Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94223502 . T A CCDS7421.1:NM_004969.3:c.2747tAt>tTt_NP_004960.2:p.916Y>F Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
 2009-11-03 TYR A:916 A:916 21.0 0.091 54.6 33.5 NA NA NA
TYR B:916 B:916 11.0 0.048 51.4 31.5 11.0 0.048 0.0 HOH
 8.194
 OH
 O
3e4a 1 P14735 98.63 0.0 X-RAY
 2009-05-19 TYR A:916 A:916 18.0 0.078 51.3 34.7 18.0 0.078 0.0 DIO
DIO
ACY
HOH
 7.160
9.304
3.473
6.520
 N
N
CD1
O
 C1'
C1'
O
O
TYR B:916 B:916 29.0 0.126 53.3 25.9 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
 2019-04-03 TYR A:916 A:916 27.0 0.117 55.6 39.5 27.0 0.117 0.0 EPE
HOH
 6.686
3.492
 N
OH
 H21
O
TYR B:916 B:916 28.0 0.122 56.8 37.9 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
 2006-10-24 TYR A:887 A:916 21.0 0.091 44.5 41.2 21.0 0.091 0.0 HOH
 4.094
 OH
 O
TYR B:887 B:916 14.0 0.061 45.0 38.8 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
 2006-10-24 TYR A:887 A:916 13.0 0.057 39.5 45.8 13.0 0.057 0.0 HOH
 3.925
 O
 O
TYR B:887 B:916 24.0 0.104 40.9 38.2 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
 2006-10-24 TYR A:887 A:916 17.0 0.074 40.4 47.0 17.0 0.074 0.0 HOH
 3.949
 OH
 O
TYR B:887 B:916 22.0 0.096 43.1 34.8 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
 2006-10-24 TYR A:887 A:916 13.0 0.057 40.8 45.2 13.0 0.057 0.0 HOH
 3.344
 O
 O
TYR B:887 B:916 16.0 0.07 41.8 43.5 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
 2006-10-24 TYR A:887 A:916 21.0 0.091 45.5 40.7 21.0 0.091 0.0 HOH
 4.113
 OH
 O
TYR B:887 B:916 14.0 0.061 41.7 43.0 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
 2007-07-03 TYR A:887 A:916 14.0 0.061 44.7 46.3 14.0 0.061 0.0
TYR B:887 B:916 9.0 0.039 46.0 29.6 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
 2009-08-18 TYR A:887 A:916 23.0 0.1 47.5 40.4 23.0 0.1 0.0 HOH
 4.248
 OH
 O
TYR B:887 B:916 24.0 0.104 47.3 35.4 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
 2011-10-26 TYR A:916 A:916 29.0 0.126 46.0 38.1 29.0 0.126 0.0 HOH
 4.404
 CE1
 O
2jg4 1 P14735 99.9 0.0 X-RAY
 2007-07-03 TYR A:887 A:916 26.0 0.113 47.0 45.4 26.0 0.113 0.0 DIO
DIO
HOH
 7.373
9.349
6.331
 N
N
O
 C1'
C1'
O
TYR B:887 B:916 31.0 0.135 59.2 25.1 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
 2011-07-27 TYR A:916 A:916 32.0 0.139 50.2 41.8 32.0 0.139 0.0 HOH
 2.845
 O
 O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
 2009-08-18 TYR A:887 A:916 23.0 0.1 49.2 35.7 23.0 0.1 0.0 HOH
 3.878
 OH
 O
TYR B:887 B:916 27.0 0.117 49.2 37.1 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
 2014-05-21 TYR A:875 A:916 21.0 0.091 54.5 37.2 21.0 0.091 0.0 EPE
