Variant

Genome Chromosome Position VCF ID Ref Alt mRNA Change mRNA Info
GRCh37 chr11 67166306 . A C CCDS8160.1:NM_002708.3:c.769Ttc>Gtc_NP_002699.1:p.257F>V Homo sapiens protein phosphatase 1 catalytic subunit alpha (PPP1CA), transcript variant 1, mRNA.
pdb_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 
alphafold_id: 
label_asym_id: 
label_seq_id: 
label_comp_id: 
auth_asym_id: 
auth_seq_id: 

PDB

Entity Residue Monomer BioUnit Ligand View
PDB Entity Uniprot Identity Evalue ExpMethod Date Name Label Auth ASA rASA SS φ ψ ASA rASA ΔASA Interaction Name Distance Atom(p) Atom(l)
1fjm 1 P08129 100.0 0.0 X-RAY
 1996-06-20 PHE A:257 A:257 49.0 0.233 E -88.9 152.9 49.0 0.233 0.0 BME
HOH
 3.452
3.685
 CE1
CB
 C2
O
PHE B:257 B:257 46.0 0.219 E -80.2 164.3 NA NA NA
4g9j 1 P62136 100.0 0.0 X-RAY
 2012-09-19 PHE A:258 A:257 59.0 0.281 E -85.2 152.8 47.0 0.224 0.057 C:None:0.057
 HOH
 4.091
 O
 O
PHE B:258 B:257 73.0 0.348 E -91.7 145.6 NA NA NA
6g0i 1 P62136 100.0 0.0 X-RAY
 2018-11-21 PHE A:258 A:257 61.0 0.29 E -85.2 159.8 61.0 0.29 0.0 HOH
 2.826
 N
 O
6g0j 1 P62136 100.0 0.0 X-RAY
 2018-11-21 PHE A:258 A:257 58.0 0.276 E -83.6 162.2 58.0 0.276 0.0 HOH
 2.901
 N
 O
5zqv 1 P62137 99.7 0.0 X-RAY
 2019-03-13 PHE A:257 A:257 72.0 0.343 E -83.9 165.1 53.0 0.252 0.091 E:Q16821:0.09
PHE B:257 B:257 71.0 0.338 E -84.1 164.7 NA NA NA
PHE C:257 C:257 73.0 0.348 E -86.9 154.9 53.0 0.252 0.096 H:Q16821:0.095
PHE D:257 D:257 76.0 0.362 E -87.5 161.6 NA NA NA
6dcx 1 P62136 100.0 0.0 X-RAY
 2019-05-15 PHE A:266 A:257 75.0 0.357 E -85.8 154.3 21.0 0.1 0.257 D:Q8WUF5:0.257
PHE B:266 B:257 72.0 0.343 E -85.4 155.7 NA NA NA
6zk6 1 P62136 99.7 0.0 X-RAY
 2020-11-18 PHE A:258 A:257 58.0 0.276 E -87.5 155.9 58.0 0.276 0.0 HOH
 2.765
 O
 O
3egg 1 P62136 100.0 0.0 X-RAY
 2010-03-23 PHE A:256 A:257 68.0 0.324 E -78.6 154.4 45.0 0.214 0.11 C:O35274:0.11
 HOH
 2.710
 O
 O
PHE B:256 B:257 70.0 0.333 E -80.1 158.8 NA NA NA
3egh 1 P62136 100.0 0.0 X-RAY
 2010-03-23 PHE A:256 A:257 66.0 0.314 E -83.7 156.0 43.0 0.205 0.109 C:O35274:0.11
 HOH
 2.743
 N
 O
PHE B:256 B:257 69.0 0.329 E -81.3 156.8 NA NA NA
3hvq 1 P62136 100.0 0.0 X-RAY
 2010-03-23 PHE A:256 A:257 62.0 0.295 E -81.4 159.2 41.0 0.195 0.1 C:O35867:0.1
