Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94228663 . G A CCDS7421.1:NM_004969.3:c.2293Cgg>Tgg_NP_004960.2:p.765R>W Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 ARG A:765 A:765 29.0 NA -86.3 147.6 NA NA NA
ARG B:765 B:765 29.0 NA -79.0 151.7 29.0 NA NA HOH
7.346
O
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 ARG A:765 A:765 36.0 0.16 -87.4 143.1 36.0 0.16 0.0 DIO
HOH
8.233
6.910
NH2
CG
O1
O
ARG B:765 B:765 28.0 0.124 -118.8 152.3 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 ARG A:765 A:765 30.0 0.133 -99.1 155.4 30.0 0.133 0.0 EPE
HOH
7.800
3.034
CD
NH1
O1S
O
ARG B:765 B:765 40.0 0.178 -101.3 155.5 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 ARG A:736 A:765 49.0 0.218 -117.0 150.9 49.0 0.218 0.0 HOH
3.608
CG
O
ARG B:736 B:765 41.0 0.182 -106.4 155.4 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:736 A:765 33.0 0.147 -132.5 129.4 33.0 0.147 0.0 HOH
3.108
NH2
O
ARG B:736 B:765 38.0 0.169 -120.8 158.1 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:736 A:765 29.0 0.129 -121.8 140.2 29.0 0.129 0.0 HOH
2.882
NH2
O
ARG B:736 B:765 35.0 0.156 -118.6 150.9 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:736 A:765 40.0 0.178 -124.0 135.8 40.0 0.178 0.0 HOH
2.878
NH2
O
ARG B:736 B:765 36.0 0.16 -116.8 147.8 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:736 A:765 29.0 0.129 -118.1 149.9 29.0 0.129 0.0 HOH
3.295
NH2
O
ARG B:736 B:765 34.0 0.151 -106.5 149.4 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 ARG A:736 A:765 40.0 0.178 -111.9 147.0 40.0 0.178 0.0 HOH
5.521
NH1
O
ARG B:736 B:765 38.0 0.169 -124.8 144.1 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 ARG A:736 A:765 35.0 0.156 -88.8 145.4 35.0 0.156 0.0 HOH
4.512
CD
O
ARG B:736 B:765 35.0 0.156 -110.8 151.9 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 ARG A:765 A:765 40.0 0.178 -114.6 141.8 40.0 0.178 0.0 HOH
3.546
NH1
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 ARG A:736 A:765 36.0 0.16 -97.5 141.0 36.0 0.16 0.0 DIO
HOH
7.325
3.660
NH2
CB
O1'
O
ARG B:736 B:765 32.0 0.142 -97.7 149.2 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 ARG A:765 A:765 49.0 0.218 -98.2 149.8 38.0 0.169 0.049 A:P35559:0.049
HOH
2.484
NH1
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 ARG A:736 A:765 39.0 0.173 -122.3 147.3 39.0 0.173 0.0 HOH
3.628
NH1
O
ARG B:736 B:765 38.0 0.169 -120.4 149.6 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 ARG A:724 A:765 32.0 0.142 -86.8 155.7 32.0 0.142 0.0 EPE
HOH
7.558
2.906
CD
NH2
O3S
O
ARG B:724 B:765 34.0 0.151 -88.1 155.5 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 ARG A:724 A:765 31.0 0.138 -90.0 158.1 31.0 0.138 0.0 EPE
7.942
NH1
O1S
ARG B:724 B:765 34.0 0.151 -91.6 157.6 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 ARG A:724 A:765 37.0 0.164 -88.7 152.7 37.0 0.164 0.0 EPE
7.528
NH1
O1S
ARG B:724 B:765 34.0 0.151 -91.1 153.4 34.0 0.151 0.0 EPE
8.204
CD
O3S
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:735 A:765 36.0 0.16 -106.8 155.6 36.0 0.16 0.0 HOH
2.859
N
O
ARG B:735 B:765 38.0 0.169 -110.1 155.4 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:735 A:765 36.0 0.16 -107.1 150.8 32.0 0.142 0.018 B:P14735:0.018
HOH
2.704
O
O
ARG B:735 B:765 36.0 0.16 -111.0 146.7 30.0 0.133 0.027 A:P14735:0.027
HOH
3.563
NH2
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:735 A:765 46.0 0.204 -106.2 156.7 37.0 0.164 0.04 B:P14735:0.04
HOH
2.901
NH2
O
ARG B:735 B:765 43.0 0.191 -106.4 146.6 35.0 0.156 0.035 A:P14735:0.036
HOH
2.994
NH2
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:735 A:765 41.0 0.182 -104.3 152.0 34.0 0.151 0.031 B:P14735:0.031
