Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94274758 . T A CCDS7421.1:NM_004969.3:c.703Att>Ttt_NP_004960.2:p.235I>F Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 ILE A:235 A:235 29.0 0.166 -69.3 136.9 NA NA NA
ILE B:235 B:235 26.0 0.149 -90.9 136.8 26.0 0.149 0.0 HOH
5.809
O
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 ILE A:235 A:235 29.0 0.166 -70.2 138.4 29.0 0.166 0.0 HOH
6.498
CD1
O
ILE B:235 B:235 25.0 0.143 -81.7 142.6 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 ILE A:235 A:235 25.0 0.143 -83.7 135.7 25.0 0.143 0.0 HOH
5.691
CD1
O
ILE B:235 B:235 27.0 0.154 -85.7 136.4 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 ILE A:206 A:235 26.0 0.149 -102.9 135.9 26.0 0.149 0.0 HOH
3.712
CD1
O
ILE B:206 B:235 26.0 0.149 -72.8 134.7 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:206 A:235 26.0 0.149 -101.7 126.2 26.0 0.149 0.0 HOH
5.991
O
O
ILE B:206 B:235 29.0 0.166 -95.0 144.4 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:206 A:235 26.0 0.149 -110.7 128.4 26.0 0.149 0.0 HOH
8.349
O
O
ILE B:206 B:235 32.0 0.183 -85.8 144.2 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:206 A:235 27.0 0.154 -97.8 132.4 27.0 0.154 0.0 HOH
8.408
O
O
ILE B:206 B:235 28.0 0.16 -101.7 137.0 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 ILE A:206 A:235 29.0 0.166 -99.2 139.7 29.0 0.166 0.0 HOH
3.549
CD1
O
ILE B:206 B:235 25.0 0.143 -86.4 126.6 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 ILE A:206 A:235 27.0 0.154 -125.1 116.8 27.0 0.154 0.0 HOH
8.401
O
O
ILE B:206 B:235 27.0 0.154 -114.2 130.1 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 ILE A:206 A:235 28.0 0.16 -77.9 137.7 28.0 0.16 0.0 HOH
3.290
O
O
ILE B:206 B:235 27.0 0.154 -83.0 137.4 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 ILE A:235 A:235 31.0 NA -83.2 136.0 31.0 NA NA HOH
9.416
CB
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 ILE A:206 A:235 31.0 0.177 -82.9 130.6 31.0 0.177 0.0 HOH
6.957
CG2
O
ILE B:206 B:235 27.0 0.154 -85.8 140.9 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 ILE A:235 A:235 82.0 0.469 101.0 127.1 82.0 0.469 0.0 HOH
2.889
N
O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 ILE A:206 A:235 26.0 0.149 -75.2 129.1 26.0 0.149 0.0 HOH
3.508
O
O
ILE B:206 B:235 27.0 0.154 -85.8 135.8 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 ILE A:194 A:235 24.0 0.137 -81.9 138.1 24.0 0.137 0.0 HOH
3.608
CD1
O
ILE B:194 B:235 26.0 0.149 -82.6 137.9 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 ILE A:194 A:235 22.0 0.126 -74.6 127.0 22.0 0.126 0.0
ILE B:194 B:235 21.0 0.12 -76.8 129.0 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 ILE A:194 A:235 26.0 0.149 -68.1 136.3 26.0 0.149 0.0
ILE B:194 B:235 27.0 0.154 -69.4 136.4 27.0 0.154 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:205 A:235 23.0 0.131 -98.2 126.9 23.0 0.131 0.0 HOH
7.729
CD1
O
ILE B:205 B:235 49.0 0.28 -98.5 130.5 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:205 A:235 21.0 0.12 -93.7 129.5 21.0 0.12 0.0 HOH
5.000
CD1
O
ILE B:205 B:235 50.0 0.286 -89.7 129.6 50.0 0.286 0.0 HOH
8.881
CG2
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:205 A:235 48.0 0.274 -96.6 128.8 48.0 0.274 0.0
ILE B:205 B:235 18.0 0.103 -86.1 126.2 18.0 0.103 0.0 HOH
7.895
CD1
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 ILE A:205 A:235 47.0 0.269 -74.8 128.1 47.0 0.269 0.0 HOH
