Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94267372 . C A CCDS7421.1:NM_004969.3:c.1205cGt>cTt_NP_004960.2:p.402R>L Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 ARG A:402 A:402 54.0 0.24 H -56.7 -51.9 NA NA NA
ARG B:402 B:402 57.0 0.253 H -49.4 -48.6 57.0 0.253 0.0 HOH
5.529
N
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 ARG A:402 A:402 62.0 0.276 H -57.5 -51.5 62.0 0.276 0.0 ACY
HOH
9.785
3.191
O
CD
OXT
O
ARG B:402 B:402 54.0 0.24 H -57.2 -47.1 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 ARG A:402 A:402 50.0 0.222 H -59.2 -43.5 50.0 0.222 0.0 HOH
3.182
CD
O
ARG B:402 B:402 57.0 0.253 H -59.8 -45.4 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 ARG A:373 A:402 59.0 0.262 H -62.4 -42.6 59.0 0.262 0.0 HOH
2.659
NH2
O
ARG B:373 B:402 57.0 0.253 H -70.9 -35.4 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:373 A:402 46.0 0.204 H -69.9 -33.2 46.0 0.204 0.0 HOH
3.365
CD
O
ARG B:373 B:402 56.0 0.249 H -62.8 -42.5 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:373 A:402 49.0 0.218 H -70.6 -39.4 49.0 0.218 0.0 HOH
3.363
CD
O
ARG B:373 B:402 56.0 0.249 H -60.0 -48.1 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:373 A:402 47.0 0.209 H -71.3 -37.6 47.0 0.209 0.0 HOH
3.448
CD
O
ARG B:373 B:402 58.0 0.258 H -67.2 -42.7 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ARG A:373 A:402 55.0 0.244 H -60.9 -45.5 55.0 0.244 0.0 HOH
2.788
NH2
O
ARG B:373 B:402 58.0 0.258 H -70.4 -40.0 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 ARG A:373 A:402 54.0 0.24 H -60.5 -46.9 54.0 0.24 0.0 HOH
4.999
NH2
O
ARG B:373 B:402 55.0 0.244 H -61.6 -45.8 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 ARG A:373 A:402 55.0 0.244 H -59.6 -43.5 55.0 0.244 0.0 HOH
3.569
CD
O
ARG B:373 B:402 57.0 0.253 H -65.2 -48.5 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 ARG A:402 A:402 50.0 0.222 H -61.8 -43.9 50.0 0.222 0.0
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 ARG A:373 A:402 56.0 0.249 H -61.0 -52.5 56.0 0.249 0.0 HOH
3.122
NH1
O
ARG B:373 B:402 56.0 0.249 H -58.8 -51.0 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 ARG A:402 A:402 42.0 0.187 H -61.3 -46.9 42.0 0.187 0.0 HOH
5.695
N
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 ARG A:373 A:402 57.0 0.253 H -65.3 -41.4 57.0 0.253 0.0 HOH
2.532
NH2
O
ARG B:373 B:402 56.0 0.249 H -62.7 -46.3 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 ARG A:361 A:402 55.0 0.244 H -61.7 -45.1 55.0 0.244 0.0 HOH
4.459
N
O
ARG B:361 B:402 57.0 0.253 H -61.6 -45.9 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 ARG A:361 A:402 55.0 0.244 H -69.4 -39.1 55.0 0.244 0.0
ARG B:361 B:402 52.0 0.231 H -69.1 -40.0 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 ARG A:361 A:402 55.0 0.244 H -73.3 -35.7 55.0 0.244 0.0
ARG B:361 B:402 58.0 0.258 H -73.4 -36.6 58.0 0.258 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:372 A:402 55.0 0.244 H -67.1 -59.2 55.0 0.244 0.0 HOH
5.647
N
O
ARG B:372 B:402 58.0 0.258 H -63.4 -53.6 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:372 A:402 57.0 0.253 H -70.8 -46.0 57.0 0.253 0.0 HOH
3.238
NE
O
ARG B:372 B:402 57.0 0.253 H -69.9 -46.7 57.0 0.253 0.0 HOH
5.937
N
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:372 A:402 58.0 0.258 H -69.8 -52.6 58.0 0.258 0.0 HOH
4.087
NH2
O
ARG B:372 B:402 58.0 0.258 H -72.1 -51.9 58.0 0.258 0.0 HOH
4.825
NH2
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 ARG A:372 A:402 63.0 0.28 H -62.8 -51.8 63.0 0.28 0.0 HOH