HOH
2.679
O
O
ARG B:735 B:765 33.0 0.147 -113.3 146.7 29.0 0.129 0.018 A:P14735:0.018
HOH
2.686
O
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 ARG A:736 A:765 33.0 0.147 -81.8 151.7 25.0 0.111 0.036 B:P14735:0.036
HOH
2.963
CD
O
ARG B:736 B:765 36.0 0.16 -53.8 157.2 35.0 0.156 0.004 A:P14735:0.004
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 ARG A:736 A:765 25.0 NA -92.8 156.4 25.0 NA NA HOH
9.711
CB
O
ARG B:736 B:765 28.0 NA -105.5 153.3 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 ARG A:736 A:765 30.0 NA -96.3 150.7 27.0 NA NA B:P14735:NA
HOH
9.385
CB
O
ARG B:736 B:765 33.0 NA -95.8 152.6 33.0 NA NA HOH
7.039
O
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 ARG A:736 A:765 42.0 0.187 -104.8 145.9 27.0 0.12 0.067 B:P14735:0.067
ARG B:736 B:765 35.0 0.156 -104.7 145.8 35.0 0.156 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 ARG A:736 A:765 31.0 NA -91.9 165.0 31.0 NA NA EPE
HOH
7.925
7.081
CB
O
O3S
O
ARG B:736 B:765 29.0 NA -92.0 165.5 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 ARG A:736 A:765 26.0 NA -88.5 152.5 26.0 NA NA
ARG B:736 B:765 17.0 NA -89.4 161.8 NA NA NA
ARG C:736 C:765 18.0 0.08 -96.6 154.4 NA NA NA
ARG D:736 D:765 35.0 0.156 -94.0 156.1 NA NA NA
ARG E:736 E:765 31.0 0.138 -84.8 154.7 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 ARG A:736 A:765 50.0 0.222 -120.7 -177.0 50.0 0.222 0.0
ARG B:736 B:765 35.0 NA -122.7 -171.4 28.0 NA NA A:P14735:NA
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 ARG A:736 A:765 33.0 0.147 -95.8 151.3 33.0 0.147 0.0 EPE
7.523
CG
O3S
ARG B:736 B:765 26.0 0.116 -98.5 162.0 26.0 0.116 0.0 EPE
7.781
NE
O2S
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 ARG A:736 A:765 42.0 0.187 -112.8 155.2 35.0 0.156 0.031 B:P14735:0.031
EPE
HOH
7.689
7.287
NH1
CA
O3S
O
ARG B:736 B:765 35.0 0.156 -106.5 162.4 33.0 0.147 0.009 A:P14735:0.009
EPE
HOH
7.040
6.214
NH1
CB
O2S
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 ARG A:736 A:765 40.0 0.178 -119.5 151.7 38.0 0.169 0.009 B:P14735:0.009
EPE
HOH
7.746
3.506
CD
CB
O3S
O
ARG B:736 B:765 27.0 0.12 -128.1 151.0 24.0 0.107 0.013 A:P14735:0.013
EPE
HOH
8.142
5.495
NE
NH1
O2S
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 ARG A:736 A:765 43.0 0.191 -104.7 146.0 43.0 0.191 0.0 HOH
3.073
N
O
ARG B:736 B:765 32.0 0.142 -80.9 142.9 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 ARG A:736 A:765 45.0 0.2 -100.6 156.7 45.0 0.2 0.0 HOH
2.927
NH2
O
ARG B:736 B:765 35.0 0.156 -90.4 161.0 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 ARG A:736 A:765 24.0 NA -83.9 144.3 24.0 NA NA HOH
7.017
O
O
ARG B:736 B:765 28.0 NA -69.4 143.7 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 ARG A:736 A:765 53.0 0.236 -79.1 144.3 48.0 0.213 0.023 B:P14735:0.022
ARG B:736 B:765 41.0 0.182 -71.3 161.8 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 ARG A:736 A:765 35.0 0.156 -92.2 162.2 35.0 0.156 0.0
ARG B:736 B:765 31.0 0.138 -109.7 150.6 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 ARG A:736 A:765 33.0 0.147 -97.4 163.2 33.0 0.147 0.0 HOH
6.461
O
O
ARG B:736 B:765 41.0 0.182 -118.9 155.7 41.0 0.182 0.0
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 ARG A:736 A:765 36.0 0.16 -102.2 151.1 36.0 0.16 0.0 DIO
HOH
6.821
6.545
CG
CG
O1'
O
ARG B:736 B:765 37.0 0.164 -87.2 161.0 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 ARG A:736 A:765 35.0 0.156 -112.0 138.2 35.0 0.156 0.0 HOH
3.321
CD
O
ARG B:736 B:765 41.0 0.182 -82.9 149.7 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 ARG A:736 A:765 47.0 0.209 -102.3 142.1 47.0 0.209 0.0 HOH
6.901
CB
O
