Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94264552 . G A CCDS7421.1:NM_004969.3:c.1429Cgg>Tgg_NP_004960.2:p.477R>W Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 ARG A:477 A:477 10.0 0.044 E -123.8 142.3 NA NA NA
ARG B:477 B:477 10.0 0.044 E -124.2 131.4 10.0 0.044 0.0 HOH
3.243
O
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 ARG A:477 A:477 11.0 0.049 E -131.7 138.3 11.0 0.049 0.0 ACY
HOH
3.771
7.161
NH2
N
O
O
ARG B:477 B:477 11.0 0.049 E -128.0 138.2 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 ARG A:477 A:477 12.0 0.053 E -134.1 132.5 12.0 0.053 0.0 J18
HOH
3.313
2.759
NH2
NE
H29
O
ARG B:477 B:477 12.0 0.053 E -134.3 133.2 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 ARG A:448 A:477 12.0 0.053 E -128.8 133.3 12.0 0.053 0.0 DIO
HOH
3.042
2.749
NH2
NE
O1
O
ARG B:448 B:477 11.0 0.049 E -129.9 131.9 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:448 A:477 11.0 0.049 E -128.3 132.4 11.0 0.049 0.0 DIO
HOH
3.519
3.326
NH1
O
C1
O
ARG B:448 B:477 10.0 0.044 E -133.4 136.9 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:448 A:477 10.0 0.044 E -129.1 129.2 10.0 0.044 0.0 DIO
HOH
3.546
3.137
NH1
O
O1
O
ARG B:448 B:477 9.0 0.04 E -133.1 132.3 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:448 A:477 9.0 0.04 E -128.9 130.2 9.0 0.04 0.0 DIO
HOH
3.143
6.077
NH1
O
O1
O
ARG B:448 B:477 9.0 0.04 E -130.0 134.1 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:448 A:477 11.0 0.049 E -128.6 132.0 11.0 0.049 0.0 DIO
HOH
3.181
2.799
NH2
NE
O1
O
ARG B:448 B:477 13.0 0.058 E -128.3 129.2 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 ARG A:448 A:477 10.0 0.044 E -128.6 133.3 10.0 0.044 0.0 DIO
3.425
NH2
C1
ARG B:448 B:477 9.0 0.04 E -134.6 121.3 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 ARG A:448 A:477 12.0 0.053 E -118.2 138.1 12.0 0.053 0.0 HOH
3.347
O
O
ARG B:448 B:477 28.0 0.124 E -124.8 133.4 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 ARG A:477 A:477 9.0 0.04 E -130.7 118.4 9.0 0.04 0.0 HOH
2.624
O
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 ARG A:448 A:477 12.0 0.053 E -130.2 133.3 12.0 0.053 0.0 HOH
6.208
O
O
ARG B:448 B:477 11.0 0.049 E -127.7 133.3 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 ARG A:477 A:477 5.0 0.022 E -113.3 136.9 5.0 0.022 0.0 HOH
3.885
O
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 ARG A:448 A:477 9.0 0.04 E -117.4 137.7 9.0 0.04 0.0 HOH
2.994
NE
O
ARG B:448 B:477 9.0 0.04 E -122.7 138.0 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 ARG A:436 A:477 12.0 0.053 E -124.5 133.9 1.0 0.004 0.049 C:None:0.049
HOH
3.509
O
O
ARG B:436 B:477 10.0 0.044 E -125.1 134.1 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 ARG A:436 A:477 13.0 0.058 E -131.9 129.6 13.0 0.058 0.0 J22
3.172
O
H311
ARG B:436 B:477 11.0 0.049 E -131.9 127.4 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 ARG A:436 A:477 15.0 0.067 E -134.8 133.2 15.0 0.067 0.0 J22
3.343
NH2
H301
ARG B:436 B:477 13.0 0.058 E -135.2 131.4 13.0 0.058 0.0 J22
3.263
O
H311
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:447 A:477 11.0 0.049 E -132.7 134.3 11.0 0.049 0.0 2PJ
HOH
3.400
2.942
NH2
NE
C8
O
ARG B:447 B:477 11.0 0.049 E -128.5 136.1 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:447 A:477 14.0 0.062 E -135.1 125.8 14.0 0.062 0.0 HOH
3.606
O
O
ARG B:447 B:477 12.0 0.053 E -127.5 124.6 12.0 0.053 0.0 HOH
3.586
NH2
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:447 A:477 11.0 0.049 E -130.8 120.3 11.0 0.049 0.0 2Q6
HOH
3.408
2.774
NH2
NE
C40
O
ARG B:447 B:477 12.0 0.053 E -133.2 124.5 12.0 0.053 0.0 2Q6
