Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94250286 . C A CCDS7421.1:NM_004969.3:c.1497caG>caT_NP_004960.2:p.499Q>H Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 GLN A:499 A:499 73.0 0.406 E -80.7 117.6 NA NA NA
GLN B:499 B:499 81.0 0.45 E -90.4 127.3 81.0 0.45 0.0 HOH
3.604
NE2
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 GLN A:499 A:499 79.0 0.439 E -82.6 116.7 79.0 0.439 0.0 ACY
HOH
9.126
2.683
O
N
OXT
O
GLN B:499 B:499 79.0 0.439 E -88.1 123.6 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 GLN A:499 A:499 92.0 0.511 E -103.2 127.9 92.0 0.511 0.0 J18
HOH
9.007
2.786
O
N
H28
O
GLN B:499 B:499 84.0 0.467 E -99.7 123.9 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 GLN A:470 A:499 80.0 0.444 E -89.4 126.7 80.0 0.444 0.0 DIO
HOH
9.665
2.780
O
N
C2'
O
GLN B:470 B:499 77.0 0.428 E -96.4 125.8 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLN A:470 A:499 88.0 0.489 E -96.7 126.3 88.0 0.489 0.0 DIO
HOH
9.281
2.820
O
OE1
C2'
O
GLN B:470 B:499 77.0 0.428 E -88.4 129.1 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLN A:470 A:499 95.0 0.528 E -99.6 128.0 95.0 0.528 0.0 DIO
HOH
9.133
2.746
O
N
C2'
O
GLN B:470 B:499 72.0 0.4 E -88.0 134.0 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLN A:470 A:499 85.0 0.472 E -96.0 125.0 85.0 0.472 0.0 DIO
HOH
9.633
2.718
O
N
C2'
O
GLN B:470 B:499 72.0 0.4 E -90.4 126.3 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLN A:470 A:499 82.0 0.456 E -89.0 127.2 82.0 0.456 0.0 DIO
HOH
9.633
2.853
O
N
C2'
O
GLN B:470 B:499 81.0 0.45 E -91.1 124.3 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 GLN A:470 A:499 84.0 0.467 E -85.3 122.7 84.0 0.467 0.0 DIO
9.054
O
C2
GLN B:470 B:499 82.0 0.456 E -94.1 119.8 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 GLN A:470 A:499 81.0 0.45 E -86.5 122.8 81.0 0.45 0.0 HOH
2.870
N
O
GLN B:470 B:499 78.0 0.433 E -91.2 130.0 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 GLN A:499 A:499 27.0 NA E -94.4 120.1 27.0 NA NA HOH
8.432
N
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 GLN A:470 A:499 82.0 0.456 E -84.6 117.3 82.0 0.456 0.0 HOH
2.717
N
O
GLN B:470 B:499 79.0 0.439 E -80.9 125.7 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 GLN A:499 A:499 57.0 0.317 E -62.6 158.0 57.0 0.317 0.0 HOH
5.222
N
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 GLN A:470 A:499 83.0 0.461 E -90.7 119.6 83.0 0.461 0.0 HOH
2.806
N
O
GLN B:470 B:499 76.0 0.422 E -86.4 125.1 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 GLN A:458 A:499 81.0 0.45 E -82.7 124.2 81.0 0.45 0.0 HOH
2.732
N
O
GLN B:458 B:499 79.0 0.439 E -82.9 124.1 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 GLN A:458 A:499 79.0 0.439 E -89.9 122.6 79.0 0.439 0.0 J22
8.761
O
H291
GLN B:458 B:499 78.0 0.433 E -87.9 124.0 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 GLN A:458 A:499 81.0 0.45 E -88.7 127.0 81.0 0.45 0.0 J22
8.555
O
H291
GLN B:458 B:499 82.0 0.456 E -88.2 128.0 82.0 0.456 0.0 J22
8.920
O
H291
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLN A:469 A:499 88.0 0.489 E -102.7 131.4 88.0 0.489 0.0 2PJ
HOH
8.957
2.642
O
OE1
C6
O
GLN B:469 B:499 82.0 0.456 E -104.5 130.0 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLN A:469 A:499 91.0 0.506 E -95.5 132.4 91.0 0.506 0.0 HOH
2.752
OE1
O
GLN B:469 B:499 82.0 0.456 E -100.3 131.1 82.0 0.456 0.0 HOH
2.684
OE1
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLN A:469 A:499 66.0 0.367 E -95.3 120.7 66.0 0.367 0.0 2Q6
HOH
9.595
3.456
O
OE1
C38
O
GLN B:469 B:499 88.0 0.489 E -88.5 127.4 88.0 0.489 0.0 2Q6
