Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94223578 . T A CCDS7421.1:NM_004969.3:c.2671Att>Ttt_NP_004960.2:p.891I>F Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 ILE A:891 A:891 32.0 0.183 H -48.4 -43.5 NA NA NA
ILE B:891 B:891 31.0 0.177 H -63.5 -37.2 31.0 0.177 0.0 HOH
4.776
CD1
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 ILE A:891 A:891 28.0 0.16 H -62.8 -44.6 28.0 0.16 0.0 HOH
4.631
CD1
O
ILE B:891 B:891 25.0 0.143 H -61.2 -37.9 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 ILE A:891 A:891 28.0 0.16 H -61.3 -39.6 28.0 0.16 0.0 HOH
2.888
CD1
O
ILE B:891 B:891 31.0 0.177 H -62.1 -38.0 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 ILE A:862 A:891 22.0 0.126 H -66.3 -40.8 22.0 0.126 0.0 HOH
5.102
CG1
O
ILE B:862 B:891 32.0 0.183 H -60.1 -43.4 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:862 A:891 23.0 0.131 H -65.6 -40.9 23.0 0.131 0.0 HOH
5.036
O
O
ILE B:862 B:891 26.0 0.149 H -63.4 -33.1 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:862 A:891 27.0 0.154 H -63.9 -37.6 27.0 0.154 0.0 HOH
5.094
CG1
O
ILE B:862 B:891 25.0 0.143 H -63.1 -31.9 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:862 A:891 23.0 0.131 H -59.9 -40.1 23.0 0.131 0.0 HOH
3.516
CD1
O
ILE B:862 B:891 23.0 0.131 H -58.4 -42.4 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:862 A:891 23.0 0.131 H -66.4 -42.6 23.0 0.131 0.0 HOH
2.920
CD1
O
ILE B:862 B:891 27.0 0.154 H -61.9 -40.1 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 ILE A:862 A:891 29.0 0.166 H -61.2 -37.0 29.0 0.166 0.0 HOH
5.156
O
O
ILE B:862 B:891 31.0 0.177 H -63.8 -46.1 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 ILE A:862 A:891 30.0 0.171 H -52.2 -44.3 30.0 0.171 0.0 HOH
5.999
CG1
O
ILE B:862 B:891 25.0 0.143 H -57.5 -44.7 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 ILE A:891 A:891 21.0 0.12 H -60.7 -40.4 21.0 0.12 0.0 ATP
HOH
6.858
3.271
O
CD1
O2G
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 ILE A:862 A:891 24.0 0.137 H -65.1 -44.7 24.0 0.137 0.0 HOH
4.362
CD1
O
ILE B:862 B:891 32.0 0.183 H -68.3 -33.1 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 ILE A:891 A:891 22.0 0.126 H -52.8 -50.7 22.0 0.126 0.0 HOH
5.069
CD1
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 ILE A:862 A:891 29.0 0.166 H -56.2 -44.0 29.0 0.166 0.0 HOH
2.713
O
O
ILE B:862 B:891 41.0 0.234 H -59.5 -44.3 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 ILE A:850 A:891 27.0 0.154 H -53.7 -46.6 27.0 0.154 0.0 HOH
7.063
N
O
ILE B:850 B:891 27.0 0.154 H -53.5 -45.8 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 ILE A:850 A:891 25.0 0.143 H -60.6 -41.6 25.0 0.143 0.0
ILE B:850 B:891 27.0 0.154 H -61.1 -42.0 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 ILE A:850 A:891 29.0 0.166 H -62.5 -49.9 29.0 0.166 0.0
ILE B:850 B:891 27.0 0.154 H -62.3 -50.5 27.0 0.154 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:861 A:891 63.0 0.36 H -61.6 -43.1 63.0 0.36 0.0 HOH
3.535
O
O
ILE B:861 B:891 94.0 0.537 H -56.9 -52.6 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:861 A:891 69.0 0.394 H -62.1 -46.5 69.0 0.394 0.0 HOH
5.539
CB
O
ILE B:861 B:891 96.0 0.549 H -61.9 -47.0 96.0 0.549 0.0 HOH
2.731
O
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:861 A:891 94.0 0.537 H -69.8 -45.5 94.0 0.537 0.0 HOH
4.049
CD1
O
ILE B:861 B:891 73.0 0.417 H -57.2 -48.3 73.0 0.417 0.0 HOH
6.572
CB