HOH
 6.817
3.713
 N
OH
 H31
O
TYR B:875 B:916 22.0 0.096 55.1 36.2 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
 2019-04-03 TYR A:875 A:916 21.0 0.091 54.6 40.6 21.0 0.091 0.0 EPE
 7.359
 N
 H52
TYR B:875 B:916 22.0 0.096 54.0 38.0 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
 2019-04-03 TYR A:875 A:916 24.0 0.104 56.5 47.6 24.0 0.104 0.0 EPE
 6.804
 N
 H21
TYR B:875 B:916 23.0 0.1 56.0 46.8 23.0 0.1 0.0 EPE
 6.755
 N
 H61
4pes 1 P14735 98.57 0.0 X-RAY
 2015-06-17 TYR A:886 A:916 8.0 0.035 57.1 30.9 8.0 0.035 0.0 HOH
 4.519
 OH
 O
TYR B:886 B:916 2.0 0.009 57.8 38.2 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
 2015-06-17 TYR A:886 A:916 9.0 0.039 50.4 29.4 9.0 0.039 0.0 HOH
 4.237
 OH
 O
TYR B:886 B:916 3.0 0.013 49.8 31.4 3.0 0.013 0.0 HOH
 2.733
 O
 O
4pf9 1 P14735 98.57 0.0 X-RAY
 2015-06-17 TYR A:886 A:916 2.0 0.009 43.7 40.4 2.0 0.009 0.0 HOH
 4.382
 CE1
 O
TYR B:886 B:916 11.0 0.048 53.5 35.7 11.0 0.048 0.0 HOH
 6.033
 N
 O
4pfc 1 P14735 98.57 0.0 X-RAY
 2015-06-17 TYR A:886 A:916 1.0 0.004 51.4 38.9 1.0 0.004 0.0 HOH
 3.105
 O
 O
TYR B:886 B:916 8.0 0.035 52.8 32.4 8.0 0.035 0.0 HOH
 4.249
 OH
 O
3qz2 1 P14735 98.67 0.0 X-RAY
 2012-01-25 TYR A:887 A:916 26.0 0.113 49.4 40.6 26.0 0.113 0.0 HOH
 4.360
 O
 O
TYR B:887 B:916 34.0 0.148 58.7 26.5 34.0 0.148 0.0
4dtt 1 P14735 98.67 0.0 X-RAY
 2013-02-27 TYR A:887 A:916 21.0 0.091 54.2 35.9 21.0 0.091 0.0 HOH
 8.776
 N
 O
TYR B:887 B:916 20.0 0.087 63.8 5.7 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
 2013-12-18 TYR A:887 A:916 32.0 0.139 49.5 30.0 32.0 0.139 0.0 HOH
 8.366
 CB
 O
TYR B:887 B:916 46.0 0.2 49.2 29.0 46.0 0.2 0.0 HOH
 4.766
 O
 O
4iof 1 P14735 98.67 0.0 X-RAY
 2013-07-24 TYR A:887 A:916 37.0 0.161 43.3 39.3 37.0 0.161 0.0
TYR B:887 B:916 20.0 0.087 43.6 39.5 20.0 0.087 0.0
4re9 1 P14735 98.67 0.0 X-RAY
 2015-09-30 TYR A:887 A:916 27.0 0.117 54.7 32.2 27.0 0.117 0.0 EPE
HOH
 6.647
6.352
 N
CB
 H62
O
TYR B:887 B:916 24.0 0.104 54.6 32.3 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
 2018-02-07 TYR A:887 A:916 30.0 0.13 54.0 28.9 30.0 0.13 0.0
TYR B:887 B:916 55.0 0.239 58.9 26.4 NA NA NA
TYR C:887 C:916 21.0 0.091 57.1 26.8 NA NA NA
TYR D:887 D:916 26.0 0.113 61.1 29.0 NA NA NA
TYR E:887 E:916 45.0 0.196 59.2 29.0 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
 2017-11-22 TYR A:887 A:916 23.0 0.1 62.0 34.4 23.0 0.1 0.0
TYR B:887 B:916 39.0 0.17 66.1 11.6 39.0 0.17 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
 2021-09-22 TYR A:887 A:916 8.0 0.035 59.7 35.7 8.0 0.035 0.0 EPE
 6.733
 N
 H62
TYR B:887 B:916 27.0 0.117 54.3 39.8 27.0 0.117 0.0 EPE
