Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94220964 . A C CCDS7421.1:NM_004969.3:c.2807aTc>aGc_NP_004960.2:p.936I>S Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 ILE A:936 A:936 1.0 0.006 H -73.8 -35.5 NA NA NA
ILE B:936 B:936 0.0 0.0 H -64.4 -40.2 0.0 0.0 0.0 HOH
7.437
O
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 ILE A:936 A:936 0.0 0.0 H -60.1 -41.0 0.0 0.0 0.0 HOH
9.310
CD1
O
ILE B:936 B:936 1.0 0.006 H -58.5 -47.8 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 ILE A:936 A:936 0.0 0.0 H -69.0 -38.6 0.0 0.0 0.0 HOH
7.569
N
O
ILE B:936 B:936 1.0 0.006 H -67.9 -37.0 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 ILE A:907 A:936 0.0 0.0 H -64.2 -42.2 0.0 0.0 0.0 HOH
6.891
O
O
ILE B:907 B:936 0.0 0.0 H -71.1 -36.5 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:907 A:936 0.0 0.0 H -65.4 -39.7 0.0 0.0 0.0 HOH
7.002
O
O
ILE B:907 B:936 0.0 0.0 H -55.6 -43.9 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:907 A:936 0.0 0.0 H -71.9 -36.1 0.0 0.0 0.0 HOH
7.003
O
O
ILE B:907 B:936 0.0 0.0 H -51.8 -37.0 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:907 A:936 0.0 0.0 H -70.9 -32.1 0.0 0.0 0.0 HOH
7.136
O
O
ILE B:907 B:936 0.0 0.0 H -60.2 -44.8 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:907 A:936 0.0 0.0 H -62.2 -39.2 0.0 0.0 0.0 HOH
7.326
O
O
ILE B:907 B:936 0.0 0.0 H -70.6 -36.2 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 ILE A:907 A:936 0.0 0.0 H -57.5 -37.7 0.0 0.0 0.0
ILE B:907 B:936 0.0 0.0 H -61.0 -50.8 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 ILE A:907 A:936 0.0 0.0 H -71.3 -35.4 0.0 0.0 0.0 HOH
7.035
O
O
ILE B:907 B:936 0.0 0.0 H -68.3 -35.0 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 ILE A:936 A:936 0.0 0.0 H -72.5 -30.8 0.0 0.0 0.0 HOH
7.721
N
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 ILE A:907 A:936 0.0 0.0 H -65.2 -43.4 0.0 0.0 0.0 HOH
7.677
N
O
ILE B:907 B:936 0.0 0.0 H -62.6 -34.3 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 ILE A:936 A:936 0.0 0.0 H -65.3 -40.1 0.0 0.0 0.0 HOH
7.638
O
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 ILE A:907 A:936 0.0 0.0 H -68.9 -37.3 0.0 0.0 0.0 HOH
7.159
O
O
ILE B:907 B:936 0.0 0.0 H -61.9 -40.3 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 ILE A:895 A:936 0.0 0.0 H -73.2 -39.0 0.0 0.0 0.0 HOH
8.124
N
O
ILE B:895 B:936 0.0 0.0 H -69.0 -39.3 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 ILE A:895 A:936 2.0 0.011 H -70.4 -33.7 2.0 0.011 0.0
ILE B:895 B:936 1.0 0.006 H -69.3 -34.1 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 ILE A:895 A:936 2.0 0.011 H -70.4 -42.3 2.0 0.011 0.0
ILE B:895 B:936 1.0 0.006 H -69.7 -42.1 1.0 0.006 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:906 A:936 0.0 0.0 H -68.3 -41.8 0.0 0.0 0.0 HOH
7.180
N
O
ILE B:906 B:936 0.0 0.0 H -65.6 -39.9 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:906 A:936 0.0 0.0 H -70.7 -39.6 0.0 0.0 0.0 HOH
6.440
N
O
ILE B:906 B:936 0.0 0.0 H -71.0 -39.5 0.0 0.0 0.0 HOH
6.262
N
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:906 A:936 0.0 0.0 H -77.0 -33.7 0.0 0.0 0.0 HOH
9.908
O
O
ILE B:906 B:936 1.0 0.006 H -72.5 -39.2 1.0 0.006 0.0 HOH
8.595
O
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:906 A:936 0.0 0.0 H -72.6 -36.2 0.0 0.0 0.0 HOH