 HOH
 2.786
 O
 O
PHE B:256 B:257 58.0 0.276 E -77.3 158.0 37.0 0.176 0.1 D:O35867:0.1
 GOL
HOH
 6.162
2.807
 O
O
 O1
O
6ghm 1 P62136 100.0 0.0 X-RAY
 2019-02-27 PHE A:256 A:257 91.0 0.433 E -82.2 155.1 30.0 0.143 0.29 D:Q13625:0.29
 EDO
GOL
HOH
 3.984
2.997
3.430
 O
N
CB
 O2
O3
O
PHE B:256 B:257 86.0 0.41 E -82.5 160.1 NA NA NA
3v4y 1 P62136 100.0 0.0 X-RAY
 2012-10-31 PHE A:256 A:257 74.0 0.352 E -82.4 159.9 57.0 0.271 0.081 B:Q12972:0.081
 HOH
 1.806
 H
 O
PHE C:256 C:257 64.0 0.305 E -80.7 157.7 NA NA NA
PHE E:256 E:257 67.0 0.319 E -81.7 162.8 NA NA NA
PHE G:256 G:257 74.0 0.352 E -75.1 159.8 NA NA NA
3n5u 1 P62136 100.0 0.0 X-RAY
 2010-08-11 PHE A:257 A:257 67.0 0.319 E -92.5 153.7 49.0 0.233 0.086 C:P06400:0.086
PHE B:257 B:257 67.0 0.319 E -91.8 153.3 67.0 0.319 0.0
6obn 1 P62136 100.0 0.0 X-RAY
 2019-09-18 PHE A:262 A:257 73.0 0.348 E -90.4 162.4 73.0 0.348 0.0 MPD
HOH
 3.823
4.048
 CE1
O
 CM
O
PHE B:262 B:257 78.0 0.371 E -88.6 165.7 NA NA NA
6obp 1 P62136 100.0 0.0 X-RAY
 2019-09-18 PHE A:262 A:257 62.0 0.295 E -98.0 154.3 62.0 0.295 0.0
6zej 1 P62136,Q4VY12 100.0 0.0 X-RAY
 2020-09-30 PHE A:256 D:256 45.0 0.214 E -88.6 160.0 45.0 0.214 0.0 HOH
 3.587
 C
 O
PHE B:256 A:256 47.0 0.224 E -87.8 153.9 NA NA NA
PHE C:256 F:256 49.0 0.233 E -87.0 158.6 NA NA NA
PHE D:256 I:256 47.0 0.224 E -78.0 169.4 NA NA NA
PHE E:256 L:256 70.0 0.333 E -86.1 158.0 NA NA NA
PHE F:256 O:256 49.0 0.233 E -90.7 159.6 NA NA NA
6zeh 1 P62136,Q13813 100.0 0.0 X-RAY
 2020-09-30 PHE A:256 A:257 78.0 0.371 E -83.2 156.8 63.0 0.3 0.071 B:Q4VY12:0.071
 HOH
 2.099
 H
 O
PHE C:256 B:257 65.0 0.31 E -83.9 156.5 NA NA NA
1it6 1 P36873 90.66 0.0 X-RAY
 2002-05-22 PHE A:257 A:257 78.0 0.371 E -84.0 147.4 78.0 0.371 0.0 HOH
 2.770
 N
 O
PHE B:257 B:257 55.0 0.262 E -84.4 153.1 NA NA NA
1jk7 1 P36873 90.66 0.0 X-RAY
 2001-08-15 PHE A:257 A:257 72.0 0.343 E -88.2 147.0 72.0 0.343 0.0 SO4
BME
BME
HOH
 4.631
3.753
7.339
2.886
 O
CD2
CE1
N
 O2
O1
C1
O
2bcd 1 P36873 90.66 0.0 X-RAY
 2006-01-17 PHE A:257 A:257 72.0 0.343 E -88.1 148.2 72.0 0.343 0.0 MN
MN
HOH
 5.676
4.309
3.614
 O
CB
C
 MN
MN
O
2bdx 1 P36873 90.66 0.0 X-RAY
 2006-01-17 PHE A:257 A:257 69.0 0.329 E -88.1 143.8 69.0 0.329 0.0 HOH
