Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94274700 . A C CCDS7421.1:NM_004969.3:c.761aTg>aGg_NP_004960.2:p.254M>R Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 MET A:254 A:254 1.0 0.005 E -114.2 140.0 NA NA NA
MET B:254 B:254 0.0 0.0 E -116.9 143.6 0.0 0.0 0.0 HOH
5.249
N
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 MET A:254 A:254 1.0 0.005 E -111.3 147.1 1.0 0.005 0.0 HOH
3.197
O
O
MET B:254 B:254 0.0 0.0 E -111.8 138.2 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 MET A:254 A:254 1.0 0.005 E -116.4 142.9 1.0 0.005 0.0 HOH
3.457
O
O
MET B:254 B:254 1.0 0.005 E -116.6 143.9 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 MET A:225 A:254 1.0 0.005 E -115.7 148.8 1.0 0.005 0.0 HOH
2.923
O
O
MET B:225 B:254 0.0 0.0 E -115.7 149.0 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 MET A:225 A:254 0.0 0.0 E -115.6 150.4 0.0 0.0 0.0 HOH
3.053
O
O
MET B:225 B:254 0.0 0.0 E -120.1 145.0 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 MET A:225 A:254 0.0 0.0 E -113.4 143.9 0.0 0.0 0.0 HOH
5.770
N
O
MET B:225 B:254 1.0 0.005 E -115.4 146.8 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 MET A:225 A:254 1.0 0.005 E -113.5 145.8 1.0 0.005 0.0 HOH
6.320
CE
O
MET B:225 B:254 0.0 0.0 E -115.1 150.2 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 MET A:225 A:254 0.0 0.0 E -118.4 146.9 0.0 0.0 0.0 HOH
2.945
O
O
MET B:225 B:254 0.0 0.0 E -115.0 146.5 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 MET A:225 A:254 2.0 0.011 E -120.8 141.2 2.0 0.011 0.0 HOH
9.539
O
O
MET B:225 B:254 1.0 0.005 E -117.3 147.2 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 MET A:225 A:254 1.0 0.005 E -118.4 147.6 1.0 0.005 0.0 HOH
2.812
O
O
MET B:225 B:254 0.0 0.0 E -112.4 146.3 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 MET A:254 A:254 2.0 0.011 E -113.8 148.1 2.0 0.011 0.0 HOH
2.590
O
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 MET A:225 A:254 1.0 0.005 E -118.0 138.3 1.0 0.005 0.0 HOH
3.188
O
O
MET B:225 B:254 3.0 0.016 E -114.1 147.2 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 MET A:254 A:254 2.0 0.011 E -116.6 143.9 2.0 0.011 0.0 HOH
4.996
N
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 MET A:225 A:254 1.0 0.005 E -115.3 148.4 1.0 0.005 0.0 HOH
6.573
CE
O
MET B:225 B:254 0.0 0.0 E -113.7 146.9 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 MET A:213 A:254 0.0 0.0 E -114.5 143.8 0.0 0.0 0.0 HOH
5.647
N
O
MET B:213 B:254 1.0 0.005 E -114.5 143.8 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 MET A:213 A:254 0.0 0.0 E -118.5 144.9 0.0 0.0 0.0
MET B:213 B:254 0.0 0.0 E -118.8 148.0 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 MET A:213 A:254 0.0 0.0 E -116.9 148.4 0.0 0.0 0.0
MET B:213 B:254 0.0 0.0 E -116.1 149.3 0.0 0.0 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 MET A:224 A:254 3.0 0.016 E -113.9 143.5 3.0 0.016 0.0 HOH
5.458
N
O
MET B:224 B:254 4.0 0.022 E -109.7 151.2 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 MET A:224 A:254 4.0 0.022 E -111.6 147.4 4.0 0.022 0.0 HOH
5.088
CE
O
MET B:224 B:254 4.0 0.022 E -110.8 148.1 4.0 0.022 0.0 HOH
6.770
CE
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 MET A:224 A:254 4.0 0.022 E -106.7 155.5 4.0 0.022 0.0 HOH
5.392
N
O
MET B:224 B:254 3.0 0.016 E -117.2 145.7 3.0 0.016 0.0 HOH
5.770
N
