Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94225589 . C A CCDS7421.1:NM_004969.3:c.2332Gtt>Ttt_NP_004960.2:p.778V>F Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 VAL A:778 A:778 9.0 0.058 E -114.5 136.4 NA NA NA
VAL B:778 B:778 9.0 0.058 E -133.1 131.0 9.0 0.058 0.0 HOH
7.190
CG2
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 VAL A:778 A:778 0.0 0.0 E -127.8 130.7 0.0 0.0 0.0 HOH
4.363
O
O
VAL B:778 B:778 0.0 0.0 E -126.2 129.6 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 VAL A:778 A:778 8.0 0.052 E -125.5 137.1 8.0 0.052 0.0 HOH
4.201
O
O
VAL B:778 B:778 12.0 0.077 E -127.7 137.4 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 VAL A:749 A:778 0.0 0.0 E -130.0 127.4 0.0 0.0 0.0 HOH
4.223
O
O
VAL B:749 B:778 0.0 0.0 E -130.7 137.4 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 VAL A:749 A:778 0.0 0.0 E -133.7 135.6 0.0 0.0 0.0 HOH
5.667
CG1
O
VAL B:749 B:778 0.0 0.0 E -129.9 132.9 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 VAL A:749 A:778 0.0 0.0 E -130.4 136.5 0.0 0.0 0.0 HOH
4.196
O
O
VAL B:749 B:778 0.0 0.0 E -135.3 128.6 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 VAL A:749 A:778 0.0 0.0 E -132.2 131.3 0.0 0.0 0.0 HOH
5.536
CG1
O
VAL B:749 B:778 0.0 0.0 E -133.9 129.7 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 VAL A:749 A:778 0.0 0.0 E -133.9 126.1 0.0 0.0 0.0 HOH
4.171
O
O
VAL B:749 B:778 0.0 0.0 E -130.2 134.2 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 VAL A:749 A:778 1.0 0.006 E -133.1 130.3 1.0 0.006 0.0
VAL B:749 B:778 2.0 0.013 E -146.4 125.6 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 VAL A:749 A:778 0.0 0.0 E -124.3 127.5 0.0 0.0 0.0 HOH
4.144
O
O
VAL B:749 B:778 0.0 0.0 E -130.2 128.5 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 VAL A:778 A:778 2.0 0.013 E -125.6 127.3 2.0 0.013 0.0 HOH
4.298
O
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 VAL A:749 A:778 0.0 0.0 E -126.7 134.0 0.0 0.0 0.0 HOH
4.072
O
O
VAL B:749 B:778 0.0 0.0 E -131.2 126.7 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 VAL A:778 A:778 6.0 0.039 E -135.1 135.3 6.0 0.039 0.0 HOH
4.278
O
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 VAL A:749 A:778 9.0 0.058 E -125.7 131.2 9.0 0.058 0.0 HOH
6.984
CG2
O
VAL B:749 B:778 9.0 0.058 E -125.0 126.3 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 VAL A:737 A:778 7.0 0.045 E -119.4 133.3 7.0 0.045 0.0 HOH
4.281
O
O
VAL B:737 B:778 9.0 0.058 E -119.5 133.6 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 VAL A:737 A:778 8.0 0.052 E -133.2 123.8 8.0 0.052 0.0
VAL B:737 B:778 9.0 0.058 E -133.8 121.6 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 VAL A:737 A:778 9.0 0.058 E -136.6 125.7 9.0 0.058 0.0
VAL B:737 B:778 11.0 0.071 E -136.7 125.3 11.0 0.071 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 VAL A:748 A:778 8.0 0.052 E -127.4 132.9 8.0 0.052 0.0 HOH
4.385
O
O
VAL B:748 B:778 3.0 0.019 E -123.9 130.5 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 VAL A:748 A:778 7.0 0.045 E -127.6 132.9 7.0 0.045 0.0 HOH
3.935
O
O
VAL B:748 B:778 4.0 0.026 E -127.3 132.8 4.0 0.026 0.0 HOH
4.159
O
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 VAL A:748 A:778 4.0 0.026 E -127.7 127.5 4.0 0.026 0.0 HOH
4.923
O
O
VAL B:748 B:778 9.0 0.058 E -124.8 133.8 9.0 0.058 0.0 HOH
4.012
O
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 VAL A:748 A:778 4.0 0.026 E -124.3 129.4 4.0 0.026 0.0 HOH