 3.555
 C
 O
4ut2 1 P36873 90.66 0.0 X-RAY
 2015-07-22 PHE A:257 A:257 69.0 0.329 E -86.0 154.3 69.0 0.329 0.0 HOH
 2.752
 N
 O
PHE B:257 B:257 70.0 0.333 E -86.4 153.9 NA NA NA
4ut3 1 P36873 90.66 0.0 X-RAY
 2015-07-22 PHE A:257 A:257 51.0 0.243 E -79.2 150.8 51.0 0.243 0.0 HOH
 2.883
 N
 O
4ut3 2 P36873 90.66 0.0 X-RAY
 2015-07-22 PHE B:257 B:257 78.0 0.371 E -79.6 152.9 NA NA NA
4v0u 2 P63087 90.66 0.0 X-RAY
 2015-03-25 PHE D:257 D:257 64.0 0.305 E -85.1 154.4 NA NA NA
PHE F:257 F:257 61.0 0.29 E -85.1 154.5 NA NA NA
PHE H:257 H:257 63.0 0.3 E -85.1 154.4 NA NA NA
PHE J:257 J:257 63.0 0.3 E -85.3 154.5 48.0 0.229 0.071 K:Q5SWA1:0.071
PHE N:257 N:257 64.0 0.305 E -85.0 154.4 NA NA NA
2o8a 1 P63088 90.63 0.0 X-RAY
 2007-07-17 PHE A:263 A:257 69.0 0.329 E -88.7 156.3 48.0 0.229 0.1 B:Q9DCL8:0.1
 HOH
 2.916
 N
 O
PHE C:263 B:257 76.0 0.362 E -93.3 156.7 NA NA NA
2o8g 1 P63088 90.63 0.0 X-RAY
 2007-07-17 PHE A:263 A:257 64.0 0.305 E -85.0 157.4 43.0 0.205 0.1 B:Q9DCL8:0.1
 HOH
 2.880
 N
 O
PHE C:263 B:257 74.0 0.352 E -84.6 155.9 NA NA NA
6zeg 1 P62136,Q9UQB8 100.0 0.0 X-RAY
 2020-09-30 PHE A:256 A:257 79.0 0.376 E -85.6 157.4 61.0 0.29 0.086 B:Q4VY12:0.086
 HOH
 2.094
 H
 O
PHE C:256 B:257 63.0 0.3 E -83.5 158.6 NA NA NA
6zei 1 P62136,Q9UQB8 100.0 0.0 X-RAY
 2020-09-30 PHE A:256 A:257 77.0 0.367 E -86.4 155.4 61.0 0.29 0.077 B:Q4VY12:0.076
 GOL
HOH
 4.299
2.048
 O
H
 O3
O
PHE C:256 B:257 62.0 0.295 E -83.8 157.2 NA NA NA
3e7a 1 P62136 99.66 0.0 X-RAY
 2008-11-04 PHE A:256 A:257 47.0 0.224 E -84.7 156.1 47.0 0.224 0.0 IOD
IOD
IOD
HOH
 9.797
4.160
3.879
2.672
 C
CE2
CB
O
 I
I
I
O
PHE B:256 B:257 51.0 0.243 E -86.2 156.7 NA NA NA
3e7b 1 P62136 99.66 0.0 X-RAY
 2008-11-04 PHE A:256 A:257 46.0 0.219 E -84.5 159.6 46.0 0.219 0.0 AZI
AZI
HOH
 4.420
3.709
2.638
 O
CB
O
 N1
N2
O
PHE B:256 B:257 46.0 0.219 E -84.4 156.4 NA NA NA
4mov 1 P62136 99.66 0.0 X-RAY
 2014-03-26 PHE A:256 A:257 51.0 0.243 E -84.7 157.3 51.0 0.243 0.0 HOH
 2.866
 O
 O
PHE B:256 B:257 52.0 0.248 E -86.9 154.3 NA NA NA
4moy 1 P62136 99.66 0.0 X-RAY
 2014-03-26 PHE A:256 A:257 65.0 0.31 E -80.7 154.2 46.0 0.219 0.091 B:O55000:0.09
 HOH
 2.649
 O
 O
4mp0 1 P62136 99.66 0.0 X-RAY
