Variant
| Genome | Chromosome | Position | VCF ID | Ref | Alt | mRNA Change | mRNA Info | GRCh37 | chr10 | 131565157 | . | C | A | CCDS7660.2:NM_002412.3:c.613Cac>Aac_NP_002403.2:p.205H>N | Homo sapiens O-6-methylguanine-DNA methyltransferase (MGMT), mRNA. |
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PDB
| Entity | Residue | Monomer | BioUnit | Ligand | View | ||||||||||||||||||
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| PDB | Entity | Uniprot | Identity | Evalue | ExpMethod | Date | Name | Label | Auth | ASA | rASA | SS | φ | ψ | ASA | rASA | ΔASA | Interaction | Name | Distance | Atom(p) | Atom(l) | |
| 1eh6 | 1 | P16455 | 100.0 | 5e-151 |
X-RAY |
2000-04-12 | HIS | A:174 | A:174 | 57.0 | 0.292 | -71.6 | 147.5 | 57.0 | 0.292 | 0.0 |
HOH |
2.790 |
NE2 |
O |
|||
| 1eh7 | 1 | P16455 | 100.0 | 5e-151 |
X-RAY |
2000-04-12 | HIS | A:174 | A:174 | 62.0 | 0.318 | -74.5 | 149.6 | 62.0 | 0.318 | 0.0 |
HOH |
2.844 |
O |
O |
|||
| 1eh8 | 1 | P16455 | 100.0 | 5e-151 |
X-RAY |
2000-04-12 | HIS | A:174 | A:174 | 57.0 | 0.292 | -68.6 | 148.0 | 57.0 | 0.292 | 0.0 |
HOH |
2.600 |
NE2 |
O |
|||
| 1yfh | 3 | P16455 | 100.0 | 1e-130 |
X-RAY |
2005-12-13 | HIS | E:174 | A:174 | 62.0 | 0.318 | -150.9 | 161.4 | NA | NA | NA | |||||||
| HIS | F:174 | B:174 | 74.0 | 0.379 | -135.9 | 118.6 | NA | NA | NA | ||||||||||||||
| HIS | G:174 | C:174 | 72.0 | 0.369 | -92.7 | 154.0 | 72.0 | 0.369 | 0.0 | ||||||||||||||
| 1t39 | 3 | P16455 | 99.44 | 5e-129 |
X-RAY |
2004-07-13 | HIS | E:186 | A:174 | 82.0 | 0.421 | -142.7 | 168.0 | 82.0 | 0.421 | 0.0 | |||||||
| HIS | F:186 | B:174 | 153.0 | 0.785 | -145.2 | 360.0 | NA | NA | NA | ||||||||||||||
| 1qnt | 1 | P16455 | 100.0 | 1e-128 |
X-RAY |
1999-12-16 | HIS | A:174 | A:174 | 55.0 | 0.282 | -72.2 | 144.7 | 55.0 | 0.282 | 0.0 |
HOH |
2.780 |
O |
O |
|||
| 1t38 | 3 | P16455 | 98.88 | 6e-128 |
X-RAY |
2004-07-13 | HIS | C:186 | A:174 | 59.0 | 0.303 | -82.7 | 141.1 | 59.0 | 0.303 | 0.0 |
HOH |
3.527 |
CA |
O |
|||
| 3kzy | 1 | ? | 89.27 | 9e-112 |
X-RAY |
2010-12-15 | HIS | A:177 | A:174 | 34.0 | 0.174 | -80.8 | 146.0 | 34.0 | 0.174 | 0.0 |
HOH |
2.798 |
O |
O |
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| HIS | B:177 | B:174 | 34.0 | 0.174 | -80.6 | 145.7 | NA | NA | NA | ||||||||||||||
| 3l00 | 1 | ? | 89.27 | 9e-112 |
X-RAY |
2010-12-15 | HIS | A:177 | A:174 | 36.0 | 0.185 | -77.8 | 142.3 | 36.0 | 0.185 | 0.0 |
HOH |
2.697 |
O |
O |
|||
| 6sc2 | 2 | E5BBQ0,B0I1S0 | 89.07 | 4e-111 |
EM |
2019-09-04 | HIS | B:174 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6sc2 | 1 | E5BBQ0,B0I1S0 | 89.07 | 4e-111 |
EM |
2019-09-04 | HIS | A:174 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| 6rla | 1 | E5BBQ0,B0I1S0 | 89.07 | 4e-111 |
EM |
2019-08-28 | HIS | A:174 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| HIS | B:174 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 6rlb | 1 | E5BBQ0,B0I1S0 | 89.07 | 4e-111 |
EM |
2019-08-28 | HIS | A:174 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | ||||||
| HIS | B:174 | NA:NA | DO | NA | DO | DO | DO | NA | NA | NA | |||||||||||||
| 3kzz | 1 | ? | 88.7 | 7e-111 |
X-RAY |
2010-12-15 | HIS | A:177 | A:174 | 34.0 | 0.174 | -78.6 | 143.8 | 34.0 | 0.174 | 0.0 |
HOH |
2.991 |
NE2 |
O |
|||
| 6y8p | 1 | E5BBQ0 | 89.14 | 4e-110 |
X-RAY |
2021-03-31 | HIS | A:172 | A:174 | 40.0 | 0.205 | -84.4 | 148.0 | 40.0 | 0.205 | 0.0 |
HOH |
2.949 |
CE1 |
O |
|||
AlphaFold DB
| Entity | Residue | Monomer | View | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ID | Entity | Uniprot | Identity | Evalue | Name | Label | Auth | ASA | rASA | SS | φ | ψ | |
| af-p16455-f1 | 1 | P16455 | 100.0 | 2e-151 | HIS | A:174 | A:174 | 33.0 | 0.169 | -79.8 | 133.8 | ||