Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr10 94291595 . C A CCDS7421.1:NM_004969.3:c.571Gag>Tag_NP_004960.2:p.191E>* Homo sapiens insulin degrading enzyme (IDE), transcript variant 1, mRNA.
pdb_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id
alphafold_id
label_asym_id
label_seq_id
label_comp_id
auth_asym_id
auth_seq_id

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
2wk3 1 P14735 98.63 0.0 X-RAY
2009-11-03 GLU A:191 A:191 57.0 0.3 H -61.1 -45.3 NA NA NA
GLU B:191 B:191 60.0 0.316 H -57.8 -50.5 60.0 0.316 0.0 HOH
3.187
OE1
O
3e4a 1 P14735 98.63 0.0 X-RAY
2009-05-19 GLU A:191 A:191 55.0 0.289 H -62.7 -41.0 55.0 0.289 0.0 ZN
HOH
9.790
3.049
N
OE2
ZN
O
GLU B:191 B:191 60.0 0.316 H -51.5 -44.7 NA NA NA
6byz 1 P14735 98.63 0.0 X-RAY
2019-04-03 GLU A:191 A:191 69.0 0.363 H -53.0 -47.4 69.0 0.363 0.0 HOH
3.094
O
O
GLU B:191 B:191 83.0 0.437 H -54.0 -47.0 NA NA NA
2g47 1 P14735 99.9 0.0 X-RAY
2006-10-24 GLU A:162 A:191 55.0 0.289 H -50.4 -43.7 55.0 0.289 0.0 HOH
2.913
O
O
GLU B:162 B:191 57.0 0.3 H -48.9 -46.8 NA NA NA
2g48 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLU A:162 A:191 53.0 0.279 H -59.3 -38.5 53.0 0.279 0.0 HOH
2.999
OE2
O
GLU B:162 B:191 62.0 0.326 H -55.1 -42.1 NA NA NA
2g49 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLU A:162 A:191 53.0 0.279 H -58.0 -39.8 53.0 0.279 0.0 HOH
2.767
OE2
O
GLU B:162 B:191 69.0 0.363 H -53.0 -42.4 NA NA NA
2g54 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLU A:162 A:191 52.0 0.274 H -57.0 -35.7 52.0 0.274 0.0 HOH
2.983
OE2
O
GLU B:162 B:191 64.0 0.337 H -58.7 -39.1 NA NA NA
2g56 1 Q5T5N2 99.9 0.0 X-RAY
2006-10-24 GLU A:162 A:191 57.0 0.3 H -54.9 -44.1 57.0 0.3 0.0 HOH
2.849
O
O
GLU B:162 B:191 57.0 0.3 H -53.1 -45.2 NA NA NA
2jbu 1 Q5T5N2 99.9 0.0 X-RAY
2007-07-03 GLU A:162 A:191 61.0 0.321 H -59.8 -49.2 61.0 0.321 0.0 HOH
9.609
CB
O
GLU B:162 B:191 63.0 0.332 H -46.5 -49.2 NA NA NA
3e50 1 P14735 99.9 0.0 X-RAY
2009-08-18 GLU A:162 A:191 57.0 0.3 H -57.4 -42.6 57.0 0.3 0.0 HOH
2.758
OE2
O
GLU B:162 B:191 61.0 0.321 H -52.8 -43.0 NA NA NA
3tuv 1 P35559 95.49 0.0 X-RAY
2011-10-26 GLU A:191 A:191 70.0 0.368 H -70.4 -18.8 70.0 0.368 0.0 HOH
5.454
OE2
O
2jg4 1 P14735 99.9 0.0 X-RAY
2007-07-03 GLU A:162 A:191 61.0 0.321 H -50.7 -50.8 61.0 0.321 0.0 HOH
3.570
OE2
O
GLU B:162 B:191 63.0 0.332 H -50.0 -44.2 NA NA NA
3p7o 1 P35559 95.39 0.0 X-RAY
2011-07-27 GLU A:191 A:191 80.0 0.421 H -56.2 -46.9 80.0 0.421 0.0
3e4z 1 Q5T5N2 98.67 0.0 X-RAY
2009-08-18 GLU A:162 A:191 63.0 0.332 H -50.8 -43.8 63.0 0.332 0.0 HOH
2.677
O
O
GLU B:162 B:191 63.0 0.332 H -55.4 -41.0 NA NA NA