 6.453
 N
 H22
7k1e 1 P14735 98.67 0.0 X-RAY
 2021-09-22 TYR A:887 A:916 7.0 0.03 57.4 32.3 7.0 0.03 0.0 EPE
HOH
 6.652
4.062
 N
CE2
 H62
O
TYR B:887 B:916 23.0 0.1 54.4 36.1 23.0 0.1 0.0 EPE
HOH
 6.636
7.312
 N
C
 H22
O
7k1f 1 P14735 98.67 0.0 X-RAY
 2021-09-22 TYR A:887 A:916 8.0 0.035 56.1 40.5 8.0 0.035 0.0 EPE
HOH
 6.671
8.282
 N
N
 H62
O
TYR B:887 B:916 21.0 0.091 56.2 33.6 21.0 0.091 0.0 EPE
HOH
 6.588
3.798
 N
O
 H22
O
2wby 1 P14735 98.57 0.0 X-RAY
 2009-03-24 TYR A:887 A:916 24.0 0.104 43.4 39.9 24.0 0.104 0.0 HOH
 4.023
 CE1
 O
TYR B:887 B:916 28.0 0.122 42.9 30.8 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
 2009-03-24 TYR A:887 A:916 19.0 0.083 43.2 37.9 19.0 0.083 0.0 HOH
 7.460
 C
 O
TYR B:887 B:916 28.0 0.122 53.7 20.7 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
 2012-11-28 TYR A:887 A:916 26.0 0.113 52.9 39.3 26.0 0.113 0.0 HOH
 4.328
 OH
 O
TYR B:887 B:916 23.0 0.1 55.1 27.3 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
 2010-04-14 TYR A:887 A:916 17.0 0.074 49.4 38.9 17.0 0.074 0.0 HOH
 6.636
 O
 O
TYR B:887 B:916 23.0 0.1 54.7 29.2 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
 2010-11-17 TYR A:887 A:916 25.0 0.109 64.7 10.5 25.0 0.109 0.0 HOH
 4.736
 CB
 O
TYR B:887 B:916 22.0 0.096 49.7 43.0 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
 2010-11-17 TYR A:887 A:916 30.0 0.13 58.8 21.5 30.0 0.13 0.0
TYR B:887 B:916 21.0 0.091 48.8 37.3 21.0 0.091 0.0
3ofi 1 P14735 98.57 0.0 X-RAY
 2010-09-08 TYR A:887 A:916 27.0 0.117 48.6 37.6 27.0 0.117 0.0 DIO
HOH
 9.266
5.963
 N
N
 C1'
O
TYR B:887 B:916 29.0 0.126 54.0 31.4 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
 2013-04-03 TYR A:887 A:916 22.0 0.096 48.6 36.3 22.0 0.096 0.0 HOH
 3.316
 O
 O
TYR B:887 B:916 25.0 0.109 59.2 25.4 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
 2013-08-28 TYR A:887 A:916 17.0 0.074 51.6 36.2 17.0 0.074 0.0 HOH
 8.788
 N
 O
TYR B:887 B:916 23.0 0.1 57.8 21.5 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
 2013-08-28 TYR A:887 A:916 18.0 0.078 46.9 37.8 18.0 0.078 0.0 HOH
 3.185
 O
 O
TYR B:887 B:916 18.0 0.078 58.4 24.1 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
 2013-08-28 TYR A:887 A:916 24.0 0.104 53.0 38.7 24.0 0.104 0.0 HOH
 3.451
 O
 O
TYR B:887 B:916 13.0 0.057 49.4 27.2 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
 2014-08-06 TYR A:887 A:916 23.0 0.1 55.3 33.9 23.0 0.1 0.0
TYR B:887 B:916 49.0 0.213 55.3 36.2 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
 2015-10-07 TYR A:887 A:916 32.0 0.139 53.6 35.4 32.0 0.139 0.0 EPE
HOH
 6.667
4.355
 N
OH
 H22
O