2.963
NH2
O
ARG B:372 B:402 57.0 0.253 H -75.2 -52.9 57.0 0.253 0.0 HOH
3.896
NH2
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 ARG A:373 A:402 54.0 0.24 H -59.2 -41.9 54.0 0.24 0.0 HOH
4.669
O
O
ARG B:373 B:402 52.0 0.231 H -54.1 -45.0 52.0 0.231 0.0 HOH
6.052
C
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 ARG A:373 A:402 53.0 0.236 H -64.8 -50.5 53.0 0.236 0.0 HOH
3.091
CD
O
ARG B:373 B:402 39.0 0.173 H -50.1 -45.2 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 ARG A:373 A:402 50.0 0.222 H -63.5 -41.6 50.0 0.222 0.0 HOH
3.740
CD
O
ARG B:373 B:402 34.0 0.151 H -63.6 -42.9 34.0 0.151 0.0 HOH
5.945
CG
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 ARG A:373 A:402 52.0 0.231 H -64.4 -43.7 31.0 0.138 0.093 C:None:0.093
ARG B:373 B:402 54.0 0.24 H -64.3 -45.1 41.0 0.182 0.058 E:None:0.058
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 ARG A:373 A:402 43.0 0.191 H -64.3 -40.7 43.0 0.191 0.0 HOH
3.264
CG
O
ARG B:373 B:402 41.0 0.182 H -63.3 -41.3 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 ARG A:373 A:402 71.0 0.316 H -72.9 -36.4 71.0 0.316 0.0
ARG B:373 B:402 64.0 0.284 H -77.0 -25.2 NA NA NA
ARG C:373 C:402 68.0 0.302 H -66.2 -41.5 NA NA NA
ARG D:373 D:402 61.0 0.271 H -73.3 -37.1 NA NA NA
ARG E:373 E:402 70.0 0.311 H -73.6 -30.0 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 ARG A:373 A:402 40.0 0.178 H -95.1 -21.8 40.0 0.178 0.0
ARG B:373 B:402 78.0 0.347 H -81.1 -35.3 78.0 0.347 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 ARG A:373 A:402 58.0 0.258 H -73.7 -38.1 58.0 0.258 0.0
ARG B:373 B:402 36.0 0.16 H -56.7 -42.2 36.0 0.16 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 ARG A:373 A:402 58.0 0.258 H -71.8 -42.2 58.0 0.258 0.0 HOH
5.967
O
O
ARG B:373 B:402 54.0 0.24 H -57.4 -42.0 54.0 0.24 0.0 HOH
4.294
NH2
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 ARG A:373 A:402 58.0 0.258 H -66.0 -43.5 58.0 0.258 0.0 HOH
3.998
NH2
O
ARG B:373 B:402 38.0 0.169 H -55.3 -47.6 38.0 0.169 0.0 HOH
3.836
NH2
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 ARG A:373 A:402 54.0 0.24 H -63.5 -44.1 54.0 0.24 0.0 HOH
2.552
NH2
O
ARG B:373 B:402 53.0 0.236 H -56.7 -48.1 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 ARG A:373 A:402 55.0 0.244 H -56.3 -42.8 55.0 0.244 0.0 HOH
2.624
NH2
O
ARG B:373 B:402 50.0 0.222 H -62.2 -45.8 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 ARG A:373 A:402 54.0 0.24 H -55.2 -47.7 54.0 0.24 0.0 HOH
2.807
NH2
O
ARG B:373 B:402 40.0 0.178 H -49.8 -49.9 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 ARG A:373 A:402 57.0 0.253 H -55.8 -49.6 57.0 0.253 0.0 HOH
5.163
NH2
O
ARG B:373 B:402 45.0 0.2 H -55.1 -48.4 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 ARG A:373 A:402 62.0 0.276 H -56.1 -47.8 62.0 0.276 0.0 HOH
4.374
NH2
O
ARG B:373 B:402 54.0 0.24 H -60.4 -43.1 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 ARG A:373 A:402 59.0 0.262 H -57.8 -48.7 59.0 0.262 0.0 HOH
7.752
CD
O
ARG B:373 B:402 58.0 0.258 H -61.0 -44.8 58.0 0.258 0.0
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 ARG A:373 A:402 57.0 0.253 H -66.5 -39.7 57.0 0.253 0.0 HOH
3.693
CD
O
ARG B:373 B:402 56.0 0.249 H -67.3 -41.2 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 ARG A:373 A:402 56.0 0.249 H -62.4 -41.1 56.0 0.249 0.0
ARG B:373 B:402 56.0 0.249 H -53.1 -51.1 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 ARG A:373 A:402 59.0 0.262 H -55.5 -46.8 59.0 0.262 0.0 HOH
3.479
CD
O
