Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94250332 . G A CCDS7421.1:NM_004969.3:c.1451tCt>tTt_NP_004960.2:p.484S>F Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 SER A:484 A:484 64.0 0.557 G -58.0 -13.8 NA NA NA
SER B:484 B:484 55.0 0.478 G -64.4 1.5 55.0 0.478 0.0 HOH
5.973
N
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 SER A:484 A:484 59.0 0.513 G -56.9 -3.9 59.0 0.513 0.0 HOH
4.607
N
O
SER B:484 B:484 54.0 0.47 G -57.0 -10.2 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 SER A:484 A:484 53.0 0.461 G -61.0 -17.5 53.0 0.461 0.0 HOH
4.816
N
O
SER B:484 B:484 63.0 0.548 G -60.5 -17.1 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 SER A:455 A:484 57.0 0.496 G -61.8 -14.5 57.0 0.496 0.0 HOH
4.093
N
O
SER B:455 B:484 58.0 0.504 G -57.4 -15.2 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 SER A:455 A:484 68.0 0.591 G -61.4 -10.9 68.0 0.591 0.0 HOH
4.188
N
O
SER B:455 B:484 50.0 0.435 G -59.7 -11.5 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 SER A:455 A:484 72.0 0.626 G -58.8 -7.7 72.0 0.626 0.0 HOH
4.158
N
O
SER B:455 B:484 57.0 0.496 G -54.8 -8.5 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 SER A:455 A:484 69.0 0.6 G -61.1 -13.1 69.0 0.6 0.0 HOH
3.410
O
O
SER B:455 B:484 52.0 0.452 G -59.8 -7.1 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 SER A:455 A:484 57.0 0.496 G -63.8 -14.7 57.0 0.496 0.0 HOH
4.113
N
O
SER B:455 B:484 54.0 0.47 G -60.0 -13.2 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 SER A:455 A:484 67.0 0.583 G -47.0 -21.2 67.0 0.583 0.0 HOH
3.112
OG
O
SER B:455 B:484 57.0 0.496 G -49.4 -6.8 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 SER A:455 A:484 69.0 0.6 G -53.0 -21.5 69.0 0.6 0.0 HOH
2.900
OG
O
SER B:455 B:484 58.0 0.504 G -55.8 -12.9 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 SER A:484 A:484 74.0 0.643 G -65.7 -31.5 74.0 0.643 0.0 HOH
4.358
N
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 SER A:455 A:484 69.0 0.6 G -62.5 -21.5 69.0 0.6 0.0 HOH
4.963
N
O
SER B:455 B:484 60.0 0.522 G -58.8 -3.9 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 SER A:484 A:484 84.0 0.73 G -67.2 -5.5 84.0 0.73 0.0
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 SER A:455 A:484 54.0 0.47 G -61.6 -13.8 54.0 0.47 0.0 HOH
3.255
O
O
SER B:455 B:484 57.0 0.496 G -65.9 -10.3 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 SER A:443 A:484 59.0 0.513 G -65.0 -11.1 59.0 0.513 0.0 HOH
4.900
N
O
SER B:443 B:484 56.0 0.487 G -64.4 -10.4 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 SER A:443 A:484 58.0 0.504 G -70.1 -6.3 58.0 0.504 0.0
SER B:443 B:484 56.0 0.487 G -70.4 -7.1 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 SER A:443 A:484 58.0 0.504 G -67.2 -15.9 58.0 0.504 0.0
SER B:443 B:484 59.0 0.513 G -67.4 -16.0 59.0 0.513 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 SER A:454 A:484 60.0 0.522 G -64.6 -5.0 60.0 0.522 0.0 HOH
3.114
O
O
SER B:454 B:484 56.0 0.487 G -63.3 -5.4 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 SER A:454 A:484 70.0 0.609 G -61.8 -9.8 70.0 0.609 0.0 HOH
2.518
OG
O
SER B:454 B:484 57.0 0.496 G -61.1 -11.2 57.0 0.496 0.0 HOH
4.611
N
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 SER A:454 A:484 59.0 0.513 G -59.3 -11.1 59.0 0.513 0.0
SER B:454 B:484 66.0 0.574 G -60.8 0.4 66.0 0.574 0.0 HOH
3.702
N
