Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr11 116707108 . A C CCDS8378.1:NM_000039.1:c.220Tgg>Ggg_NP_000030.1:p.74W>G Homo sapiens apolipoprotein A-I (APOA1), mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
3k2s 1 P02647 100.0 4e-177 SOLUTION SCATTERING
 2010-04-07 TRP A:50 A:50 164.0 0.643 H -77.2 -6.4 164.0 0.643 0.0 POV
POV
POV
POV
POV
POV
 3.766
6.401
2.824
6.928
9.397
7.309
 CZ3
CD1
NE1
CZ2
CZ3
CZ3
 C214
C13
O22
C33
C218
C212
TRP B:50 B:50 146.0 0.573 T -92.9 -53.3 146.0 0.573 0.0 POV
POV
POV
POV
POV
POV
POV
 4.350
6.529
3.234
8.600
4.266
6.196
7.694
 CZ3
CZ3
CD1
CH2
N
CH2
CZ3
 C315
C316
O32
C38
C218
C26
C314
1av1 1 P02647 100.0 3e-142 X-RAY
 1998-02-04 TRP A:8 A:50 196.0 0.769 H -72.1 -52.1 175.0 0.686 0.083 D:P02647:0.082
TRP B:8 B:50 184.0 0.722 H -66.2 -24.8 128.0 0.502 0.22 C:P02647:0.22
TRP C:8 C:50 197.0 0.773 H -72.1 -52.2 175.0 0.686 0.087 B:P02647:0.086
TRP D:8 D:50 183.0 0.718 H -66.2 -24.8 126.0 0.494 0.224 A:P02647:0.224
4v6m 5 P02647 100.0 3e-142 EM
 2014-07-09 TRP E:7 A0:50 168.0 0.659 S -115.5 -144.1 168.0 0.659 0.0 PGV
PEV
PGV
PEV
PEV
 9.254
9.711
6.342
8.222
3.787
 CH2
CZ3
CZ3
CZ3
CZ3
 C34
C41
C15
C14
C19
TRP F:7 A1:50 204.0 0.8 S -137.4 -127.3 203.0 0.796 0.004 E:P02647:0.004
 PEV
PEV
PEV
PEV
 4.452
9.250
9.478
6.747
 CZ2
CH2
CZ2
NE1
 C21
C25
C26
C18
6pts 1 P02647 100.0 2e-140 NMR
 2020-05-13 TRP A:7 A:207 171.0 0.671 H -66.4 -40.1 156.0 0.612 0.059 C:P01116:0.059
 PCW
PCW
 7.493
7.960
 HE1
O
 C13
C28
TRP B:7 C:405 177.0 0.694 H -59.4 -33.5 177.0 0.694 0.0 17F
PCW
PCW
 9.509
9.188
7.465
 N
HE1
HE1
 C30
C25
C40
6ptw 1 P02647 100.0 2e-140 NMR
 2020-05-13 TRP A:7 A:207 166.0 0.651 H -60.8 -34.7 140.0 0.549 0.102 D:P04049:0.102
 PCW
PCW
PCW
 8.309
9.412
9.016
 HE1
O
H
 C13
C28
C28
TRP B:7 C:405 158.0 0.62 H -59.5 -38.6 158.0 0.62 0.0 17F
PCW
PCW
 8.888
7.115
8.229
 N
CZ2
CH2
 C30
C44
C25
2msc 1 P02647 100.0 4e-140 NMR
 2015-06-03 TRP A:9 A:207 182.0 0.714 H -65.6 -35.5 182.0 0.714 0.0
TRP B:9 C:405 160.0 0.627 H -69.7 -26.3 160.0 0.627 0.0 PCW
PCW
 4.683
8.916
 CZ2
CZ2
 C39
C36
2msd 1 P02647 100.0 4e-140 NMR
 2015-06-03 TRP A:9 A:207 172.0 0.675 H -66.6 -30.6 172.0 0.675 0.0 PCW
PCW
 8.758
8.868
 NE1
O
 C14
C28
TRP B:9 C:405 180.0 0.706 H -60.8 -38.1 180.0 0.706 0.0 PCW
PCW
 7.892
8.800
 NE1
CZ2
 C40
C35
2mse 1 P02647 100.0 4e-140 NMR
 2015-06-03 TRP A:9 A:207 164.0 0.643 H -68.5 -26.3 164.0 0.643 0.0 PCW
PCW
PCW
 7.984
8.500
9.921
 CZ2
CH2
N
 C40
C19
C28
TRP B:9 C:405 142.0 0.557 H -65.5 -29.2 142.0 0.557 0.0 PCW
PCW
 3.363
6.940
 NE1
CZ2
 C39
C37
6cc9 1 P02647 100.0 4e-140 NMR
 2018-09-05 TRP A:9 A:207 182.0 0.714 H -58.3 -41.7 182.0 0.714 0.0 PCW
 8.242
 CZ2
 C40
TRP C:9 C:405 184.0 0.722 H -64.7 -33.9 184.0 0.722 0.0 PCW
 9.767
 NE1
 C37
6cch 1 P02647 100.0 4e-140 NMR
 2018-08-29 TRP A:9 A:207 159.0 0.624 H -68.5 -26.3 159.0 0.624 0.0 PCW
 9.427
 CZ3
 C14
TRP C:9 C:405 142.0 0.557 H -65.5 -29.2 142.0 0.557 0.0
6ccx 1 P02647 100.0 4e-140 NMR
 2018-09-05 TRP A:9 A:207 176.0 0.69 H -63.0 -28.8 176.0 0.69 0.0 PCW
 8.828
 NE1
 C16
TRP C:9 C:405 176.0 0.69 H -66.1 -31.8 176.0 0.69 0.0 PCW
 8.195
 CZ2
 C36
6w4e 1 P02647 100.0 4e-140 NMR
 2020-04-15 TRP A:9 A:207 160.0 0.627 H -71.1 -32.9 160.0 0.627 0.0 PCW
PCW
PCW
 9.168
9.172
8.328
 HE1
HE1
H
 C14
C28
C28
TRP B:9 D:405 165.0 0.647 H -66.1 -26.7 165.0 0.647 0.0 17F
PCW
PCW
PCW
 7.234
8.830
6.729
9.719
 CZ2
HE1
CZ2
CH2
 C30
C25
C40
C25
6w4f 1 P02647 100.0 4e-140 NMR
 2020-04-29 TRP A:9 A:207 158.0 0.62 H -60.0 -35.1 158.0 0.62 0.0 PCW
PCW
 9.024
9.153
 HE1
H
 C14
C28
TRP B:9 D:405 195.0 0.765 H -65.7 -35.6 195.0 0.765 0.0 17F
PCW
PCW
PCW
 9.061
9.051
6.557
8.700
 HE1
HE1
HE1
CZ2
 C30
C25
C42
C25
7rsc 2 P02647 100.0 4e-140 NMR
 2021-09-22 TRP C:9 NA:NA DO NA DO DO DO NA NA NA
TRP D:9 NA:NA DO NA DO DO DO NA NA NA
7rse 2 P02647 100.0 4e-140 NMR
 2021-09-22 TRP C:9 NA:NA DO NA DO DO DO NA NA NA
TRP D:9 NA:NA DO NA DO DO DO NA NA NA
3r2p 1 P02647 100.0 4e-132 X-RAY
 2011-09-21 TRP A:51 A:50 75.0 0.294 -61.7 -50.9 5.0 0.02 0.274 A:P02647:0.275
 HOH
 3.499
 NE1
 O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p02647-f1 1 P02647 100.0 0.0 TRP A:74 A:74 184.0 0.722 H -77.3 -38.5