Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94223656 . C A CCDS7421.1:NM_004969.3:c.2593Gct>Tct_NP_004960.2:p.865A>S Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 ALA A:865 A:865 0.0 0.0 H -51.7 -48.7 NA NA NA
ALA B:865 B:865 0.0 0.0 H -59.1 -43.1 0.0 0.0 0.0 HOH
6.850
O
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 ALA A:865 A:865 0.0 0.0 H -54.9 -47.2 0.0 0.0 0.0 HOH
3.691
CB
O
ALA B:865 B:865 0.0 0.0 H -52.7 -40.2 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 ALA A:865 A:865 1.0 0.009 H -64.1 -38.8 1.0 0.009 0.0 HOH
3.979
C
O
ALA B:865 B:865 1.0 0.009 H -62.1 -37.3 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 ALA A:836 A:865 0.0 0.0 H -65.6 -45.5 0.0 0.0 0.0 HOH
2.869
O
O
ALA B:836 B:865 0.0 0.0 H -66.1 -42.1 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ALA A:836 A:865 1.0 0.009 H -67.1 -40.5 1.0 0.009 0.0 HOH
3.669
O
O
ALA B:836 B:865 0.0 0.0 H -65.8 -42.8 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ALA A:836 A:865 0.0 0.0 H -65.4 -42.6 0.0 0.0 0.0 HOH
3.644
O
O
ALA B:836 B:865 0.0 0.0 H -65.4 -49.4 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ALA A:836 A:865 0.0 0.0 H -67.7 -38.6 0.0 0.0 0.0 HOH
3.566
O
O
ALA B:836 B:865 0.0 0.0 H -67.1 -44.7 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ALA A:836 A:865 0.0 0.0 H -66.5 -41.6 0.0 0.0 0.0 HOH
2.865
O
O
ALA B:836 B:865 0.0 0.0 H -68.9 -38.6 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 ALA A:836 A:865 1.0 0.009 H -65.0 -54.3 1.0 0.009 0.0 HOH
7.427
O
O
ALA B:836 B:865 2.0 0.017 H -61.1 -51.7 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 ALA A:836 A:865 0.0 0.0 H -66.1 -44.1 0.0 0.0 0.0 HOH
3.882
CB
O
ALA B:836 B:865 0.0 0.0 H -61.5 -43.5 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 ALA A:865 A:865 2.0 0.017 H -70.0 -37.8 2.0 0.017 0.0 HOH
3.832
C
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 ALA A:836 A:865 1.0 0.009 H -50.2 -52.8 1.0 0.009 0.0 HOH
3.780
CB
O
ALA B:836 B:865 2.0 0.017 H -64.5 -55.5 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 ALA A:865 A:865 1.0 0.009 H -60.2 -43.9 1.0 0.009 0.0 HOH
2.648
O
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 ALA A:836 A:865 1.0 0.009 H -61.3 -40.7 1.0 0.009 0.0 HOH
2.730
O
O
ALA B:836 B:865 1.0 0.009 H -61.2 -43.9 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 ALA A:824 A:865 1.0 0.009 H -62.5 -37.9 1.0 0.009 0.0 HOH
2.863
O
O
ALA B:824 B:865 1.0 0.009 H -61.6 -38.0 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 ALA A:824 A:865 1.0 0.009 H -57.9 -44.1 1.0 0.009 0.0
ALA B:824 B:865 0.0 0.0 H -58.3 -44.6 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 ALA A:824 A:865 1.0 0.009 H -65.1 -34.5 1.0 0.009 0.0
ALA B:824 B:865 1.0 0.009 H -65.3 -36.0 1.0 0.009 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 ALA A:835 A:865 1.0 0.009 H -58.5 -49.2 1.0 0.009 0.0 HOH
3.936
CB
O
ALA B:835 B:865 0.0 0.0 H -64.9 -45.9 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 ALA A:835 A:865 0.0 0.0 H -60.1 -47.1 0.0 0.0 0.0 HOH
3.943
CB
O
ALA B:835 B:865 0.0 0.0 H -67.0 -42.2 0.0 0.0 0.0 HOH
3.956
CB
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 ALA A:835 A:865 0.0 0.0 H -61.0 -45.2 0.0 0.0 0.0 HOH
3.041
O
O
ALA B:835 B:865 0.0 0.0 H -61.0 -43.8 0.0 0.0 0.0 HOH
3.979
CB