ARG B:373 B:402 55.0 0.244 H -60.1 -57.4 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 ARG A:373 A:402 53.0 0.236 H -57.1 -51.0 53.0 0.236 0.0 HOH
3.320
CD
O
ARG B:373 B:402 51.0 0.227 H -61.3 -49.0 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 ARG A:373 A:402 55.0 0.244 H -52.4 -47.5 55.0 0.244 0.0 HOH
3.180
NH1
O
ARG B:373 B:402 33.0 0.147 H -63.3 -46.9 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 ARG A:373 A:402 51.0 0.227 H -67.4 -31.6 41.0 0.182 0.045 C:None:0.044
ARG B:373 B:402 61.0 0.271 H -71.0 -31.1 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 ARG A:373 A:402 56.0 0.249 H -64.3 -40.9 56.0 0.249 0.0 HOH
4.987
NH2
O
ARG B:373 B:402 58.0 0.258 H -63.5 -40.5 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 ARG A:373 A:402 46.0 0.204 H -55.6 -32.8 46.0 0.204 0.0
ARG B:373 B:402 53.0 0.236 H -56.2 -41.7 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 ARG A:373 A:402 53.0 0.236 H -67.4 -34.7 53.0 0.236 0.0
ARG B:373 B:402 25.0 0.111 H -73.4 -24.1 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 ARG A:373 A:402 58.0 0.258 H -72.2 -35.4 50.0 0.222 0.036 B:None:0.036
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 ARG A:373 A:402 52.0 0.231 H -70.1 -30.3 23.0 0.102 0.129 Q:None:0.129
ARG B:373 B:402 62.0 0.276 H -68.2 -29.4 28.0 0.124 0.152 R:None:0.151
ARG C:373 C:402 52.0 0.231 H -66.4 -35.1 NA NA NA
ARG D:373 D:402 54.0 0.24 H -66.3 -32.5 NA NA NA
ARG E:373 E:402 55.0 0.244 H -66.1 -32.1 NA NA NA
ARG F:373 F:402 58.0 0.258 H -63.0 -33.0 NA NA NA
ARG G:373 G:402 55.0 0.244 H -65.1 -35.2 NA NA NA
ARG H:373 H:402 54.0 0.24 H -63.2 -31.1 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 ARG A:360 A:402 53.0 0.236 H -59.2 -59.2 53.0 0.236 0.0 HOH
3.054
CD
O
ARG B:360 B:402 57.0 0.253 H -57.6 -56.3 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 ARG A:357 A:402 59.0 0.262 H -93.1 11.6 59.0 0.262 0.0
ARG B:357 B:402 46.0 0.204 H -72.8 -32.0 46.0 0.204 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 ARG A:357 A:402 80.0 0.356 H -83.3 -19.0 80.0 0.356 0.0
ARG B:357 B:402 89.0 0.396 H -81.8 -22.5 89.0 0.396 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 ARG A:357 A:402 141.0 0.627 H -60.9 -38.1 141.0 0.627 0.0
ARG B:357 B:402 88.0 0.391 H -82.7 -42.1 88.0 0.391 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 ARG A:357 A:402 85.0 0.378 H -75.2 -25.0 85.0 0.378 0.0
ARG B:357 B:402 80.0 0.356 H -72.9 -27.4 80.0 0.356 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 ARG A:357 A:402 110.0 0.489 H -76.6 -23.8 110.0 0.489 0.0
ARG B:357 B:402 97.0 0.431 H -72.3 -27.5 97.0 0.431 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 ARG A:357 A:402 56.0 0.249 H -85.6 -14.0 56.0 0.249 0.0
ARG B:357 B:402 101.0 0.449 H -71.6 -28.1 101.0 0.449 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 ARG A:357 A:402 91.0 0.404 H -80.0 -21.2 91.0 0.404 0.0
ARG B:357 B:402 121.0 0.538 H -79.8 -21.7 121.0 0.538 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 ARG A:357 A:402 37.0 0.164 H -92.0 -24.8 37.0 0.164 0.0
ARG B:357 B:402 73.0 0.324 H -80.7 -35.7 73.0 0.324 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 ARG A:361 A:402 51.0 0.227 H -61.0 -37.3 51.0 0.227 0.0 HOH
2.615
NH2
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 ARG A:373 A:402 57.0 0.253 H -65.1 -40.1 57.0 0.253 0.0 HOH
2.335
NH2
O
ARG B:373 B:402 55.0 0.244 H -65.8 -37.9 55.0 0.244 0.0 HOH
2.402
NH2
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 ARG A:402 A:402 59.0 0.262 H -66.9 -40.2