4lte 1 P14735 98.57 0.0 X-RAY
2014-05-21 GLU A:150 A:191 60.0 0.316 H -53.0 -40.0 60.0 0.316 0.0 HOH
2.763
OE1
O
GLU B:150 B:191 64.0 0.337 H -52.7 -39.7 NA NA NA
6eds 1 P14735 98.57 0.0 X-RAY
2019-04-03 GLU A:150 A:191 57.0 0.3 H -51.1 -45.3 57.0 0.3 0.0
GLU B:150 B:191 60.0 0.316 H -52.7 -45.1 NA NA NA
6mq3 1 P14735 98.57 0.0 X-RAY
2019-04-03 GLU A:150 A:191 59.0 0.311 H -55.0 -46.2 59.0 0.311 0.0
GLU B:150 B:191 60.0 0.316 H -55.9 -45.8 60.0 0.316 0.0
4pes 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLU A:161 A:191 95.0 0.5 H -64.6 -34.3 95.0 0.5 0.0 HOH
9.174
CB
O
GLU B:161 B:191 93.0 0.489 H -55.6 -27.9 NA NA NA
4pf7 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLU A:161 A:191 106.0 0.558 H -60.0 -27.4 106.0 0.558 0.0 HOH
8.497
OE1
O
GLU B:161 B:191 92.0 0.484 H -53.5 -31.5 92.0 0.484 0.0 HOH
5.685
N
O
4pf9 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLU A:161 A:191 90.0 0.474 H -60.6 -28.9 90.0 0.474 0.0 HOH
7.136
C
O
GLU B:161 B:191 109.0 0.574 H -65.6 -24.6 109.0 0.574 0.0 HOH
5.716
OE1
O
4pfc 1 P14735 98.57 0.0 X-RAY
2015-06-17 GLU A:161 A:191 90.0 0.474 H -60.4 -27.8 90.0 0.474 0.0 HOH
5.844
N
O
GLU B:161 B:191 111.0 0.584 H -62.6 -31.4 111.0 0.584 0.0 HOH
2.682
OE1
O
3qz2 1 P14735 98.67 0.0 X-RAY
2012-01-25 GLU A:162 A:191 56.0 0.295 H -55.8 -51.7 56.0 0.295 0.0 HOH
3.921
CB
O
GLU B:162 B:191 72.0 0.379 H -50.4 -47.9 72.0 0.379 0.0 HOH
2.777
OE1
O
4dtt 1 P14735 98.67 0.0 X-RAY
2013-02-27 GLU A:162 A:191 52.0 0.274 H -56.8 -51.8 52.0 0.274 0.0
GLU B:162 B:191 64.0 0.337 H -42.2 -49.0 NA NA NA
4ifh 1 P14735 98.67 0.0 X-RAY
2013-12-18 GLU A:162 A:191 64.0 0.337 H -56.9 -48.7 64.0 0.337 0.0 ZN
HOH
9.984
4.518
N
CG
ZN
O
GLU B:162 B:191 64.0 0.337 H -57.6 -49.8 64.0 0.337 0.0
4iof 1 P14735 98.67 0.0 X-RAY
2013-07-24 GLU A:162 A:191 57.0 0.3 H -48.0 -53.8 57.0 0.3 0.0
GLU B:162 NA:NA DO NA DO DO DO NA NA NA
4re9 1 P14735 98.67 0.0 X-RAY
2015-09-30 GLU A:162 A:191 49.0 0.258 H -57.9 -40.1 49.0 0.258 0.0 HOH
5.059
CB
O
GLU B:162 B:191 47.0 0.247 H -58.0 -39.9 NA NA NA
5uoe 1 P14735 98.67 0.0 X-RAY
2018-02-07 GLU A:162 A:191 53.0 0.279 H -59.5 -28.7 53.0 0.279 0.0
GLU B:162 B:191 62.0 0.326 H -61.5 -22.2 NA NA NA
GLU C:162 C:191 67.0 0.353 H -61.7 -18.8 NA NA NA
GLU D:162 D:191 53.0 0.279 H -60.6 -22.9 NA NA NA
GLU E:162 E:191 44.0 0.232 H -58.9 -27.0 NA NA NA
6b3q 1 P14735 98.67 0.0 EM
2017-11-22 GLU A:162 A:191 47.0 0.247 H -77.0 -19.5 47.0 0.247 0.0
GLU B:162 B:191 55.0 0.289 H -72.6 -28.0 55.0 0.289 0.0
7k1d 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLU A:162 A:191 69.0 0.363 H -58.4 -47.6 69.0 0.363 0.0