TYR B:887 B:916 26.0 0.113 53.4 35.3 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
 2015-05-13 TYR A:887 A:916 40.0 0.174 59.2 31.8 40.0 0.174 0.0
TYR B:887 B:916 45.0 0.196 55.9 38.4 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
 2015-05-13 TYR A:887 A:916 14.0 0.061 53.3 37.7 14.0 0.061 0.0
TYR B:887 B:916 15.0 0.065 51.9 35.7 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
 2016-07-20 TYR A:887 A:916 4.0 0.017 57.5 27.0 4.0 0.017 0.0 EPE
 8.340
 N
 C5
5wob 1 P14735 98.57 0.0 X-RAY
 2018-04-18 TYR A:887 A:916 22.0 0.096 55.9 36.5 22.0 0.096 0.0
TYR B:887 B:916 56.0 0.243 56.8 31.3 56.0 0.243 0.0
TYR C:887 C:916 27.0 0.117 56.4 38.7 NA NA NA
TYR D:887 D:916 45.0 0.196 57.3 33.5 NA NA NA
TYR E:887 E:916 52.0 0.226 59.9 30.7 NA NA NA
TYR F:887 F:916 23.0 0.1 57.2 28.4 NA NA NA
TYR G:887 G:916 47.0 0.204 59.1 35.4 NA NA NA
TYR H:887 H:916 38.0 0.165 58.0 27.8 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
 2009-12-08 TYR A:874 A:916 12.0 0.052 46.9 39.5 12.0 0.052 0.0 HOH
 4.293
 CE1
 O
TYR B:874 B:916 22.0 0.096 55.5 22.8 NA NA NA
6b70 1 P14735 98.86 0.0 EM
 2017-12-27 TYR A:871 A:916 35.0 0.152 70.1 4.5 35.0 0.152 0.0
TYR B:871 B:916 30.0 0.13 66.0 5.3 30.0 0.13 0.0
6b7y 1 P14735 98.86 0.0 EM
 2017-11-08 TYR A:871 A:916 16.0 0.07 67.6 8.5 16.0 0.07 0.0
TYR B:871 B:916 32.0 0.139 67.5 28.8 32.0 0.139 0.0
6b7z 1 P14735 98.86 0.0 EM
 2018-01-10 TYR A:871 A:916 54.0 0.235 69.0 -7.0 54.0 0.235 0.0
TYR B:871 B:916 9.0 0.039 62.7 16.1 9.0 0.039 0.0
6bf6 1 P14735 98.86 0.0 EM
 2018-02-07 TYR A:871 A:916 25.0 0.109 68.9 9.7 25.0 0.109 0.0
TYR B:871 B:916 21.0 0.091 70.2 9.6 21.0 0.091 0.0
6bf7 1 P14735 98.86 0.0 EM
 2018-02-07 TYR A:871 A:916 24.0 0.104 70.3 5.1 24.0 0.104 0.0
TYR B:871 B:916 29.0 0.126 71.6 5.0 29.0 0.126 0.0
6bf8 1 P14735 98.86 0.0 EM
 2018-04-04 TYR A:871 A:916 26.0 0.113 70.5 6.2 26.0 0.113 0.0
TYR B:871 B:916 14.0 0.061 69.8 4.9 14.0 0.061 0.0
6bf9 1 P14735 98.86 0.0 EM
 2018-02-07 TYR A:871 A:916 32.0 0.139 69.5 0.5 32.0 0.139 0.0
TYR B:871 B:916 33.0 0.143 71.5 5.5 33.0 0.143 0.0
6bfc 1 P14735 98.86 0.0 EM
 2017-12-27 TYR A:871 A:916 25.0 0.109 61.1 33.6 25.0 0.109 0.0
TYR B:871 B:916 40.0 0.174 65.4 10.7 40.0 0.174 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
 2011-07-20 TYR A:875 A:916 25.0 0.109 47.5 43.8 25.0 0.109 0.0 HOH
 2.827
 O
 O
3cww 1 P14735 97.34 0.0 X-RAY
 2008-11-25 TYR A:887 A:916 29.0 0.126 50.1 36.4 29.0 0.126 0.0 DIO
HOH
 7.304
3.150
 N
O
 C1'
O
TYR B:887 B:916 31.0 0.135 48.3 37.5 31.0 0.135 0.0 DIO
HOH
 7.227
3.238
 N
O
 C2
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 TYR A:916 A:916 6.0 0.026 53.3 32.5