5.170
N
O
ILE B:205 B:235 23.0 0.131 -94.1 132.4 23.0 0.131 0.0 HOH
5.795
CD1
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 ILE A:206 A:235 29.0 0.166 -80.0 134.6 29.0 0.166 0.0 HOH
4.789
CD1
O
ILE B:206 B:235 29.0 0.166 -72.8 157.1 29.0 0.166 0.0 HOH
6.613
CG2
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 ILE A:206 A:235 25.0 0.143 -91.4 127.0 25.0 0.143 0.0 HOH
5.812
CG2
O
ILE B:206 B:235 25.0 0.143 -78.3 138.3 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 ILE A:206 A:235 33.0 0.189 -72.6 140.5 33.0 0.189 0.0 HOH
9.494
CD1
O
ILE B:206 B:235 25.0 0.143 -74.0 141.4 25.0 0.143 0.0 HOH
5.764
CD1
O
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 ILE A:206 A:235 31.0 0.177 -107.9 124.8 31.0 0.177 0.0
ILE B:206 NA:NA DO NA DO DO DO NA NA NA
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 ILE A:206 A:235 25.0 0.143 -90.5 136.2 25.0 0.143 0.0 HOH
7.598
CG2
O
ILE B:206 B:235 22.0 0.126 -90.1 135.8 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 ILE A:206 A:235 30.0 0.171 -125.3 121.5 30.0 0.171 0.0
ILE B:206 B:235 38.0 0.217 -124.4 127.0 NA NA NA
ILE C:206 C:235 36.0 0.206 -129.5 122.5 NA NA NA
ILE D:206 D:235 40.0 0.229 -134.2 129.0 NA NA NA
ILE E:206 E:235 33.0 0.189 -124.2 124.3 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 ILE A:206 A:235 50.0 0.286 -78.1 128.3 50.0 0.286 0.0
ILE B:206 B:235 52.0 0.297 -83.6 131.5 52.0 0.297 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 ILE A:206 A:235 26.0 0.149 -75.1 132.7 26.0 0.149 0.0
ILE B:206 B:235 27.0 0.154 -81.5 141.4 27.0 0.154 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 ILE A:206 A:235 36.0 0.206 -70.1 133.2 36.0 0.206 0.0 HOH
9.249
C
O
ILE B:206 B:235 26.0 0.149 -73.5 143.5 26.0 0.149 0.0 HOH
6.051
CD1
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 ILE A:206 A:235 27.0 0.154 -81.9 134.4 27.0 0.154 0.0 HOH
3.249
O
O
ILE B:206 B:235 26.0 0.149 -77.4 140.3 26.0 0.149 0.0 HOH
3.273
CD1
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 ILE A:206 A:235 28.0 0.16 -80.9 129.0 28.0 0.16 0.0 HOH
2.825
O
O
ILE B:206 B:235 30.0 0.171 -100.6 136.0 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 ILE A:206 A:235 30.0 0.171 -81.6 131.5 30.0 0.171 0.0 HOH
3.164
CD1
O
ILE B:206 B:235 30.0 0.171 -80.5 153.4 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 ILE A:206 A:235 26.0 0.149 -66.8 139.0 26.0 0.149 0.0 HOH
8.227
N
O
ILE B:206 B:235 28.0 0.16 -87.2 153.0 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 ILE A:206 A:235 27.0 0.154 -100.1 127.9 27.0 0.154 0.0 HOH
6.818
CG2
O
ILE B:206 B:235 29.0 0.166 -75.9 139.0 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 ILE A:206 A:235 25.0 0.143 -103.7 134.7 25.0 0.143 0.0 HOH
4.454
CA
O
ILE B:206 B:235 33.0 0.189 -98.5 132.1 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 ILE A:206 A:235 38.0 0.217 -69.1 150.0 38.0 0.217 0.0 HOH
3.685
CG2
O
ILE B:206 B:235 25.0 0.143 -104.8 128.1 25.0 0.143 0.0 HOH
9.168
CD1
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 ILE A:206 A:235 29.0 0.166 -81.7 132.4 29.0 0.166 0.0 HOH
8.422
CD1
O
ILE B:206 B:235 35.0 0.2 -88.6 135.3 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 ILE A:206 A:235 24.0 0.137 -77.5 134.8 24.0 0.137 0.0 HOH
4.615
CG1
O
ILE B:206 B:235 28.0 0.16 -62.8 142.7 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 ILE A:206 A:235 25.0 0.143 -80.9 135.2 25.0 0.143 0.0