GLU B:162 B:191 62.0 0.326 H -61.1 -40.5 62.0 0.326 0.0
7k1e 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLU A:162 A:191 69.0 0.363 H -60.1 -42.1 69.0 0.363 0.0 HOH
4.649
CB
O
GLU B:162 B:191 61.0 0.321 H -60.7 -38.9 61.0 0.321 0.0 HOH
4.693
CB
O
7k1f 1 P14735 98.67 0.0 X-RAY
2021-09-22 GLU A:162 A:191 69.0 0.363 H -61.0 -42.7 69.0 0.363 0.0 HOH
2.819
OE2
O
GLU B:162 B:191 62.0 0.326 H -64.5 -40.9 62.0 0.326 0.0 HOH
2.606
O
O
2wby 1 P14735 98.57 0.0 X-RAY
2009-03-24 GLU A:162 A:191 65.0 0.342 H -47.0 -52.9 65.0 0.342 0.0 HOH
3.517
OE2
O
GLU B:162 B:191 62.0 0.326 H -60.9 -42.3 NA NA NA
2wc0 1 P14735 98.57 0.0 X-RAY
2009-03-24 GLU A:162 A:191 60.0 0.316 H -47.6 -63.9 60.0 0.316 0.0 HOH
3.164
OE1
O
GLU B:162 B:191 60.0 0.316 H -53.2 -51.4 NA NA NA
2ypu 1 P14735 98.57 0.0 X-RAY
2012-11-28 GLU A:162 A:191 54.0 0.284 H -51.7 -50.1 54.0 0.284 0.0 HOH
2.535
OE2
O
GLU B:162 B:191 62.0 0.326 H -55.2 -48.0 NA NA NA
3h44 1 P14735 98.57 0.0 X-RAY
2010-04-14 GLU A:162 A:191 70.0 0.368 H -50.8 -54.8 70.0 0.368 0.0 HOH
4.211
CB
O
GLU B:162 B:191 67.0 0.353 H -51.4 -58.2 NA NA NA
3n56 1 P14735 98.57 0.0 X-RAY
2010-11-17 GLU A:162 A:191 65.0 0.342 H -47.0 -52.5 65.0 0.342 0.0
GLU B:162 B:191 61.0 0.321 H -57.9 -44.4 NA NA NA
3n57 1 P14735 98.57 0.0 X-RAY
2010-11-17 GLU A:162 A:191 64.0 0.337 H -63.1 -43.8 64.0 0.337 0.0 ZN
9.905
N
ZN
GLU B:162 B:191 60.0 0.316 H -52.9 -53.6 60.0 0.316 0.0 HOH
9.535
OE2
O
3ofi 1 P14735 98.57 0.0 X-RAY
2010-09-08 GLU A:162 A:191 63.0 0.332 H -49.9 -46.3 63.0 0.332 0.0 HOH
3.233
OE2
O
GLU B:162 B:191 68.0 0.358 H -61.7 -44.4 NA NA NA
4dwk 1 P14735 98.57 0.0 X-RAY
2013-04-03 GLU A:162 A:191 68.0 0.358 H -56.6 -44.9 68.0 0.358 0.0 HOH
5.919
N
O
GLU B:162 B:191 57.0 0.3 H -62.2 -40.1 NA NA NA
4gs8 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLU A:162 A:191 64.0 0.337 H -57.9 -49.6 64.0 0.337 0.0 HOH
5.884
N
O
GLU B:162 B:191 62.0 0.326 H -67.1 -48.3 NA NA NA
4gsc 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLU A:162 A:191 67.0 0.353 H -54.2 -39.3 67.0 0.353 0.0 HOH
5.154
OE2
O
GLU B:162 B:191 64.0 0.337 H -53.2 -49.0 NA NA NA
4gsf 1 P14735 98.57 0.0 X-RAY
2013-08-28 GLU A:162 A:191 58.0 0.305 H -51.4 -45.4 58.0 0.305 0.0 HOH
4.239
CB
O
GLU B:162 B:191 59.0 0.311 H -54.4 -47.5 NA NA NA
4m1c 1 P14735 98.57 0.0 X-RAY
2014-08-06 GLU A:162 A:191 58.0 0.305 H -65.4 -31.2 58.0 0.305 0.0
GLU B:162 B:191 74.0 0.389 H -59.4 -25.8 NA NA NA
4nxo 1 P14735 98.57 0.0 X-RAY
2015-10-07 GLU A:162 A:191 49.0 0.258 H -55.8 -38.3 49.0 0.258 0.0 HOH
4.298
CB
O
GLU B:162 B:191 42.0 0.221 H -55.5 -40.0 NA NA NA
4qia 1 P14735 98.57 0.0 X-RAY
