Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94250315 . C A CCDS7421.1:NM_004969.3:c.1468Gat>Tat_NP_004960.2:p.490D>Y Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 ASP A:490 A:490 107.0 0.713 -125.4 6.0 NA NA NA
ASP B:490 B:490 108.0 0.72 -132.8 4.4 108.0 0.72 0.0 HOH
2.603
OD1
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 ASP A:490 A:490 112.0 0.747 -142.5 16.9 112.0 0.747 0.0 HOH
2.783
OD1
O
ASP B:490 B:490 108.0 0.72 -137.6 5.6 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 ASP A:490 A:490 109.0 0.727 -119.0 4.7 109.0 0.727 0.0 HOH
2.893
OD1
O
ASP B:490 B:490 109.0 0.727 -119.5 5.1 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 ASP A:461 A:490 109.0 0.727 -130.6 7.6 109.0 0.727 0.0 HOH
2.811
OD1
O
ASP B:461 B:490 104.0 0.693 -131.4 5.4 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ASP A:461 A:490 105.0 0.7 -134.3 14.6 105.0 0.7 0.0 HOH
3.328
OD2
O
ASP B:461 B:490 108.0 0.72 -119.9 5.5 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ASP A:461 A:490 96.0 0.64 -124.7 12.2 96.0 0.64 0.0 HOH
3.287
OD2
O
ASP B:461 B:490 106.0 0.707 -125.2 0.1 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ASP A:461 A:490 103.0 0.687 -126.7 11.2 103.0 0.687 0.0 HOH
2.685
OD1
O
ASP B:461 B:490 110.0 0.733 -125.4 6.7 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ASP A:461 A:490 109.0 0.727 -130.5 8.6 109.0 0.727 0.0 HOH
2.690
OD1
O
ASP B:461 B:490 108.0 0.72 -125.3 5.0 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 ASP A:461 A:490 103.0 0.687 -141.3 28.5 103.0 0.687 0.0
ASP B:461 B:490 116.0 0.773 -125.9 14.4 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 ASP A:461 A:490 110.0 0.733 -137.4 11.3 110.0 0.733 0.0 HOH
2.697
OD1
O
ASP B:461 B:490 106.0 0.707 -124.1 8.0 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 ASP A:490 A:490 106.0 0.707 -129.0 -9.1 106.0 0.707 0.0 HOH
5.896
OD1
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 ASP A:461 A:490 109.0 0.727 -128.9 11.1 109.0 0.727 0.0 HOH
3.292
N
O
ASP B:461 B:490 106.0 0.707 -120.3 5.0 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 ASP A:490 A:490 111.0 0.74 -93.5 -38.5 111.0 0.74 0.0 HOH
6.446
CB
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 ASP A:461 A:490 109.0 0.727 -130.7 5.9 109.0 0.727 0.0 HOH
2.673
OD1
O
ASP B:461 B:490 115.0 0.767 -128.1 3.2 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 ASP A:449 A:490 115.0 0.767 -127.5 3.2 115.0 0.767 0.0 HOH
3.511
N
O
ASP B:449 B:490 113.0 0.753 -125.9 4.3 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 ASP A:449 A:490 95.0 0.633 -116.2 10.4 95.0 0.633 0.0
ASP B:449 B:490 94.0 0.627 -116.2 11.7 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 ASP A:449 A:490 98.0 0.653 -122.8 -2.1 98.0 0.653 0.0
ASP B:449 B:490 94.0 0.627 -121.7 -1.2 94.0 0.627 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 ASP A:460 A:490 120.0 0.8 -104.8 -11.2 120.0 0.8 0.0 HOH
2.644
OD1
O
ASP B:460 B:490 118.0 0.787 -125.5 -1.9 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 ASP A:460 A:490 122.0 0.813 -111.2 -11.7 122.0 0.813 0.0 HOH
2.630
OD1
O
ASP B:460 B:490 124.0 0.827 -117.6 -10.6 124.0 0.827 0.0 HOH
2.740
OD1
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 ASP A:460 A:490 116.0 0.773 -111.4 -19.6 116.0 0.773 0.0 HOH
3.009
OD1
O
ASP B:460 B:490 119.0 0.793 -116.7 -22.6 119.0 0.793 0.0 HOH
3.030
O
