.0 H -65.0 -43.6 230.0 1.0 0.0 HOH
 2.761
 NH1
 O
1yfh 3 P16455 100.0 1e-130 X-RAY
 2005-12-13 ARG E:128 A:128 236.0 1.0 H -71.4 -32.4 NA NA NA
ARG F:128 B:128 233.0 1.0 H -65.6 -41.3 NA NA NA
ARG G:128 C:128 231.0 1.0 H -74.1 -33.2 231.0 1.0 0.0 DT
DG
XCY
DG
DT
DG
DC
DA
DC
DA
DC
DA
DT
HOH
 6.476
3.125
5.518
3.033
5.893
9.951
9.034
6.037
4.011
2.882
4.656
6.866
8.691
2.578
 NH2
NH2
O
NH1
N
NH1
NH1
NH1
NH1
NH1
CB
C
O
NH2
 C2'
N7
O3'
O6
C5'
O6
N4
N6
N4
N1
O2
O4'
O4'
O
1t39 3 P16455 99.44 5e-129 X-RAY
 2004-07-13 ARG E:140 A:128 240.0 1.0 H -52.5 -32.7 240.0 1.0 0.0 DA
DT
DG
E1X
DC
DT
DT
DA
DG
DC
DC
DA
DT
 8.956
5.527
2.839
5.934
2.956
6.178
9.064
5.912
4.337
2.757
3.731
6.559
8.421
 NH2
NH2
NH2
O
NH1
NH1
NH1
NH1
NH2
NH2
NH2
C
O
 C6
O4
O6
C2'
N4
O4
C7
N6
O6
N4
N4
O4'
O4'
ARG F:140 B:128 239.0 1.0 H -52.6 -32.1 NA NA NA
1qnt 1 P16455 100.0 1e-128 X-RAY
 1999-12-16 ARG A:128 A:128 233.0 1.0 H -68.4 -42.9 233.0 1.0 0.0 HOH
 2.939
 N
 O
1t38 3 P16455 98.88 6e-128 X-RAY
 2004-07-13 ARG C:140 A:128 235.0 1.0 H -54.1 -47.1 235.0 1.0 0.0 DA
DT
DG
6OG
DC
DT
DA
DT
DA
DG
DC
DC
DA
DT
 9.894
6.698
3.356
5.607
3.147
6.221
9.434
8.087
5.680
3.026
3.509
4.473
6.592
9.056
 NH2
NH2
NE
O
NH1
NH1
NH2
NH1
NH2
NH2
NH2
CD
C
O
 N7
O4
C6
C2'
N4
O4
N6
C7
N6
O6
N4
N3
O4'
O4'
3kzy 1 ? 89.27 9e-112 X-RAY
 2010-12-15 ALA A:131 A:128 65.0 0.565 H -67.7 -37.3 65.0 0.565 0.0 HOH
 2.842
 O
 O
ALA B:131 B:128 73.0 0.635 H -61.3 -42.2 NA NA NA
3l00 1 ? 89.27 9e-112 X-RAY
 2010-12-15 ALA A:131 A:128 74.0 0.643 H -61.9 -43.2 74.0 0.643 0.0 HOH
 3.034
 O
 O
6sc2 2 E5BBQ0,B0I1S0 89.07 4e-111 EM
 2019-09-04 ALA B:128 NA:NA DO NA DO DO DO NA NA NA
6sc2 1 E5BBQ0,B0I1S0 89.07 4e-111 EM
 2019-09-04 ALA A:128 NA:NA DO NA DO DO DO NA NA NA
6rla 1 E5BBQ0,B0I1S0 89.07 4e-111 EM
 2019-08-28 ALA A:128 NA:NA DO NA DO DO DO NA NA NA
ALA B:128 NA:NA DO NA DO DO DO NA NA NA
6rlb 1 E5BBQ0,B0I1S0 89.07 4e-111 EM
 2019-08-28 ALA A:128 NA:NA DO NA DO DO DO NA NA NA
ALA B:128 NA:NA DO NA DO DO DO NA NA NA
3kzz 1 ? 88.7 7e-111 X-RAY
 2010-12-15 ALA A:131 A:128 71.0 0.617 H -64.4 -39.7 71.0 0.617 0.0 OBG
HOH
 7.811
2.946
 O
O
 N4
O
6y8p 1 E5BBQ0 89.14 4e-110 X-RAY
 2021-03-31 ALA A:126 A:128 74.0 0.643 H -57.6 -35.4 74.0 0.643 0.0 OGQ
HOH
 8.704
3.447
 O
O
 CBA
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p16455-f1 1 P16455 100.0 2e-151 ARG A:128 A:128 238.0 1.0 H -65.2 -39.2