Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94291562 . A C CCDS7421.1:NM_004969.3:c.604Ttt>Gtt_NP_004960.2:p.202F>V Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
 2009-11-03 PHE A:202 A:202 100.0 0.476 H -61.4 -42.0 NA NA NA
PHE B:202 B:202 99.0 0.471 H -55.3 -49.9 58.0 0.276 0.195 D:P05067:0.195
 HOH
 2.692
 O
 O
3e4a 1 P14735 98.63 0.0 X-RAY
 2009-05-19 PHE A:202 A:202 99.0 0.471 H -51.4 -46.5 99.0 0.471 0.0 ACY
HOH
 6.494
3.793
 N
CE1
 OXT
O
PHE B:202 B:202 106.0 0.505 H -55.3 -48.4 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
 2019-04-03 PHE A:202 A:202 101.0 0.481 H -52.9 -51.5 101.0 0.481 0.0 J18
HOH
 2.714
3.069
 N
O
 O01
O
PHE B:202 B:202 102.0 0.486 H -50.6 -51.0 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
 2006-10-24 PHE A:173 A:202 100.0 0.476 H -54.7 -51.6 59.0 0.281 0.195 C:None:0.195
 DIO
HOH
 6.013
2.919
 N
O
 O1'
O
PHE B:173 B:202 101.0 0.481 H -57.6 -46.9 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
 2006-10-24 PHE A:173 A:202 107.0 0.51 H -65.8 -41.5 74.0 0.352 0.158 C:P10997:0.157
 DIO
HOH
 6.102
2.867
 N
O
 O1'
O
PHE B:173 B:202 100.0 0.476 H -60.8 -47.4 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
 2006-10-24 PHE A:173 A:202 104.0 0.495 H -61.9 -45.8 57.0 0.271 0.224 C:4503945:0.224
 DIO
HOH
 6.196
2.775
 N
O
 O1'
O
PHE B:173 B:202 101.0 0.481 H -55.8 -46.2 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
 2006-10-24 PHE A:173 A:202 102.0 0.486 H -61.1 -45.8 59.0 0.281 0.205 C:P01308:0.205
 DIO
HOH
 6.031
2.672
 N
O
 O1'
O
PHE B:173 B:202 100.0 0.476 H -56.1 -51.3 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
 2006-10-24 PHE A:173 A:202 99.0 0.471 H -56.2 -50.6 50.0 0.238 0.233 C:P01308:0.233
 DIO
HOH
 5.965
2.924
 N
O
 O1'
O
PHE B:173 B:202 106.0 0.505 H -58.3 -48.3 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
 2007-07-03 PHE A:173 A:202 103.0 0.49 H -57.4 -45.9 70.0 0.333 0.157 C:None:0.157
 DIO
 5.725
 N
 C2'
PHE B:173 B:202 104.0 0.495 H -54.7 -57.4 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
 2009-08-18 PHE A:173 A:202 107.0 0.51 H -51.6 -47.4 107.0 0.51 0.0 HOH
 3.612
 CE1
 O
PHE B:173 B:202 104.0 0.495 H -53.9 -47.5 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
 2011-10-26 PHE A:202 A:202 95.0 0.452 H -63.2 -48.0 95.0 0.452 0.0 HOH
 3.929
 CZ
 O
2jg4 1 P14735 99.9 0.0 X-RAY
 2007-07-03 PHE A:173 A:202 102.0 0.486 H -47.6 -56.0 102.0 0.486 0.0 HOH
 3.269
 N
 O
PHE B:173 B:202 99.0 0.471 H -52.6 -54.8 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
 2011-07-27 PHE A:202 A:202 102.0 0.486 H -50.3 -65.7 79.0 0.376 0.11 B:None:0.067
C:None:0.043
 HOH
 8.803
 N
 O
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
 2009-08-18 PHE A:173 A:202 106.0 0.505 H -50.4 -53.3 59.0 0.281 0.224 C:P01344:0.224
 HOH
 2.660
 O
 O
PHE B:173 B:202 99.0 0.471 H -59.3 -52.2 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
 2014-05-21 PHE A:161 A:202 95.0 0.452 H -52.2 -51.3 56.0 0.267 0.185 C:None:0.186