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 SER A:454 A:484 56.0 0.487 G -59.7 -10.4 56.0 0.487 0.0 HOH
3.955
N
O
SER B:454 B:484 62.0 0.539 G -58.1 -4.7 62.0 0.539 0.0 HOH
3.056
O
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 SER A:455 A:484 61.0 0.53 G -72.0 -4.6 61.0 0.53 0.0 HOH
7.051
CB
O
SER B:455 B:484 59.0 0.513 G -73.6 -0.9 59.0 0.513 0.0
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 SER A:455 A:484 60.0 0.522 G -59.9 -9.8 60.0 0.522 0.0
SER B:455 B:484 74.0 0.643 G -72.4 10.5 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 SER A:455 A:484 63.0 0.548 G -78.0 -0.9 63.0 0.548 0.0
SER B:455 B:484 60.0 0.522 G -76.1 0.8 60.0 0.522 0.0
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 SER A:455 A:484 57.0 0.496 G -58.9 -16.3 57.0 0.496 0.0
SER B:455 B:484 74.0 0.643 G -58.4 -16.0 74.0 0.643 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 SER A:455 A:484 57.0 0.496 G -60.6 -13.3 57.0 0.496 0.0 HOH
6.424
N
O
SER B:455 B:484 57.0 0.496 G -61.7 -16.1 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 SER A:455 A:484 67.0 0.583 G -63.4 -10.0 67.0 0.583 0.0
SER B:455 B:484 78.0 0.678 G -62.4 -4.7 NA NA NA
SER C:455 C:484 79.0 0.687 G -72.0 -9.7 NA NA NA
SER D:455 D:484 56.0 0.487 G -75.5 -4.1 NA NA NA
SER E:455 E:484 77.0 0.67 G -70.1 -5.8 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 SER A:455 A:484 78.0 0.678 T -86.9 7.7 78.0 0.678 0.0
SER B:455 B:484 78.0 0.678 G -69.0 -10.4 78.0 0.678 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 SER A:455 A:484 59.0 0.513 G -71.1 -6.3 59.0 0.513 0.0
SER B:455 B:484 54.0 0.47 G -63.7 -16.6 54.0 0.47 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 SER A:455 A:484 56.0 0.487 G -68.9 -12.2 56.0 0.487 0.0 HOH
3.955
CB
O
SER B:455 B:484 59.0 0.513 G -66.1 -14.3 59.0 0.513 0.0 HOH
6.429
N
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 SER A:455 A:484 58.0 0.504 G -62.6 -13.8 58.0 0.504 0.0 HOH
2.753
OG
O
SER B:455 B:484 59.0 0.513 G -67.8 -14.6 59.0 0.513 0.0 HOH
2.466
OG
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 SER A:455 A:484 62.0 0.539 G -58.2 -15.9 62.0 0.539 0.0 HOH
4.006
N
O
SER B:455 B:484 60.0 0.522 G -69.5 0.6 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 SER A:455 A:484 71.0 0.617 G -51.8 -19.8 71.0 0.617 0.0 HOH
3.266
O
O
SER B:455 B:484 59.0 0.513 G -53.5 -5.6 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 SER A:455 A:484 64.0 0.557 G -63.0 -13.8 64.0 0.557 0.0 HOH
4.749
N
O
SER B:455 B:484 61.0 0.53 G -64.9 -2.1 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 SER A:455 A:484 61.0 0.53 G -70.7 -11.5 61.0 0.53 0.0
SER B:455 B:484 62.0 0.539 G -81.3 0.5 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 SER A:455 A:484 56.0 0.487 G -78.9 6.4 56.0 0.487 0.0
SER B:455 B:484 66.0 0.574 G -69.2 6.6 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 SER A:455 A:484 54.0 0.47 G -74.8 1.7 54.0 0.47 0.0 HOH
7.859
C
O
SER B:455 B:484 63.0 0.548 G -68.8 1.4 63.0 0.548 0.0
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 SER A:455 A:484 58.0 0.504 G -58.3 -13.6 58.0 0.504 0.0 HOH
4.088
N
O
SER B:455 B:484 58.0 0.504 G -68.5 -8.9 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 SER A:455 A:484 70.0 0.609 G -61.8 0.6 70.0 0.609 0.0 HOH
4.880
N
O
SER B:455 B:484 60.0 0.522 G -68.8 -0.9 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 SER A:455 A:484 72.0 0.626 G -58.9 -10.1 72.0 0.626 0.0