HOH
3.434
2.794
NH2
NE
C40
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:447 A:477 9.0 0.04 E -131.6 129.5 9.0 0.04 0.0 2QX
HOH
3.518
2.741
NH2
NE
C1
O
ARG B:447 B:477 11.0 0.049 E -129.8 125.9 11.0 0.049 0.0 2QX
HOH
3.401
2.875
NH2
NE
C
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 ARG A:448 A:477 8.0 0.036 E -127.9 139.2 8.0 0.036 0.0 HOH
7.578
NH2
O
ARG B:448 B:477 7.0 0.031 E -125.5 132.8 7.0 0.031 0.0 HOH
6.267
O
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 ARG A:448 A:477 12.0 0.053 E -121.6 129.5 12.0 0.053 0.0 HOH
4.781
NH2
O
ARG B:448 B:477 10.0 0.044 E -125.6 123.8 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 ARG A:448 A:477 13.0 0.058 E -119.7 134.6 13.0 0.058 0.0 HOH
4.478
NH2
O
ARG B:448 B:477 10.0 0.044 E -122.8 134.4 10.0 0.044 0.0 HOH
4.485
NH2
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 ARG A:448 A:477 32.0 0.142 E -124.7 132.4 32.0 0.142 0.0
ARG B:448 B:477 73.0 0.324 E -125.9 132.6 73.0 0.324 0.0 HOH
2.891
NH2
O
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 ARG A:448 A:477 12.0 0.053 E -124.4 132.5 12.0 0.053 0.0 PEG
3.526
NH2
HO1
ARG B:448 B:477 12.0 0.053 E -125.5 133.9 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 ARG A:448 A:477 12.0 0.053 E -137.6 126.2 12.0 0.053 0.0
ARG B:448 B:477 11.0 0.049 E -137.1 119.9 NA NA NA
ARG C:448 C:477 14.0 0.062 E -140.7 121.1 NA NA NA
ARG D:448 D:477 14.0 0.062 E -136.2 123.0 NA NA NA
ARG E:448 E:477 14.0 0.062 E -139.0 124.6 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 ARG A:448 A:477 15.0 0.067 E -142.0 99.1 15.0 0.067 0.0
ARG B:448 B:477 8.0 0.036 -138.8 86.2 8.0 0.036 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 ARG A:448 A:477 11.0 0.049 E -122.8 135.1 11.0 0.049 0.0
ARG B:448 B:477 11.0 0.049 E -119.7 132.7 11.0 0.049 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 ARG A:448 A:477 10.0 0.044 E -122.7 137.1 10.0 0.044 0.0 HOH
6.324
O
O
ARG B:448 B:477 12.0 0.053 E -125.4 138.1 12.0 0.053 0.0 HOH
6.313
O
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 ARG A:448 A:477 10.0 0.044 E -120.6 134.1 10.0 0.044 0.0 HOH
3.131
NE
O
ARG B:448 B:477 11.0 0.049 E -118.3 139.5 11.0 0.049 0.0 HOH
2.856
NE
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 ARG A:448 A:477 9.0 0.04 E -125.5 133.2 9.0 0.04 0.0 HOH
2.890
NE
O
ARG B:448 B:477 10.0 0.044 E -128.1 139.7 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 ARG A:448 A:477 7.0 0.031 E -118.7 135.4 7.0 0.031 0.0 DIO
DIO
HOH
3.563
8.328
3.040
NH2
C
NE
O1
O1
O
ARG B:448 B:477 11.0 0.049 E -122.4 142.5 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 ARG A:448 A:477 9.0 0.04 E -117.8 137.2 9.0 0.04 0.0 HOH
6.261
O
O
ARG B:448 B:477 10.0 0.044 E -117.3 134.7 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 ARG A:448 A:477 8.0 0.036 E -115.0 140.2 8.0 0.036 0.0 DIO
DIO
HOH
7.796
3.519
9.002
NH2
NH2
O
C2'
C2'
O
ARG B:448 B:477 8.0 0.036 E -114.3 132.3 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 ARG A:448 A:477 9.0 0.04 E -115.3 133.9 9.0 0.04 0.0 DIO
2.874
NH2
O1
ARG B:448 B:477 10.0 0.044 E -124.3 133.0 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 ARG A:448 A:477 12.0 0.053 E -117.4 139.9 12.0 0.053 0.0 HOH
9.846
C
O
ARG B:448 B:477 10.0 0.044 E -130.0 136.7 10.0 0.044 0.0 HOH
8.590
NH1
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 ARG A:448 A:477 9.0 0.04 E -116.2 137.4 9.0 0.04 0.0 HOH
6.173
O
O
ARG B:448 B:477 9.0 0.04 E -121.2 144.3 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 ARG A:448 A:477 6.0 0.027 E -121.1 133.4 6.0 0.027 0.0