ARG B:736 B:765 38.0 0.169 -84.5 158.2 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 ARG A:736 A:765 42.0 0.187 -105.3 150.0 42.0 0.187 0.0 HOH
3.128
CD
O
ARG B:736 B:765 35.0 0.156 -92.4 138.8 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 ARG A:736 A:765 28.0 NA -106.2 135.2 28.0 NA NA HOH
5.770
N
O
ARG B:736 B:765 22.0 NA -86.2 154.5 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 ARG A:736 A:765 17.0 NA -106.4 139.8 17.0 NA NA
ARG B:736 B:765 20.0 NA -72.1 150.2 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 ARG A:736 A:765 25.0 NA -78.8 169.2 25.0 NA NA EPE
8.222
CB
O2S
ARG B:736 B:765 22.0 NA -78.0 169.4 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 ARG A:736 A:765 52.0 0.231 -145.9 137.3 52.0 0.231 0.0
ARG B:736 B:765 49.0 0.218 -111.7 156.5 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 ARG A:736 A:765 30.0 0.133 -97.4 -172.0 30.0 0.133 0.0 HOH
9.880
NH2
O
ARG B:736 B:765 38.0 0.169 -93.9 -172.1 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 ARG A:736 A:765 23.0 0.102 -113.5 149.0 20.0 0.089 0.013 A:P14735:0.013
EPE
8.175
CD
O1S
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 ARG A:736 A:765 42.0 0.187 -92.2 157.7 37.0 0.164 0.023 B:P14735:0.022
ARG B:736 B:765 29.0 0.129 -97.8 139.6 22.0 0.098 0.031 A:P14735:0.031
ARG C:736 C:765 37.0 0.164 -90.3 148.3 NA NA NA
ARG D:736 D:765 37.0 0.164 -104.3 137.4 NA NA NA
ARG E:736 E:765 47.0 0.209 -95.7 141.1 NA NA NA
ARG F:736 F:765 34.0 0.151 -93.8 137.7 NA NA NA
ARG G:736 G:765 49.0 0.218 -99.8 144.2 NA NA NA
ARG H:736 H:765 33.0 0.147 -91.0 140.6 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 ARG A:723 A:765 38.0 0.169 -89.7 138.4 38.0 0.169 0.0 HOH
5.413
NH1
O
ARG B:723 B:765 33.0 0.147 -74.1 162.0 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 ARG A:720 A:765 45.0 0.2 -131.8 177.4 37.0 0.164 0.036 B:P14735:0.036
ARG B:720 B:765 31.0 NA -120.5 172.8 28.0 NA NA A:P14735:NA
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 ARG A:720 A:765 57.0 0.253 -125.2 162.9 49.0 0.218 0.035 B:P14735:0.036
ARG B:720 B:765 42.0 NA -126.3 169.3 38.0 NA NA A:P14735:NA
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 ARG A:720 A:765 100.0 0.444 -124.4 162.0 90.0 0.4 0.044 B:P14735:0.044
ARG B:720 B:765 51.0 NA -126.2 156.2 45.0 NA NA A:P14735:NA
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 ARG A:720 A:765 71.0 0.316 -128.7 167.3 62.0 0.276 0.04 B:P14735:0.04
ARG B:720 B:765 50.0 NA -127.5 168.7 44.0 NA NA A:P14735:NA
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 ARG A:720 A:765 87.0 0.387 -128.9 168.7 81.0 0.36 0.027 B:P14735:0.027
ARG B:720 B:765 61.0 NA -130.7 169.9 57.0 NA NA A:P14735:NA
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 ARG A:720 A:765 56.0 0.249 -122.0 -177.5 43.0 0.191 0.058 B:P14735:0.058
ARG B:720 B:765 27.0 NA -119.0 -178.6 26.0 NA NA A:P14735:NA
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 ARG A:720 A:765 73.0 0.324 -132.7 168.6 58.0 0.258 0.066 B:P14735:0.067
ARG B:720 B:765 42.0 NA -130.1 164.4 35.0 NA NA A:P14735:NA
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 ARG A:720 A:765 52.0 0.231 -118.8 -177.6 52.0 0.231 0.0
ARG B:720 B:765 35.0 NA -122.2 -171.4 28.0 NA NA A:P14735:NA
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 ARG A:724 A:765 38.0 0.169 -121.8 148.4 27.0 0.12 0.049 A:P35559:0.049
HOH
2.541
NH1
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 ALA A:736 A:765 35.0 0.304 -99.5 148.8 35.0 0.304 0.0 HOH
2.663
O
O
ALA B:736 B:765 31.0 0.27 -117.0 156.9 31.0 0.27 0.0 HOH
2.705
O
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 ARG A:765 A:765 22.0 0.098 -97.9 148.5