SER B:455 B:484 62.0 0.539 G -77.9 2.7 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 SER A:455 A:484 61.0 0.53 G -49.5 -30.6 61.0 0.53 0.0 HOH
9.097
O
O
SER B:455 B:484 68.0 0.591 G -92.1 15.3 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 SER A:455 A:484 71.0 0.617 G -61.0 -14.0 71.0 0.617 0.0 HOH
4.853
N
O
SER B:455 B:484 58.0 0.504 G -68.0 5.8 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 SER A:455 A:484 58.0 0.504 G -73.4 -16.2 58.0 0.504 0.0
SER B:455 B:484 56.0 0.487 G -75.4 -11.0 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 SER A:455 A:484 56.0 0.487 G -67.0 -10.2 56.0 0.487 0.0
SER B:455 B:484 60.0 0.522 G -66.8 -10.7 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 SER A:455 A:484 62.0 0.539 G -70.1 1.4 62.0 0.539 0.0
SER B:455 B:484 63.0 0.548 G -62.4 -8.5 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 SER A:455 A:484 73.0 0.635 G -67.6 -13.9 73.0 0.635 0.0
SER B:455 B:484 57.0 0.496 G -68.5 -14.0 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 SER A:455 A:484 56.0 0.487 G -91.1 10.7 56.0 0.487 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 SER A:455 A:484 65.0 0.565 G -62.6 -14.3 65.0 0.565 0.0
SER B:455 B:484 57.0 0.496 G -61.9 -15.9 57.0 0.496 0.0
SER C:455 C:484 61.0 0.53 G -61.6 -13.4 NA NA NA
SER D:455 D:484 62.0 0.539 G -62.6 -10.5 NA NA NA
SER E:455 E:484 67.0 0.583 G -61.3 -16.3 NA NA NA
SER F:455 F:484 70.0 0.609 G -62.2 -12.1 NA NA NA
SER G:455 G:484 66.0 0.574 G -61.1 -19.4 NA NA NA
SER H:455 H:484 60.0 0.522 G -61.3 -14.5 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 SER A:442 A:484 60.0 0.522 G -69.0 -9.4 60.0 0.522 0.0 HOH
2.891
O
O
SER B:442 B:484 62.0 0.539 G -71.7 3.2 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 SER A:439 A:484 75.0 0.652 T -70.7 -6.1 75.0 0.652 0.0
SER B:439 B:484 71.0 0.617 S -72.1 -5.0 71.0 0.617 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 SER A:439 A:484 78.0 0.678 G -71.7 6.5 78.0 0.678 0.0
SER B:439 B:484 91.0 0.791 G -78.4 9.2 91.0 0.791 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 SER A:439 A:484 85.0 0.739 T -80.7 17.4 85.0 0.739 0.0
SER B:439 B:484 95.0 0.826 G -73.0 2.5 95.0 0.826 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 SER A:439 A:484 78.0 0.678 T -87.9 12.5 78.0 0.678 0.0
SER B:439 B:484 82.0 0.713 T -65.5 -7.4 82.0 0.713 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 SER A:439 A:484 87.0 0.757 T -90.3 11.8 87.0 0.757 0.0
SER B:439 B:484 79.0 0.687 T -65.0 -8.6 79.0 0.687 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 SER A:439 A:484 79.0 0.687 T -66.9 -2.8 79.0 0.687 0.0
SER B:439 B:484 61.0 0.53 T -69.9 -2.6 61.0 0.53 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 SER A:439 A:484 85.0 0.739 T -72.5 10.1 85.0 0.739 0.0
SER B:439 B:484 72.0 0.626 T -71.7 6.9 72.0 0.626 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 SER A:439 A:484 73.0 0.635 T -85.5 7.3 73.0 0.635 0.0
SER B:439 B:484 80.0 0.696 G -68.4 -10.9 80.0 0.696 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 SER A:443 A:484 80.0 0.696 G -71.1 12.6 80.0 0.696 0.0 HOH
4.427
N
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 SER A:455 A:484 60.0 0.522 G -62.5 -14.9 60.0 0.522 0.0 HOH
2.901
OG
O
SER B:455 B:484 59.0 0.513 G -65.5 -14.3 59.0 0.513 0.0 HOH
2.788
OG
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 SER A:484 A:484 50.0 0.435 G -61.6 -12.8