Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94291530 . T A CCDS7421.1:NM_004969.3:c.636aaA>aaT_NP_004960.2:p.212K>N Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 LYS A:212 A:212 176.0 0.88 T -103.7 -2.3 NA NA NA
LYS B:212 B:212 91.0 NA T -91.2 -16.8 91.0 NA NA HOH
5.889
N
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 LYS A:212 A:212 183.0 0.915 T -90.1 -20.0 183.0 0.915 0.0 ACY
HOH
4.310
3.225
O
O
CH3
O
LYS B:212 B:212 196.0 0.98 T -88.1 -6.3 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 LYS A:212 A:212 200.0 1.0 T -75.9 -11.5 200.0 1.0 0.0 HOH
4.040
O
O
LYS B:212 B:212 198.0 0.99 T -75.7 -12.2 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 LYS A:183 A:212 188.0 0.94 T -87.4 -12.2 188.0 0.94 0.0 HOH
3.630
O
O
LYS B:183 B:212 183.0 0.915 T -84.2 -13.4 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 LYS A:183 A:212 188.0 0.94 T -71.4 -29.7 188.0 0.94 0.0 HOH
3.100
O
O
LYS B:183 B:212 191.0 0.955 T -82.4 -14.4 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 LYS A:183 A:212 188.0 0.94 T -86.8 -22.8 188.0 0.94 0.0 HOH
5.436
N
O
LYS B:183 B:212 180.0 0.9 T -85.7 -8.4 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 LYS A:183 A:212 191.0 0.955 T -79.6 -20.0 191.0 0.955 0.0 HOH
5.665
N
O
LYS B:183 B:212 193.0 0.965 T -86.7 -13.2 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 LYS A:183 A:212 189.0 0.945 T -89.0 -13.8 189.0 0.945 0.0 HOH
3.556
O
O
LYS B:183 B:212 188.0 0.94 T -80.8 -19.5 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 LYS A:183 A:212 194.0 0.97 T -65.2 -30.9 194.0 0.97 0.0
LYS B:183 B:212 193.0 0.965 T -68.9 -20.9 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 LYS A:183 A:212 183.0 0.915 T -90.2 -15.2 183.0 0.915 0.0 HOH
5.935
N
O
LYS B:183 B:212 185.0 0.925 T -91.7 -11.8 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 LYS A:212 A:212 190.0 0.95 S -74.8 -30.4 190.0 0.95 0.0 HOH
9.805
O
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 LYS A:183 A:212 189.0 0.945 T -70.6 -28.4 189.0 0.945 0.0 HOH
2.947
O
O
LYS B:183 B:212 184.0 0.92 T -76.7 -23.3 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 LYS A:212 A:212 148.0 0.74 T -90.6 8.1 148.0 0.74 0.0
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 LYS A:183 A:212 194.0 0.97 T -83.6 -14.1 194.0 0.97 0.0 HOH
5.471
N
O
LYS B:183 B:212 186.0 0.93 T -91.0 -15.0 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 LYS A:171 A:212 188.0 0.94 T -80.5 -19.9 188.0 0.94 0.0 HOH
6.004
CE
O
LYS B:171 B:212 195.0 0.975 T -80.7 -19.6 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 LYS A:171 A:212 194.0 0.97 T -70.6 -20.8 194.0 0.97 0.0
LYS B:171 B:212 189.0 0.945 T -70.7 -23.2 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 LYS A:171 A:212 191.0 0.955 T -81.1 -18.1 191.0 0.955 0.0
LYS B:171 B:212 189.0 0.945 T -80.7 -18.8 189.0 0.945 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 LYS A:182 A:212 152.0 0.76 T -86.6 -14.9 152.0 0.76 0.0 HOH
4.411
NZ
O
LYS B:182 B:212 193.0 0.965 T -86.3 -16.8 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 LYS A:182 A:212 156.0 0.78 T -86.4 -17.5 156.0 0.78 0.0 HOH
3.608
CD
O
LYS B:182 B:212 195.0 0.975 T -75.9 -21.1 195.0 0.975 0.0 HOH
2.900
O
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 LYS A:182 A:212 199.0 0.995 T -74.1 -12.4 199.0 0.995 0.0 HOH
2.938
O
O
LYS B:182 B:212 163.0 0.815 T -81.1 -10.4 163.0 0.815 0.0 HOH
4.193
NZ