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 MET A:224 A:254 4.0 0.022 E -107.5 151.2 4.0 0.022 0.0 HOH
2.693
O
O
MET B:224 B:254 4.0 0.022 E -111.4 148.0 4.0 0.022 0.0 HOH
5.278
N
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 MET A:225 A:254 0.0 0.0 E -118.1 137.6 0.0 0.0 0.0 HOH
2.955
O
O
MET B:225 B:254 0.0 0.0 E -111.3 150.2 0.0 0.0 0.0 HOH
9.216
N
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 MET A:225 A:254 0.0 0.0 E -129.6 135.5 0.0 0.0 0.0 HOH
5.532
N
O
MET B:225 B:254 0.0 0.0 E -109.3 150.8 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 MET A:225 A:254 0.0 0.0 E -112.1 145.2 0.0 0.0 0.0 HOH
5.831
N
O
MET B:225 B:254 0.0 0.0 E -112.0 145.1 0.0 0.0 0.0 HOH
5.783
N
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 MET A:225 A:254 3.0 0.016 E -111.6 147.3 3.0 0.016 0.0
MET B:225 B:254 2.0 0.011 -110.9 147.0 2.0 0.011 0.0
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 MET A:225 A:254 1.0 0.005 E -118.7 144.6 1.0 0.005 0.0
MET B:225 B:254 1.0 0.005 E -119.2 143.3 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 MET A:225 A:254 0.0 0.0 E -122.0 152.6 0.0 0.0 0.0
MET B:225 B:254 0.0 0.0 E -120.1 153.6 NA NA NA
MET C:225 C:254 0.0 0.0 E -118.5 153.2 NA NA NA
MET D:225 D:254 0.0 0.0 E -120.3 148.6 NA NA NA
MET E:225 E:254 0.0 0.0 E -117.6 150.9 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 MET A:225 A:254 3.0 0.016 -74.8 147.5 3.0 0.016 0.0
MET B:225 B:254 10.0 0.054 E -162.3 119.2 10.0 0.054 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 MET A:225 A:254 0.0 0.0 E -108.4 151.4 0.0 0.0 0.0
MET B:225 B:254 1.0 0.005 E -122.4 132.6 1.0 0.005 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 MET A:225 A:254 0.0 0.0 E -116.1 137.7 0.0 0.0 0.0
MET B:225 B:254 1.0 0.005 E -120.7 130.0 1.0 0.005 0.0 HOH
3.041
O
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 MET A:225 A:254 0.0 0.0 E -105.1 142.1 0.0 0.0 0.0 HOH
9.391
CE
O
MET B:225 B:254 1.0 0.005 E -116.6 138.0 1.0 0.005 0.0 HOH
2.880
O
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 MET A:225 A:254 0.0 0.0 E -111.3 146.9 0.0 0.0 0.0 HOH
3.029
O
O
MET B:225 B:254 0.0 0.0 E -113.2 146.0 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 MET A:225 A:254 1.0 0.005 E -118.7 143.8 1.0 0.005 0.0 HOH
5.490
N
O
MET B:225 B:254 0.0 0.0 E -118.5 148.3 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 MET A:225 A:254 0.0 0.0 E -121.1 143.4 0.0 0.0 0.0 HOH
2.947
O
O
MET B:225 B:254 0.0 0.0 E -120.7 146.6 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 MET A:225 A:254 0.0 0.0 E -132.5 138.1 0.0 0.0 0.0 HOH
6.012
N
O
MET B:225 B:254 0.0 0.0 E -112.2 149.9 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 MET A:225 A:254 0.0 0.0 E -119.8 135.9 0.0 0.0 0.0 HOH
5.561
N
O
MET B:225 B:254 0.0 0.0 E -118.8 143.3 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 MET A:225 A:254 0.0 0.0 E -113.9 142.2 0.0 0.0 0.0 HOH
5.402
N
O
MET B:225 B:254 0.0 0.0 E -118.4 136.6 0.0 0.0 0.0 HOH
5.431
N
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 MET A:225 A:254 0.0 0.0 E -109.3 145.5 0.0 0.0 0.0 HOH
5.550
N
O
MET B:225 B:254 1.0 0.005 E -113.3 149.1 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 MET A:225 A:254 0.0 0.0 E -120.1 145.5 0.0 0.0 0.0 HOH
5.279
N
O
MET B:225 B:254 0.0 0.0 E -109.7 152.2 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 MET A:225 A:254 1.0 0.005 E -129.8 141.7 1.0 0.005 0.0 HOH
3.188