 HOH
 2.618
 O
 O
PHE B:161 B:202 96.0 0.457 H -51.8 -51.0 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
 2019-04-03 PHE A:161 A:202 97.0 0.462 H -49.9 -58.6 83.0 0.395 0.067 C:P01275:0.067
 J22
 2.983
 CB
 H181
PHE B:161 B:202 94.0 0.448 H -49.4 -56.7 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
 2019-04-03 PHE A:161 A:202 95.0 0.452 H -47.0 -61.1 95.0 0.452 0.0 J22
 3.035
 CB
 H181
PHE B:161 B:202 95.0 0.452 H -46.9 -61.1 95.0 0.452 0.0 J22
 3.769
 N
 H181
4pes 1 P14735 98.57 0.0 X-RAY
 2015-06-17 PHE A:172 A:202 101.0 0.481 H -61.1 -49.5 101.0 0.481 0.0 2PJ
HOH
 3.595
2.846
 CD2
O
 C29
O
PHE B:172 B:202 89.0 0.424 H -61.4 -43.0 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
 2015-06-17 PHE A:172 A:202 92.0 0.438 H -60.8 -47.0 92.0 0.438 0.0 HOH
 3.832
 CE1
 O
PHE B:172 B:202 85.0 0.405 H -57.7 -45.8 85.0 0.405 0.0 HOH
 3.748
 CE1
 O
4pf9 1 P14735 98.57 0.0 X-RAY
 2015-06-17 PHE A:172 A:202 91.0 0.433 H -49.5 -50.5 91.0 0.433 0.0 2Q6
HOH
 3.565
3.485
 CA
CE1
 N3
O
PHE B:172 B:202 98.0 0.467 H -46.3 -45.9 98.0 0.467 0.0 2Q6
HOH
 3.273
5.906
 CD2
CZ
 O4
O
4pfc 1 P14735 98.57 0.0 X-RAY
 2015-06-17 PHE A:172 A:202 94.0 0.448 H -57.0 -50.0 94.0 0.448 0.0 2QX
HOH
 3.441
4.176
 N
CG
 C41
O
PHE B:172 B:202 96.0 0.457 H -57.1 -44.6 96.0 0.457 0.0 2QX
HOH
 3.134
2.714
 CD2
O
 O3
O
3qz2 1 P14735 98.67 0.0 X-RAY
 2012-01-25 PHE A:173 A:202 104.0 0.495 H -50.4 -53.8 104.0 0.495 0.0 HOH
 2.272
 O
 O
PHE B:173 B:202 104.0 0.495 H -54.1 -48.0 104.0 0.495 0.0 HOH
 5.475
 CZ
 O
4dtt 1 P14735 98.67 0.0 X-RAY
 2013-02-27 PHE A:173 A:202 102.0 0.486 H -49.2 -49.8 102.0 0.486 0.0 I41
HOH
 8.663
4.263
 CD2
CB
 C25
O
PHE B:173 B:202 101.0 0.481 H -47.5 -49.2 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
 2013-12-18 PHE A:173 A:202 95.0 0.452 H -42.7 -49.9 95.0 0.452 0.0 HOH
 4.536
 CB
 O
PHE B:173 B:202 99.0 0.471 H -41.9 -48.6 99.0 0.471 0.0 HOH
 4.417
 CG
 O
4iof 1 P14735 98.67 0.0 X-RAY
 2013-07-24 PHE A:173 A:202 78.0 0.371 H -48.2 -53.3 78.0 0.371 0.0
PHE B:173 NA:NA DO NA DO DO DO NA NA NA
4re9 1 P14735 98.67 0.0 X-RAY
 2015-09-30 PHE A:173 A:202 97.0 0.462 H -53.8 -50.2 97.0 0.462 0.0 PEG
PEG
PEG
HOH
 3.835
2.746
9.922
7.215
 N
CD1
CD1
CD2
 H41
H12
HO1
O
PHE B:173 B:202 97.0 0.462 H -53.8 -50.1 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
 2018-02-07 PHE A:173 A:202 86.0 0.41 H -58.1 -43.9 86.0 0.41 0.0
PHE B:173 B:202 90.0 0.429 H -62.2 -42.9 NA NA NA
PHE C:173 C:202 91.0 0.433 H -60.5 -41.1 NA NA NA
PHE D:173 D:202 95.0 0.452 H -56.2 -41.2 NA NA NA
PHE E:173 E:202 100.0 0.476 H -56.9 -42.6 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
 2017-11-22 PHE A:173 A:202 103.0 0.49 H -67.3 -50.8 50.0 0.238 0.252 C:P01308:0.252
PHE B:173 B:202 77.0 0.367 H -71.6 -45.9 32.0 0.152 0.215 D:P01308:0.214
7k1d 1 P14735 98.67 0.0 X-RAY
 2021-09-22 PHE A:173 A:202 102.0 0.486 H -41.2 -54.5 102.0 0.486 0.0 DIO
 2.776
 CG
 H1'1
PHE B:173 B:202 101.0 0.481 H -56.3 -48.7 101.0 0.481 0.0 DIO