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 ALA A:835 A:865 0.0 0.0 H -67.8 -36.9 0.0 0.0 0.0 HOH
3.813
C
O
ALA B:835 B:865 0.0 0.0 H -60.5 -46.0 0.0 0.0 0.0 HOH
8.703
CB
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 ALA A:836 A:865 0.0 0.0 H -73.0 -41.4 0.0 0.0 0.0 HOH
9.560
O
O
ALA B:836 B:865 0.0 0.0 H -67.9 -56.3 0.0 0.0 0.0 HOH
2.330
O
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 ALA A:836 A:865 0.0 0.0 H -63.4 -48.0 0.0 0.0 0.0 HOH
6.838
CA
O
ALA B:836 B:865 1.0 0.009 H -71.5 -42.9 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 ALA A:836 A:865 1.0 0.009 H -65.5 -42.4 1.0 0.009 0.0
ALA B:836 B:865 1.0 0.009 H -88.6 -27.1 1.0 0.009 0.0
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 ALA A:836 A:865 0.0 0.0 H -62.5 -37.0 0.0 0.0 0.0
ALA B:836 B:865 1.0 0.009 H -62.9 -37.1 1.0 0.009 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 ALA A:836 A:865 1.0 0.009 H -62.1 -40.9 1.0 0.009 0.0 HOH
3.755
O
O
ALA B:836 B:865 0.0 0.0 H -62.6 -38.5 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 ALA A:836 A:865 2.0 0.017 H -62.9 -32.2 2.0 0.017 0.0
ALA B:836 B:865 4.0 0.035 H -66.0 -29.3 NA NA NA
ALA C:836 C:865 1.0 0.009 H -66.3 -28.7 NA NA NA
ALA D:836 D:865 2.0 0.017 H -65.4 -31.8 NA NA NA
ALA E:836 E:865 2.0 0.017 H -62.2 -31.3 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 ALA A:836 A:865 3.0 0.026 H -62.0 -39.9 3.0 0.026 0.0
ALA B:836 B:865 27.0 0.235 H -69.7 -27.8 27.0 0.235 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 ALA A:836 A:865 0.0 0.0 H -56.3 -48.7 0.0 0.0 0.0
ALA B:836 B:865 0.0 0.0 H -51.3 -46.2 0.0 0.0 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 ALA A:836 A:865 0.0 0.0 H -61.6 -46.7 0.0 0.0 0.0 HOH
5.224
N
O
ALA B:836 B:865 1.0 0.009 H -54.8 -40.5 1.0 0.009 0.0 HOH
3.627
O
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 ALA A:836 A:865 0.0 0.0 H -53.4 -48.0 0.0 0.0 0.0 HOH
3.842
O
O
ALA B:836 B:865 0.0 0.0 H -52.7 -42.2 0.0 0.0 0.0 HOH
3.552
O
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 ALA A:836 A:865 1.0 0.009 H -62.7 -36.5 1.0 0.009 0.0 HOH
2.793
O
O
ALA B:836 B:865 0.0 0.0 H -54.9 -51.0 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 ALA A:836 A:865 1.0 0.009 H -45.2 -46.3 1.0 0.009 0.0 HOH
2.637
O
O
ALA B:836 B:865 0.0 0.0 H -64.7 -47.9 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 ALA A:836 A:865 0.0 0.0 H -49.3 -49.2 0.0 0.0 0.0 HOH
4.421
N
O
ALA B:836 B:865 1.0 0.009 H -58.3 -47.3 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 ALA A:836 A:865 0.0 0.0 H -50.0 -64.8 0.0 0.0 0.0
ALA B:836 B:865 0.0 0.0 H -55.1 -49.3 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 ALA A:836 A:865 0.0 0.0 H -62.2 -42.7 0.0 0.0 0.0
ALA B:836 B:865 0.0 0.0 H -64.8 -36.1 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 ALA A:836 A:865 0.0 0.0 H -53.5 -48.5 0.0 0.0 0.0
ALA B:836 B:865 0.0 0.0 H -59.7 -37.4 0.0 0.0 0.0
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 ALA A:836 A:865 0.0 0.0 H -65.2 -37.8 0.0 0.0 0.0 HOH
3.799
CB
O
ALA B:836 B:865 0.0 0.0 H -58.4 -46.2 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 ALA A:836 A:865 1.0 0.009 H -57.5 -48.4 1.0 0.009 0.0 HOH
7.259
CA
O
ALA B:836 B:865 0.0 0.0 H -70.6 -44.5 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 ALA A:836 A:865 0.0 0.0 H -60.7 -52.8 0.0 0.0 0.0