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 ASP A:460 A:490 119.0 0.793 -132.1 -9.9 119.0 0.793 0.0 HOH
2.737
OD2
O
ASP B:460 B:490 120.0 0.8 -119.3 -19.4 120.0 0.8 0.0 HOH
2.606
OD1
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 ASP A:461 A:490 107.0 0.713 -112.9 15.9 107.0 0.713 0.0 HOH
4.054
N
O
ASP B:461 B:490 105.0 0.7 -119.6 -23.7 105.0 0.7 0.0 HOH
3.731
OD2
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 ASP A:461 A:490 106.0 0.707 -140.9 7.4 106.0 0.707 0.0
ASP B:461 B:490 103.0 0.687 -120.4 -24.7 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 ASP A:461 A:490 109.0 0.727 -134.1 3.6 109.0 0.727 0.0
ASP B:461 B:490 105.0 0.7 -133.2 4.0 105.0 0.7 0.0
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 ASP A:461 A:490 114.0 0.76 -137.6 2.6 114.0 0.76 0.0
ASP B:461 B:490 107.0 0.713 -137.6 2.3 107.0 0.713 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 ASP A:461 A:490 97.0 0.647 -123.6 11.5 97.0 0.647 0.0
ASP B:461 B:490 102.0 0.68 -123.0 11.5 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 ASP A:461 A:490 100.0 0.667 -114.7 2.6 100.0 0.667 0.0
ASP B:461 B:490 87.0 0.58 -99.8 -52.7 NA NA NA
ASP C:461 C:490 111.0 0.74 -98.9 -52.2 NA NA NA
ASP D:461 D:490 117.0 0.78 -96.9 -53.3 NA NA NA
ASP E:461 E:490 84.0 0.56 -91.5 -62.8 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 ASP A:461 A:490 137.0 0.913 -87.7 -54.9 137.0 0.913 0.0
ASP B:461 B:490 140.0 0.933 -130.6 29.0 140.0 0.933 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 ASP A:461 A:490 98.0 0.653 -136.8 6.8 98.0 0.653 0.0
ASP B:461 B:490 103.0 0.687 -131.1 13.4 103.0 0.687 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 ASP A:461 A:490 95.0 0.633 -142.5 4.6 95.0 0.633 0.0 HOH
10.000
N
O
ASP B:461 B:490 116.0 0.773 -132.1 15.5 116.0 0.773 0.0 HOH
6.404
N
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 ASP A:461 A:490 101.0 0.673 -136.4 6.7 101.0 0.673 0.0 HOH
2.694
OD1
O
ASP B:461 B:490 111.0 0.74 -138.0 20.3 111.0 0.74 0.0 HOH
2.559
OD2
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 ASP A:461 A:490 112.0 0.747 -137.5 2.7 112.0 0.747 0.0 HOH
2.678
OD1
O
ASP B:461 B:490 107.0 0.713 -141.4 6.6 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 ASP A:461 A:490 107.0 0.713 -148.4 20.5 107.0 0.713 0.0 HOH
3.175
N
O
ASP B:461 B:490 113.0 0.753 -134.3 3.4 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 ASP A:461 A:490 106.0 0.707 -131.6 -1.3 106.0 0.707 0.0 HOH
3.259
O
O
ASP B:461 B:490 110.0 0.733 -129.5 9.8 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 ASP A:461 A:490 109.0 0.727 -118.1 7.7 109.0 0.727 0.0
ASP B:461 B:490 102.0 0.68 -103.7 13.7 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 ASP A:461 A:490 116.0 0.773 -133.1 3.5 116.0 0.773 0.0
ASP B:461 B:490 118.0 0.787 -133.7 2.1 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 ASP A:461 A:490 115.0 0.767 -126.4 -9.8 115.0 0.767 0.0 HOH
6.071
N
O
ASP B:461 B:490 112.0 0.747 -119.7 -3.8 112.0 0.747 0.0
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 ASP A:461 A:490 103.0 0.687 -132.7 6.6 103.0 0.687 0.0 HOH
3.467
N
O
ASP B:461 B:490 107.0 0.713 -136.3 9.7 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 ASP A:461 A:490 112.0 0.747 -137.0 8.6 112.0 0.747 0.0
ASP B:461 B:490 108.0 0.72 -117.1 -0.6 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 ASP A:461 A:490 103.0 0.687 -126.8 0.6 103.0 0.687 0.0