HOH
9.020
5.671
O
CG
C38
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLN A:469 A:499 70.0 0.389 E -92.4 117.5 70.0 0.389 0.0 2QX
HOH
9.494
3.636
O
OE1
C3
O
GLN B:469 B:499 91.0 0.506 E -95.3 126.5 91.0 0.506 0.0 2QX
HOH
9.196
2.775
O
NE2
C2
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 GLN A:470 A:499 82.0 0.456 E -76.2 124.2 82.0 0.456 0.0 HOH
3.074
OE1
O
GLN B:470 B:499 75.0 0.417 E -88.9 118.0 75.0 0.417 0.0
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 GLN A:470 A:499 81.0 0.45 E -90.3 123.7 81.0 0.45 0.0 HOH
9.910
O
O
GLN B:470 B:499 81.0 0.45 E -91.7 117.7 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 GLN A:470 A:499 78.0 0.433 E -108.6 122.7 78.0 0.433 0.0 HOH
8.780
NE2
O
GLN B:470 B:499 73.0 0.406 E -104.7 118.2 73.0 0.406 0.0
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 GLN A:470 A:499 89.0 0.494 E -95.3 127.7 89.0 0.494 0.0
GLN B:470 B:499 118.0 0.656 -94.9 127.4 118.0 0.656 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 GLN A:470 A:499 88.0 0.489 E -86.9 119.2 88.0 0.489 0.0 PEG
9.439
O
H11
GLN B:470 B:499 84.0 0.467 E -87.0 116.7 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 GLN A:470 A:499 86.0 0.478 E -84.1 126.1 86.0 0.478 0.0
GLN B:470 B:499 84.0 0.467 -88.4 122.1 NA NA NA
GLN C:470 C:499 80.0 0.444 -73.6 116.9 NA NA NA
GLN D:470 D:499 73.0 0.406 E -79.4 125.4 NA NA NA
GLN E:470 E:499 100.0 0.556 -78.2 121.3 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 GLN A:470 A:499 68.0 0.378 E -118.9 143.4 68.0 0.378 0.0
GLN B:470 B:499 77.0 0.428 -111.0 124.0 77.0 0.428 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLN A:470 A:499 77.0 0.428 E -93.5 116.5 77.0 0.428 0.0
GLN B:470 B:499 75.0 0.417 E -96.6 117.2 75.0 0.417 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLN A:470 A:499 75.0 0.417 E -94.6 127.3 75.0 0.417 0.0 HOH
2.903
N
O
GLN B:470 B:499 72.0 0.4 E -96.2 123.0 72.0 0.4 0.0 HOH
2.939
N
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLN A:470 A:499 78.0 0.433 E -91.2 124.3 78.0 0.433 0.0 HOH
2.705
N
O
GLN B:470 B:499 72.0 0.4 E -93.5 123.1 72.0 0.4 0.0 HOH
2.882
N
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 GLN A:470 A:499 82.0 0.456 E -95.0 127.0 82.0 0.456 0.0 HOH
2.749
N
O
GLN B:470 B:499 81.0 0.45 E -91.3 136.0 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 GLN A:470 A:499 74.0 0.411 E -84.1 126.3 74.0 0.411 0.0 DIO
HOH
9.285
3.675
O
OE1
C1'
O
GLN B:470 B:499 70.0 0.389 E -82.9 134.9 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 GLN A:470 A:499 86.0 0.478 E -90.5 126.0 86.0 0.478 0.0 HOH
2.997
N
O
GLN B:470 B:499 76.0 0.422 E -89.8 129.5 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 GLN A:470 A:499 82.0 0.456 E -72.9 115.9 82.0 0.456 0.0 DIO
9.747
O
O1
GLN B:470 B:499 70.0 0.389 E -75.8 117.3 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 GLN A:470 A:499 74.0 0.411 E -77.7 127.4 74.0 0.411 0.0 DIO
9.321
O
C2'
GLN B:470 B:499 77.0 0.428 E -101.6 128.7 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 GLN A:470 A:499 74.0 0.411 E -91.6 126.0 74.0 0.411 0.0 HOH
3.681
NE2
O
GLN B:470 B:499 85.0 0.472 E -103.0 124.2 85.0 0.472 0.0
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 GLN A:470 A:499 78.0 0.433 E -98.1 120.7 78.0 0.433 0.0 HOH
2.901
N
O
GLN B:470 B:499 85.0 0.472 E -87.5 130.3 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 GLN A:470 A:499 80.0 0.444 E -101.2 138.9 80.0 0.444 0.0 HOH
3.051
NE2
O
GLN B:470 B:499 86.0 0.478 E -68.8 123.8 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLN A:470 A:499 79.0 0.439 E -78.0 129.5 79.0 0.439 0.0 HOH