ALA B:836 B:865 0.0 0.0 H -68.8 -45.1 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 ALA A:836 A:865 0.0 0.0 H -58.7 -42.8 0.0 0.0 0.0 HOH
3.780
CB
O
ALA B:836 B:865 1.0 0.009 H -64.2 -47.1 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 ALA A:836 A:865 0.0 0.0 H -56.9 -38.8 0.0 0.0 0.0 HOH
4.062
CB
O
ALA B:836 B:865 0.0 0.0 H -59.2 -46.3 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 ALA A:836 A:865 2.0 0.017 H -70.0 -28.1 2.0 0.017 0.0
ALA B:836 B:865 1.0 0.009 H -67.8 -31.5 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 ALA A:836 A:865 0.0 0.0 H -56.6 -43.5 0.0 0.0 0.0 HOH
3.726
C
O
ALA B:836 B:865 0.0 0.0 H -57.9 -44.7 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 ALA A:836 A:865 0.0 0.0 H -56.9 -46.0 0.0 0.0 0.0
ALA B:836 B:865 0.0 0.0 H -52.6 -48.7 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 ALA A:836 A:865 1.0 0.009 H -69.8 -37.4 1.0 0.009 0.0
ALA B:836 B:865 0.0 0.0 H -69.4 -37.7 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 ALA A:836 A:865 2.0 0.017 H -68.8 -32.5 2.0 0.017 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 ALA A:836 A:865 5.0 0.043 H -58.5 -37.4 5.0 0.043 0.0
ALA B:836 B:865 1.0 0.009 H -58.9 -37.6 1.0 0.009 0.0
ALA C:836 C:865 12.0 0.104 H -58.4 -37.0 NA NA NA
ALA D:836 D:865 1.0 0.009 H -60.0 -36.5 NA NA NA
ALA E:836 E:865 2.0 0.017 H -59.5 -40.4 NA NA NA
ALA F:836 F:865 1.0 0.009 H -58.8 -38.0 NA NA NA
ALA G:836 G:865 1.0 0.009 H -59.7 -41.5 NA NA NA
ALA H:836 H:865 12.0 0.104 H -60.0 -36.0 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 ALA A:823 A:865 0.0 0.0 H -51.7 -54.7 0.0 0.0 0.0 HOH
3.819
CB
O
ALA B:823 B:865 0.0 0.0 H -59.7 -46.6 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 ALA A:820 A:865 6.0 0.052 H -65.5 -38.2 6.0 0.052 0.0
ALA B:820 B:865 25.0 0.217 H -67.2 -31.7 25.0 0.217 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 ALA A:820 A:865 9.0 0.078 H -62.6 -40.6 9.0 0.078 0.0
ALA B:820 B:865 44.0 0.383 H -65.1 -39.5 44.0 0.383 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 ALA A:820 A:865 29.0 0.252 H -62.9 -39.1 29.0 0.252 0.0
ALA B:820 B:865 44.0 0.383 H -66.4 -35.3 44.0 0.383 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 ALA A:820 A:865 17.0 0.148 H -63.6 -40.5 17.0 0.148 0.0
ALA B:820 B:865 42.0 0.365 H -63.7 -40.5 42.0 0.365 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 ALA A:820 A:865 23.0 0.2 H -63.6 -40.4 23.0 0.2 0.0
ALA B:820 B:865 40.0 0.348 H -64.0 -40.4 40.0 0.348 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 ALA A:820 A:865 3.0 0.026 H -63.0 -38.9 3.0 0.026 0.0
ALA B:820 B:865 48.0 0.417 H -63.2 -38.4 48.0 0.417 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 ALA A:820 A:865 16.0 0.139 H -64.0 -39.4 16.0 0.139 0.0
ALA B:820 B:865 37.0 0.322 H -64.1 -39.1 37.0 0.322 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 ALA A:820 A:865 2.0 0.017 H -62.4 -39.2 2.0 0.017 0.0
ALA B:820 B:865 26.0 0.226 H -69.7 -28.6 26.0 0.226 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 ALA A:824 A:865 1.0 0.009 H -63.4 -42.3 1.0 0.009 0.0 HOH
2.863
O
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 ALA A:836 A:865 0.0 0.0 H -58.2 -44.5 0.0 0.0 0.0 HOH
2.746
O
O
ALA B:836 B:865 0.0 0.0 H -63.1 -36.6 0.0 0.0 0.0 HOH
2.751
O
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 ALA A:865 A:865 0.0 0.0 H -62.2 -39.2