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 LYS A:182 A:212 196.0 0.98 T -74.7 -20.2 196.0 0.98 0.0 HOH
2.964
O
O
LYS B:182 B:212 151.0 0.755 T -78.7 -29.9 151.0 0.755 0.0 HOH
3.798
CD
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 LYS A:183 A:212 188.0 0.94 T -68.7 -12.2 188.0 0.94 0.0 HOH
5.925
N
O
LYS B:183 B:212 179.0 0.895 T -73.9 -7.5 179.0 0.895 0.0 HOH
6.031
N
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 LYS A:183 A:212 196.0 0.98 T -75.5 -13.1 196.0 0.98 0.0
LYS B:183 B:212 192.0 0.96 S -77.1 -27.4 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 LYS A:183 A:212 187.0 0.935 T -75.3 -19.6 187.0 0.935 0.0 HOH
5.855
NZ
O
LYS B:183 B:212 183.0 0.915 T -75.0 -18.5 183.0 0.915 0.0
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 LYS A:183 NA:NA DO NA DO DO DO NA NA NA
LYS B:183 NA:NA DO NA DO DO DO NA NA NA
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 LYS A:183 A:212 188.0 0.94 T -71.0 -14.2 188.0 0.94 0.0
LYS B:183 B:212 190.0 0.95 T -70.1 -14.0 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 LYS A:183 A:212 178.0 0.89 T -93.5 7.2 178.0 0.89 0.0
LYS B:183 B:212 189.0 0.945 T -82.2 -8.5 NA NA NA
LYS C:183 C:212 149.0 0.745 T -78.5 -18.9 NA NA NA
LYS D:183 D:212 183.0 0.915 T -79.0 -4.6 NA NA NA
LYS E:183 E:212 170.0 0.85 T -70.1 -7.7 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 LYS A:183 A:212 176.0 0.88 T -89.3 0.4 176.0 0.88 0.0
LYS B:183 B:212 178.0 0.89 S -93.2 -29.5 178.0 0.89 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 LYS A:183 A:212 174.0 0.87 T -84.1 -9.5 174.0 0.87 0.0
LYS B:183 B:212 188.0 0.94 T -92.7 1.3 188.0 0.94 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 LYS A:183 A:212 195.0 0.975 T -84.1 -7.7 195.0 0.975 0.0 HOH
8.992
N
O
LYS B:183 B:212 196.0 0.98 T -83.8 -2.8 196.0 0.98 0.0
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 LYS A:183 A:212 188.0 0.94 T -78.5 -11.8 188.0 0.94 0.0 HOH
3.201
O
O
LYS B:183 B:212 187.0 0.935 T -89.9 1.2 187.0 0.935 0.0 HOH
5.480
N
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 LYS A:183 A:212 187.0 0.935 T -87.4 -11.4 187.0 0.935 0.0 HOH
3.384
O
O
LYS B:183 B:212 184.0 0.92 T -90.8 -4.2 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 LYS A:183 A:212 186.0 0.93 T -63.4 -18.4 186.0 0.93 0.0 HOH
7.699
N
O
LYS B:183 B:212 197.0 0.985 T -61.8 -26.1 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 LYS A:183 A:212 185.0 0.925 T -81.0 -13.3 185.0 0.925 0.0 HOH
3.851
O
O
LYS B:183 B:212 196.0 0.98 T -73.3 -16.9 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 LYS A:183 A:212 177.0 0.885 T -74.4 -32.0 177.0 0.885 0.0 HOH
8.365
N
O
LYS B:183 B:212 160.0 0.8 S -83.1 -25.3 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 LYS A:183 A:212 184.0 0.92 T -77.1 -26.9 184.0 0.92 0.0 HOH
6.779
N
O
LYS B:183 B:212 188.0 0.94 T -80.1 -16.5 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 LYS A:183 A:212 182.0 0.91 T -74.6 -20.0 182.0 0.91 0.0 HOH
7.570
N
O
LYS B:183 B:212 200.0 1.0 T -65.5 -18.4 200.0 1.0 0.0 HOH
6.866
N
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 LYS A:183 A:212 192.0 0.96 T -93.4 -9.6 192.0 0.96 0.0 HOH
3.457
O
O
LYS B:183 B:212 185.0 0.925 T -93.3 -13.3 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 LYS A:183 A:212 193.0 0.965 T -70.9 -8.1 193.0 0.965 0.0 HOH
8.425
N
O
LYS B:183 B:212 177.0 0.885 T -76.7 -18.3 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 LYS A:183 A:212 184.0 0.92 T -54.8 -36.2 184.0 0.92 0.0 HOH
6.702
N
O
