Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94230054 . C A CCDS7421.1:NM_004969.3:c.2165cGg>cTg_NP_004960.2:p.722R>L Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 ARG A:722 A:722 116.0 0.516 B -144.1 125.5 NA NA NA
ARG B:722 B:722 22.0 NA E -140.8 130.3 22.0 NA NA
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 ARG A:722 A:722 109.0 0.484 E -136.1 125.1 109.0 0.484 0.0
ARG B:722 B:722 106.0 0.471 E -128.8 129.2 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 ARG A:722 A:722 119.0 0.529 E -131.9 128.1 119.0 0.529 0.0 HOH
8.336
CD
O
ARG B:722 B:722 101.0 0.449 E -133.8 126.7 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 ARG A:693 A:722 95.0 0.422 E -137.0 123.7 95.0 0.422 0.0 HOH
2.493
O
O
ARG B:693 B:722 95.0 0.422 E -136.8 122.8 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:693 A:722 95.0 0.422 E -129.1 121.0 95.0 0.422 0.0 HOH
2.361
O
O
ARG B:693 B:722 88.0 0.391 E -122.7 130.0 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:693 A:722 93.0 0.413 E -128.0 122.7 93.0 0.413 0.0 HOH
8.161
CG
O
ARG B:693 B:722 86.0 0.382 E -128.5 127.6 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:693 A:722 94.0 0.418 E -132.7 125.7 94.0 0.418 0.0 HOH
2.487
O
O
ARG B:693 B:722 83.0 0.369 E -125.7 125.2 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:693 A:722 93.0 0.413 E -134.6 125.8 93.0 0.413 0.0 HOH
2.382
O
O
ARG B:693 B:722 100.0 0.444 E -134.8 124.0 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 ARG A:693 A:722 113.0 0.502 E -130.9 119.5 113.0 0.502 0.0
ARG B:693 B:722 107.0 0.476 E -133.5 127.8 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 ARG A:693 A:722 112.0 0.498 E -142.1 126.6 112.0 0.498 0.0 HOH
9.037
O
O
ARG B:693 B:722 91.0 0.404 E -135.2 122.0 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 ARG A:722 A:722 107.0 0.476 E -131.1 120.7 107.0 0.476 0.0 HOH
2.499
O
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 ARG A:693 A:722 111.0 0.493 E -131.9 124.3 111.0 0.493 0.0
ARG B:693 B:722 98.0 0.436 E -130.0 126.5 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 ARG A:722 A:722 91.0 0.404 E -138.5 135.8 15.0 0.067 0.337 A:P35559:0.338
HOH
3.076
CD
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 ARG A:693 A:722 92.0 0.409 E -138.3 127.8 92.0 0.409 0.0 HOH
2.270
O
O
ARG B:693 B:722 96.0 0.427 E -130.6 124.0 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 ARG A:681 A:722 121.0 0.538 E -133.2 126.0 121.0 0.538 0.0 HOH
9.122
O
O
ARG B:681 B:722 122.0 0.542 E -132.6 126.3 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 ARG A:681 A:722 110.0 0.489 E -132.9 128.3 110.0 0.489 0.0
ARG B:681 B:722 104.0 0.462 E -133.3 127.7 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 ARG A:681 A:722 108.0 0.48 B -138.9 122.8 108.0 0.48 0.0
ARG B:681 B:722 100.0 0.444 B -138.6 123.3 100.0 0.444 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:692 A:722 90.0 0.4 E -141.0 124.3 90.0 0.4 0.0 HOH
2.840
O
O
ARG B:692 B:722 108.0 0.48 E -138.3 122.1 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:692 A:722 93.0 0.413 E -138.4 118.5 27.0 0.12 0.293 B:P14735:0.293
HOH
2.675
O
O
ARG B:692 B:722 106.0 0.471 E -136.2 118.4 40.0 0.178 0.293 A:P14735:0.293
HOH
2.655
O
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:692 A:722 107.0 0.476 B -134.9 121.3 47.0 0.209 0.267 B:P14735:0.267
HOH
2.730
O
O
ARG B:692 B:722 92.0 0.409 E -135.0 118.0 35.0 0.156 0.253 A:P14735:0.253
HOH
2.899
O
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:692 A:722 101.0 0.449 E -134.9 122.0 45.0 0.2 0.249 B:P14735:0.249
HOH
2.656
O
O
ARG B:692 B:722 85.0 0.378 E -141.5 114.7 32.0 0.142 0.236 A:P14735:0.236
HOH
2.826
O
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 ARG A:693 A:722 107.0 0.476 E -125.7 119.4 23.0 0.102 0.374 B:P14735:0.373