4.058
O
O
VAL B:748 B:778 9.0 0.058 E -124.9 136.0 9.0 0.058 0.0 HOH
4.755
O
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 VAL A:749 A:778 9.0 0.058 E -130.0 123.7 9.0 0.058 0.0 HOH
3.544
O
O
VAL B:749 B:778 12.0 0.077 E -135.0 127.8 12.0 0.077 0.0 HOH
5.658
CG1
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 VAL A:749 A:778 6.0 0.039 E -125.7 129.6 6.0 0.039 0.0 HOH
9.783
CG1
O
VAL B:749 B:778 9.0 0.058 E -134.7 125.5 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 VAL A:749 A:778 9.0 0.058 E -124.2 136.1 9.0 0.058 0.0 HOH
4.412
O
O
VAL B:749 B:778 9.0 0.058 E -123.5 136.5 9.0 0.058 0.0 HOH
5.439
CG1
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 VAL A:749 A:778 11.0 0.071 E -120.3 136.0 11.0 0.071 0.0
VAL B:749 B:778 10.0 0.065 E -120.1 136.2 10.0 0.065 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 VAL A:749 A:778 12.0 0.077 E -127.3 137.1 12.0 0.077 0.0
VAL B:749 B:778 11.0 0.071 E -127.4 139.1 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 VAL A:749 A:778 8.0 0.052 E -125.6 120.3 8.0 0.052 0.0
VAL B:749 B:778 7.0 0.045 E -123.4 122.4 NA NA NA
VAL C:749 C:778 3.0 0.019 E -132.3 120.8 NA NA NA
VAL D:749 D:778 9.0 0.058 E -130.0 123.2 NA NA NA
VAL E:749 E:778 8.0 0.052 E -124.0 120.2 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 VAL A:749 A:778 13.0 0.084 E -161.0 142.4 13.0 0.084 0.0
VAL B:749 B:778 20.0 0.129 E -127.5 133.8 20.0 0.129 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 VAL A:749 A:778 12.0 0.077 E -129.0 139.0 12.0 0.077 0.0
VAL B:749 B:778 9.0 0.058 E -126.2 137.8 9.0 0.058 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 VAL A:749 A:778 11.0 0.071 E -136.5 132.5 11.0 0.071 0.0
VAL B:749 B:778 11.0 0.071 E -122.1 129.4 11.0 0.071 0.0
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 VAL A:749 A:778 10.0 0.065 E -132.3 132.0 10.0 0.065 0.0 HOH
4.404
O
O
VAL B:749 B:778 11.0 0.071 E -132.6 133.2 11.0 0.071 0.0 HOH
5.757
CG1
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 VAL A:749 A:778 9.0 0.058 E -120.2 135.4 9.0 0.058 0.0 HOH
4.123
O
O
VAL B:749 B:778 3.0 0.019 E -123.6 130.3 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 VAL A:749 A:778 8.0 0.052 E -120.4 139.5 8.0 0.052 0.0 HOH
4.187
O
O
VAL B:749 B:778 7.0 0.045 E -125.9 129.6 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 VAL A:749 A:778 9.0 0.058 E -125.2 134.2 9.0 0.058 0.0 HOH
4.293
O
O
VAL B:749 B:778 11.0 0.071 E -129.7 129.0 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 VAL A:749 A:778 9.0 0.058 E -135.7 127.6 9.0 0.058 0.0 HOH
4.491
O
O
VAL B:749 B:778 10.0 0.065 E -133.0 129.3 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 VAL A:749 A:778 8.0 0.052 E -123.9 125.1 8.0 0.052 0.0 HOH
6.336
O
O
VAL B:749 B:778 8.0 0.052 E -134.1 121.6 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 VAL A:749 A:778 6.0 0.039 E -127.3 124.6 6.0 0.039 0.0 HOH
4.154
O
O
VAL B:749 B:778 9.0 0.058 E -125.0 133.5 9.0 0.058 0.0 HOH
5.354
CG1
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 VAL A:749 A:778 9.0 0.058 E -119.1 138.8 9.0 0.058 0.0 HOH
4.360
O
O
VAL B:749 B:778 11.0 0.071 E -127.3 126.4 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 VAL A:749 A:778 6.0 0.039 E -128.1 140.0 6.0 0.039 0.0 HOH
4.175
O
O
VAL B:749 B:778 10.0 0.065 E -132.5 138.4 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 VAL A:749 A:778 9.0 0.058 E -134.4 135.9 9.0 0.058 0.0 HOH