5.750
N
O
GLN B:470 B:499 76.0 0.422 E -80.7 125.6 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLN A:470 A:499 75.0 0.417 E -86.5 121.0 75.0 0.417 0.0 HOH
5.306
NE2
O
GLN B:470 B:499 79.0 0.439 E -84.4 122.6 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLN A:470 A:499 90.0 0.5 E -98.6 117.2 90.0 0.5 0.0 HOH
2.745
N
O
GLN B:470 B:499 86.0 0.478 E -89.2 123.0 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 GLN A:470 A:499 81.0 0.45 E -78.6 118.2 81.0 0.45 0.0
GLN B:470 B:499 71.0 0.394 E -74.7 125.0 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 GLN A:470 A:499 85.0 0.472 E -81.5 116.6 85.0 0.472 0.0
GLN B:470 B:499 75.0 0.417 E -82.0 117.2 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 GLN A:470 A:499 80.0 0.444 E -87.3 114.3 80.0 0.444 0.0
GLN B:470 B:499 82.0 0.456 E -77.9 116.4 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 GLN A:470 A:499 84.0 0.467 E -79.8 119.2 84.0 0.467 0.0 HOH
2.853
N
O
GLN B:470 B:499 78.0 0.433 E -77.6 121.7 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 GLN A:470 A:499 71.0 0.394 E -85.8 118.7 71.0 0.394 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 GLN A:470 A:499 80.0 0.444 E -85.2 126.5 80.0 0.444 0.0
GLN B:470 B:499 85.0 0.472 E -77.3 129.9 85.0 0.472 0.0
GLN C:470 C:499 89.0 0.494 E -89.8 131.2 NA NA NA
GLN D:470 D:499 85.0 0.472 E -77.9 127.6 NA NA NA
GLN E:470 E:499 84.0 0.467 E -88.8 133.5 NA NA NA
GLN F:470 F:499 80.0 0.444 E -83.3 132.7 NA NA NA
GLN G:470 G:499 81.0 0.45 E -86.7 134.3 NA NA NA
GLN H:470 H:499 90.0 0.5 E -86.1 131.4 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 GLN A:457 A:499 85.0 0.472 E -78.1 124.1 85.0 0.472 0.0 HOH
2.574
N
O
GLN B:457 B:499 75.0 0.417 E -83.8 122.3 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 GLN A:454 A:499 85.0 0.472 E -130.3 130.1 85.0 0.472 0.0
GLN B:454 B:499 72.0 0.4 E -126.5 131.2 72.0 0.4 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 GLN A:454 A:499 78.0 0.433 E -129.1 136.5 78.0 0.433 0.0
GLN B:454 B:499 68.0 0.378 E -126.2 140.9 68.0 0.378 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 GLN A:454 A:499 41.0 0.228 E -105.7 128.3 41.0 0.228 0.0
GLN B:454 B:499 82.0 0.456 E -113.1 143.8 82.0 0.456 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 GLN A:454 A:499 79.0 0.439 E -129.1 141.4 79.0 0.439 0.0
GLN B:454 B:499 76.0 0.422 E -130.6 142.4 76.0 0.422 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 GLN A:454 A:499 81.0 0.45 E -128.7 139.2 81.0 0.45 0.0
GLN B:454 B:499 81.0 0.45 E -130.0 138.5 81.0 0.45 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 GLN A:454 A:499 58.0 0.322 E -130.6 137.6 58.0 0.322 0.0
GLN B:454 B:499 91.0 0.506 E -125.8 143.7 91.0 0.506 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 GLN A:454 A:499 78.0 0.433 E -130.6 140.8 78.0 0.433 0.0
GLN B:454 B:499 87.0 0.483 E -127.0 139.4 87.0 0.483 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 GLN A:454 A:499 71.0 0.394 E -118.4 143.2 71.0 0.394 0.0
GLN B:454 B:499 76.0 0.422 -110.7 122.2 76.0 0.422 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 GLN A:458 A:499 56.0 0.311 E -104.9 126.5 56.0 0.311 0.0 HOH
5.582
N
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 GLN A:470 A:499 79.0 0.439 E -90.3 124.1 79.0 0.439 0.0 DIO
HOH
9.585
2.900
O
N
O1
O
GLN B:470 B:499 79.0 0.439 E -90.1 124.8 79.0 0.439 0.0 DIO
HOH
9.618
2.935
O
OE1
C1'
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 GLN A:499 A:499 72.0 0.4 E -79.4 121.4