Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94246993 . G A CCDS7421.1:NM_004969.3:c.1616cCg>cTg_NP_004960.2:p.539P>L Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 PRO A:539 A:539 98.0 0.676 -66.3 149.3 NA NA NA
PRO B:539 B:539 106.0 0.731 -65.5 155.6 106.0 0.731 0.0
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 PRO A:539 A:539 104.0 0.717 -64.1 149.7 104.0 0.717 0.0 HOH
8.865
O
O
PRO B:539 B:539 103.0 0.71 -65.4 138.5 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 PRO A:539 A:539 102.0 0.703 -64.4 152.3 102.0 0.703 0.0 HOH
7.365
N
O
PRO B:539 B:539 105.0 0.724 -65.1 151.0 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 PRO A:510 A:539 108.0 0.745 -62.7 144.9 108.0 0.745 0.0 HOH
3.702
N
O
PRO B:510 B:539 107.0 0.738 -63.5 147.0 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 PRO A:510 A:539 108.0 0.745 -71.0 139.8 108.0 0.745 0.0 HOH
4.049
CA
O
PRO B:510 B:539 101.0 0.697 -68.7 138.5 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 PRO A:510 A:539 106.0 0.731 -68.3 150.0 106.0 0.731 0.0 HOH
3.815
C
O
PRO B:510 B:539 103.0 0.71 -71.5 141.9 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 PRO A:510 A:539 103.0 0.71 -66.1 144.6 103.0 0.71 0.0 HOH
3.669
C
O
PRO B:510 B:539 100.0 0.69 -66.1 137.5 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 PRO A:510 A:539 112.0 0.772 -62.6 142.6 112.0 0.772 0.0 HOH
3.783
N
O
PRO B:510 B:539 101.0 0.697 -62.6 147.9 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 PRO A:510 A:539 103.0 0.71 -59.1 160.2 103.0 0.71 0.0
PRO B:510 B:539 108.0 0.745 -73.8 140.5 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 PRO A:510 A:539 100.0 0.69 -66.8 151.8 100.0 0.69 0.0 HOH
3.747
C
O
PRO B:510 B:539 100.0 0.69 -61.4 149.4 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 ALA A:539 A:539 85.0 0.739 -54.0 136.0 85.0 0.739 0.0 HOH
4.099
C
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 PRO A:510 A:539 102.0 0.703 -60.7 144.7 102.0 0.703 0.0 HOH
6.444
O
O
PRO B:510 B:539 101.0 0.697 -66.5 144.5 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 ALA A:539 A:539 85.0 0.739 -60.3 154.8 85.0 0.739 0.0 HOH
3.136
CA
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 PRO A:510 A:539 104.0 0.717 -64.3 151.3 104.0 0.717 0.0 HOH
3.464
CA
O
PRO B:510 B:539 103.0 0.71 -64.0 140.7 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 PRO A:498 A:539 103.0 0.71 -60.4 147.9 103.0 0.71 0.0 HOH
3.523
C
O
PRO B:498 B:539 102.0 0.703 -60.4 147.9 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 PRO A:498 A:539 101.0 0.697 -63.7 152.0 101.0 0.697 0.0 PEG
7.924
N
H11
PRO B:498 B:539 102.0 0.703 -64.4 152.9 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 PRO A:498 A:539 96.0 0.662 -65.5 147.6 96.0 0.662 0.0
PRO B:498 B:539 100.0 0.69 -67.0 148.2 100.0 0.69 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 PRO A:509 A:539 100.0 0.69 -58.6 143.2 100.0 0.69 0.0 HOH
2.596
O
O
PRO B:509 B:539 100.0 0.69 -58.3 142.5 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 PRO A:509 A:539 101.0 0.697 -57.4 144.1 101.0 0.697 0.0 HOH
2.731
O
O
PRO B:509 B:539 99.0 0.683 -56.8 143.1 99.0 0.683 0.0 HOH
3.271
CA
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 PRO A:509 A:539 96.0 0.662 -52.5 139.8 96.0 0.662 0.0 HOH
2.788
O
O
PRO B:509 B:539 100.0 0.69 -61.6 148.5 100.0 0.69 0.0 HOH
2.697
O