ILE B:206 B:235 25.0 0.143 -79.5 138.0 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 ILE A:206 A:235 27.0 0.154 -73.0 129.0 27.0 0.154 0.0 HOH
5.604
CG1
O
ILE B:206 B:235 27.0 0.154 -85.4 145.7 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 ILE A:206 A:235 27.0 0.154 -73.7 125.7 27.0 0.154 0.0 HOH
3.117
O
O
ILE B:206 B:235 27.0 0.154 -83.4 147.5 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 ILE A:206 A:235 58.0 0.331 -125.3 360.0 58.0 0.331 0.0
ILE B:206 B:235 33.0 0.189 -127.5 124.3 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 ILE A:206 A:235 33.0 0.189 -66.7 139.4 33.0 0.189 0.0
ILE B:206 B:235 38.0 0.217 -68.1 140.0 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 ILE A:206 A:235 21.0 0.12 -72.6 125.7 21.0 0.12 0.0
ILE B:206 B:235 34.0 0.194 -75.6 134.3 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 ILE A:206 A:235 22.0 0.126 -88.5 126.9 22.0 0.126 0.0 HOH
6.067
CD1
O
ILE B:206 B:235 30.0 0.171 -90.2 125.3 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 ILE A:206 A:235 31.0 0.177 -97.5 123.3 31.0 0.177 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 ILE A:206 A:235 27.0 0.154 -94.3 137.0 27.0 0.154 0.0
ILE B:206 B:235 57.0 0.326 -124.7 149.3 57.0 0.326 0.0
ILE C:206 C:235 29.0 0.166 -101.7 136.3 NA NA NA
ILE D:206 D:235 48.0 0.274 -127.3 145.2 NA NA NA
ILE E:206 E:235 33.0 0.189 -108.4 138.9 NA NA NA
ILE F:206 F:235 33.0 0.189 -107.8 137.1 NA NA NA
ILE G:206 G:235 33.0 0.189 -101.0 140.2 NA NA NA
ILE H:206 H:235 36.0 0.206 -107.1 136.4 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 ILE A:193 A:235 35.0 0.2 -77.9 136.0 35.0 0.2 0.0 HOH
2.739
O
O
ILE B:193 B:235 28.0 0.16 -84.6 139.1 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 ILE A:190 A:235 43.0 0.246 -72.6 130.5 43.0 0.246 0.0
ILE B:190 B:235 54.0 0.309 -75.4 127.0 54.0 0.309 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 ILE A:190 A:235 41.0 0.234 -82.1 121.8 41.0 0.234 0.0
ILE B:190 B:235 39.0 0.223 -81.4 126.4 39.0 0.223 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 ILE A:190 A:235 53.0 0.303 -85.4 93.1 53.0 0.303 0.0
ILE B:190 B:235 69.0 0.394 -119.1 125.9 69.0 0.394 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 ILE A:190 A:235 45.0 0.257 -80.2 126.7 45.0 0.257 0.0
ILE B:190 B:235 39.0 0.223 -80.2 123.6 39.0 0.223 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 ILE A:190 A:235 60.0 0.343 -80.9 126.4 60.0 0.343 0.0
ILE B:190 B:235 48.0 0.274 -80.4 126.2 48.0 0.274 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 ILE A:190 A:235 42.0 0.24 -76.4 126.0 42.0 0.24 0.0
ILE B:190 B:235 43.0 0.246 -78.9 131.0 43.0 0.246 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 ILE A:190 A:235 41.0 0.234 -81.0 129.0 41.0 0.234 0.0
ILE B:190 B:235 60.0 0.343 -77.3 129.9 60.0 0.343 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 ILE A:190 A:235 50.0 0.286 -78.0 127.6 50.0 0.286 0.0
ILE B:190 B:235 55.0 0.314 -84.6 131.1 55.0 0.314 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 ILE A:194 A:235 40.0 0.229 -120.3 125.7 40.0 0.229 0.0 HOH
9.081
CD1
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 ILE A:206 A:235 25.0 0.143 -83.0 133.5 25.0 0.143 0.0 ACT
HOH
4.266
3.190
CD1
O
O
O
ILE B:206 B:235 23.0 0.131 -92.8 134.3 23.0 0.131 0.0 HOH
3.142
O
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 ILE A:235 A:235 29.0 0.166 -89.1 124.6