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:861 A:891 90.0 0.514 H -60.0 -49.0 90.0 0.514 0.0 HOH
2.719
O
O
ILE B:861 B:891 69.0 0.394 H -66.1 -46.2 69.0 0.394 0.0 HOH
7.742
CD1
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 ILE A:862 A:891 23.0 0.131 H -69.3 -38.2 23.0 0.131 0.0 HOH
6.442
C
O
ILE B:862 B:891 29.0 0.166 H -60.3 -40.8 29.0 0.166 0.0 HOH
5.181
O
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 ILE A:862 A:891 26.0 0.149 H -56.9 -45.4 26.0 0.149 0.0 HOH
7.480
C
O
ILE B:862 B:891 25.0 0.143 H -61.2 -34.0 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 ILE A:862 A:891 23.0 0.131 H -56.4 -34.1 23.0 0.131 0.0
ILE B:862 B:891 34.0 0.194 H -57.7 -31.2 34.0 0.194 0.0
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 ILE A:862 A:891 52.0 0.297 H -56.8 -41.2 52.0 0.297 0.0
ILE B:862 B:891 89.0 0.509 H -57.2 -40.9 89.0 0.509 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 ILE A:862 A:891 28.0 0.16 H -56.5 -44.3 28.0 0.16 0.0
ILE B:862 B:891 27.0 0.154 H -56.7 -44.1 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 ILE A:862 A:891 26.0 0.149 H -70.7 -42.8 26.0 0.149 0.0
ILE B:862 B:891 18.0 0.103 H -74.0 -43.0 NA NA NA
ILE C:862 C:891 17.0 0.097 H -70.6 -46.5 NA NA NA
ILE D:862 D:891 23.0 0.131 H -74.5 -40.6 NA NA NA
ILE E:862 E:891 29.0 0.166 H -73.2 -41.1 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 ILE A:862 A:891 35.0 0.2 H -92.6 -34.9 35.0 0.2 0.0
ILE B:862 B:891 28.0 0.16 H -98.1 -39.8 28.0 0.16 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 ILE A:862 A:891 26.0 0.149 H -57.9 -44.5 26.0 0.149 0.0
ILE B:862 B:891 25.0 0.143 H -53.9 -41.8 25.0 0.143 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 ILE A:862 A:891 19.0 0.109 H -59.2 -47.1 19.0 0.109 0.0
ILE B:862 B:891 22.0 0.126 H -57.2 -45.4 22.0 0.126 0.0 HOH
4.180
CD1
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 ILE A:862 A:891 19.0 0.109 H -62.6 -44.4 19.0 0.109 0.0 HOH
6.159
CG1
O
ILE B:862 B:891 22.0 0.126 H -59.4 -44.9 22.0 0.126 0.0 HOH
2.614
O
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 ILE A:862 A:891 28.0 0.16 H -56.8 -40.8 28.0 0.16 0.0 HOH
2.636
O
O
ILE B:862 B:891 34.0 0.194 H -55.5 -44.4 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 ILE A:862 A:891 37.0 0.211 H -61.4 -43.1 37.0 0.211 0.0 HOH
3.619
CD1
O
ILE B:862 B:891 35.0 0.2 H -60.5 -37.4 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 ILE A:862 A:891 32.0 0.183 H -58.6 -44.5 32.0 0.183 0.0 HOH
7.229
N
O
ILE B:862 B:891 28.0 0.16 H -58.0 -44.6 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 ILE A:862 A:891 26.0 0.149 H -57.5 -45.0 26.0 0.149 0.0 DIO
HOH
8.230
5.235
O
O
C1'
O
ILE B:862 B:891 24.0 0.137 H -58.0 -44.1 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 ILE A:862 A:891 32.0 0.183 H -60.8 -36.2 32.0 0.183 0.0
ILE B:862 B:891 31.0 0.177 H -59.9 -44.3 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 ILE A:862 A:891 32.0 0.183 H -54.9 -42.5 32.0 0.183 0.0
ILE B:862 B:891 29.0 0.166 H -55.3 -42.4 29.0 0.166 0.0
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 ILE A:862 A:891 28.0 0.16 H -49.9 -44.1 28.0 0.16 0.0 HOH
4.623
CD1
O
ILE B:862 B:891 26.0 0.149 H -58.0 -48.3 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 ILE A:862 A:891 25.0 0.143 H -69.6 -43.6 25.0 0.143 0.0 HOH
4.976
CG1
O
ILE B:862 B:891 29.0 0.166 H -60.3 -37.8 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 ILE A:862 A:891 30.0 0.171 H -60.8 -42.6 30.0 0.171 0.0