 3.159
 CB
 H21
7k1e 1 P14735 98.67 0.0 X-RAY
 2021-09-22 PHE A:173 A:202 100.0 0.476 H -50.5 -51.0 100.0 0.476 0.0 DIO
HOH
 2.812
3.167
 CG
O
 H1'1
O
PHE B:173 B:202 101.0 0.481 H -57.4 -47.8 101.0 0.481 0.0 DIO
HOH
 2.940
2.750
 CB
O
 H21
O
7k1f 1 P14735 98.67 0.0 X-RAY
 2021-09-22 PHE A:173 A:202 102.0 0.486 H -46.3 -55.6 102.0 0.486 0.0 DIO
HOH
 2.826
2.929
 CG
O
 H1'1
O
PHE B:173 B:202 99.0 0.471 H -63.1 -44.7 99.0 0.471 0.0 DIO
HOH
 2.856
2.848
 CB
O
 H21
O
2wby 1 P14735 98.57 0.0 X-RAY
 2009-03-24 PHE A:173 A:202 106.0 0.505 H -47.2 -52.4 37.0 0.176 0.329 C:P01308:0.1
D:P01308:0.295
 HOH
 2.640
 O
 O
PHE B:173 B:202 106.0 0.505 H -47.8 -53.4 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
 2009-03-24 PHE A:173 A:202 104.0 0.495 H -56.9 -44.2 42.0 0.2 0.295 D:P01308:0.281
C:P01308:0.076
 DIO
HOH
 5.668
4.069
 N
CE1
 O1'
O
PHE B:173 B:202 113.0 0.538 H -62.1 -54.9 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
 2012-11-28 PHE A:173 A:202 101.0 0.481 H -56.0 -44.8 101.0 0.481 0.0 HOH
 2.709
 O
 O
PHE B:173 B:202 101.0 0.481 H -63.7 -46.5 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
 2010-04-14 PHE A:173 A:202 101.0 0.481 H -71.1 -40.4 60.0 0.286 0.195 C:P10147:0.195
 DIO
DIO
HOH
 3.489
6.233
7.185
 N
N
CD1
 O1
C1
O
PHE B:173 B:202 103.0 0.49 H -62.7 -47.9 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
 2010-11-17 PHE A:173 A:202 99.0 0.471 H -56.4 -50.1 99.0 0.471 0.0 DIO
 6.158
 N
 O1'
PHE B:173 B:202 108.0 0.514 H -45.0 -49.5 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
 2010-11-17 PHE A:173 A:202 103.0 0.49 H -53.7 -50.4 103.0 0.49 0.0
PHE B:173 B:202 103.0 0.49 H -54.8 -51.2 103.0 0.49 0.0
3ofi 1 P14735 98.57 0.0 X-RAY
 2010-09-08 PHE A:173 A:202 101.0 0.481 H -59.7 -49.6 101.0 0.481 0.0 HOH
 3.814
 CD1
 O
PHE B:173 B:202 103.0 0.49 H -61.5 -47.7 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
 2013-04-03 PHE A:173 A:202 100.0 0.476 H -56.5 -48.0 100.0 0.476 0.0 MGK
HOH
 6.477
5.908
 CD2
CZ
 C22
O
PHE B:173 B:202 104.0 0.495 H -59.1 -50.6 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
 2013-08-28 PHE A:173 A:202 104.0 0.495 H -61.2 -47.8 104.0 0.495 0.0 MGJ
HOH
 7.240
4.283
 CD2
CB
 C24
O
PHE B:173 B:202 110.0 0.524 H -52.3 -49.0 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
 2013-08-28 PHE A:173 A:202 108.0 0.514 H -51.6 -45.4 108.0 0.514 0.0 MGW
HOH
 7.087
3.690
 CD2
CE1
 C22
O
PHE B:173 B:202 106.0 0.505 H -53.5 -41.4 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
 2013-08-28 PHE A:173 A:202 105.0 0.5 H -57.0 -47.7 105.0 0.5 0.0 MGH
HOH
 6.573
3.858
 CD2
CA
 C28
O
PHE B:173 B:202 103.0 0.49 H -56.3 -47.1 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
 2014-08-06 PHE A:173 A:202 77.0 0.367 H -75.4 -39.5 39.0 0.186 0.181 G:P05067:0.181
PHE B:173 B:202 89.0 0.424 H -68.5 -47.9 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
 2015-10-07 PHE A:173 A:202 102.0 0.486 H -56.7 -46.8 102.0 0.486 0.0 PEG
HOH