2015-05-13 GLU A:162 A:191 80.0 0.421 H -58.2 -33.3 80.0 0.421 0.0
GLU B:162 B:191 83.0 0.437 H -57.9 -39.1 NA NA NA
4ral 1 P14735 98.57 0.0 X-RAY
2015-05-13 GLU A:162 A:191 46.0 0.242 H -60.6 -36.9 46.0 0.242 0.0 HOH
3.395
CG
O
GLU B:162 B:191 57.0 0.3 H -59.6 -34.5 NA NA NA
5cjo 1 P14735 98.57 0.0 X-RAY
2016-07-20 GLU A:162 A:191 54.0 0.284 H -65.1 -35.4 54.0 0.284 0.0
5wob 1 P14735 98.57 0.0 X-RAY
2018-04-18 GLU A:162 A:191 58.0 0.305 H -60.3 -34.4 58.0 0.305 0.0
GLU B:162 B:191 47.0 0.247 H -62.2 -39.2 47.0 0.247 0.0
GLU C:162 C:191 63.0 0.332 H -59.9 -32.2 NA NA NA
GLU D:162 D:191 37.0 0.195 H -64.4 -32.5 NA NA NA
GLU E:162 E:191 44.0 0.232 H -70.6 -35.3 NA NA NA
GLU F:162 F:191 60.0 0.316 H -59.3 -34.8 NA NA NA
GLU G:162 G:191 51.0 0.268 G -63.2 -34.0 NA NA NA
GLU H:162 H:191 57.0 0.3 H -60.8 -35.6 NA NA NA
3hgz 1 P14735 98.56 0.0 X-RAY
2009-12-08 GLU A:149 A:191 53.0 0.279 H -55.0 -47.6 53.0 0.279 0.0 ZN
HOH
9.765
5.904
N
N
ZN
O
GLU B:149 B:191 66.0 0.347 H -51.3 -56.1 NA NA NA
6b70 1 P14735 98.86 0.0 EM
2017-12-27 GLU A:146 A:191 38.0 0.2 H -67.9 -25.6 38.0 0.2 0.0
GLU B:146 B:191 43.0 0.226 H -65.7 -34.7 43.0 0.226 0.0
6b7y 1 P14735 98.86 0.0 EM
2017-11-08 GLU A:146 A:191 116.0 0.611 H -74.0 -38.4 116.0 0.611 0.0
GLU B:146 B:191 122.0 0.642 H -77.2 -32.2 122.0 0.642 0.0
6b7z 1 P14735 98.86 0.0 EM
2018-01-10 GLU A:146 A:191 101.0 0.532 H -71.4 -37.7 101.0 0.532 0.0
GLU B:146 B:191 107.0 0.563 H -66.0 -35.1 107.0 0.563 0.0
6bf6 1 P14735 98.86 0.0 EM
2018-02-07 GLU A:146 A:191 116.0 0.611 H -71.8 -38.8 116.0 0.611 0.0
GLU B:146 B:191 121.0 0.637 H -71.0 -38.2 121.0 0.637 0.0
6bf7 1 P14735 98.86 0.0 EM
2018-02-07 GLU A:146 A:191 119.0 0.626 H -72.1 -38.5 119.0 0.626 0.0
GLU B:146 B:191 109.0 0.574 H -69.9 -35.0 109.0 0.574 0.0
6bf8 1 P14735 98.86 0.0 EM
2018-04-04 GLU A:146 A:191 103.0 0.542 H -73.5 -35.8 103.0 0.542 0.0
GLU B:146 B:191 112.0 0.589 H -74.0 -28.9 112.0 0.589 0.0
6bf9 1 P14735 98.86 0.0 EM
2018-02-07 GLU A:146 A:191 111.0 0.584 H -70.9 -35.2 111.0 0.584 0.0
GLU B:146 B:191 108.0 0.568 H -71.5 -38.4 108.0 0.568 0.0
6bfc 1 P14735 98.86 0.0 EM
2017-12-27 GLU A:146 A:191 46.0 0.242 H -77.9 -20.0 46.0 0.242 0.0
GLU B:146 B:191 58.0 0.305 H -72.8 -27.0 58.0 0.305 0.0
3p7l 1 P35559 96.63 0.0 X-RAY
2011-07-20 GLU A:150 A:191 68.0 0.358 H -63.8 -30.7 68.0 0.358 0.0 HOH
4.469
OE2
O
3cww 1 P14735 97.34 0.0 X-RAY
2008-11-25 GLU A:162 A:191 60.0 0.316 H -51.1 -53.3 60.0 0.316 0.0 HOH
3.152
OE2
O
GLU B:162 B:191 61.0 0.321 H -49.6 -58.8 61.0 0.321 0.0 HOH
2.380
OE2
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p14735-f1 1 P14735 100.0 0.0 GLU A:191 A:191 54.0 0.284 H -59.0 -40.8