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 PRO A:509 A:539 98.0 0.676 -59.2 144.6 98.0 0.676 0.0 HOH
5.791
C
O
PRO B:509 B:539 99.0 0.683 -55.8 143.1 99.0 0.683 0.0 HOH
2.683
O
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 PRO A:510 A:539 99.0 0.683 -67.6 153.7 99.0 0.683 0.0 HOH
7.983
O
O
PRO B:510 B:539 101.0 0.697 -67.9 154.9 101.0 0.697 0.0 HOH
6.969
O
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 PRO A:510 A:539 101.0 0.697 -68.6 150.8 101.0 0.697 0.0
PRO B:510 B:539 111.0 0.766 -65.9 138.4 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 PRO A:510 A:539 99.0 0.683 -59.6 145.7 99.0 0.683 0.0
PRO B:510 B:539 101.0 0.697 -60.4 145.6 101.0 0.697 0.0 HOH
4.677
N
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 PRO A:510 A:539 109.0 0.752 -67.2 146.4 109.0 0.752 0.0
PRO B:510 B:539 97.0 0.669 -67.4 145.9 97.0 0.669 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 PRO A:510 A:539 98.0 0.676 -63.1 149.2 98.0 0.676 0.0
PRO B:510 B:539 98.0 0.676 -63.5 147.6 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 PRO A:510 A:539 107.0 0.738 -58.1 145.7 107.0 0.738 0.0
PRO B:510 B:539 94.0 0.648 -73.8 115.5 NA NA NA
PRO C:510 C:539 107.0 0.738 -66.0 146.5 NA NA NA
PRO D:510 D:539 108.0 0.745 -55.6 145.0 NA NA NA
PRO E:510 E:539 109.0 0.752 -56.2 147.5 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 PRO A:510 A:539 98.0 0.676 -73.9 159.0 98.0 0.676 0.0
PRO B:510 B:539 92.0 0.634 -69.7 163.0 92.0 0.634 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 PRO A:510 A:539 98.0 0.676 -70.5 147.1 98.0 0.676 0.0
PRO B:510 B:539 97.0 0.669 -75.0 155.7 97.0 0.669 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 PRO A:510 A:539 98.0 0.676 -71.8 143.0 98.0 0.676 0.0
PRO B:510 B:539 101.0 0.697 -71.6 155.6 101.0 0.697 0.0 HOH
6.391
O
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 PRO A:510 A:539 99.0 0.683 -69.9 143.7 99.0 0.683 0.0 HOH
6.519
O
O
PRO B:510 B:539 100.0 0.69 -64.3 153.6 100.0 0.69 0.0 HOH
3.523
C
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 PRO A:510 A:539 104.0 0.717 -66.6 146.8 104.0 0.717 0.0 HOH
6.627
O
O
PRO B:510 B:539 98.0 0.676 -59.9 146.5 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 PRO A:510 A:539 104.0 0.717 -64.5 153.0 104.0 0.717 0.0 HOH
7.227
C
O
PRO B:510 B:539 106.0 0.731 -68.1 142.6 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 PRO A:510 A:539 104.0 0.717 -62.0 150.5 104.0 0.717 0.0 HOH
7.011
C
O
PRO B:510 B:539 105.0 0.724 -63.7 148.3 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 PRO A:510 A:539 102.0 0.703 -52.5 139.8 102.0 0.703 0.0
PRO B:510 B:539 104.0 0.717 -65.7 145.2 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 PRO A:510 A:539 103.0 0.71 -54.3 147.4 103.0 0.71 0.0 HOH
8.791
O
O
PRO B:510 B:539 103.0 0.71 -63.1 149.6 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 PRO A:510 A:539 109.0 0.752 -57.1 139.8 109.0 0.752 0.0
PRO B:510 B:539 106.0 0.731 -64.2 151.0 106.0 0.731 0.0
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 PRO A:510 A:539 101.0 0.697 -63.6 148.9 101.0 0.697 0.0 HOH
6.527
O
O
PRO B:510 B:539 104.0 0.717 -61.5 140.9 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 PRO A:510 A:539 99.0 0.683 -72.0 158.3 99.0 0.683 0.0
PRO B:510 B:539 105.0 0.724 -71.9 142.9 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 PRO A:510 A:539 102.0 0.703 -55.2 148.9 102.0 0.703 0.0 HOH
8.323
O