ARG B:448 B:477 7.0 0.031 E -113.7 136.1 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 ARG A:448 A:477 9.0 0.04 E -119.6 135.9 9.0 0.04 0.0 HOH
4.790
NH2
O
ARG B:448 B:477 6.0 0.027 E -122.7 135.6 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 ARG A:448 A:477 7.0 0.031 E -122.4 142.4 7.0 0.031 0.0
ARG B:448 B:477 7.0 0.031 E -140.7 131.6 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 ARG A:448 A:477 8.0 0.036 E -118.3 141.9 8.0 0.036 0.0 HOH
6.153
O
O
ARG B:448 B:477 9.0 0.04 E -128.0 138.4 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 ARG A:448 A:477 9.0 0.04 E -126.9 110.7 9.0 0.04 0.0
ARG B:448 B:477 6.0 0.027 E -139.1 113.2 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 ARG A:448 A:477 10.0 0.044 E -124.4 132.2 10.0 0.044 0.0 HOH
3.981
NH2
O
ARG B:448 B:477 10.0 0.044 E -125.7 133.6 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 ARG A:448 A:477 12.0 0.053 E -123.3 131.7 12.0 0.053 0.0
ARG B:448 B:477 10.0 0.044 E -125.4 127.8 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 ARG A:448 A:477 12.0 0.053 E -130.4 121.4 12.0 0.053 0.0
ARG B:448 B:477 10.0 0.044 E -132.8 121.6 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 ARG A:448 A:477 15.0 0.067 E -127.2 111.1 15.0 0.067 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 ARG A:448 A:477 10.0 0.044 E -137.8 129.1 10.0 0.044 0.0
ARG B:448 B:477 11.0 0.049 E -125.9 128.8 11.0 0.049 0.0
ARG C:448 C:477 10.0 0.044 E -136.4 129.5 NA NA NA
ARG D:448 D:477 13.0 0.058 E -125.4 126.6 NA NA NA
ARG E:448 E:477 13.0 0.058 E -129.3 126.4 NA NA NA
ARG F:448 F:477 7.0 0.031 E -128.2 123.3 NA NA NA
ARG G:448 G:477 14.0 0.062 E -134.7 127.1 NA NA NA
ARG H:448 H:477 11.0 0.049 E -126.8 127.3 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 ARG A:435 A:477 9.0 0.04 E -118.3 136.8 9.0 0.04 0.0 HOH
8.836
NH2
O
ARG B:435 B:477 9.0 0.04 E -121.3 129.6 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 ARG A:432 A:477 10.0 0.044 E -112.9 153.6 10.0 0.044 0.0
ARG B:432 B:477 9.0 0.04 E -97.3 152.2 9.0 0.04 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 ARG A:432 A:477 10.0 0.044 E -123.5 135.1 10.0 0.044 0.0
ARG B:432 B:477 15.0 0.067 E -107.3 139.1 15.0 0.067 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 ARG A:432 A:477 13.0 0.058 E -119.5 132.9 13.0 0.058 0.0
ARG B:432 B:477 13.0 0.058 E -93.9 141.1 13.0 0.058 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 ARG A:432 A:477 13.0 0.058 E -111.8 139.7 13.0 0.058 0.0
ARG B:432 B:477 14.0 0.062 B -116.7 135.4 14.0 0.062 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 ARG A:432 A:477 13.0 0.058 E -107.9 139.3 13.0 0.058 0.0
ARG B:432 B:477 17.0 0.076 B -116.7 136.3 17.0 0.076 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 ARG A:432 A:477 13.0 0.058 E -111.1 138.9 13.0 0.058 0.0
ARG B:432 B:477 7.0 0.031 E -120.1 132.3 7.0 0.031 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 ARG A:432 A:477 16.0 0.071 E -112.1 137.9 16.0 0.071 0.0
ARG B:432 B:477 13.0 0.058 E -127.6 122.8 13.0 0.058 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 ARG A:432 A:477 11.0 0.049 E -141.6 99.7 11.0 0.049 0.0
ARG B:432 B:477 6.0 0.027 -137.5 86.3 6.0 0.027 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 ARG A:436 A:477 9.0 0.04 E -116.2 142.6 9.0 0.04 0.0 HOH
3.339
NH1
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 ARG A:448 A:477 12.0 0.053 E -120.0 141.0 12.0 0.053 0.0 DIO
HOH
3.232
2.909
NH2
NE
C2'
O
ARG B:448 B:477 12.0 0.053 E -126.1 138.7 12.0 0.053 0.0 DIO
HOH
3.233
2.756
NH2
NE
C2'
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 ARG A:477 A:477 10.0 0.044 E -120.2 135.4