HOH
2.496
NH1
O
ARG B:693 B:722 107.0 0.476 E -138.4 125.9 56.0 0.249 0.227 A:P14735:0.227
HOH
3.062
NE
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 ARG A:693 A:722 95.0 0.422 E -123.3 126.0 95.0 0.422 0.0
ARG B:693 B:722 114.0 0.507 B -143.6 113.1 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 ARG A:693 A:722 98.0 0.436 E -127.4 123.0 20.0 0.089 0.347 B:P14735:0.347
HOH
2.506
NH1
O
ARG B:693 B:722 109.0 0.484 E -127.2 123.7 65.0 0.289 0.195 A:P14735:0.196
HOH
9.149
NH1
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 ARG A:693 A:722 92.0 0.409 E -146.1 125.7 22.0 0.098 0.311 B:P14735:0.311
ARG B:693 B:722 102.0 0.453 E -146.2 126.1 41.0 0.182 0.271 A:P14735:0.271
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 ARG A:693 A:722 112.0 0.498 E -135.0 121.6 112.0 0.498 0.0
ARG B:693 B:722 116.0 0.516 E -133.5 121.9 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 ARG A:693 A:722 105.0 0.467 E -124.6 126.3 105.0 0.467 0.0
ARG B:693 B:722 106.0 0.471 E -129.9 130.7 NA NA NA
ARG C:693 C:722 103.0 0.458 E -137.3 136.2 NA NA NA
ARG D:693 D:722 86.0 0.382 E -132.0 128.9 NA NA NA
ARG E:693 E:722 97.0 0.431 E -131.8 130.3 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 ARG A:693 A:722 90.0 0.4 B -134.7 130.0 15.0 0.067 0.333 B:P14735:0.333
ARG B:693 B:722 114.0 0.507 B -139.8 112.5 18.0 0.08 0.427 A:P14735:0.427
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 ARG A:693 A:722 116.0 0.516 E -139.5 135.7 32.0 0.142 0.374 B:P14735:0.373
ARG B:693 B:722 108.0 0.48 E -132.8 127.5 29.0 0.129 0.351 A:P14735:0.351
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 ARG A:693 A:722 118.0 0.524 E -128.6 143.0 31.0 0.138 0.386 B:P14735:0.387
HOH
7.197
CD
O
ARG B:693 B:722 103.0 0.458 E -119.9 125.1 45.0 0.2 0.258 A:P14735:0.258
HOH
3.222
NH1
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 ARG A:693 A:722 117.0 0.52 E -143.3 129.0 34.0 0.151 0.369 B:P14735:0.369
HOH
2.651
O
O
ARG B:693 B:722 102.0 0.453 E -129.9 132.0 29.0 0.129 0.324 A:P14735:0.324
HOH
3.609
CD
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 ARG A:693 A:722 96.0 0.427 E -146.6 126.5 96.0 0.427 0.0 HOH
9.933
NH2
O
ARG B:693 B:722 106.0 0.471 E -146.5 117.6 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 ARG A:693 A:722 101.0 0.449 B -123.6 124.2 101.0 0.449 0.0 HOH
2.510
NH1
O
ARG B:693 B:722 122.0 0.542 E -134.2 135.0 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 ARG A:693 A:722 105.0 0.467 E -136.6 125.3 105.0 0.467 0.0 HOH
3.423
NH1
O
ARG B:693 B:722 120.0 0.533 E -139.0 127.5 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 ARG A:693 A:722 113.0 0.502 B -131.1 116.3 25.0 0.111 0.391 B:P14735:0.391
HOH
7.953
NE
O
ARG B:693 B:722 116.0 0.516 B -140.9 121.2 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 ARG A:693 A:722 117.0 0.52 B -134.2 114.7 117.0 0.52 0.0
ARG B:693 B:722 105.0 0.467 B -143.6 127.4 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 ARG A:693 A:722 126.0 0.56 E -131.9 124.3 126.0 0.56 0.0
ARG B:693 B:722 117.0 0.52 E -132.5 120.9 117.0 0.52 0.0
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 ARG A:693 A:722 97.0 0.431 E -136.7 128.5 97.0 0.431 0.0 HOH
9.639
NH2
O
ARG B:693 B:722 98.0 0.436 E -138.5 124.7 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 ARG A:693 A:722 104.0 0.462 E -119.1 128.2 104.0 0.462 0.0
ARG B:693 B:722 110.0 0.489 E -132.8 121.6 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 ARG A:693 A:722 101.0 0.449 E -132.1 120.4 101.0 0.449 0.0 HOH
6.772
CD
O
ARG B:693 B:722 100.0 0.444 E -139.8 117.8 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 ARG A:693 A:722 108.0 0.48 B -117.7 128.7 108.0 0.48 0.0 HOH