O
PRO B:510 B:539 105.0 0.724 -63.4 143.6 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 PRO A:510 A:539 107.0 0.738 -62.6 147.8 107.0 0.738 0.0 HOH
8.389
O
O
PRO B:510 B:539 98.0 0.676 -61.2 157.7 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 PRO A:510 A:539 98.0 0.676 -61.1 146.5 98.0 0.676 0.0 HOH
8.553
O
O
PRO B:510 B:539 105.0 0.724 -63.0 145.1 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 PRO A:510 A:539 101.0 0.697 -57.3 150.8 101.0 0.697 0.0
PRO B:510 B:539 105.0 0.724 -67.9 150.6 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 PRO A:510 A:539 99.0 0.683 -70.6 138.9 99.0 0.683 0.0
PRO B:510 B:539 103.0 0.71 -69.2 137.2 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 PRO A:510 A:539 105.0 0.724 -62.2 146.3 105.0 0.724 0.0
PRO B:510 B:539 103.0 0.71 -60.8 152.6 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 PRO A:510 A:539 109.0 0.752 -63.1 148.1 109.0 0.752 0.0
PRO B:510 B:539 99.0 0.683 -64.2 149.2 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 PRO A:510 A:539 104.0 0.717 -55.8 141.2 104.0 0.717 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 PRO A:510 A:539 103.0 0.71 -61.9 146.7 103.0 0.71 0.0
PRO B:510 B:539 113.0 0.779 -61.9 145.5 113.0 0.779 0.0
PRO C:510 C:539 103.0 0.71 -62.5 148.8 NA NA NA
PRO D:510 D:539 113.0 0.779 -66.5 141.7 NA NA NA
PRO E:510 E:539 109.0 0.752 -64.0 144.0 NA NA NA
PRO F:510 F:539 101.0 0.697 -63.1 140.2 NA NA NA
PRO G:510 G:539 108.0 0.745 -64.5 147.9 NA NA NA
PRO H:510 H:539 102.0 0.703 -63.8 142.5 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 PRO A:497 A:539 106.0 0.731 -62.1 152.7 106.0 0.731 0.0 HOH
8.294
O
O
PRO B:497 B:539 106.0 0.731 -59.6 147.3 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 PRO A:494 A:539 93.0 0.641 -74.1 151.4 93.0 0.641 0.0
PRO B:494 B:539 110.0 0.759 -67.9 137.8 110.0 0.759 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 PRO A:494 A:539 102.0 0.703 -75.3 147.1 102.0 0.703 0.0
PRO B:494 B:539 94.0 0.648 -73.7 152.5 94.0 0.648 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 PRO A:494 A:539 105.0 0.724 -76.8 141.6 105.0 0.724 0.0
PRO B:494 B:539 95.0 0.655 -70.0 153.9 95.0 0.655 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 PRO A:494 A:539 106.0 0.731 -74.9 146.3 106.0 0.731 0.0
PRO B:494 B:539 98.0 0.676 -73.9 151.7 98.0 0.676 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 PRO A:494 A:539 109.0 0.752 -75.9 148.0 109.0 0.752 0.0
PRO B:494 B:539 98.0 0.676 -76.2 150.9 98.0 0.676 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 PRO A:494 A:539 107.0 0.738 -69.5 141.4 107.0 0.738 0.0
PRO B:494 B:539 85.0 0.586 -74.4 146.9 85.0 0.586 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 PRO A:494 A:539 107.0 0.738 -71.5 134.1 107.0 0.738 0.0
PRO B:494 B:539 98.0 0.676 -75.9 147.8 98.0 0.676 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 PRO A:494 A:539 97.0 0.669 -73.2 158.7 97.0 0.669 0.0
PRO B:494 B:539 96.0 0.662 -68.8 161.3 96.0 0.662 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 ALA A:498 A:539 86.0 0.748 -56.6 146.6 86.0 0.748 0.0 HOH
4.534
O
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 PRO A:510 A:539 100.0 0.69 -57.0 144.5 100.0 0.69 0.0 HOH
3.469
CA
O
PRO B:510 B:539 98.0 0.676 -58.0 140.1 98.0 0.676 0.0 HOH
2.688
O
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 PRO A:539 A:539 100.0 0.69 -55.7 140.8