 3.325
6.760
 CE1
N
 H42
O
PHE B:173 B:202 102.0 0.486 H -57.7 -48.9 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
 2015-05-13 PHE A:173 A:202 101.0 0.481 H -51.2 -47.3 101.0 0.481 0.0 33K
 7.982
 CD2
 C23
PHE B:173 B:202 96.0 0.457 H -52.4 -58.4 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
 2015-05-13 PHE A:173 A:202 95.0 0.452 H -58.6 -46.2 56.0 0.267 0.185 C:P13236:0.186
 HOH
 7.646
 N
 O
PHE B:173 B:202 80.0 0.381 H -59.4 -46.0 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
 2016-07-20 PHE A:173 A:202 92.0 0.438 H -62.2 -40.2 71.0 0.338 0.1 D:P01308:0.1
5wob 1 P14735 98.57 0.0 X-RAY
 2018-04-18 PHE A:173 A:202 84.0 0.4 H -66.7 -55.7 17.0 0.081 0.319 I:P01308:0.319
PHE B:173 B:202 92.0 0.438 H -68.0 -55.4 92.0 0.438 0.0
PHE C:173 C:202 90.0 0.429 H -67.2 -56.8 NA NA NA
PHE D:173 D:202 90.0 0.429 H -65.1 -53.4 NA NA NA
PHE E:173 E:202 92.0 0.438 H -66.3 -54.4 NA NA NA
PHE F:173 F:202 90.0 0.429 H -66.3 -52.7 NA NA NA
PHE G:173 G:202 95.0 0.452 H -70.1 -56.9 NA NA NA
PHE H:173 H:202 91.0 0.433 H -66.0 -57.3 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
 2009-12-08 PHE A:160 A:202 105.0 0.5 H -50.5 -50.1 63.0 0.3 0.2 C:P10997:0.2
 HOH
 2.560
 O
 O
PHE B:160 B:202 103.0 0.49 H -50.6 -47.9 NA NA NA
6b70 1 P14735 98.86 0.0 EM
 2017-12-27 PHE A:157 A:202 88.0 0.419 H -62.5 -46.1 39.0 0.186 0.233 G:P01308:0.233
PHE B:157 B:202 78.0 0.371 H -61.5 -45.0 34.0 0.162 0.209 H:P01308:0.21
6b7y 1 P14735 98.86 0.0 EM
 2017-11-08 PHE A:157 A:202 69.0 0.329 H -65.0 -46.3 69.0 0.329 0.0
PHE B:157 B:202 72.0 0.343 H -69.6 -40.5 72.0 0.343 0.0
6b7z 1 P14735 98.86 0.0 EM
 2018-01-10 PHE A:157 A:202 54.0 0.257 H -60.4 -52.6 54.0 0.257 0.0
PHE B:157 B:202 47.0 0.224 H -73.9 -42.9 47.0 0.224 0.0
6bf6 1 P14735 98.86 0.0 EM
 2018-02-07 PHE A:157 A:202 58.0 0.276 H -62.9 -53.1 58.0 0.276 0.0
PHE B:157 B:202 61.0 0.29 H -61.3 -57.0 61.0 0.29 0.0
6bf7 1 P14735 98.86 0.0 EM
 2018-02-07 PHE A:157 A:202 64.0 0.305 H -62.8 -51.6 64.0 0.305 0.0
PHE B:157 B:202 61.0 0.29 H -58.6 -58.7 61.0 0.29 0.0
6bf8 1 P14735 98.86 0.0 EM
 2018-04-04 PHE A:157 A:202 62.0 0.295 H -58.7 -59.0 62.0 0.295 0.0
PHE B:157 B:202 80.0 0.381 H -67.4 -40.2 80.0 0.381 0.0
6bf9 1 P14735 98.86 0.0 EM
 2018-02-07 PHE A:157 A:202 60.0 0.286 H -59.1 -58.1 60.0 0.286 0.0
PHE B:157 B:202 68.0 0.324 H -62.4 -49.2 68.0 0.324 0.0
6bfc 1 P14735 98.86 0.0 EM
 2017-12-27 PHE A:157 A:202 101.0 0.481 H -68.0 -49.2 72.0 0.343 0.138 C:P01308:0.138
PHE B:157 B:202 76.0 0.362 H -71.5 -46.2 57.0 0.271 0.091 D:P01308:0.09
3p7l 1 P35559 96.63 0.0 X-RAY
 2011-07-20 PHE A:161 A:202 101.0 0.481 H -48.0 -54.7 101.0 0.481 0.0 HOH
 3.771
 CE1
 O
3cww 1 P14735 97.34 0.0 X-RAY
 2008-11-25 PHE A:173 A:202 102.0 0.486 H -52.0 -50.8 102.0 0.486 0.0 DIO
HOH
 5.917
2.808
 N
O
 C1
O
PHE B:173 B:202 102.0 0.486 H -55.8 -51.3 102.0 0.486 0.0 DIO
HOH
 6.022
2.863
 N
O
 C1
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 PHE A:202 A:202 88.0 0.419 H -59.4 -49.3