5.384
CG1
O
VAL B:749 B:778 14.0 0.09 E -137.2 124.1 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 VAL A:749 A:778 8.0 0.052 E -132.7 137.4 8.0 0.052 0.0
VAL B:749 B:778 14.0 0.09 E -126.5 127.5 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 VAL A:749 A:778 8.0 0.052 E -119.0 138.4 8.0 0.052 0.0 HOH
4.267
O
O
VAL B:749 B:778 8.0 0.052 E -127.5 133.9 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 VAL A:749 A:778 12.0 0.077 E -131.6 125.5 12.0 0.077 0.0
VAL B:749 B:778 11.0 0.071 E -139.0 122.5 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 VAL A:749 A:778 7.0 0.045 E -127.4 133.6 7.0 0.045 0.0
VAL B:749 B:778 10.0 0.065 E -128.7 135.7 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 VAL A:749 A:778 9.0 0.058 E -132.9 128.3 9.0 0.058 0.0
VAL B:749 B:778 11.0 0.071 E -130.2 128.5 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 VAL A:749 A:778 11.0 0.071 E -134.1 124.9 11.0 0.071 0.0 HOH
8.990
O
O
VAL B:749 B:778 8.0 0.052 E -134.4 124.2 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 VAL A:749 A:778 11.0 0.071 E -131.1 118.8 11.0 0.071 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 VAL A:749 A:778 9.0 0.058 E -130.1 123.0 9.0 0.058 0.0
VAL B:749 B:778 6.0 0.039 E -130.6 123.6 6.0 0.039 0.0
VAL C:749 C:778 14.0 0.09 E -134.6 121.9 NA NA NA
VAL D:749 D:778 12.0 0.077 E -131.2 121.9 NA NA NA
VAL E:749 E:778 9.0 0.058 E -133.7 127.9 NA NA NA
VAL F:749 F:778 11.0 0.071 E -130.2 122.5 NA NA NA
VAL G:749 G:778 4.0 0.026 E -130.4 125.2 NA NA NA
VAL H:749 H:778 12.0 0.077 E -132.9 118.4 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 VAL A:736 A:778 9.0 0.058 E -136.1 127.4 9.0 0.058 0.0 HOH
3.935
O
O
VAL B:736 B:778 1.0 0.006 E -127.7 124.0 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 VAL A:733 A:778 14.0 0.09 E -163.3 152.4 14.0 0.09 0.0
VAL B:733 B:778 13.0 0.084 E -160.8 148.6 13.0 0.084 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 VAL A:733 A:778 12.0 0.077 -155.8 160.9 12.0 0.077 0.0
VAL B:733 B:778 20.0 0.129 -156.3 160.4 20.0 0.129 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 VAL A:733 A:778 13.0 0.084 -158.6 156.6 13.0 0.084 0.0
VAL B:733 B:778 16.0 0.103 -160.3 149.0 16.0 0.103 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 VAL A:733 A:778 12.0 0.077 -154.5 157.4 12.0 0.077 0.0
VAL B:733 B:778 15.0 0.097 -157.5 158.0 15.0 0.097 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 VAL A:733 A:778 12.0 0.077 -154.4 157.6 12.0 0.077 0.0
VAL B:733 B:778 15.0 0.097 E -157.5 159.6 15.0 0.097 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 VAL A:733 A:778 9.0 0.058 -159.8 159.1 9.0 0.058 0.0
VAL B:733 B:778 22.0 0.142 -154.4 157.4 22.0 0.142 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 VAL A:733 A:778 9.0 0.058 -160.1 155.5 9.0 0.058 0.0
VAL B:733 B:778 29.0 0.187 -155.0 155.3 29.0 0.187 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 VAL A:733 A:778 12.0 0.077 E -161.9 141.5 12.0 0.077 0.0
VAL B:733 B:778 19.0 0.123 E -129.8 135.5 19.0 0.123 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 VAL A:737 A:778 9.0 0.058 E -133.0 135.6 9.0 0.058 0.0 HOH
7.466
N
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 VAL A:749 A:778 8.0 0.052 E -126.0 132.1 8.0 0.052 0.0 HOH
4.241
O
O
VAL B:749 B:778 6.0 0.039 E -129.3 128.8 6.0 0.039 0.0 HOH
4.117
O
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 VAL A:778 A:778 0.0 0.0 E -127.3 128.7