9.271
O
O
ARG B:693 B:722 91.0 0.404 E -137.7 120.1 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 ARG A:693 A:722 102.0 0.453 E -135.5 125.7 102.0 0.453 0.0 HOH
2.583
NH2
O
ARG B:693 B:722 119.0 0.529 E -135.1 126.8 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 ARG A:693 A:722 95.0 0.422 E -132.3 124.7 95.0 0.422 0.0
ARG B:693 B:722 80.0 0.356 E -127.8 123.4 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 ARG A:693 A:722 97.0 0.431 B -134.5 116.1 97.0 0.431 0.0 HOH
6.593
CG
O
ARG B:693 B:722 108.0 0.48 B -138.9 117.5 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 ARG A:693 A:722 104.0 0.462 B -129.6 125.0 104.0 0.462 0.0
ARG B:693 B:722 117.0 0.52 E -133.5 118.7 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 ARG A:693 A:722 120.0 0.533 E -135.1 130.4 120.0 0.533 0.0 HOH
2.428
NH2
O
ARG B:693 B:722 135.0 0.6 E -136.5 131.9 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 ARG A:693 A:722 99.0 0.44 E -135.9 116.4 52.0 0.231 0.209 A:P14735:0.209
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 ARG A:693 A:722 95.0 0.422 E -138.2 117.5 44.0 0.196 0.226 B:P14735:0.227
ARG B:693 B:722 122.0 0.542 E -129.9 131.0 25.0 0.111 0.431 A:P14735:0.431
ARG C:693 C:722 83.0 0.369 E -139.2 116.5 NA NA NA
ARG D:693 D:722 126.0 0.56 E -125.8 132.2 NA NA NA
ARG E:693 E:722 117.0 0.52 E -136.5 129.7 NA NA NA
ARG F:693 F:722 93.0 0.413 B -131.3 118.8 NA NA NA
ARG G:693 G:722 116.0 0.516 E -130.7 131.7 NA NA NA
ARG H:693 H:722 96.0 0.427 B -146.5 112.5 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 ARG A:680 A:722 98.0 0.436 B -137.0 121.8 98.0 0.436 0.0 HOH
9.240
N
O
ARG B:680 B:722 115.0 0.511 E -138.5 124.2 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 ARG A:677 A:722 102.0 0.453 B -146.5 110.6 24.0 0.107 0.346 B:P14735:0.347
ARG B:677 B:722 102.0 0.453 B -145.1 112.3 20.0 0.089 0.364 A:P14735:0.364
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 ARG A:677 A:722 95.0 0.422 B -138.3 110.1 43.0 0.191 0.231 B:P14735:0.231
ARG B:677 B:722 74.0 0.329 B -143.6 117.9 20.0 0.089 0.24 A:P14735:0.24
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 ARG A:677 A:722 71.0 0.316 B -153.5 123.8 34.0 0.151 0.165 B:P14735:0.164
ARG B:677 B:722 98.0 0.436 S -156.0 111.4 60.0 0.267 0.169 A:P14735:0.169
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 ARG A:677 A:722 83.0 0.369 B -155.4 114.9 23.0 0.102 0.267 B:P14735:0.267
ARG B:677 B:722 105.0 0.467 B -158.6 112.6 44.0 0.196 0.271 A:P14735:0.271
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 ARG A:677 A:722 78.0 0.347 B -153.9 112.0 54.0 0.24 0.107 B:P14735:0.107
ARG B:677 B:722 78.0 0.347 B -156.2 111.3 43.0 0.191 0.156 A:P14735:0.156
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 ARG A:677 A:722 100.0 0.444 B -150.1 114.9 36.0 0.16 0.284 B:P14735:0.284
ARG B:677 B:722 105.0 0.467 B -151.4 117.6 39.0 0.173 0.294 A:P14735:0.293
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 ARG A:677 A:722 79.0 0.351 B -129.2 146.5 68.0 0.302 0.049 B:P14735:0.049
ARG B:677 B:722 90.0 0.4 B -141.3 116.0 47.0 0.209 0.191 A:P14735:0.191
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 ARG A:677 A:722 92.0 0.409 E -133.9 129.4 18.0 0.08 0.329 B:P14735:0.329
ARG B:677 B:722 115.0 0.511 B -139.5 112.0 20.0 0.089 0.422 A:P14735:0.422
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 ARG A:681 A:722 105.0 0.467 E -132.2 129.4 17.0 0.076 0.391 A:P35559:0.391
HOH
2.683
O
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 ARG A:693 A:722 108.0 0.48 E -144.3 123.8 108.0 0.48 0.0 HOH
2.551
O
O
ARG B:693 B:722 103.0 0.458 E -141.8 125.1 103.0 0.458 0.0 HOH
2.608
O
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 ARG A:722 A:722 95.0 0.422 E -139.7 116.2