ASP B:461 B:490 112.0 0.747 -128.2 9.7 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 ASP A:461 A:490 105.0 0.7 -119.1 9.1 105.0 0.7 0.0 HOH
3.716
O
O
ASP B:461 B:490 114.0 0.76 -125.0 -12.4 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 ASP A:461 A:490 104.0 0.693 -133.8 18.2 104.0 0.693 0.0 HOH
3.545
N
O
ASP B:461 B:490 114.0 0.76 -126.6 0.2 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 ASP A:461 A:490 130.0 0.867 -111.0 -39.2 130.0 0.867 0.0
ASP B:461 B:490 97.0 0.647 -104.8 -57.7 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 ASP A:461 A:490 112.0 0.747 -132.8 -7.4 112.0 0.747 0.0 HOH
8.240
OD2
O
ASP B:461 B:490 113.0 0.753 -134.6 -6.2 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 ASP A:461 A:490 98.0 0.653 -121.2 -5.1 98.0 0.653 0.0
ASP B:461 B:490 106.0 0.707 -135.9 -19.7 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 ASP A:461 A:490 102.0 0.68 -115.6 -43.5 102.0 0.68 0.0
ASP B:461 B:490 91.0 0.607 -115.3 -47.4 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 ASP A:461 A:490 118.0 0.787 -97.5 -45.5 118.0 0.787 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 ASP A:461 A:490 98.0 0.653 -125.1 -6.0 98.0 0.653 0.0
ASP B:461 B:490 112.0 0.747 -133.4 -1.1 112.0 0.747 0.0
ASP C:461 C:490 108.0 0.72 -121.4 -7.2 NA NA NA
ASP D:461 D:490 108.0 0.72 -132.6 -0.5 NA NA NA
ASP E:461 E:490 107.0 0.713 -136.1 2.2 NA NA NA
ASP F:461 F:490 102.0 0.68 -131.3 1.8 NA NA NA
ASP G:461 G:490 112.0 0.747 -128.5 -0.2 NA NA NA
ASP H:461 H:490 106.0 0.707 -133.1 -6.4 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 ASP A:448 A:490 99.0 0.66 -130.0 11.2 99.0 0.66 0.0 HOH
3.518
N
O
ASP B:448 B:490 112.0 0.747 -133.4 9.6 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 ASP A:445 A:490 119.0 0.793 -93.6 -57.9 119.0 0.793 0.0
ASP B:445 B:490 118.0 0.787 -111.1 -13.5 118.0 0.787 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 ASP A:445 A:490 111.0 0.74 -92.7 -39.6 111.0 0.74 0.0
ASP B:445 B:490 117.0 0.78 -95.4 -15.7 117.0 0.78 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 ASP A:445 A:490 101.0 0.673 -130.2 -29.1 101.0 0.673 0.0
ASP B:445 B:490 102.0 0.68 -128.8 -38.6 102.0 0.68 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 ASP A:445 A:490 102.0 0.68 -89.2 -39.9 102.0 0.68 0.0
ASP B:445 B:490 116.0 0.773 -89.7 -39.0 116.0 0.773 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 ASP A:445 A:490 105.0 0.7 -88.1 -40.3 105.0 0.7 0.0
ASP B:445 B:490 113.0 0.753 -86.2 -38.9 113.0 0.753 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 ASP A:445 A:490 111.0 0.74 -90.7 -40.0 111.0 0.74 0.0
ASP B:445 B:490 105.0 0.7 -94.2 -43.9 105.0 0.7 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 ASP A:445 A:490 113.0 0.753 -95.2 -40.2 113.0 0.753 0.0
ASP B:445 B:490 119.0 0.793 -92.4 -36.0 119.0 0.793 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 ASP A:445 A:490 137.0 0.913 -89.5 -54.8 137.0 0.913 0.0
ASP B:445 B:490 138.0 0.92 -130.2 28.8 138.0 0.92 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 ASP A:449 A:490 100.0 0.667 -131.9 5.7 100.0 0.667 0.0 HOH
7.409
OD1
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 ASP A:461 A:490 118.0 0.787 -134.5 7.1 118.0 0.787 0.0 HOH
2.608
OD2
O
ASP B:461 B:490 113.0 0.753 -132.4 7.5 113.0 0.753 0.0 HOH
2.669
OD1
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 ASP A:490 A:490 109.0 0.727 -125.6 1.8