O
O
MET B:225 B:254 0.0 0.0 E -116.6 154.7 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 MET A:225 A:254 0.0 0.0 E -118.4 139.1 0.0 0.0 0.0 HOH
7.596
N
O
MET B:225 B:254 0.0 0.0 E -117.1 151.1 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 MET A:225 A:254 0.0 0.0 E -124.9 137.3 0.0 0.0 0.0 HOH
3.087
O
O
MET B:225 B:254 0.0 0.0 E -122.0 146.9 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 MET A:225 A:254 2.0 0.011 E -128.2 151.1 2.0 0.011 0.0
MET B:225 B:254 4.0 0.022 E -125.4 147.2 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 MET A:225 A:254 3.0 0.016 E -112.3 143.5 3.0 0.016 0.0 HOH
9.540
CE
O
MET B:225 B:254 3.0 0.016 E -113.9 143.0 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 MET A:225 A:254 1.0 0.005 E -129.3 141.7 1.0 0.005 0.0
MET B:225 B:254 0.0 0.0 E -117.9 143.0 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 MET A:225 A:254 0.0 0.0 E -120.2 148.7 0.0 0.0 0.0 HOH
5.717
N
O
MET B:225 B:254 0.0 0.0 E -120.7 149.4 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 MET A:225 A:254 1.0 0.005 E -109.0 155.7 1.0 0.005 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 MET A:225 A:254 2.0 0.011 E -128.0 140.7 2.0 0.011 0.0
MET B:225 B:254 4.0 0.022 E -119.9 160.8 4.0 0.022 0.0
MET C:225 C:254 2.0 0.011 E -126.2 137.2 NA NA NA
MET D:225 D:254 5.0 0.027 E -111.0 160.7 NA NA NA
MET E:225 E:254 3.0 0.016 E -123.4 153.0 NA NA NA
MET F:225 F:254 6.0 0.032 E -122.8 143.7 NA NA NA
MET G:225 G:254 1.0 0.005 E -115.4 159.4 NA NA NA
MET H:225 H:254 5.0 0.027 E -124.7 139.4 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 MET A:212 A:254 0.0 0.0 E -127.6 134.2 0.0 0.0 0.0 HOH
8.229
O
O
MET B:212 B:254 0.0 0.0 E -125.9 137.3 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 MET A:209 A:254 3.0 0.016 E -79.8 139.9 3.0 0.016 0.0
MET B:209 B:254 1.0 0.005 E -69.7 136.2 1.0 0.005 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 MET A:209 A:254 4.0 0.022 E -73.6 154.9 4.0 0.022 0.0
MET B:209 B:254 9.0 0.049 E -90.1 140.2 9.0 0.049 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 MET A:209 A:254 8.0 0.043 E -72.5 137.2 8.0 0.043 0.0
MET B:209 B:254 1.0 0.005 E -103.0 86.1 1.0 0.005 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 MET A:209 A:254 4.0 0.022 E -75.8 154.3 4.0 0.022 0.0
MET B:209 B:254 1.0 0.005 E -74.6 155.1 1.0 0.005 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 MET A:209 A:254 4.0 0.022 E -72.9 155.8 4.0 0.022 0.0
MET B:209 B:254 1.0 0.005 E -75.2 156.7 1.0 0.005 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 MET A:209 A:254 1.0 0.005 E -70.1 160.0 1.0 0.005 0.0
MET B:209 B:254 3.0 0.016 E -71.7 153.1 3.0 0.016 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 MET A:209 A:254 0.0 0.0 E -73.3 158.5 0.0 0.0 0.0
MET B:209 B:254 2.0 0.011 E -70.6 157.6 2.0 0.011 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 MET A:209 A:254 3.0 0.016 -75.8 149.3 3.0 0.016 0.0
MET B:209 B:254 8.0 0.043 E -162.6 118.7 8.0 0.043 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 MET A:213 A:254 1.0 0.005 E -99.1 148.8 1.0 0.005 0.0 HOH
2.400
O
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 MET A:225 A:254 0.0 0.0 E -111.1 147.1 0.0 0.0 0.0 HOH
2.781
O
O
MET B:225 B:254 0.0 0.0 E -113.4 149.0 0.0 0.0 0.0 HOH
2.740
O
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 MET A:254 A:254 2.0 0.011 E -110.1 141.5