7.836
CG1
O
ILE B:906 B:936 0.0 0.0 H -67.6 -41.4 0.0 0.0 0.0 HOH
7.839
CG1
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 ILE A:907 A:936 1.0 0.006 H -72.9 -39.6 1.0 0.006 0.0 HOH
8.359
CD1
O
ILE B:907 B:936 1.0 0.006 H -52.6 -49.2 1.0 0.006 0.0 HOH
8.901
O
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 ILE A:907 A:936 0.0 0.0 H -64.5 -34.4 0.0 0.0 0.0 HOH
7.927
N
O
ILE B:907 B:936 0.0 0.0 H -58.7 -42.3 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 ILE A:907 A:936 0.0 0.0 H -80.2 -47.0 0.0 0.0 0.0
ILE B:907 B:936 1.0 0.006 H -78.0 -47.0 1.0 0.006 0.0
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 ILE A:907 A:936 0.0 0.0 H -69.0 -38.4 0.0 0.0 0.0
ILE B:907 B:936 1.0 0.006 H -69.0 -38.7 1.0 0.006 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 ILE A:907 A:936 0.0 0.0 H -69.3 -37.7 0.0 0.0 0.0 HOH
9.961
O
O
ILE B:907 B:936 0.0 0.0 H -71.8 -36.6 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 ILE A:907 A:936 0.0 0.0 H -71.3 -37.7 0.0 0.0 0.0
ILE B:907 B:936 1.0 0.006 H -70.8 -34.0 NA NA NA
ILE C:907 C:936 1.0 0.006 H -79.9 -34.3 NA NA NA
ILE D:907 D:936 1.0 0.006 H -80.1 -32.4 NA NA NA
ILE E:907 E:936 1.0 0.006 H -76.3 -37.8 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 ILE A:907 A:936 8.0 0.046 H -63.5 -34.1 8.0 0.046 0.0
ILE B:907 B:936 3.0 0.017 H -71.4 -28.7 3.0 0.017 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 ILE A:907 A:936 0.0 0.0 H -66.2 -36.8 0.0 0.0 0.0
ILE B:907 B:936 0.0 0.0 H -75.9 -31.4 0.0 0.0 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 ILE A:907 A:936 0.0 0.0 H -70.3 -39.6 0.0 0.0 0.0
ILE B:907 B:936 0.0 0.0 H -65.0 -36.7 0.0 0.0 0.0 HOH
9.003
CG1
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 ILE A:907 A:936 0.0 0.0 H -70.0 -36.5 0.0 0.0 0.0 HOH
8.556
O
O
ILE B:907 B:936 0.0 0.0 H -73.0 -35.4 0.0 0.0 0.0 HOH
8.875
CG1
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 ILE A:907 A:936 0.0 0.0 H -69.0 -38.2 0.0 0.0 0.0 HOH
7.306
N
O
ILE B:907 B:936 0.0 0.0 H -62.5 -39.8 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 ILE A:907 A:936 0.0 0.0 H -69.2 -42.1 0.0 0.0 0.0 HOH
6.798
O
O
ILE B:907 B:936 0.0 0.0 H -48.1 -50.6 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 ILE A:907 A:936 0.0 0.0 H -76.9 -41.3 0.0 0.0 0.0 HOH
7.044
N
O
ILE B:907 B:936 0.0 0.0 H -62.3 -43.1 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 ILE A:907 A:936 1.0 0.006 H -76.2 -43.6 1.0 0.006 0.0 HOH
8.222
N
O
ILE B:907 B:936 0.0 0.0 H -50.4 -42.6 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 ILE A:907 A:936 0.0 0.0 H -56.4 -42.4 0.0 0.0 0.0
ILE B:907 B:936 0.0 0.0 H -69.8 -46.7 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 ILE A:907 A:936 0.0 0.0 H -65.7 -47.2 0.0 0.0 0.0
ILE B:907 B:936 0.0 0.0 H -74.3 -24.0 0.0 0.0 0.0 HOH
7.490
N
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 ILE A:907 A:936 0.0 0.0 H -74.9 -36.5 0.0 0.0 0.0 HOH
7.652
N
O
ILE B:907 B:936 0.0 0.0 H -68.1 -40.5 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 ILE A:907 A:936 0.0 0.0 H -83.6 -39.5 0.0 0.0 0.0 HOH
7.401
N
O
ILE B:907 B:936 0.0 0.0 H -63.5 -43.5 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 ILE A:907 A:936 1.0 0.006 H -87.3 -40.0 1.0 0.006 0.0 HOH
8.538
N
O