 2014-03-26 PHE A:256 A:257 70.0 0.333 E -80.9 155.8 52.0 0.248 0.085 C:O55000:0.086
 HOH
 2.733
 N
 O
PHE B:256 C:257 66.0 0.314 E -82.2 154.8 NA NA NA
4xpn 1 P62136 99.66 0.0 X-RAY
 2015-07-01 PHE A:256 A:257 74.0 0.352 E -81.0 153.9 55.0 0.262 0.09 B:O75807:0.09
 HOH
 3.019
 N
 O
PHE C:256 C:257 72.0 0.343 E -82.0 154.1 NA NA NA
5ioh 1 P62136 99.66 0.0 X-RAY
 2016-10-05 PHE A:256 A:257 64.0 0.305 E -77.6 161.4 50.0 0.238 0.067 B:Q69YH5:0.067
 HOH
 2.786
 N
 O
PHE C:256 C:257 70.0 0.333 E -78.5 160.0 NA NA NA
6alz 1 P62136 99.66 0.0 X-RAY
 2017-11-29 PHE A:256 A:257 52.0 0.248 E -85.2 161.2 52.0 0.248 0.0 HOH
 2.722
 O
 O
PHE B:256 B:257 52.0 0.248 E -84.9 163.0 NA NA NA
6czo 1 P62136 99.66 0.0 X-RAY
 2019-01-23 PHE A:256 A:257 72.0 0.343 E -86.2 156.8 55.0 0.262 0.081 B:Q05C46:0.081
 HOH
 3.595
 CB
 O
PHE C:256 C:257 66.0 0.314 E -92.9 159.1 NA NA NA
6dno 1 P62136 99.66 0.0 X-RAY
 2019-01-23 PHE A:256 A:257 68.0 0.324 E -81.3 156.6 50.0 0.238 0.086 B:Q00756:0.086
 HOH
 2.696
 O
 O
6zee 1 P62136 99.66 0.0 X-RAY
 2020-09-30 PHE A:256 P:257 66.0 0.314 E -87.2 164.3 52.0 0.248 0.066 G:Q4VY12:0.067
 HOH
 3.601
 O
 O
PHE B:256 Q:257 95.0 0.452 E -88.7 167.1 49.0 0.233 0.219 H:Q4VY12:0.11
L:Q4VY12:0.114
 EDO
HOH
 3.255
4.022
 O
O
 HO2
O
PHE C:256 B:257 52.0 0.248 E -85.1 158.7 41.0 0.195 0.053 I:Q4VY12:0.052
 EDO
SO4
HOH
 3.418
5.387
2.144
 O
O
H
 HO2
O3
O
PHE D:256 A:257 61.0 0.29 E -87.2 158.8 49.0 0.233 0.057 J:Q4VY12:0.057
 HOH
 2.804
 HB3
 O
PHE E:256 I:257 60.0 0.286 E -92.8 161.0 42.0 0.2 0.086 K:Q4VY12:0.081
G:Q4VY12:0.01
 EDO
SO4
EDO
HOH
 9.584
4.976
3.709
2.115
 HD2
HB3
O
H
 H22
O3
HO1
O
PHE F:256 K:257 67.0 0.319 E -82.3 161.3 54.0 0.257 0.062 H:Q4VY12:0.062
 EDO
HOH
 4.419
2.325
 O
H
 HO1
O
6zef 1 P62136 99.66 0.0 X-RAY
 2020-09-30 PHE A:256 A:257 69.0 0.329 E -84.5 156.7 55.0 0.262 0.067 C:Q4VY12:0.067
 HOH
 2.062
 H
 O
PHE B:256 B:257 69.0 0.329 E -82.3 158.0 NA NA NA
5zt0 1 P62137 99.66 0.0 X-RAY
 2019-03-13 PHE A:251 A:257 64.0 0.305 E -76.7 167.6 43.0 0.205 0.1 G:Q86XI6:0.1
PHE B:251 B:257 69.0 0.329 E -82.8 160.2 NA NA NA
PHE C:251 C:257 67.0 0.319 E -83.4 160.2 NA NA NA
PHE D:251 D:257 69.0 0.329 E -81.9 159.8 NA NA NA
PHE E:251 E:257 66.0 0.314 E -75.6 164.3 NA NA NA
PHE F:251 F:257 68.0 0.324 E -74.1 156.5 NA NA NA