ILE B:862 B:891 25.0 0.143 H -57.5 -26.7 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 ILE A:862 A:891 24.0 0.137 H -60.5 -42.8 24.0 0.137 0.0 HOH
7.175
C
O
ILE B:862 B:891 27.0 0.154 H -55.0 -46.6 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 ILE A:862 A:891 30.0 0.171 H -60.3 -41.4 30.0 0.171 0.0 HOH
4.607
CD1
O
ILE B:862 B:891 27.0 0.154 H -58.0 -41.0 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 ILE A:862 A:891 26.0 0.149 H -64.2 -36.3 26.0 0.149 0.0
ILE B:862 B:891 23.0 0.131 H -71.0 -44.9 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 ILE A:862 A:891 24.0 0.137 H -60.8 -45.4 24.0 0.137 0.0 HOH
7.942
CG2
O
ILE B:862 B:891 30.0 0.171 H -60.4 -45.8 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 ILE A:862 A:891 22.0 0.126 H -64.6 -47.9 22.0 0.126 0.0
ILE B:862 B:891 22.0 0.126 H -59.6 -41.5 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 ILE A:862 A:891 30.0 0.171 H -62.0 -39.7 30.0 0.171 0.0 HOH
5.761
CG1
O
ILE B:862 B:891 29.0 0.166 H -63.5 -40.1 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 ILE A:862 A:891 27.0 0.154 H -63.1 -40.1 27.0 0.154 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 ILE A:862 A:891 30.0 0.171 H -65.6 -33.9 30.0 0.171 0.0
ILE B:862 B:891 36.0 0.206 H -68.1 -40.9 36.0 0.206 0.0
ILE C:862 C:891 34.0 0.194 H -64.8 -34.8 NA NA NA
ILE D:862 D:891 29.0 0.166 H -69.3 -40.6 NA NA NA
ILE E:862 E:891 23.0 0.131 H -66.4 -40.4 NA NA NA
ILE F:862 F:891 36.0 0.206 H -66.5 -34.7 NA NA NA
ILE G:862 G:891 24.0 0.137 H -68.7 -42.2 NA NA NA
ILE H:862 H:891 44.0 0.251 H -65.3 -36.1 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 ILE A:849 A:891 29.0 0.166 H -57.5 -43.6 29.0 0.166 0.0 HOH
5.940
CG1
O
ILE B:849 B:891 23.0 0.131 H -63.3 -37.2 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 ILE A:846 A:891 45.0 0.257 H -77.2 -26.1 45.0 0.257 0.0
ILE B:846 B:891 43.0 0.246 H -77.2 -21.1 43.0 0.246 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 ILE A:846 A:891 109.0 0.623 H -73.5 -26.1 109.0 0.623 0.0
ILE B:846 B:891 93.0 0.531 H -72.6 -23.7 93.0 0.531 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 ILE A:846 A:891 109.0 0.623 H -66.9 -33.8 109.0 0.623 0.0
ILE B:846 B:891 99.0 0.566 H -66.7 -25.5 99.0 0.566 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 ILE A:846 A:891 104.0 0.594 H -71.9 -26.7 104.0 0.594 0.0
ILE B:846 B:891 106.0 0.606 H -71.0 -26.5 106.0 0.606 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 ILE A:846 A:891 108.0 0.617 H -71.9 -26.2 108.0 0.617 0.0
ILE B:846 B:891 92.0 0.526 H -71.7 -24.7 92.0 0.526 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 ILE A:846 A:891 102.0 0.583 H -74.7 -24.0 102.0 0.583 0.0
ILE B:846 B:891 107.0 0.611 T -71.3 -24.3 107.0 0.611 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 ILE A:846 A:891 100.0 0.571 H -72.4 -26.7 100.0 0.571 0.0
ILE B:846 B:891 110.0 0.629 H -72.2 -26.1 110.0 0.629 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 ILE A:846 A:891 38.0 0.217 H -90.7 -35.5 38.0 0.217 0.0
ILE B:846 B:891 27.0 0.154 H -96.5 -39.1 27.0 0.154 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 ILE A:850 A:891 23.0 0.131 H -65.0 -39.5 23.0 0.131 0.0 HOH
2.820
O
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 ILE A:862 A:891 28.0 0.16 H -58.4 -41.7 28.0 0.16 0.0 HOH
2.887
O
O
ILE B:862 B:891 25.0 0.143 H -59.8 -45.9 25.0 0.143 0.0 HOH
2.943
O
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 ILE A:891 A:891 25.0 0.143 H -64.9 -43.1