LYS B:183 B:212 197.0 0.985 T -83.3 -12.3 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 LYS A:183 A:212 188.0 0.94 T -66.0 -23.8 188.0 0.94 0.0 HOH
3.160
O
O
LYS B:183 B:212 198.0 0.99 T -63.0 -24.2 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 LYS A:183 A:212 183.0 0.915 T -103.2 3.6 183.0 0.915 0.0 HOH
6.707
N
O
LYS B:183 B:212 193.0 0.965 T -76.6 -16.0 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 LYS A:183 A:212 148.0 0.74 S -76.9 -43.3 148.0 0.74 0.0
LYS B:183 B:212 190.0 0.95 T -88.4 -2.0 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 LYS A:183 A:212 183.0 0.915 T -93.5 -2.6 183.0 0.915 0.0
LYS B:183 B:212 177.0 0.885 T -93.0 -0.3 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 LYS A:183 A:212 181.0 0.905 T -87.6 -5.9 181.0 0.905 0.0
LYS B:183 B:212 175.0 0.875 T -98.2 -0.0 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 LYS A:183 A:212 133.0 0.665 T -118.7 42.0 133.0 0.665 0.0 HOH
9.334
O
O
LYS B:183 B:212 186.0 0.93 T -112.8 31.8 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 LYS A:183 A:212 183.0 0.915 T -103.0 -12.5 183.0 0.915 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 LYS A:183 A:212 185.0 0.925 T -76.8 -10.2 185.0 0.925 0.0
LYS B:183 B:212 177.0 0.885 T -92.6 7.5 177.0 0.885 0.0
LYS C:183 C:212 186.0 0.93 T -77.7 -10.0 NA NA NA
LYS D:183 D:212 173.0 0.865 T -95.3 1.4 NA NA NA
LYS E:183 E:212 175.0 0.875 T -87.4 -1.2 NA NA NA
LYS F:183 F:212 186.0 0.93 T -79.3 -14.5 NA NA NA
LYS G:183 G:212 176.0 0.88 T -87.4 4.0 NA NA NA
LYS H:183 H:212 183.0 0.915 T -88.6 -5.0 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 LYS A:170 A:212 180.0 0.9 T -63.2 -28.8 180.0 0.9 0.0 HOH
6.898
O
O
LYS B:170 B:212 187.0 0.935 T -87.7 -17.0 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 LYS A:167 A:212 176.0 0.88 T -86.3 -19.5 176.0 0.88 0.0
LYS B:167 B:212 168.0 0.84 S -99.2 -23.0 168.0 0.84 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 LYS A:167 A:212 179.0 0.895 S -96.9 -25.6 179.0 0.895 0.0
LYS B:167 B:212 178.0 0.89 S -81.5 -28.5 178.0 0.89 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 LYS A:167 A:212 186.0 0.93 S -73.2 -37.4 186.0 0.93 0.0
LYS B:167 B:212 179.0 0.895 S -99.6 -27.7 179.0 0.895 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 LYS A:167 A:212 179.0 0.895 S -94.4 -26.9 179.0 0.895 0.0
LYS B:167 B:212 178.0 0.89 S -90.8 -24.7 178.0 0.89 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 LYS A:167 A:212 178.0 0.89 S -95.5 -26.4 178.0 0.89 0.0
LYS B:167 B:212 180.0 0.9 S -93.1 -23.5 180.0 0.9 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 LYS A:167 A:212 170.0 0.85 T -83.9 -27.9 170.0 0.85 0.0
LYS B:167 B:212 178.0 0.89 S -90.7 -26.7 178.0 0.89 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 LYS A:167 A:212 171.0 0.855 S -86.6 -28.1 171.0 0.855 0.0
LYS B:167 B:212 176.0 0.88 S -94.4 -23.4 176.0 0.88 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 LYS A:167 A:212 176.0 0.88 T -91.0 0.9 176.0 0.88 0.0
LYS B:167 B:212 176.0 0.88 S -93.3 -29.5 176.0 0.88 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 LYS A:171 A:212 177.0 0.885 T -70.2 -34.6 177.0 0.885 0.0 HOH
4.384
CG
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 LYS A:183 A:212 194.0 0.97 T -86.8 -13.4 194.0 0.97 0.0 HOH
3.492
O
O
LYS B:183 B:212 194.0 0.97 T -88.7 -10.2 194.0 0.97 0.0 HOH
3.286
CE
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 LYS A:212 A:212 191.0 0.955 T -81.0 -17.9