ILE B:907 B:936 1.0 0.006 H -54.1 -44.8 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 ILE A:907 A:936 0.0 0.0 H -72.9 -49.6 0.0 0.0 0.0
ILE B:907 B:936 1.0 0.006 H -56.1 -45.6 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 ILE A:907 A:936 0.0 0.0 H -72.3 -43.7 0.0 0.0 0.0 HOH
7.717
N
O
ILE B:907 B:936 1.0 0.006 H -58.0 -45.2 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 ILE A:907 A:936 1.0 0.006 H -71.3 -40.2 1.0 0.006 0.0
ILE B:907 B:936 1.0 0.006 H -66.3 -38.0 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 ILE A:907 A:936 0.0 0.0 H -70.3 -39.1 0.0 0.0 0.0 HOH
8.432
N
O
ILE B:907 B:936 0.0 0.0 H -70.9 -37.6 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 ILE A:907 A:936 1.0 0.006 H -68.7 -39.6 1.0 0.006 0.0
ILE B:907 B:936 2.0 0.011 H -63.5 -40.6 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 ILE A:907 A:936 1.0 0.006 H -69.6 -36.9 1.0 0.006 0.0
ILE B:907 B:936 0.0 0.0 H -69.2 -37.4 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 ILE A:907 A:936 0.0 0.0 H -79.1 -42.8 0.0 0.0 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 ILE A:907 A:936 1.0 0.006 H -67.7 -34.1 1.0 0.006 0.0
ILE B:907 B:936 0.0 0.0 H -65.9 -42.7 0.0 0.0 0.0
ILE C:907 C:936 1.0 0.006 H -65.4 -37.8 NA NA NA
ILE D:907 D:936 0.0 0.0 H -65.5 -40.2 NA NA NA
ILE E:907 E:936 3.0 0.017 H -80.8 -29.0 NA NA NA
ILE F:907 F:936 0.0 0.0 H -85.3 -15.2 NA NA NA
ILE G:907 G:936 4.0 0.023 H -73.9 -37.3 NA NA NA
ILE H:907 H:936 0.0 0.0 H -73.9 -33.2 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 ILE A:894 A:936 0.0 0.0 H -77.4 -40.1 0.0 0.0 0.0 HOH
9.092
O
O
ILE B:894 B:936 0.0 0.0 H -54.5 -48.9 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 ILE A:891 A:936 8.0 0.046 H -74.2 -23.4 8.0 0.046 0.0
ILE B:891 B:936 5.0 0.029 H -80.7 -17.7 5.0 0.029 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 ILE A:891 A:936 28.0 0.16 H -74.8 -21.5 28.0 0.16 0.0
ILE B:891 B:936 16.0 0.091 H -81.4 -18.9 16.0 0.091 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 ILE A:891 A:936 54.0 0.309 H -83.1 -17.7 54.0 0.309 0.0
ILE B:891 B:936 14.0 0.08 H -71.2 -27.7 14.0 0.08 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 ILE A:891 A:936 24.0 0.137 H -80.9 -18.4 24.0 0.137 0.0
ILE B:891 B:936 9.0 0.051 H -80.0 -16.7 9.0 0.051 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 ILE A:891 A:936 31.0 0.177 H -83.1 -19.3 31.0 0.177 0.0
ILE B:891 B:936 20.0 0.114 H -79.8 -18.1 20.0 0.114 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 ILE A:891 A:936 5.0 0.029 H -66.4 -39.1 5.0 0.029 0.0
ILE B:891 B:936 5.0 0.029 H -82.9 -16.4 5.0 0.029 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 ILE A:891 A:936 21.0 0.12 H -79.0 -19.4 21.0 0.12 0.0
ILE B:891 B:936 13.0 0.074 H -94.3 -18.1 13.0 0.074 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 ILE A:891 A:936 6.0 0.034 H -64.6 -32.5 6.0 0.034 0.0
ILE B:891 B:936 3.0 0.017 H -71.5 -29.3 3.0 0.017 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 ILE A:895 A:936 0.0 0.0 H -66.8 -37.4 0.0 0.0 0.0 HOH
5.126
N
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 ILE A:907 A:936 0.0 0.0 H -73.7 -38.2 0.0 0.0 0.0 HOH
6.954
O
O
ILE B:907 B:936 0.0 0.0 H -66.7 -42.1 0.0 0.0 0.0 HOH
5.206
N
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 ILE A:936 A:936 0.0 0.0 H -71.0 -38.7