7nzm 2 P62139 99.66 0.0 EM
 2021-09-29 PHE B:251 B:257 55.0 0.262 B -86.3 156.9 55.0 0.262 0.0
6obq 1 P62136 99.66 0.0 X-RAY
 2019-09-18 PHE A:256 A:257 46.0 0.219 E -83.3 159.7 46.0 0.219 0.0 HOH
 2.971
 N
 O
PHE B:256 B:257 43.0 0.205 E -86.5 158.5 NA NA NA
6obr 1 P62136 99.32 0.0 X-RAY
 2019-09-18 PHE A:256 A:257 45.0 0.214 E -85.8 156.5 45.0 0.214 0.0 HOH
 3.551
 C
 O
PHE B:256 B:257 47.0 0.224 E -86.1 157.4 NA NA NA
6obs 1 P62136 99.66 0.0 X-RAY
 2019-09-18 PHE A:256 A:257 48.0 0.229 E -86.0 159.8 48.0 0.229 0.0 HOH
 3.015
 N
 O
PHE B:256 B:257 45.0 0.214 E -86.8 159.5 NA NA NA
6obu 1 P62136 99.66 0.0 X-RAY
 2019-09-18 PHE A:256 A:257 70.0 0.333 E -85.7 156.8 70.0 0.333 0.0 GOL
HOH
 3.623
2.582
 CE2
O
 O2
O
PHE B:256 B:257 52.0 0.248 E -85.1 157.4 NA NA NA
1s70 1 P62140 88.79 0.0 X-RAY
 2004-06-22 PHE A:259 A:257 88.0 0.419 E -78.2 162.4 38.0 0.181 0.238 B:Q90624:0.238
 HOH
 3.548
 N
 O
5inb 1 P36873 97.31 0.0 X-RAY
 2016-10-05 PHE A:254 A:257 63.0 0.3 E -82.2 156.4 50.0 0.238 0.062 B:Q69YH5:0.062
 GOL
HOH
 3.765
2.735
 O
O
 O1
O
5j28 1 P36873 97.31 0.0 X-RAY
 2016-10-05 PHE A:254 A:257 78.0 0.371 E -83.5 161.6 65.0 0.31 0.061 C:P46013:0.062
 HOH
 2.655
 N
 O
PHE B:254 B:257 62.0 0.295 E -77.5 156.6 NA NA NA
4v0v 1 P63087 97.62 0.0 X-RAY
 2015-03-25 PHE A:252 A:257 64.0 0.305 E -84.1 155.6 48.0 0.229 0.076 B:Q5SWA1:0.076
 HOH
 2.632
 O
 O
PHE C:252 C:257 60.0 0.286 E -83.0 154.8 NA NA NA
4v0w 1 P63087 97.62 0.0 X-RAY
 2015-03-25 PHE A:252 A:257 65.0 0.31 E -82.6 154.3 51.0 0.243 0.067 B:Q5SWA1:0.067
 HOH
 3.081
 N
 O
PHE C:252 C:257 69.0 0.329 E -83.8 154.0 NA NA NA
4v0x 1 P63087 97.62 0.0 X-RAY
 2015-03-25 PHE A:252 A:257 69.0 0.329 E -84.1 155.5 51.0 0.243 0.086 B:Q5SWA1:0.086
 HOH
 3.948
 C
 O
1u32 1 P36873 96.25 0.0 X-RAY
 2004-08-17 PHE A:252 A:257 69.0 0.329 E -90.1 145.9 69.0 0.329 0.0 BME
HOH
 6.016
3.077
 CE1
N
 O1
O

AlphaFold DB

Entity Residue Monomer View
ID Entity Uniprot Identity Evalue Name Label Auth ASA rASA SS φ ψ
af-p62136-f1 1 P62136 100.0 0.0 PHE A:257 A:257 65.0 0.31 E -87.3 143.7
af-p36873-f1 1 P36873 90.66 0.0 PHE A:257 A:257 71.0 0.338 E -89.7 143.5
af-p62140-f1 1 P62140 88.79 0.0 PHE A:256 A:256 62.0 0.295 E -84.1 147.8